24,388 results match your criteria urticaria

Lachnospira is a signature of antihistamine efficacy in chronic spontaneous urticarial.

Exp Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Chronic spontaneous urticaria (CSU) is a mast cell-driven disease with many advances in its etiology and pathogenesis over the past years. The main treatment of CSU is oral second-generation antihistamines. However, only an average of 50% of CSU patients responded adequately to conventional or quadruple doses of non-sedative antihistamines. Read More

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September 2021

Redback spider bites in children in South Australia: A 10-year review of antivenom effectiveness.

Emerg Med Australas 2021 Sep 23. Epub 2021 Sep 23.

Paediatric Emergency Department, Flinders Medical Centre, Adelaide, South Australia, Australia.

Objective: To describe the South Australian paediatric redback spider bite experience and to examine the hypothesis that redback antivenom (RBAV) treatment in children is clinically effective.

Methods: Retrospective chart review of all children under 18 years of age presenting to the EDs of the three major paediatric or mixed hospitals in Adelaide, South Australia, with a discharge diagnosis of redback spider envenomation between 1 January 2010 and 31 March 2020. The main outcome measures include: patient and bite demographics; presenting symptoms and signs; treatment provided; clinical effects at 2 h post RBAV administration on pain, diaphoresis, blood pressure, heart rate and systemic features; overall clinical impression of RBAV effectiveness and resolution of symptoms prior to discharge. Read More

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September 2021

Association of Chronic Spontaneous Urticaria With Anxiety and Depression in Adolescents: A Mediation Analysis.

Front Psychiatry 2021 7;12:655802. Epub 2021 Sep 7.

Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China.

Chronic spontaneous urticaria (CSU) is related to psychiatric comorbidities. It is not clear whether the relationship is affected by modifiable factors. To investigate whether the effect of CSU on anxiety and depression in adolescents is mediated by the symptoms of itching and sleep disturbance. Read More

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September 2021

COVID-19 Vaccines and the Skin: The Landscape of Cutaneous Vaccine Reactions Worldwide.

Dermatol Clin 2021 Oct 31;39(4):653-673. Epub 2021 May 31.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:

In 2021, we entered a new phase of the COVID-19 pandemic. As mass vaccinations are underway and more vaccines are approved, it is important to recognize cutaneous adverse events. We review the dermatologic manifestations of COVID-19 vaccines as reported in clinical trial data and summarize additional observational reports of skin reactions to COVID-19 vaccines. Read More

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October 2021

Clinical Patterns and Morphology of COVID-19 Dermatology.

Dermatol Clin 2021 Oct 31;39(4):487-503. Epub 2021 May 31.

Department of Dermatology, University of California San Francisco, 1701 Divisadero Street, 3rd Floor, San Francisco, CA 94115, USA. Electronic address:

Coronavirus disease 2019 (COVID-19), an emergent disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread throughout the globe since its discovery in December 2019. Although first appreciated to cause pneumonia, numerous organ systems are now known to be involved. The objective of this article is to review the broad spectrum of cutaneous manifestations reported in association with SARS-CoV-2 infection. Read More

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October 2021

Intravenous Cetirizine vs Intravenous Diphenhydramine for the Prevention of Hypersensitivity Infusion Reactions: Results of an Exploratory Phase 2 Study.

J Infus Nurs 2021 Sep 22. Epub 2021 Sep 22.

St. Joseph Health Cancer Center, Santa Rosa, California (Dr Holmes); Oncology Consultants PA, Department of Research, Houston, Texas (Dr Peguero); Baylor Scott & White Medical Center, Temple, Texas (Dr Garland); and TerSera Therapeutics, Deerfield, Illinois (Ms North and Drs Young, Brent, and Joseph-Ridge). Jarrod P. Holmes, MD, FACP, is a hematologist/oncologist and associate medical director of oncology for Northern California, Providence Medical Group, in Santa Rosa, California. Julio A. Peguero, MD, is board certified in internal medicine and medical oncology and the director of research at Oncology Consultants in Houston, Texas. R. Campbell Garland, DO, is a hematologist/oncologist at Baylor Scott & White Medical Center based in Central Texas. Janine North, BS, is executive director of clinical development at TerSera Therapeutics, in Deerfield, Illinois. Stacia Young, PharmD, BCOP, MBA, is director of oncology medical science liaisons at TerSera Therapeutics. Lonnie D. Brent, PharmD, is vice president of medical affairs at TerSera Therapeutics. Nancy Joseph-Ridge, MD, is executive vice president of research and development and chief medical officer at TerSera Therapeutics.

