11,436 results match your criteria uptake tracer

A complete magnetic sentinel lymph node biopsy procedure in oral cancer patients: A pilot study.

Oral Oncol 2021 Jul 27;121:105464. Epub 2021 Jul 27.

Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.

Objectives: To assess the feasibility and merits of a complete magnetic approach for a sentinel lymph node biopsy (SLNB) procedure in oral cancer patients.

Materials And Methods: This study included ten oral cancer patients (stage cT1-T2N0M0) scheduled for elective neck dissection (END). Superparamagnetic iron oxide nanoparticles (SPIO) were administered peritumorally prior to surgery. Read More

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Harmonisation of PET imaging features with different amyloid ligands using machine learning-based classifier.

Eur J Nucl Med Mol Imaging 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, 06351, Seoul, South Korea.

Purpose: In this study, we used machine learning to develop a new method derived from a ligand-independent amyloid (Aβ) positron emission tomography (PET) classifier to harmonise different Aβ ligands.

Methods: We obtained 107 paired F-florbetaben (FBB) and F-flutemetamol (FMM) PET images at the Samsung Medical Centre. To apply the method to FMM ligand, we transferred the previously developed FBB PET classifier to test similar features from the FMM PET images for application to FMM, which in turn developed a ligand-independent Aβ PET classifier. Read More

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Development of a Tc-Labeled Single-Domain Antibody for SPECT/CT Assessment of HER2 Expression in Breast Cancer.

Mol Pharm 2021 Jul 30. Epub 2021 Jul 30.

Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China.

Accurate determination of human epidermal growth factor receptor 2 (HER2) expression is essential for HER2-targeted therapy in patients with cancer. HER2 expression in a complex environment, such as in a heterogeneous tumor, makes the precise assessment of the HER2 status difficult using current methods. In this study, we developed a novel Tc-labeled anti-HER2 single-domain antibody (Tc-NM-02) as a molecular imaging tracer for the noninvasive detection of HER2 expression and investigated its safety, radiation dosimetry, biodistribution, and tumor-targeting potential in 10 patients with breast cancer. Read More

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First-in-human evaluation of a PD-L1-binding peptide radiotracer in non-small cell lung cancer patients with PET.

J Nucl Med 2021 Jul 29. Epub 2021 Jul 29.

Peking University Cancer Hospital and Institute, China.

Ga-NOTA-WL12 is a peptide-based positron emission tomography (PET) imaging agent. We conducted a first-in-human study of Ga-NOTA-WL12 for PET to study the in vivo biodistribution, metabolism, radiation dosimetry, safety, and potential for quantifying programmed death ligand-1 (PD-L1) expression levels in advanced non-small cell lung cancer (NSCLC) patients. In vitro assessment of the relationship between PD-L1 expression and cellular uptake of Ga-NOTA-WL12 was performed, followed by in vivo evaluation of Ga-NOTA-WL12 uptake in animal models. Read More

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Diffuse bone marrow uptake related to granulocyte colony-stimulating factor-producing maxillary sinus carcinoma on 4-borono-2-F-fluoro-L-phenylalanine positron emission tomography/computed tomography.

World J Nucl Med 2021 Apr-Jun;20(2):188-191. Epub 2020 Oct 23.

Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nangoku, Kochi, Japan.

Granulocyte colony-stimulating factor (G-CSF) can be produced by tumor cells and is known to promote tumor growth, thereby potentially accelerating disease progression. Squamous cell carcinoma (SCC) at maxillary sinus is aggressive growth with poor prognosis. Maxillary sinus carcinomas are rare and can be clinically silent in the early stages or manifest with the same signs and symptoms of more common illnesses, leading to their delayed diagnosis of disease. Read More

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October 2020

Myelofibrosis Pattern in 68Ga-PSMA PET/CT of a Patient With Recurrence Prostate Cancer.

Clin Nucl Med 2021 Jul 26. Epub 2021 Jul 26.

From the Department of Nuclear Medicine Department of Methodology, Laboratory of Center for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.

