7,039 results match your criteria uterus included


A randomized controlled study on an integrated approach to prevent and treat re-adhesion after transcervical resection of moderate-to-severe intrauterine adhesions.

Clinics (Sao Paulo) 2021 5;76:e1987. Epub 2021 May 5.

Department of Obstetrics and Gynecology, Nanping People's Hospital to Fujian University of Traditional Chinese Medicine, Nanping 353000, Fujian, China.

Objectives: This study aims to compare the clinical efficacy of an integrated approach to prevent and treat the recurrence of moderate-to-severe intrauterine adhesions (IUA) after hysteroscopic transcervical resection of adhesion (TCRA).

Methods: The study included a total of 70 patients with moderate-to-severe IUAs who underwent TCRA. Patients were randomly divided into two groups: treatment group (n=35) and control group n=35). Read More

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Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy Experience in Peritoneal Carcinomatosis: Single-Center Analysis of 180 Cases.

Int J Surg Oncol 2021 22;2021:8851751. Epub 2021 Apr 22.

Department of Surgical Oncology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.

Background: In peritoneal carcinomatosis (PC), increased life span and disease-free survival times are shown in patients with hyperthermic intraperitoneal chemotherapy (HIPEC) and early postoperative intraperitoneal chemotherapy (EPIC) following cytoreductive surgery (SRC). In this study, our main objective was to present our experience of performing SRC and perioperative intraperitoneal chemotherapy (HIPEC and EPIC) on patients with PC, in light of the literature.

Methods: Demographic data, follow-up results, peritoneal carcinomatosis index (PCI), completeness of cytoreduction (CCR) score, and morbidity and mortality rates of 180 patients treated with SRC + HIPEC + EPIC for PC at the Department of Surgical Oncology at Sivas Cumhuriyet University between January 2008 and July 2020 were analyzed retrospectively. Read More

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Diode Laser Hysteroscopic Metroplasty for Dysmorphic Uterus: a Pilot Study.

Reprod Sci 2021 May 8. Epub 2021 May 8.

Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel.

This paper aims to study the efficacy and safety of diode laser hysteroscopic metroplasty for dysmorphic uterus and the impact on reproductive outcomes. This is a retrospective, single-center pilot study with prospective follow-up. The study was performed at a university-affiliated, tertiary hospital. Read More

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Two-port, exteriorized uterus, fetoscopic meningomyelocele closure has fewer adverse neonatal outcomes than open hysterotomy closure.

Am J Obstet Gynecol 2021 May 3. Epub 2021 May 3.

Baylor College of Medicine Department of Obstetrics and Gynecology, Division of Fetal Therapy and Surgery, and Texas Children's Hospital Fetal Center, Houston, TX; Michael E. DeBakey Department of Surgery, Baylor College of Medicine.

Background: In-utero closure of meningomyelocele using an open hysterotomy approach is associated with preterm delivery and its attendant adverse neonatal outcomes.

Objectives: This study compares neonatal outcomes between in-utero closure of meningomyelocele using a 2-port, exteriorized uterus, fetoscopic approach and the conventional open hysterotomy approach.

Study Design: This retrospective cohort study included all consecutive patients who underwent in-utero meningomyelocele closure using open hysterotomy (n=44) or a 2- port, exteriorized uterus, fetoscopic approach (n=46) at a single institution, between 2012 and 2020. Read More

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Maternal Serum Placental Protein-13 Levels in the Prediction of Pregnancies with Abnormal Invasive Placentation.

Z Geburtshilfe Neonatol 2021 May 5. Epub 2021 May 5.

Department of Obstetrics and Gynecology, Veris delli Ponti Hospital, Scorrano, Lecce, Italy, Lecce, Italy.

Objective: To evaluate whether placental protein-13 (PP-13) measured in the serum of pregnant women could predict abnormal invasive placentation (AIP) detected by color Doppler ultrasound (US) and magnetic resonance imaging scan in addition to the routine US scan during the third trimester.

Materials And Methods: The prospective case-control study included patients subdivided in 2 groups: 42 pregnant women with a singleton pregnancy at 28-32 weeks of gestation with only suspected AIP, and 32 healthy pregnant women. The serum PP-13 levels were measured in both groups using an enzyme-linked immunosorbent assay (ELISA) method and statistically compared. Read More

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Incidence of and risk factors for vaginal cuff dehiscence following total laparoscopic hysterectomy: a monocentric hospital analysis.

Arch Gynecol Obstet 2021 May 3. Epub 2021 May 3.