Pretreatment with antihistamines for the prevention of hypersensitivity infusion reactions is recommended for certain biologics and chemotherapies. Cetirizine is the first injectable second-generation antihistamine recently approved for acute urticaria. A randomized, exploratory phase 2 study evaluated intravenous (IV) cetirizine 10 mg versus IV diphenhydramine 50 mg as pretreatment in patients receiving an anti-CD20 agent or paclitaxel. Read More

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September 2021

Localized cold urticaria: an unusual form of cold urticaria.

J Eur Acad Dermatol Venereol 2021 Sep 22. Epub 2021 Sep 22.

Dermatology Department, Coimbra University Hospital Center, Coimbra, Portugal.

Cold urticaria (ColdU) is a common type of inducible urticaria, characterized by the appearance of wheals, angioedema or both upon cold exposure, either by direct contact or exposure to a cold ambient. Patients may have generalized cutaneous lesions and up to 30% may develop systemic symptoms, including dizziness, nausea, diarrhoea, abdominal pain, muscle weakness, respiratory distress or even anaphylaxis. ColdU can be familial or acquired, the latter being further classified into primary or secondary to an underlying cause, such as cryoglobulins, infections or drugs. Read More

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September 2021

Symptomatic dermographism in Chinese population: an epidemiological study of hospital-based multicenter questionnaire survey.

Curr Med Res Opin 2021 Sep 22. Epub 2021 Sep 22.

Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, 95 Yong An Road, Xicheng District, Beijing, China.

Objective: There are few epidemiological studies on SD in China. This study aims to clarify the epidemic distribution characteristics of SD in China and provide ideas and clues for the prevention and treatment of the disease.

Methods: The cross-sectional study was conducted in 2019 based on the hospital's epidemiological questionnaire. Read More

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September 2021

Effect of the Mediterranean diet in patients with chronic spontaneous urticaria.

Rev Assoc Med Bras (1992) 2021 Jun;67(5):675-680

Suleyman Demirel University, Faculty of Health Sciences, Department of Nutrition and Dietetics - Isparta, Turkey.

Objective: Patients with chronic spontaneous urticaria often want to be informed about dietary modifications. There have been many studies evaluating dietary approaches in chronic spontaneous urticaria. In this study, we aimed to investigate the relationship between adherence to the Mediterranean diet and chronic spontaneous urticaria. Read More

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Relationship between local weather, air pollution and hospital attendances for urticaria in children: time stratified analysis of 12 000 cases.

Clin Exp Allergy 2021 Sep 22. Epub 2021 Sep 22.

Department of Emergency Medicine, Singapore General Hospital, Singapore.

Ambient air pollution is an increasingly important global public health issue, accounting for significant cardiovascular[1] and respiratory[2] morbidity and mortality. Singapore, an island city, is routinely affected by the Southeast Asia (SEA) transboundary haze. Read More

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September 2021

Allergy to Mammalian Meat Linked to Alpha-Gal Syndrome Potentially After Tick Bite in the Amazon: A Case Series.

Am J Trop Med Hyg 2021 Sep 20. Epub 2021 Sep 20.

Tenon Hospital, Dermatology-Allergology Department, Sorbonne University, Paris, France.

The past decade has seen the emergence of a new type of food allergy occurring after ingestion of mammalian meat. This allergy is related to immunoglobulin (Ig)E specific for galactose-alpha-1,3 galactose (α-Gal). Originally described in the United States in 2009, other cases have subsequently been described in Australia and in Europe, but still very few in Latin America. Read More

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September 2021

Silent celiac disease in dermatology.

Rev Med Inst Mex Seguro Soc 2020 ;58(4):437-443

Hospital Nacional, Servicio de Dermatología. Itauguá, Paraguay.

IntroducciÓn: La enfermedad celíaca puede estar asociada de forma silente a varias enfermedades de la piel y las mucosas.

Objetivo: Determinar la frecuencia de enfermedad celíaca en portadores de urticaria crónica, vitíligo, alopecia areata, psoriasis y estomatitis aftosa, en el Hospital Nacional de Itauguá, Paraguay, en los años 2017 y 2018.

Material Y MÉtodos: Diseño observacional de corte transversal, prospectivo. Read More

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January 2020

Granulomatosis with polyangiitis and neurofibromatosis type 1: a fortuitous association? (a case report).

Pan Afr Med J 2021 1;39:162. Epub 2021 Jul 1.

Department of Endocrinology and Internal Medicine, Tahar Sfar University Hospital of Mahdia, Mahdia, Tunisia.

Neurofibromatosis type 1 is a common neurocutaneous syndrome, caused by an alteration of the NF-1 gene, which is a tumor suppressor. It has been reported to be associated with different types of benign and malignant tumors but its association to systemic diseases is uncommon and has not been reported previously to be associated with vasculitis particularly granulomatosis with polyangiitis (GPA). We report a case of a 17-year-old male patient, who, during his follow-up for neurofibromatosis type 1, in our outpatient consultation; we objectified hypereosinophilia at 1700 eosinophils/μl without a history of asthma or atopy. Read More

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Genome-Wide DNA Methylation Profile in Whole Blood of Patients With Chronic Spontaneous Urticaria.