Abstract: We present the case of a 64-year-old man with prostate adenocarcinoma, Gleason score 7, after radical prostatectomy and adjuvant radiotherapy in 2015. Because of high risk and perineural invasion, hormonotherapy was indicated. PSA levels began to rise, and at PSA level of 0. Read More

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Positive Multifocal PSMA PET/CT in a Patient With Prostate Cancer and Follicular Lymphoma.

Clin Nucl Med 2021 Jul 26. Epub 2021 Jul 26.

From the Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National, Institutes of Health, Bethesda, MD Department of Nuclear Medicine, University Hospital Düsseldorf, Düsseldorf Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center Translational Lung Research Center Heidelberg, German Center for Lung Research National Center for Tumor Diseases, Heidelberg, Germany.

Abstract: Prostate-specific membrane antigen (PSMA) PET/CT is a highly reliable nuclear tracer for diagnostic imaging of prostate cancer. However, PSMA is also expressed by some nonprostatic tissues such as benign tumors, inflammatory processes, and malignant neoplasms. This case presents a patient with prostate cancer and follicular lymphoma undergoing PSMA PET/CT. Read More

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Extracardiac Accumulation of Technetium-99m-Pyrophosphate in Transthyretin Cardiac Amyloidosis.

JACC Case Rep 2021 Jul 12;3(7):1069-1074. Epub 2021 May 12.

Department of Clinical Pathology, Yawatahama City General Hospital, Ehime, Japan.

This report presents a rare case of acute decompensated heart failure with technetium-99m-pyrophosphate accumulation in extracardiac sites, such as chest and abdominal walls, in addition to intense myocardial uptake of the tracer. Subsequently, an abdominal fat pad fine-needle aspiration biopsy, which provided positive findings for transthyretin amyloidosis, was performed. (). Read More

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Dynamic FDG-PET in localization of focal epilepsy: A pilot study.

Epilepsy Behav 2021 Jul 23;122:108204. Epub 2021 Jul 23.

Neurology, University of Virginia, Charlottesville, VA, USA. Electronic address:

Epilepsy surgery remains underutilized, in part because non-invasive methods of potential seizure foci localization are inadequate. We used high-resolution, parametric quantification from dynamic 2-[18F] fluoro-2-deoxy-d-glucose positron emission tomography (dFDG-PET) imaging to locate hypometabolic foci in patients whose standard clinical static PET images were normal. We obtained dFDG-PET brain images with simultaneous EEG in a one-hour acquisition on seven patients with no MRI evidence of focal epilepsy to record uptake and focal radiation decay. Read More

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FDG/PET-CT findings in a first series of 10 patients with polyarteritis nodosa.

Rheumatology (Oxford) 2021 Jul 24. Epub 2021 Jul 24.

Department of Internal Medicine and Nephrology, Centre Hospitalier de Valenciennes, Valenciennes, France.

Objective: 18F-fluorodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT) is widely used in patients with large-vessel vasculitis. The benefits of FDG-PET/CT in polyarteritis nodosa (PAN) has only ever been assessed in three case reports. Our aim was to describe FDG-PET/CT findings in 10 patients with newly diagnosed PAN. Read More

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Lessons learned from post-COVID-19 vaccination PET/CT studies.

J Nucl Med 2021 Jul 22. Epub 2021 Jul 22.

Department of Nuclear Medicine and Biophysics, Hadassah Medical Organization, Israel.

Anti-COVID-19 vaccination has created new challenges. Lymphadenopathy (LA) with increased uptake in patients undergoing PET/CT may mislead to unnecessary further evaluation. We have analyzed routinely performed PET/CT studies following Pfizer-BioNTech vaccination to familiarize with PET/CT appearances with various PET tracers and to prevent consequences of misinterpretation. Read More

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COVID-19 vaccination effect on tracer uptake with FDG-PET/CT.

Hyo Jin Lee

QJM 2021 Jul 23. Epub 2021 Jul 23.

Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.

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Preclinical and clinical study on [F]DRKXH1: a novel β-amyloid PET tracer for Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2021 Jul 22. Epub 2021 Jul 22.

