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iNetModels 2.0: an interactive visualization and database of multi-omics data.

Nucleic Acids Res 2021 Apr 13. Epub 2021 Apr 13.

Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm SE-171 21, Sweden.

It is essential to reveal the associations between various omics data for a comprehensive understanding of the altered biological process in human wellness and disease. To date, very few studies have focused on collecting and exhibiting multi-omics associations in a single database. Here, we present iNetModels, an interactive database and visualization platform of Multi-Omics Biological Networks (MOBNs). Read More

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Expasy, the Swiss Bioinformatics Resource Portal, as designed by its users.

Nucleic Acids Res 2021 Apr 13. Epub 2021 Apr 13.

SIB Swiss Institute of Bioinformatics, Quartier Sorge - Bâtiment Amphipôle, CH-1015 Lausanne, Switzerland.

The SIB Swiss Institute of Bioinformatics (https://www.sib.swiss) creates, maintains and disseminates a portfolio of reliable and state-of-the-art bioinformatics services and resources for the storage, analysis and interpretation of biological data. Read More

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Residual Hearing Affects Contralateral Routing of Signals in Cochlear Implant Users.

Audiol Neurootol 2021 Apr 13:1-8. Epub 2021 Apr 13.

Department of Otorhinolaryngology, Leiden University Medical Center, Leiden, The Netherlands.

Introduction: Contralateral routing of signals (CROS) can be used to eliminate the head shadow effect. In unilateral cochlear implant (CI) users, CROS can be achieved with placement of a microphone on the contralateral ear, with the signal streamed to the CI ear. CROS was originally developed for unilateral CI users without any residual hearing in the nonimplanted ear. Read More

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Long-Term Medical Therapy after Laparoscopic Excision of Ovarian Endometriomas: Can We Reduce and Predict the Risk of Recurrence?

Gynecol Obstet Invest 2021 Apr 13:1-7. Epub 2021 Apr 13.

Gynecology and Human Reproduction Physiopathology, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Objectives: Up to 32% of women experience anatomic recurrence after conservative surgery for endometriomas, while pain recurs in 10-40% of cases. Long-term postoperative hormonal therapy is recommended to prevent disease recurrence. We evaluated the efficacy of long-term therapy with estroprogestins (EPs) or progestins (Ps) in preventing endometrioma recurrence, as identifiable cysts and subjective symptoms, after laparoscopic excision. Read More

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Use of cannabis in patients with multiple sclerosis from Argentina.

Mult Scler Relat Disord 2021 Apr 6;51:102932. Epub 2021 Apr 6.

Neurology Department, Hospital J.M. Ramos Mejía, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.

Background: The use of cannabis to treat some symptoms of neurological diseases, including multiple sclerosis (MS), has increased worldwide. We aimed to assess the use of cannabis in patients with MS (PwMS) from Argentina, its reasons and patients' perceptions on the management of MS symptoms. Additionally, we assessed their association with socio-demographic and clinical aspects. Read More

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Toward a crowdsourcing solution to identify high-risk highway segments through mining driving jerks.

Accid Anal Prev 2021 Apr 10;155:106101. Epub 2021 Apr 10.

Gulf Coast Research Center for Evacuation and Transportation Resiliency, Louisiana State University, Baton Rouge, LA, 70803, USA. Electronic address:

Traffic crashes have become a leading cause of preventable deaths globally. Identifying high-risk segments not only benefits safety specialists to better understand crash patterns but also reminds road users to be aware of driving risks. This study reports on a new crowdsourcing solution to identify high-risk highway segments by analyzing driving jerks. Read More

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Nicotine and energy balance: A review examining the effect of nicotine on hormonal appetite regulation and energy expenditure.

Appetite 2021 Apr 10:105260. Epub 2021 Apr 10.