Front Immunol 2021 3;12:681714. Epub 2021 Sep 3.

Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China.

Background: Chronic spontaneous urticaria (CSU) is a common autoimmune skin disease. Little is known about the role of epigenetics in the pathogenesis of CSU. This study aimed to investigate genome-wide DNA methylation profile in whole blood of patients with CSU. Read More

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September 2021

The International EAACI/GA²LEN/EuroGuiDerm/APAAACI Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.

Allergy 2021 Sep 18. Epub 2021 Sep 18.

Centre Hospitalier Université Laval/Centre Hospitalier Universitaire de Québec, Service d'allergie, Québec, QC, Canada.

This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. Read More

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September 2021

Irritable bowel syndrome is strongly associated with the primary and idiopathic mast cell disorders.

Neurogastroenterol Motil 2021 Sep 17:e14265. Epub 2021 Sep 17.

University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.

Background: Mounting evidence supports a mechanistic association between irritable bowel syndrome (IBS) symptoms and mast cell hyperactivity. Yet, association between IBS and mast cell disorders (MCDs) has not been studied. We examined this association using two large databases and verified with manual chart review. Read More

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September 2021

Pegaspargase: Two Pediatric Case Studies of Delayed Urticaria Preceding Anaphylactic Reactions Postadministration.

Clin J Oncol Nurs 2021 Oct;25(5):511-513

Nationwide Children's Hospital.

Pegaspargase, a chemotherapy drug known to improve survival outcomes in acute lymphoblastic leukemia, is associated with a risk for hypersensitivity reactions. At a children's hospital in the midwestern United States, two patients developed unusual reactions consisting of disseminated urticaria about two weeks after their second dose of pegaspargase. Both patients then proceeded to have severe anaphylaxis with the third dose of pegaspargase. Read More

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October 2021

Unsatisfactory agreement using current classification of maculopapular cutaneous mastocytosis.

K Brockow

J Eur Acad Dermatol Venereol 2021 Oct;35(10):1917-1918

Department of Dermatology and Allergy Biederstein, Faculty of Medicine, Technical University of Munich, Munich, Germany.

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October 2021

An unusual case of concurrent Kounis syndrome and prolonged QT in a young patient.

Cardiol Young 2021 Sep 17:1-3. Epub 2021 Sep 17.

Hammersmith Hospital, Imperial College Trust, London, UK.

Allergic reactions related to drug use is a common entity presenting often from minor urticaria to life-threatening anaphylactoid reactions. A common but easily overlooked diagnosis, Kounis syndrome, is an established hypersensitivity coronary disorder induced by drugs, foods, environmental factors, and coronary stents that can present in the same way as non-allergy-induced acute coronary syndrome. Here within, we present a unique case of dual presentation of Kounis syndrome and prolonged QTc in a young patient after a single dose of Domperidone and Lansoprazole. Read More

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September 2021

Chronic Urticaria: Advances in Understanding of the Disease and Clinical Management.

Clin Rev Allergy Immunol 2021 Sep 16. Epub 2021 Sep 16.

Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Hunan, 410011, Changsha, China.

Chronic urticaria (CU) is a common skin condition characterized by the recurrence of wheals, with or without angioedema, which lasts for at least 6 weeks. Owing to its pruritus and incurability, this disease adversely affects the patients' physical and mental health and diminishes the quality of life. CU is generally classified into two subtypes based on the relevance of eliciting factors: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), the latter of which is further divided into several subtypes. Read More

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September 2021

Comparison between Kimura's disease and angiolymphoid hyperplasia with eosinophilia: case reports and literature review.

J Int Med Res 2021 Sep;49(9):3000605211040976

Department of Dermatology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Health Care Group, Huangshi, Hubei Province, China.

Kimura's disease (KD) is a rare chronic inflammatory or allergic disease. Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign vascular neoplasm. Their relationship has always been debated. Read More

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September 2021

[Cutaneous manifestations in patients with COVID-19 with significant attention to urticaria].

Rev Alerg Mex 2021 Apr-Jun;68(2):112-116

Clínica El Ávila, Caracas, Venezuela.

Objectives: To describe the most frequent dermatological conditions observed in COVID-19 patients and to determine whether their presence could be used to establish an early diagnosis or to predict the progression of the infection.

Methods: There was a review in PubMed/MEDLINE and EMBASE of all the articles that had been published between January 1st and November 1st, 2020, with the search terms focused on "SARS-CoV-2", "COVID-19" and "Skin diseases".