Department of Gynecology and Obstetrics, Saarland University Hospital, Kirrbergerstraße 100, 66421, Homburg, Saar, Germany.

Purpose: Vaginal cuff dehiscence (VCD) is one of the major surgical complications following hysterectomy with data on incidence rates varying largely and studies assessing risk factors being sparse with contradictive results. The aim of this study was to assess the incidence rate of and risk factors for VCD in a homogenous cohort of women treated for benign uterine pathologies via total laparoscopic hysterectomy (TLH) with standardized follow-up.

Methods: All patients undergoing TLH at the Department of Gynecology and Obstetrics, Saarland University Hospital between November 2010 and February 2019 were retrospectively identified from a prospectively maintained service database. Read More

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Incidence, Management and Outcomes in Women Undergoing Peripartum Hysterectomy in a Tertiary Care Centre in India.

Cureus 2021 Mar 29;13(3):e14171. Epub 2021 Mar 29.

Department of Obstetrics and Gynaecology, Lady Hardinge Medical College, Delhi, IND.

Background Peripartum hysterectomy (PRH) is the surgical removal of the uterus performed in obstetrical complications such as uncontrolled postpartum haemorrhage (PPH), unrepairable uterine rupture, and sepsis. Its incidence has increased in recent years. The objective of this study was to review all the cases of PRH in a tertiary care teaching hospital over three years (January 2017-December 2019) to determine its incidence and analyse clinico-demographic characteristics in these women. Read More

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Peri-parturient hypocalcemia in goats: Clinical, hematobiochemical profiles and ultrasonographic measurements of postpartum uterine involution.

Vet World 2021 Mar 2;14(3):558-568. Epub 2021 Mar 2.

Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Egypt.

Background And Aim: Hypocalcemia in goats occurs around the time of parturition and is caused by decreasing level of calcium less than 10 mg/dL. This investigation characterized the hematological and biochemical profiles of peri-parturient hypocalcemia in goats and study the effects of hypocalcemia on uterine involution during the postpartum period on day 0 and then weekly postpartum (day +7, +14, +21, +28, +35, till +42).

Materials And Methods: Forty-five polyparous native breed does age 3-5 years and weighing 40-60 kg were assigned to control and hypocalcemia groups based on their health history, clinical and biochemical findings. Read More

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Gestational diabetes mellitus and risks of gynecologic cancers: Results from a nationwide Swedish twin study.

Gynecol Oncol 2021 Apr 29. Epub 2021 Apr 29.

Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China; Tianjin Center for International Collaborative Research in Environment, Nutrition and Public Health, Tianjin, China; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden. Electronic address:

Background: Type 2 diabetes has been associated with increased risk of gynecologic cancers, yet the effect of gestational diabetes mellitus (GDM) on gynecologic cancers is unclear.

Objectives: To examine associations between GDM history and subsequent gynecologic cancers in parous women, and to explore whether gestational hypertension (GH) plays a role in the associations.

Study Design: The population-based cohort study included 15,941 individuals from the Swedish Twin Registry. Read More

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Ten years of uterine rupture in an Australian tertiary hospital.

Aust N Z J Obstet Gynaecol 2021 Apr 30. Epub 2021 Apr 30.

Department of Obstetrics and Gynaecology, Westmead Hospital, Sydney, New South Wales, Australia.

Aims: Complete uterine rupture is a rare and serious complication of pregnancy. Although most commonly associated with attempted vaginal birth after caesarean (VBAC), rupture also occurs in atypical/non-VBAC cases. This retrospective, single-tertiary-institution observational study aimed to assess the prevalence and morbidity of complete uterine rupture during 2010-2020. Read More

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Clinicopathological and ultrasound features of endometrial cancer in postmenopausal women: a retrospective study in a single institute in South Korea.

Pan Afr Med J 2021 10;38:148. Epub 2021 Feb 10.

Department of Occupational and Environmental Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea.

Introduction: endometrial cancer is the most common type of cancer in the female genital tract. Most patients are diagnosed during postmenopausal periods. This study aimed to investigate the demographic characteristics as well as cutoff value of endometrial thickness and ultrasound characteristics of endometrial cancer in postmenopausal patients. Read More

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The impact of adenomyosis on IVF outcomes: a prospective cohort study.

Hum Reprod Open 2021 19;2021(2):hoab015. Epub 2021 Apr 19.

Newlife IVF, Box Hill, VIC, Australia.

Study Question: Does the presence of adenomyosis in women treated with IVF alter IVF outcomes?