School of Nutrition, Ryerson University, Toronto, Ontario, Canada. Electronic address:

Nicotine has been shown to decrease appetite, food intake (FI) and body weight, but the mechanisms are unclear. The purpose of this review was to examine research on the effects of nicotine on energy balance by exploring physiological mechanisms and hormone regulation related to FI, subjective appetite and energy expenditure (EE). We searched PubMed and MEDLINE, and included articles investigating the effects of nicotine on central appetite regulation, FI, leptin, peptide-YY (PYY), ghrelin, glucagon-like peptide-1 (GLP-1), adiponectin, cholecystokinin (CCK), orexin, and EE. Read More

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Sex-Based Differences in Symptoms with Mouthguard Use Following Pediatric Sport-Related Concussion.

J Athl Train 2021 Apr 13. Epub 2021 Apr 13.

Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada.

Context: Current evidence regarding the protective effect of mouthguard use on symptom severity in children and adolescents who sustain sport-related concussions is insufficient to make clinical recommendations.

Objective: To compare the association between mouthguard-use and symptoms stratified by sex in the first 4-weeks after pediatric sport-related concussion. We hypothesized that mouthguard-use would be associated with lower symptoms. Read More

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The relationship between trauma exposure and adult tobacco use: Analysis of the National Epidemiologic Survey on Alcohol and Related Conditions (III).

Nicotine Tob Res 2021 Apr 13. Epub 2021 Apr 13.

Tobacco Control Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD.

Introduction: Previous research has examined cigarette smoking in trauma exposed populations. However, the relationships between trauma exposure and use of other tobacco products (e.g. Read More

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Progress in the implementation of massively parallel sequencing for forensic genetics: results of a European-wide survey among professional users.

Int J Legal Med 2021 Apr 13. Epub 2021 Apr 13.

Institute of Legal Medicine, Faculty of Medicine and University Clinic, University of Cologne, Melatengürtel 60/62, 50823, Cologne, Germany.

A European-wide online survey was conducted to generate an overview on the state-of-the-art using massively parallel sequencing (MPS) platforms for forensic DNA analysis and DNA phenotyping among forensic practitioners in Europe. The survey was part of the dissemination activities of the "VISible Attributes through GEnomics - VISAGE" Horizon 2020 funded European research project [30], in preparation of a series of educational training activities. A total of 105 replies from 32 European countries representing participants from police, governmental, academic, and private laboratories providing professional services in the field of forensic genetics were included in the final analysis. Read More

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Quality of health care perceived by users in Catalan prisons.

Rev Esp Sanid Penit 2021 Jan-Apr;23(1):9-19

Mas D'Enric Prison. Catalonian Institute of Health. Tarragona.

Objectives: To describe inmates' perceptions of healthcare quality in Catalonian prisons.

Material And Method: Transversal study of 6,856 inmates in Catalan prisons in September 2017. Randomized simple screening was used to randomly distribute 1,048 polls in which different aspects of perceived quality of healthcare were evaluated. Read More

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Effects of continuous positive airway pressure treatment in obstructive sleep apnea patients with atrial fibrillation: A meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25438

Department of Cardiology, First Affiliated Hospital of Zhejiang Chinese Medical University.

Background: Obstructive sleep apnea (OSA) is correlated with atrial fibrillation (AF). Over the past decade, there has been an increasing interest in the relationship between OSA with continuous positive airway pressure (CPAP) and progression or recurrence of AF.

Methods: This investigation was an analysis of studies searched in the Cochrane Library, PubMed, EMBASE, EBSCO, OVID, and Web of Science databases from inception to July 2020 to evaluate the recurrence or progression of AF in CPAP users, CPAP nonusers, and patients without OSA. Read More

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Smartphone Users' Persuasion Knowledge in the Context of Consumer mHealth Apps: Qualitative Study.

JMIR Mhealth Uhealth 2021 Apr 13;9(4):e16518. Epub 2021 Apr 13.

Department of Sociology, Anthropology, and Criminal Justice, Clemson University, Clemson, SC, United States.