Department of Nuclear Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1665, Kongjiang Street, Yangpu District, Shanghai, 200092, China.

Background: The deposition of β-amyloid (Aβ) in the brain is a biomarker of Alzheimer's disease (AD). Highly sensitive Aβ positron emission tomography (PET) imaging plays an essential role in diagnosing and evaluating the therapeutic effects of AD.

Aim: To synthesize a new Aβ tracer [F]DRKXH1 (5-(4-(6-(2-[18]fluoroethoxy)ethoxy)imidazo[1,2-alpha]pyridin-2-yl)phenyl) and evaluate the tracer performance by biodistribution analysis, in vivo small-animal PET-CT dynamic scan, ex vivo and in vitro autoradiography, and PET in human subjects. Read More

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Tumor response evaluation in patients with malignant melanoma undergoing immune checkpoint inhibitor therapy and prognosis prediction using F-FDG PET/CT: multicenter study for comparison of EORTC, PERCIST, and imPERCIST.

Jpn J Radiol 2021 Jul 21. Epub 2021 Jul 21.

Department of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Objective: In malignant melanoma patients treated with immune checkpoint inhibitor (ICI) therapy, three different FDG-PET criteria, European Organization for Research and Treatment of Cancer (EORTC), PET Response Criteria in Solid Tumors (PERCIST), immunotherapy-modified PERCIST (imPERCIST), were compared regarding response evaluation and prognosis prediction using standardized uptake value (SUV) harmonization of results obtained with various PET/CT scanners installed at different centers.

Materials And Methods: Malignant melanoma patients (n = 27) underwent FDG-PET/CT examinations before and again 3 to 9 months after therapy initiation (nivolumab, n = 21; pembrolizumab, n = 6) with different PET scanners at five hospitals. EORTC, PERCIST, and imPERCIST criteria were used to evaluate therapeutic response, then concordance of the results was assessed using Cohen's κ coefficient. Read More

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Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans.

Sci Rep 2021 07 20;11(1):14796. Epub 2021 Jul 20.

Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Lead exposure can cause substantial organ damage. Enteral lead absorption may be reduced by concomitant intake of clinoptilolite tuff, a zeolite from natural sources. This study aimed to assess the effect of purified clinoptilolite tuff (G-PUR) on enteral lead uptake in adults using stable lead isotope Pb as a tracer. Read More

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Fibroblast Activation Protein specific PET/CT imaging in fibrotic interstitial lung diseases and lung cancer: a translational exploratory study.

J Nucl Med 2021 Jul 16. Epub 2021 Jul 16.

University Hospital Heidelberg, Germany.

Interstitial lung diseases (ILD) comprise over 200 parenchymal lung disorders. Among them, fibrosing ILDs, especially idiopathic pulmonary fibrosis (IPF) in particular are associated with a poor prognosis, while some others ILDs like sarcoidosis have a much better prognosis. A high proportion of ILD manifests as fibrotic ILD (fILD). Read More

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First-in-human study of Zr-pembrolizumab PET/CT in patients with advanced stage non-small-cell lung cancer.

J Nucl Med 2021 Jul 16. Epub 2021 Jul 16.

NKI-AvL, Netherlands.

Tumor programmed-death ligand-1 (PD-L1) proportion score is the current method to select non-small-cell lung cancer (NSCLC) patients for single agent treatment with pembrolizumab, a programmed cell death-1 (PD-1) monoclonal antibody. However, not all patients respond to therapy. Better understanding of in vivo drug behavior may help to select patients that benefit most. Read More

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Physiological 2-deoxy-2-[fluorine-18] fluoro-D-glucose accumulation in the thenar eminence in adults: a single-center retrospective study.

Ann Nucl Med 2021 Jul 16. Epub 2021 Jul 16.

Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Objective: This study evaluated the frequency, and effect of physiological 2-deoxy-2-[fluorine-18] fluoro-D-glucose (FDG) tracer injection and its association with the penetration rates of mobile devices.

Methods: This retrospective analysis included 213 patients (mean age ± standard deviation, 66.2 ± 14. Read More

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Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using C-BU99008 PET and its relationship with amyloid load.