Summary Answer: Adenomyosis does not significantly alter IVF outcomes when adjusted for confounding factors including maternal age and smoking status.

What Is Known Already: Studies evaluating adenomyosis and its impact on infertility, particularly when focusing on IVF, remain controversial. Many studies report that adenomyosis has a detrimental effect on IVF outcomes, however age is strongly related with both the prevalence of adenomyosis and worse reproductive outcomes. Read More

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Trends, characteristics, and outcomes of placenta accreta spectrum: A national study in the United States.

Am J Obstet Gynecol 2021 Apr 21. Epub 2021 Apr 21.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address:

Background: Although an infrequent occurrence, the placenta can adhere abnormally to the gravid uterus leading to significantly high maternal morbidity and mortality during cesarean section (CS). Contemporary national statistics related to a morbidly adherent placenta, referred to as placenta accreta spectrum (PAS), are needed.

Objective: To examine national trends, characteristics, and perioperative outcomes of women who underwent CS for PAS in the United States. Read More

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Plasma concentration and uterine and ovarian expressions of insulin-like growth factor-2 in dogs with cystic endometrial hyperplasia-pyometra.

Acta Vet Hung 2021 Apr 22. Epub 2021 Apr 22.

1Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, University of Ondokuz Mayis,Samsun, Turkey.

The objective of this study was to investigate the plasma concentrations of insulin-like growth factor-2 (IGF-2) as well as its expression in the uterus and ovary of healthy dogs and those with cystic endometrial hyperplasia (CEH)-pyometra complex. Group 1 (n = 10) included bitches with open cervix pyometra, while Group 2 (n = 7) consisted of clinically healthy bitches in dioestrus. The number of IGF-2 immunopositive interstitial cells was significantly higher in Group 1, whereas in Group 2 there were only two cases in which a few cells were IGF-2 immunopositive. Read More

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Anatomy of the sonographic post-cesarean uterus.

Arch Gynecol Obstet 2021 Apr 23. Epub 2021 Apr 23.

Department of Obstetrics and Gynecology, Buergerhospital - Dr. Senckenberg Foundation, Nibelungenallee 37-41, 60318, Frankfurt am Main, Hessen, Germany.

Purpose: We aim to describe the sonographic uterine anatomy after a cesarean section (CS), test the reproducibility of predefined measurements from the BSUM study, and report the distribution of these measurements.

Methods: This is a descriptive observational study where 200 women with a history of only one CS were recruited 12-24 months postoperatively. A 5-13 MHz micro-convex transvaginal transducer was used for the acquisition of volumetric datasets for evaluating the CS scars. Read More

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Integrated mutational landscape analysis of uterine leiomyosarcomas.

Proc Natl Acad Sci U S A 2021 Apr;118(15)

Department of Pathology, University of Brescia, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, 25100 Brescia, Italy.

Uterine leiomyosarcomas (uLMS) are aggressive tumors arising from the smooth muscle layer of the uterus. We analyzed 83 uLMS sample genetics, including 56 from Yale and 27 from The Cancer Genome Atlas (TCGA). Among them, a total of 55 Yale samples including two patient-derived xenografts (PDXs) and 27 TCGA samples have whole-exome sequencing (WES) data; 10 Yale and 27 TCGA samples have RNA-sequencing (RNA-Seq) data; and 11 Yale and 10 TCGA samples have whole-genome sequencing (WGS) data. Read More

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The attributive value of comprehensive surgical staging in clinically early-stage epithelial ovarian carcinoma: A systematic review and meta-analysis.

Gynecol Oncol 2021 Apr 10. Epub 2021 Apr 10.

Department of Gynecological Oncology, Division of Imaging and Oncology, University Medical Centre Utrecht, Utrecht, the Netherlands.

Background: Tumor positivity and upstaging rates from various surgical staging steps performed in clinically early-stage epithelial ovarian carcinoma (EOC) vary widely in literature.

Aim: To quantify tumor positivity and upstaging rates for all staging surgery steps in EOC patients. Differences between subgroups based on their clinical and histological characteristics are explored. Read More

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The efficacy of amniotic membrane-mediated sequential double-barrier therapy for the treatment of postoperative intrauterine adhesions.

Medicine (Baltimore) 2021 Apr;100(15):e25416

Department of Gynecology, Changzhou Maternal and Child Health Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.