Background: Persuasion knowledge, commonly referred to as advertising literacy, is a cognitive dimension that embraces recognition of advertising, its source and audience, and understanding of advertisers' persuasive and selling intents as well as tactics. There is little understanding of users' awareness of organizations that develop or sponsor mobile health (mHealth) apps, especially in light of personal data privacy. Persuasion knowledge or recognition of a supporting organization's presence, characteristics, competencies, intents, and persuasion tactics are crucial to investigate because app users have the right to know about entities that support apps and make informed decisions about app usage. Read More

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Perceptions of and Opinions on a Computerized Behavioral Activation Program for the Treatment of Depression in Young People: Thematic Analysis.

J Med Internet Res 2021 Apr 13;23(4):e19743. Epub 2021 Apr 13.

Department of Health Sciences, University of York, York, United Kingdom.

Background: Depression is one of the leading causes of illness and disability in young people, with approximately 20% having experienced a depressive episode by the age of 18 years. Behavioral activation (BA), a National Institute for Health and Care Excellence-recommended treatment for adults with depression, has shown preliminary support for its use with young people. BA may have the potential to be adapted and delivered in a computerized format to address the barriers often associated with young people accessing support. Read More

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Blockchain Personal Health Records: Systematic Review.

J Med Internet Res 2021 Apr 13;23(4):e25094. Epub 2021 Apr 13.

National University Health System, Singapore, Singapore.

Background: Blockchain technology has the potential to enable more secure, transparent, and equitable data management. In the health care domain, it has been applied most frequently to electronic health records. In addition to securely managing data, blockchain has significant advantages in distributing data access, control, and ownership to end users. Read More

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Treatment usage patterns of oral appliances for obstructive sleep apnea over the first 60 days: a cluster analysis.

J Clin Sleep Med 2021 Apr 13. Epub 2021 Apr 13.

Sleep Research Group, Charles Perkins Centre & Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.

Study Objectives: Oral appliance (OA) therapy usage can be objectively measured through temperature-sensing data chips embedded in the appliance. Initial reports of group data for short-term treatment usage suggest good nightly hours of usage. However, individual variability in treatment usage patterns has not been assessed. Read More

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A method for systematically ranking therapeutic drug candidates using multiple uncertain screening criteria.

Stat Methods Med Res 2021 Apr 13:9622802211002861. Epub 2021 Apr 13.

Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.

Multiple different screening tests for candidate leads in drug development may often yield conflicting or ambiguous results, sometimes making the selection of leads a nontrivial maximum-likelihood ranking problem. Here, we employ methods from the field of multiple criteria decision making (MCDM) to the problem of screening candidate antibody therapeutics. We employ the SMAA-TOPSIS method to rank a large cohort of antibodies using up to eight weighted screening criteria, in order to find lead candidate therapeutics for Alzheimer's disease, and determine their robustness to both uncertainty in screening measurements, as well as uncertainty in the user-defined weights of importance attributed to each screening criterion. Read More

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Case Management and Telehealth: A Scoping Review.

Telemed J E Health 2021 Apr 12. Epub 2021 Apr 12.

Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Canada.

Case management (CM) is an intervention adapted to the needs of patients with chronic conditions or complex needs. Factors associated with effectiveness of CM, such as high intervention intensity, can represent challenges to its implementation. Telehealth has the potential to help overcome these challenges, but little work has been done to synthesize available evidence on telehealth CM. Read More

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Quantitative Three-dimensional Assessment of Knee Joint Space Width from Weight-bearing CT.

Radiology 2021 Apr 13:203928. Epub 2021 Apr 13.

From the Department of Radiology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Colney Lane, Norwich NR4 7UY, England (T.D.T., J.W.M.); Norwich Medical School, University of East Anglia, Norwich, England (T.D.T., J.W.M.); Royal Liverpool University Hospital, Liverpool, England (S.B.L.); Department of Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England (S.R.); Departments of Engineering (G.M.T., A.H.G.) and Medicine (K.E.S.P.), University of Cambridge, Cambridge, England; Department of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, Calif (J.A.L.); and Department of Physical Medicine and Rehabilitation, Kansas University Medical Center, Kansas City, Kan (N.A.S.).

