36,458 results match your criteria users clinical


Socioeconomic Disparities and Risk Factors in Patients Presenting with Ischemic Priapism: A Multi-Institutional Study.

Urology 2021 Jul 19. Epub 2021 Jul 19.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

Objectives: To evaluate contemporary clinical presentations of priapism, their association with socioeconomic characteristics, and the role of prescribing providers in priapism episodes in a large cohort of patients managed at three major academic health systems.

Methods: We identified all consecutive patients presenting with ischemic priapism to the emergency departments of three major academic health systems (2014-2019). Demographic characteristics, priapism etiologies, and clinical management were evaluated. Read More

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International research priorities on the role of cognition in power mobility device use: In pursuit of informed clinical practices and knowledge translation.

Assist Technol 2021 Jul 22. Epub 2021 Jul 22.

Department of Rehabilitation, Université Laval, Quebec City, Quebec, Canada.

Cognition is an important factor affecting power mobility device (PMD) use. However, a gap in knowledge on the role of cognition in PMD use limits evidence of best practices for screening, assessment and training. The overall goal of this research activity was to identify strategic research priorities to delineate the next steps in research. Read More

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PrEP monitoring and HIV incidence after PrEP initiation in France: 2016-18 nationwide cohort study.

J Antimicrob Chemother 2021 Jul 22. Epub 2021 Jul 22.

INSERM U1259, Université de Tours, France.

Background: Clinical trials have demonstrated that oral pre-exposure prophylaxis (PrEP) has high efficacy in preventing HIV transmission. In many countries, HIV testing is recommended prior to PrEP initiation, 1 month after and quarterly thereafter. We assessed the uptake of HIV testing and estimated the incidence of HIV infections after oral PrEP initiation, by using the French national health database (SNDS). Read More

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Digital surveillance through an online decision support tool for COVID-19 over one year of pandemic in Italy: an observational study.

J Med Internet Res 2021 Jul 18. Epub 2021 Jul 18.

Clinical Pathways and Epidemiology Unit, Bambino Gesù Children's Hospital IRCCS, Rome, IT.

Background: Italy has experienced very severe consequences in terms of hospitalizations and deaths during the COVID-19 pandemic. Online decision support systems and self-triage applications have been used in several settings to supplement recommendations from health authorities to prevent and manage COVID-19. A digital Italian health tech startup developed a non-commercial online decision support system to assist individuals in managing their potential exposure to COVID-19 and interpret their symptoms, with a chat user interface, available since the early phases of the pandemic in Italy. Read More

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Effects of anticholinergic and sedative medication use on fractures: A self-controlled design study.

J Am Geriatr Soc 2021 Jul 22. Epub 2021 Jul 22.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Background/objectives: Unintentional falls are a leading cause of injury for older adults, and evidence is needed to understand modifiable risk factors. We evaluated 1-year fall-related fracture risk and whether dispensing of medications with anticholinergic/sedating properties is temporally associated with an increased odds of these fractures.

Design: A retrospective cohort study with nested self-controlled analyses conducted between January 1, 2014, and December 31, 2016. Read More

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Automated Insulin Delivery Systems: Today, Tomorrow and User Requirements.

J Diabetes Sci Technol 2021 Jul 22:19322968211029937. Epub 2021 Jul 22.

Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.

Automated insulin delivery (AID) is the most recent advance in type 1 diabetes (T1D) management. It has the potential to achieve glycemic targets without disabling hypoglycemia, to improve quality of life and reduce diabetes distress and burden associated with self-management. Several AID systems are currently licensed for use by people with T1D in Europe, United States, and the rest of the world. Read More

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Comparative safety of dipeptidyl peptidase-4 inhibitors and sulfonylureas among frail older adults.

J Am Geriatr Soc 2021 Jul 21. Epub 2021 Jul 21.

Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, Rhode Island, USA.

Background: Studies comparing dipeptidyl peptidase-4 inhibitors (DPP4Is) to sulfonylureas (SUs) are unavailable for frail older adults, especially nursing home (NH) residents. We examined the effects of DPP4Is versus SUs on severe adverse glycemic events, cardiovascular events, and death among NH residents.

Methods: We conducted a national retrospective cohort study of long-stay NH residents aged ≥65 years using 2008-2010 national US Minimum Data Set clinical assessment data and linked Medicare claims. Read More

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A systematic review of clinical trials on Ginkgo () effectiveness on sexual function and its safety.

Avicenna J Phytomed 2021 Jul-Aug;11(4):324-331

Clinical Instructor Mpilo School of Midwifery Zimbabwe. Zimbabwe Confederation of Midwives, Bulawayo, Zimbabwe.