Mol Psychiatry 2021 Jul 15. Epub 2021 Jul 15.

Department of Brain Sciences, Imperial College London, London, UK.

C-BU99008 is a novel positron emission tomography (PET) tracer that enables selective imaging of astrocyte reactivity in vivo. To explore astrocyte reactivity associated with Alzheimer's disease, 11 older, cognitively impaired (CI) subjects and 9 age-matched healthy controls (HC) underwent 3T magnetic resonance imaging (MRI), F-florbetaben and C-BU99008 PET. The 8 amyloid (Aβ)-positive CI subjects had higher C-BU99008 uptake relative to HC across the whole brain, but particularly in frontal, temporal, medial temporal and occipital lobes. Read More

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Subcutaneous adipose tissue metabolic function and insulin sensitivity in people with obesity.

Diabetes 2021 Jul 15. Epub 2021 Jul 15.

Division of Geriatrics and Nutritional Science, University School of Medicine, St. Louis, MO

We used stable isotope-labeled glucose and palmitate tracer infusions, a hyperinsulinemic-euglycemic clamp, positron-emission tomography of muscles and adipose tissue after [F]fluorodeoxyglucose and [O]water injections, and subcutaneous adipose tissue (SAT) biopsy to test the hypotheses that: i) increased glucose uptake in SAT is responsible for high insulin-stimulated whole-body glucose uptake in people with obesity who are insulin-sensitive, and ii) putative SAT factors thought to cause insulin resistance are present in people with obesity who are insulin-resistant but not in those who are insulin-sensitive. We found high insulin-stimulated whole-body glucose uptake in insulin-sensitive participants with obesity was not due to channeling of glucose into SAT, but was due to high insulin-stimulated muscle glucose uptake. Furthermore, insulin-stimulated muscle glucose uptake was not different between insulin-sensitive obese and lean participants even though adipocytes were larger, SAT perfusion and oxygenation were lower, and markers of SAT inflammation, fatty acid appearance in plasma in relation to fat-free mass, and plasma fatty acid concentration were higher in the insulin-sensitive obese than lean participants. Read More

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The more the merrier! Barriers and facilitators to the general public's use of a COVID-19 contact tracing app in New Zealand.

Inform Health Soc Care 2021 Jul 14:1-12. Epub 2021 Jul 14.

Department of Psychological Medicine, University of Auckland, Auckland, New Zealand.

Contact tracing for infectious diseases can be partially automated using mobile applications. However, the success of these tools is dependent on significant uptake and frequent use by the public. This study explored the barriers and facilitators to the New Zealand (NZ) general public's use of the COVID-19 contact app. Read More

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First-in-human study of the biodistribution and pharmacokinetics of Zr-CX-072, a novel immunoPET tracer based on an anti-PD-L1 probody.

Clin Cancer Res 2021 Jul 12. Epub 2021 Jul 12.

Medical Oncology, University Medical Center Groningen

Purpose: CX-072, a PD-L1-targeting Probody therapeutic, is engineered to be activated by tumor proteases that remove a masking peptide. To study effects on biodistribution and pharmacokinetics, we performed Zr-CX-072 positron emission tomography (PET) imaging.

Patients And Methods: Patients received ~1 mg, 37 MBq Zr-CX-072 plus 0, 4, or 9 mg unlabeled CX-072 and PET scans days 2, 4, and 7. Read More

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Limitations and Pitfalls of FDG-PET/CT in Infection and Inflammation.

Semin Nucl Med 2021 Jul 7. Epub 2021 Jul 7.

Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus N. Electronic address:

White blood cells activated by either a pathogen or as part of a systemic inflammatory disease are characterized by high energy consumption and are therefore taking up the glucose analogue PET tracer FDG avidly. It is therefore not surprising that a steadily growing body of research and clinical reports now supports the use of FDG PET/CT to diagnose a wide range of patients with non-oncological diseases. However, using FDG PET/CT in patients with infectious or inflammatory diseases has some limitations and potential pitfalls that are not necessarily as pronounced in oncology FDG PET/CT. Read More

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Correlation of lesional uptake parameters and ratios with miPSMA score and estimating normal physiological concentration: an exploratory analysis in mCRPC patients with Ga-PSMA-11 PET-CT.