Background Imaging of structural disease in osteoarthritis has traditionally relied on MRI and radiography. Joint space mapping (JSM) can be used to quantitatively map joint space width (JSW) in three dimensions from CT images. Purpose To demonstrate the reproducibility, repeatability, and feasibility of JSM of the knee using weight-bearing CT images. Read More

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Psychometric properties of the TEMPA for the assessment of arm motor activity capacity in hemiparetic Japanese patients after stroke.

Disabil Rehabil 2021 Apr 13:1-8. Epub 2021 Apr 13.

Department of Rehabilitation Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Purpose: To investigate the psychometric properties of the Test d'Evaluation des Membres Suprieurs de Personnes Agres (TEMPA) for the affected upper extremity in a population of Japanese patients with stroke.

Materials And Methods: A prospective, cross-sectional, single-center study involving 30 patients with stroke was conducted. The inter-rater reliability, the validity, and the internal consistency were assessed. Read More

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High Prevalence of Human Immunodeficiency Virus Infection among Inmates in Korean Correctional Facilities.

J Korean Med Sci 2021 Apr 12;36(14):e92. Epub 2021 Apr 12.

Division of Infectious Diseases, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.

Background: Epidemiological data are crucial in designing policies for the control of human immunodeficiency virus (HIV) infections. There is a lack of data on the epidemiology of HIV in Korean correctional facilities such as jails and prisons.

Methods: Clinical characteristics of the study population were collected through a medical record review. Read More

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Making of Mobile SunSmart: Co-designing a Just-in-Time Sun Protection Intervention for Children and Parents.

Int J Behav Med 2021 Apr 13. Epub 2021 Apr 13.

Information School, University of Washington, Seattle, WA, USA.

Background: In this study, we describe a participatory design process to develop a technology-based intervention for sun protection for children and their parents. Our methodology embraces and leverages the expert knowledge of the target users, children and their parents, about their sun protection practices to directly influence the design of our mobile just-in-time adaptive intervention (JITAI). The objectives of this paper are to describe our research procedures and summarize primary findings incorporated into developing our JITAI modules. Read More

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Drassanes Exprés: a public and confidential testing service for asymptomatic STIs with same-day result notification.

Sex Transm Infect 2021 Apr 12. Epub 2021 Apr 12.

Department of Microbiology, Vall d'Hebron University Hospital, Barcelona, Spain.

Background: STIs are a major public health concern. Screening programmes for asymptomatic users are key components of STI control. Traditional limitations of screening programmes include low population coverage and delays in treatments, thus reducing the expected impact on STI control. Read More

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Estimating private sector out-of-pocket expenditures on family planning commodities in low-and-middle-income countries.

BMJ Glob Health 2021 Apr;6(4)

Avenir Health, Glastonbury, Connecticut, USA.

Introduction: The role of the private sector in family planning (FP) is well studied; however, few efforts have been made to quantify the role of private out-of-pocket (OOP) expenditures on FP commodities across low-and-middle-income countries (LMICs). Calculating OOP expenditures is important to illuminate the magnitude of these contributions and to inform discussions on how financial burdens can be reduced.

Methods: Estimates of FP users and commodities consumed by women getting their FP methods from the private sector were made for 132 LMICs. Read More

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The NSW Pathology Atlas of Variation: Part II-The Association of Variation in Emergency Department Laboratory Investigations With Outcomes for Patients Presenting With Chest Pain.

Ann Emerg Med 2021 Apr 9. Epub 2021 Apr 9.

Centre for Health Systems and Safety Research, Australian Institute of Health Innovation, Macquarie University, New South Wales, Australia.