Objective: During recent years, evidence-based practice as a way to support higher standards of care was emphasized by health care policymakers. Sexual dysfunction (SD) is a common problem that affects the quality of life in individuals. Today, the use of extract (GBE) for treating SD has been considered, so this study was performed to evaluate the current evidence for the efficacy and safety of ginkgo in treating SD. Read More

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November 2020

Association of Benzodiazepine Receptor Agonist Use With Changes in Psoriasis Severity in Adult Population: A Population-Based Study.

Front Pharmacol 2021 5;12:596375. Epub 2021 Jul 5.

Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan.

To date, it remains uncertain whether benzodiazepine receptor agonists (BZRAs) are aggravating factors even though these drugs can elevate the levels of biomarkers associated with the development of psoriasis. Therefore, this study aimed to investigate the association of BZRA use with changes in psoriasis severity. All data were sourced from the National Health Insurance system in Taiwan. Read More

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Assessment of antigens and CRP in dried blood spots with multiplex malaria array.

J Parasit Dis 2021 Jun 3;45(2):479-489. Epub 2021 Jan 3.

Diagnostics Program, PATH, Seattle, WA USA.

Dried blood spots (DBS) typically prepared on filter papers are an ideal sample type for malaria surveillance by offering easy and cost-effective methods in terms of sample collection, storage, and transport. The objective of this study was to evaluate the applicability of DBS with a commercial multiplex malaria assay, developed to concurrently measure antigens, histidine-rich protein 2 (HRP2), lactate dehydrogenase (pLDH), and a host inflammatory biomarker, C-reactive protein (CRP), in whole blood. The assay conditions were optimized for DBS, and thermal stability for measurement of antigens and CRP in dried blood were determined. Read More

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Contemporary issues in the implementation of lung cancer screening.

Eur Respir Rev 2021 Sep 20;30(161). Epub 2021 Jul 20.

Dept of Health Sciences, Brock University, St Catharines, ON, Canada.

Lung cancer screening with low-dose computed tomography can reduce death from lung cancer by 20-24% in high-risk smokers. National lung cancer screening programmes have been implemented in the USA and Korea and are being implemented in Europe, Canada and other countries. Lung cancer screening is a process, not a test. Read More

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September 2021

Association between the use of social networking sites and mental health of young generation in Bangladesh: A cross-sectional study.

J Community Psychol 2021 Jul 21. Epub 2021 Jul 21.

Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.

The social networking sites (SNS) are popular among people of all levels. Here we aimed to evaluate the relationship between the use of SNS and the mental health of the young generation in Bangladesh. We conducted this cross-sectional study among 791 subjects aged between 15 and 40 years. Read More

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Dual versus single long-acting bronchodilator use could raise acute coronary syndrome risk by over 50%: A population-based nested case-control study.

J Intern Med 2021 Jul 21. Epub 2021 Jul 21.

Pharmacoepidemiology Research Network, University of Otago, Dunedin, New Zealand.

Background: Coronary heart disease occurs more frequently among patients with chronic obstructive pulmonary disease (COPD) compared to those without COPD. While some research suggests that long-acting bronchodilators might confer an additional risk of acute coronary syndrome (ACS), information from real-world clinical practice about the cardiovascular impact of using two versus one long-acting bronchodilator for COPD is limited. We undertook a population-based nested case-control study to estimate the risk of ACS in users of both a long-acting muscarinic antagonist (LAMA) and a long-acting beta2-agonist (LABA) relative to users of a LAMA. Read More

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Posttraumatic Stress Disorder Symptoms and Coping Motives are Independently Associated with Cannabis Craving Elicited by Trauma Cues.

J Trauma Stress 2021 Jul 19. Epub 2021 Jul 19.

Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada.

Cannabis use is common among individuals with posttraumatic stress disorder (PTSD), although its use can ultimately worsen PTSD outcomes. Cannabis-use coping motives may help explain the PTSD-cannabis relationship. Frequent pairing of trauma cues with substance use to cope with negative affect can lead to conditioned substance craving. Read More

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Association between Use of Pharmacokinetic-Interacting Drugs and Effectiveness and Safety of Direct Acting Oral Anticoagulants: Nested Case-Control Study.

Clin Pharmacol Ther 2021 Jul 19. Epub 2021 Jul 19.

Department of Medicine, Hadassah Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel.

Concomitant use of direct oral anticoagulants (DOACs) and medications with inhibition/induction effect on P-gp/CYP3A might increase risk of bleeding/treatment failure, respectively. We designed a nested case-control study within a Clalit cohort of atrial fibrillation (AF) patients and a cohort of venous thromboembolic patients, new users of a DOAC (1.1. Read More

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Evaluation of Three Feasibility Tools for Identifying Patient Data and Biospecimen Availability: Comparative Usability Study.

JMIR Med Inform 2021 Jul 21;9(7):e25531. Epub 2021 Jul 21.