Abstract: To study the efficacy of using amniotic membrane, balloon and intrauterine device (IUD) as barrier therapy to prevent re-adhesion after hysteroscopic adhesiolysis.A total of 45 patients diagnosed with intrauterine adhesions in Changzhou Maternal and Child Health Hospital from June 2014 to December 2017 were included in this retrospective case control study. According to different postoperative isolation barrier methods, the patients were divided into group A (Foley balloon + fresh amniotic membrane Day1 + IUD Day7) (22 cases) and group B (Foley balloon Day1 + IUD Day7) (23 cases). Read More

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The analysis of vaginal hysterectomy results depending on the uterine size.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Institute of Information Technology, Lodz University of Technology, Poland.

Objectives: Vaginal hysterectomy is one of the oldest but still rarely used minimally invasive techniques. Although new surgical methods making use of robots in laparoscopy have been introduced recently, when compared with vaginal hysterectomy, these approaches do not offer significant benefits for the patients and the doctors operating on them. The purpose of this study was a thorough analysis of vaginal removal of non-prolapsed uterus with benign pathology. Read More

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Robotic Excision of the Vagina in a 46 XX DSD Male Patient. First Pediatric Report.

Urol J 2021 04 11:6470. Epub 2021 Apr 11.

Department of Pediatric Surgery, Pediatric Urology and Urodynamics Unit, Bambino Gesù Children's Hospital, Research Institute, Palidoro, Rome, Italy.

The Disorders of Sex Differentiation (DSD) represent a wide range of congenital anomalies of the genitalia. Surgical treatment of these cases may become a challenge. We present a case of a 16-year-old boy with 46 XX DSD, SRY negative, presented with persistent dribbling incontinence, recurrent UTI and perineal pain. Read More

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Gene expression signature of endometrial samples from women with and without endometriosis.

J Minim Invasive Gynecol 2021 Apr 8. Epub 2021 Apr 8.

OmicsWay Corp., Walnut, CA, 91789, USA; I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation; Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, 141701 Moscow, Russia Federation; World-Class Research Center "Digital biodesign and personalized healthcare", Sechenov First Moscow State Medical University, Moscow, Russia.

Study Objective: to develop a prototype of complex gene expression biomarker for the diagnosis of endometriosis based on differences between molecular signatures of endometrium from women with and without endometriosis.

Design: Prospective observational cohort study. II-1. Read More

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Clinical features of congenital complete vaginal atresia combined with cervical aplasia: A retrospective study of 19 patients and literature review.

Congenit Anom (Kyoto) 2021 Apr 8. Epub 2021 Apr 8.

Gynecologic Department, West China Second Hospital of Sichuan University, Chengdu, Sichuan, China.

Congenital vaginal atresia is a rare congenital reproductive tract abnormality. To assess the clinical manifestations and feasibility of preserving uterus for congenital complete vaginal atresia with cervical aplasia, nineteen cases who underwent surgical treatment in West China Second Hospital of Sichuan University were retrospectively studied. The cervical status, clinical manifestations, the rate of vaginal re-stenosis and pelvic inflammation after surgery were assessed. Read More

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Complete androgen insensitivity syndrome and risk of gonadal malignancy: systematic review.

Ann Pediatr Endocrinol Metab 2021 Mar 31;26(1):19-23. Epub 2021 Mar 31.

Interdisciplinary Group for the Study of Sex Determination and Differentiation (GIEDDS), State University of Campinas (UNICAMP), Campinas/São Paulo, Brazil.

Complete androgen insensitivity syndrome (CAIS) is a rare condition characterized by 46,XY karyotype, female external genitalia, absence of uterus, and testes located intra-abdominally, in the inguinal ring or in the labia majora. In the present study, the frequency of testicular malignancy in prepubertal and pubertal patients with CAIS who underwent gonadectomy or gonadal biopsy were evaluated. Systematic review was performed using electronic databases according to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) guidelines. Read More

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Insights into molecular pathways of endometriosis and endometriosis-related ovarian carcinoma.

Rom J Morphol Embryol 2020 Jul-Sep;61(3):739-749

Department of Morphofunctional Sciences I - Histology, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania;

Background: Endometriosis is a benign estrogen-dependent gynecological disease involving components of the female genital tract (uterus, Fallopian tubes, ovaries, large, round, and utero-sacral ligaments) and intra- and extraperitoneal regions. Since the moment of its etiopathogeny has been identified, the intrinsic capacity of endometriosis malignant transformation has been hypothesized.

Patients, Materials And Methods: Our study included a total number of 50 patients diagnosed with endometriosis (31 cases) and endometriosis-related ovarian carcinoma (EOC) (19 cases). Read More

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Malignancy in an Undescended Intra-abdominal Testis: a Single Institution Experience.