Study Objective: Laboratory test use varies across emergency departments (EDs), yet little is known about the effect of this variation on outcomes. The aim of this study is 2-fold: to stratify EDs into clusters based on similar test use, and to determine whether the clusters differ in patient operational outcomes among patients presenting to EDs with undifferentiated chest pain.

Methods: We conducted a retrospective cohort study of 222,788 patients presenting with undifferentiated chest pain at 44 EDs across New South Wales, Australia, from January 2017 to September 2018. Read More

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Effects of metformin withdrawal after long and short term treatment in PCOS: observational longitudinal study.

Diabetol Metab Syndr 2021 Apr 12;13(1):43. Epub 2021 Apr 12.

Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Zaloška 7, 1000, Ljubljana, Slovenia.

Background: Metformin plays a consolidated role in the management of polycystic ovary syndrome (PCOS). However, there is no clear answer on how long we should treat and on how long its beneficial impact sustain after we stop treatment. We compared the effects of metformin withdrawal after long-term (LT) and short term (ST) treatment in PCOS women that had previously well responded to metformin. Read More

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A 2020 Update on Public Awareness of Head and Neck Cancers.

Otolaryngol Head Neck Surg 2021 Apr 13:1945998211006932. Epub 2021 Apr 13.

Division of Otolaryngology, Department of Surgery, School of Medicine, Yale University, New Haven, Connecticut, USA.

Objective: To assess knowledge regarding head and neck cancers (HNCs) in 2020, factors associated with knowledge of the role of human papillomavirus (HPV) in HNCs, and factors associated with exposure to Oral, Head and Neck Cancer Awareness Week (OHANCAW).

Study Design: Cross-sectional survey.

Setting: Online. Read More

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Association between a low dose of proton pump inhibitors and kidney function decline in elderly hypertensive patients: a retrospective observational study.

J Int Med Res 2021 Apr;49(4):3000605211006653

Department of Nephrology, Kenwakai Hospital, Nagano, Japan.

Objectives: Proton pump inhibitors (PPIs) are widely used for acid suppression therapy. Recently, PPI use was reported to be associated with chronic kidney disease (CKD); however, whether a low dose of PPIs is associated with CKD remains unknown.

Methods: This retrospective observational study included hypertensive patients who visited Kenwakai Hospital between 2017 and 2019. Read More

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Factors Related to Regional Variation in the High-risk Drinking Rate in Korea: Using Quantile Regression.

J Prev Med Public Health 2021 Mar 16;54(2):145-152. Epub 2021 Mar 16.

Department of Preventive Medicine and Public Health and Research Institute for Medical Sciences, Chungnam National University College of Medicine, Daejeon, Korea.

Objectives: This study aimed to identify regional differences in the high-risk drinking rate among yearly alcohol users in Korea and to identify relevant regional factors for each quintile using quantile regression.

Methods: Data from 227 counties surveyed by the 2017 Korean Community Health Survey (KCHS) were analyzed. The analysis dataset included secondary data extracted from the Korean Statistical Information Service and data from the KCHS. Read More

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Development and dosimetric assessment of an automatic dental artifact classification tool to guide artifact management techniques in a fully automated treatment planning workflow.

Comput Med Imaging Graph 2021 Mar 26;90:101907. Epub 2021 Mar 26.

The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences, Houston, TX, USA; The University of Texas MD Anderson Cancer Center, Department of Radiation Physics, Houston, TX, USA.

Purpose: We conducted our study to develop a tool capable of automatically detecting dental artifacts in a CT scan on a slice-by-slice basis and to assess the dosimetric impact of implementing the tool into the Radiation Planning Assistant (RPA), a web-based platform designed to fully automate the radiation therapy treatment planning process.

Methods: We developed an automatic dental artifact identification tool and assessed the dosimetric impact of its use in the RPA. Three users manually annotated 83,676 head-and-neck (HN) CT slices (549 patients). Read More

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