Institute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

Background: To meet the growing importance of real-word data analysis, clinical data and biosamples must be timely made available. Feasibility platforms are often the first contact point for determining the availability of such data for specific research questions. Therefore, a user-friendly interface should be provided to enable access to this information easily. Read More

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Chest X-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: an individual patient data meta-analysis of diagnostic accuracy.

Clin Infect Dis 2021 Jul 21. Epub 2021 Jul 21.

McGill International TB Centre, Research Institute of the McGill University Health Centre, Montreal, Canada.

Background: Automated radiologic analysis using computer-aided detection software (CAD) could facilitate chest X-ray (CXR) use in tuberculosis diagnosis. There is little to no evidence on the accuracy of commercially-available deep learning-based CAD in different populations, including patients with smear-negative tuberculosis and people living with HIV (PLWH).

Methods: We collected CXRs and individual patient data (IPD) from studies evaluating CAD in patients self-referring for tuberculosis symptoms with culture or nucleic acid amplification testing as the reference. Read More

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Antipsychotics Use Is Associated With Greater Adherence to Cardiometabolic Medications in Patients With Schizophrenia: Results From a Nationwide, Within-subject Design Study.

Schizophr Bull 2021 Jul 21. Epub 2021 Jul 21.

Niuvanniemi Hospital, Kuopio,Finland.

Background: People with schizophrenia/schizoaffective disorder (schizophrenia) die early, largely due to cardiovascular-related mortality. Antipsychotics are associated with lower mortality. We aimed to explore whether antipsychotic use can reduce discontinuation of medications for cardiovascular risk factors and diseases ("cardiometacolic drugs"), using a within-study design controlling for subject-related factors. Read More

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A Comparative Study of Efficacy and Functionality of Ten Commercially Available Wrist-Hand Orthoses in Healthy Females: Wrist Range of Motion and Grip Strength Analysis.

Front Rehabilit Sci 2021 15;2:687554. Epub 2021 Jun 15.

University of Hasselt, Belgium.

Objective: Wrist-hand orthoses (WHOs) are prescribed for a range of musculoskeletal/neurological conditions to optimise wrist/hand position at rest and enhance performance by controlling its range of motion (ROM), improving alignment, reducing pain, and optimising grip strength. The objective of this research was to study the efficacy and functionality of ten commercially available WHOs on wrist ROM and grip strength.

Design: Randomised comparative functional study of the wrist/hand with and without WHOs. Read More

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ERpred: a web server for the prediction of subtype-specific estrogen receptor antagonists.

PeerJ 2021 9;9:e11716. Epub 2021 Jul 9.

Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.

Estrogen receptors alpha and beta (ERα and ERβ) are responsible for breast cancer metastasis through their involvement of clinical outcomes. Estradiol and hormone replacement therapy targets both ERs, but this often leads to an increased risk of breast and endometrial cancers as well as thromboembolism. A major challenge is posed for the development of compounds possessing ER subtype specificity. Read More

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Understanding the information-seeking behavior of pharmacy college faculty, staff, and students: implications for improving embedded librarian services.

J Med Libr Assoc 2021 Apr;109(2):286-294

Associate Librarian, (Retired), Research & Learning, Arizona Health Sciences Library, The University of Arizona, Tucson, AZ.

Objective: Research was conducted on the embedded librarian program at The University of Arizona College of Pharmacy and the Health Sciences Library to understand how this service is relevant to users and identify the potential for further improvement. This study examined users' information-seeking behaviors and considered the implications for the effectiveness of the embedded librarian service.

Methods: The authors conducted 18 semi-structured interviews of faculty, researchers, and students at the College of Pharmacy to obtain descriptive accounts of how they seek information, manage information, and use the library and library services. Read More

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Discoverability of information on clinical trial data-sharing platforms.

J Med Libr Assoc 2021 Apr;109(2):240-247

Staff Scientist, National Institutes of Health, Bethesda, MD.

Objective: This study was intended to (1) provide clinical trial data-sharing platform designers with insight into users' experiences when attempting to evaluate and access datasets, (2) spark conversations about improving the transparency and discoverability of clinical trial data, and (3) provide a partial view of the current information-sharing landscape for clinical trials.

Methods: We evaluated preview information provided for 10 datasets in each of 7 clinical trial data-sharing platforms between February and April 2019. Specifically, we evaluated the platforms in terms of the extent to which we found (1) preview information about the dataset, (2) trial information on ClinicalTrials. Read More

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Prevalence of Cannabidiol Use in Patients With Spine Complaints: Results of an Anonymous Survey.

Int J Spine Surg 2021 Jul 20. Epub 2021 Jul 20.

Hospital for Special Surgery, Spine Service, New York, New York.

Background: Cannabidiol (CBD) is a cannabis derivative that has been popularized as a medicinal product with analgesic and anti-inflammatory effects. Given the anecdotal observations that several patients have reported use of CBD for spine-related pain, this study was designed to characterize CBD consumption patterns and perceived effects in patients with spine-related complaints.