Indian J Surg Oncol 2021 Mar 7;12(1):133-138. Epub 2021 Jan 7.

Department of Surgical Oncology, Basavatarakam Indo American Cancer Hospital & Research Institute, Road No. 10, Banjara Hills, Hyderabad, Telangana 500034 India.

Cryptorchidism is one of the most common congenital anomalies of the genitourinary tract, encountered in 1% of men. The cancer risk in an ectopic testis is 40 times higher than a scrotal testis. However, not much literature is available on the management of this rare presentation of testicular cancer. Read More

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HEALTHCARE ASSOCIATED DEEP PELVIC TISSUE INFECTION AND OTHER INFECTIONS OF THE FEMALE REPRODUCTIVE TRACT IN UKRAINE.

Wiad Lek 2021 ;74(3 cz 1):406-412

SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE.

Objective: The aim: To obtain the first estimates of the current prevalence of healthcare-associated deep pelvic tissue infection and other infections of the female reproductive tract (vagina, ovaries, uterus) including chorioamnionitis, and antimicrobial resistance of causing pathogens in Ukraine.

Patients And Methods: Materials and methods: We performed a retrospective multicenter cohort study was based on surveillance data. The study population included 3,053 women's who underwent gynecological surgery or other procedures from 2017 to 2019 in 7 women hospitals in Ukraine. Read More

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Assessment of Dysfunction in the Urinary System as Well as Comfort in the Life of Women during and after Combination Therapy Due to Ovarian and Endometrial Cancer Based on the SWL, II-Q7 and UDI-6 Scales.

J Clin Med 2021 Mar 16;10(6). Epub 2021 Mar 16.

Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, 31-826 Kraków, Poland.

This work aimed to assess the influence of oncological combination therapy that was done on endometrial or ovarian cancer and how the urinary system is influenced as well as the quality of life in comparison to a group of female patients after the removal of the uterus with appendages due to endometrial cancer, which did not require the supplementation of therapy after operative treatment. The study included 87 patients with endometrial cancer, where, after the removal of the uterus, there was no need for conducting adjuvant therapy (C), as well as 92 female patients with endometrial cancer or 38 patients with ovarian cancer in whom combination therapy was conducted (group A, B). The assessment of the quality of life was conducted using the questionnaires: Satisfaction Life Scale (SWLS), Incontinence Impact Questionnaire, Short Form (IIQ-7), and Urogenital Distress Inventory (UDI-6) for three, six, nine, and 12 months after the conclusion of oncological treatment. Read More

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Diagnostic performance of preoperative MR imaging findings for differentiation of uterine leiomyoma with intraligamentous growth from subserosal leiomyoma.

Abdom Radiol (NY) 2021 Apr 2. Epub 2021 Apr 2.

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Purpose: To evaluate the diagnostic performance of MRI findings for differentiating uterine leiomyoma with intraligamentous growth, or broad ligament fibroid, from subserosal leiomyoma.

Methods: This study included 37 patients with surgically confirmed uterine smooth muscle tumors (36 leiomyomas and one smooth muscle tumor of uncertain malignant potential) with intraligamentous growth (IL) and size-matched control of 37 patients with subserosal leiomyoma (SS). Two radiologists independently evaluated eight preoperative MRI findings: tumor shape, degeneration, attachment to uterus, ovary elevation, ureter displacement, bladder deformation, rectal displacement, and separation of round ligament (RL) and uterine artery (UA). Read More

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Relationships between highly recurrent tumor suppressor alterations in 489 leiomyosarcomas.

Cancer 2021 Mar 31. Epub 2021 Mar 31.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Leiomyosarcoma (LMS) is the most common soft tissue and uterine sarcoma, but no standard therapy is available for recurrent or metastatic LMS. TP53, p16/RB1, and PI3K/mTOR pathway dysregulations are recurrent events, and some LMS express estrogen receptor (ER) and/or progesterone receptor (PR). To characterize relationships between these pathway perturbations, the authors evaluated protein expression in soft tissue and uterine nonprimary leiomyosarcoma (np-LMS), including local recurrences and distant metastases. Read More

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mRNA expression and DNA methylation level of the MMP-2 gene in peritoneal endometriosis.

J Pak Med Assoc 2021 Feb;71(Suppl 2)(2):S112-S115

Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Objective: Endometriosis is a multifactorial disease that affects 10% of women of childbearing age. Its development is known to be related to the MMP-2 gene. Specifically, the expression of MMP-2 is increase in endometriosis. Read More

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February 2021