Results: Eighty three studies met the inclusion criteria. Read More

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September 2021

[Frequency and clinical characterization of chronic urticaria in a tertiary care hospital].

Rev Alerg Mex 2021 Apr-Jun;68(2):94-100

Instituto Mexicano del Seguro Social, Centro Médico Nacional de Occidente, Hospital de Especialidades, Departamento de Inmunología Clínica y Alergia, Guadalajara, Jalisco, México.

Objective: To estimate the frequency of chronic urticaria in patients who attended an allergy service in a tertiary care hospital; in addition, the main clinical characteristics are described.

Methods: In a period of 7 months, a total of 96 patients who were over 18 years of age were analyzed; they had been diagnosed with chronic spontaneous urticaria and chronic inducible urticaria.

Results: The frequency of chronic urticaria was of 1. Read More

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September 2021

Pilot study: specific immunotherapy in patients with Papular urticaria by Cimex lectularius.

Eur Ann Allergy Clin Immunol 2021 Sep 15. Epub 2021 Sep 15.

Department of Clinical Immunology and Allergy, Hospital General De México (Dr Eduardo Liceaga), Ciudad De Mexico, Mexico.

Summary: Papular urticaria is a chronic allergic reaction induced by insect bites. In México the most common causative arthropods reported are bed bugs, fleas and mosquitoes. Approximately 70% of people who are bitten by experience hypersensitive reactions, papular urticaria, extensive erythema, urticaria, and even anaphylaxis has been reported, Pruritus is the major complaint, impairing quality of life and sleep. Read More

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September 2021

[Swimmer's dermatoses].

Ned Tijdschr Geneeskd 2021 Aug 19;165. Epub 2021 Aug 19.

Amsterdam UMC, afd. Dermatologie, Amsterdam.

In the summer people like to cool down by swimming. However, swimming may lead to annoying skin reactions, the so called swimmer's dermatoses. We present three different cases: an 8-year-old girl with skin complaints after blue-green algae, a 7-year-old boy with a late immune response after a jellyfish sting and a 40-year-old woman with contact urticaria due to latex in the bathing suit. Read More

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Unique basophil microRNA signature in chronic spontaneous urticaria patients who respond to omalizumab.

Clin Exp Allergy 2021 Sep 14. Epub 2021 Sep 14.

Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA.

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September 2021

Predictive features associated with chronic spontaneous urticaria recurrence.

J Dermatol 2021 Sep 14. Epub 2021 Sep 14.

Proteomic and Flow Cytometry Unit, Bnai-Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel.

When chronic spontaneous urticaria (CSU) is resolved, patients are often apprehensive about the likelihood of recurrence, and want to know if we can predict this using clinical or laboratory markers. This question is crucial because CSU is frequently accompanied by a high incidence of stressful comorbidities, and the fear of experiencing this again can be devastating to the patient. This study was designed with the aim of focusing on the prevalence and characteristics of the recurrence of CSU. Read More

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September 2021

Advances and highlights in biomarkers of allergic diseases.

Allergy 2021 Sep 14. Epub 2021 Sep 14.

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

During the past years, there has been a global outbreak of allergic diseases, presenting a considerable medical and socioeconomical burden. A large fraction of allergic diseases is characterized by a type 2 immune response involving Th2 cells, type 2 innate lymphoid cells, eosinophils, mast cells, and M2 macrophages. Biomarkers are valuable parameters for precision medicine as they provide information on the disease endotypes, clusters, precision diagnoses, identification of therapeutic targets, and monitoring of treatment efficacies. Read More

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September 2021

Efficiency and safety of desloratadine in combination with compound glycyrrhizin in the treatment of chronic urticaria: a meta-analysis and systematic review of randomised controlled trials.

Pharm Biol 2021 Dec;59(1):1276-1285

School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Context: Desloratadine, an H1 receptor antagonist, is suggested as an effective first-line drug for chronic urticarial (CU). However, the efficacy of desloratadine alone is limited, and the recurrence rate of CU is relatively high.

Objective: We sought to evaluate the efficacy and clinical feasibility of desloratadine in combination with compound glycyrrhizin in the treatment of CU. Read More

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December 2021

Clinical and Pathologic Correlation of Cutaneous COVID-19 Vaccine Reactions including V-REPP: A Registry Based Study.

J Am Acad Dermatol 2021 Sep 10. Epub 2021 Sep 10.

Massachusetts General Hospital, Harvard Medical School, Boston, MA; Medical Practice Evaluation Center, Mongan Institute, Massachusetts General Hospital, Boston, MA. Electronic address:

Background: Cutaneous reactions after COVID-19 vaccination have been commonly reported. However, histopathologic features and clinical correlations have not been well characterized.

Methods: From an international registry, we evaluated all reports of COVID-19 associated vaccination reactions for history of skin biopsy. Read More

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September 2021