Methods: The study design was a cross-sectional survey. Read More

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The association of phosphodiesterase-5 inhibitors with the biochemical recurrence-free and overall survival of patients with prostate cancer following radical prostatectomy.

Urol Oncol 2021 Jul 18. Epub 2021 Jul 18.

Division of Hematology/Oncology/Cell Therapy, Department of Internal Medicine, Rush University Medical Center, Chicago, IL.

Purpose: To determine whether phosphodiesterase-5 inhibitor documentation is associated with biochemical relapse-free and overall survival of patients with prostate cancer treated with radical prostatectomy.

Materials And Methods: We undertook a retrospective cohort analysis of 3,100 patients with prostate cancer treated with radical prostatectomy between 2003 and 2015. The patients were categorized as a phosphodiesterase- 5- inhibitor user or non-user. Read More

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Diagnoses and Healthcare Utilization for After-hours Telemedicine versus Primary Care Visits.

Acad Pediatr 2021 Jul 17. Epub 2021 Jul 17.

Clalit Health Services, Tel Aviv 6209804, Israel.

Objective: The use of a nation-wide, pediatricians online (PO) after-hours telemedicine service has been offered in Israel for more than a decade. We sought to compare PO visits with those to the primary care pediatrician (PCP).

Methods: This is a retrospective cross-sectional study using Israel's largest health care provider database. Read More

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Appetitive Motivation and Regulatory Processes in Adolescent Ketamine Users.

Subst Use Misuse 2021 Jul 20:1-8. Epub 2021 Jul 20.

Department of Psychology, Chung Shan Medical University, Taichung, Taiwan.

Background: Ketamine has remained the most commonly used illicit drug among adolescents in Taiwan. A dual process model proposes that addictive behaviors develop in adolescents as a result of an imbalance between an appetitive, approach-oriented system (implicit and explicit attitudes) and a regulatory executive system (cool and hot executive functions). We aimed to examine the appetitive and regulatory processes in adolescent ketamine users in comparison to matched healthy adolescents. Read More

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EXPRESS: Prehemorrhage antiplatelet use in aneurysmal subarachnoid hemorrhage and impact on clinical outcome.

Int J Stroke 2021 Jul 20:17474930211035647. Epub 2021 Jul 20.

University Hospital Zurich, Department of Neurosurgery, Zurich, Switzerland.

Background: Literature is inconclusive regarding the association between antiplatelet agents use and outcome after aneurysmal subarachnoid hemorrhage (aSAH).

Aims: To investigate the association between clinical outcome and prehemorrhage use in aSAH patients as well as the impact of thrombocyte transfusion on rebleed and clinical outcome.

Methods: Data were collected from prospective databases of two European tertiary reference centers for aSAH patients. Read More

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Adverse events of recreational cannabis use reported to the French addictovigilance network (2012-2017).

Br J Clin Pharmacol 2021 Mar 16. Epub 2021 Mar 16.

Addictovigilance Center, Department of Clinical Pharmacology, Poitiers University Hospital, France.

Aims: To describe the adverse events (AEs) of recreational cannabis use in France between 2012 and 2017.

Methods: AEs related to recreational cannabis use, alone or in combination with alcohol and/or tobacco reported to the French Addictovigilance Network were analysed (excluding cannabidiol and synthetic cannabinoids).

Results: Reporting of AEs tripled between 2012 (n = 179, 6. Read More

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Why Is the Electronic Health Record So Challenging for Research and Clinical Care?

Methods Inf Med 2021 Jul 19. Epub 2021 Jul 19.

Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States.

Background:  The electronic health record (EHR) has become increasingly ubiquitous. At the same time, health professionals have been turning to this resource for access to data that is needed for the delivery of health care and for clinical research. There is little doubt that the EHR has made both of these functions easier than earlier days when we relied on paper-based clinical records. Read More

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Health workers' perspectives of a mobile health tool to improve diagnosis and management of paediatric acute respiratory illnesses in Uganda: a qualitative study.

BMJ Open 2021 Jul 19;11(7):e049708. Epub 2021 Jul 19.

Makerere University Lung Institute, Makerere University College of Health Sciences, Kampala, Uganda.

Objectives: Mobile health tools have potential to improve the diagnosis and management of acute lower respiratory illnesses (ALRI), a leading cause of paediatric mortality worldwide. The objectives were to evaluate health workers' perceptions of acceptability, usability and feasibility of Acute Lower Respiratory Illness Treatment and Evaluation (ALRITE), a novel mobile health tool to help frontline health workers diagnose, treat and provide education about ALRI in children <5 years.

Design: A qualitative study including semistructured interviews with health facility administrators and focus groups with primary care health workers. Read More

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