J Nucl Med Technol 2021 Jul 9. Epub 2021 Jul 9.

Radiation Medicine Centre (BARC), India.

The employment of prostate-specific membrane antigen (PSMA)-based PET-CT imaging has grown rapidly over the recent years. The aim of the present study was to estimate the lesional uptake across the different levels of molecular imaging PSMA (miPSMA) expression score along with normal physiological concentration of Ga-PSMA-11 in a cohort of mCRPC patients including their temporal variation on delayed imaging. Fifty patients of mCRPC who were being evaluated for Lu-PSMA PRLT, and underwent Ga-PSMA-11 PET-CT for evaluation of disease status, were retrospectively evaluated. Read More

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Detection of Diffuse Peritoneal and Omental Metastases From Prostate Cancer With 18F-PSMA-1007 PET/CT.

Clin Nucl Med 2021 Jul 6. Epub 2021 Jul 6.

From the Department of Nuclear Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Abstract: Diffuse peritoneal and omental infiltration of prostate cancer detected by 18F-PSMA-1007 PET/CT was rarely reported. We report a case of an 80-year-old man who was suspected of prostate carcinoma metastasis and underwent 18F-PSMA-1007 PET/CT for restaging the disease. PET/CT imaging presented intense tracer uptake in the prostate gland, multiple lymph nodes, and bones. Read More

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Preclinical development and characterisation of Tc-NM-01 for SPECT/CT imaging of human PD-L1.

Am J Nucl Med Mol Imaging 2021 15;11(3):154-166. Epub 2021 Jun 15.

Department of Nuclear Medicine, University Hospital RWTH Aachen Germany.

The level of expression of programmed cell death-1 (PD-1)/programmed death ligand-1 (PD-L1) is a predictive biomarker for cancer immunotherapy, however, its detection remains challenging due to tumour heterogeneity and the influence from the binding of therapeutic agents. We recently developed [Tc]-NM-01 as a companion diagnostic imaging agent for non-invasive molecular imaging of PD-L1 by single-photon emission computed tomography (SPECT). The aim of the study was to evaluate the [Tc] radiolabelling of GMP graded NM-01 and its pharmacology, pharmacokinetics and toxicology. Read More

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Whole-body uptake classification and prostate cancer staging in Ga-PSMA-11 PET/CT using dual-tracer learning.

Eur J Nucl Med Mol Imaging 2021 Jul 7. Epub 2021 Jul 7.

School of Medicine, Department of Nuclear Medicine, Technische Universität München, Munich, Germany.

Purpose: In PSMA-ligand PET/CT imaging, standardized evaluation frameworks and image-derived parameters are increasingly used to support prostate cancer staging. Clinical applicability remains challenging wherever manual measurements of numerous suspected lesions are required. Deep learning methods are promising for automated image analysis, typically requiring extensive expert-annotated image datasets to reach sufficient accuracy. Read More

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Radionuclide, magnetic resonance and computed tomography imaging in European round back slugs (Arionidae) and leopard slugs (Limacidae).

Sci Rep 2021 Jul 5;11(1):13798. Epub 2021 Jul 5.

US National Institutes of Health/NCI/DCTD, Bethesda, USA.

Other than in animal models of human disease, little functional imaging has been performed in most of the animal world. The aim of this study was to explore the functional anatomy of the European round back slug (Arionidae) and leopard slug (Limacidae) and to establish an imaging protocol for comparative species study. Radionuclide images with single photon emission computed tomography (SPECT) and positron emission tomography (PET) were obtained after injections of standard clinical radiopharmaceuticals technetium dicarboxypropane diphosphonate (bone scintigraphy), technetium mercaptoacetyltriglycine (kidney function), technetium diethylenetriaminepentaacetic acid (kidney function), technetium pertechnetate (mediated by the sodium-iodide symporter), technetium sestamibi (cardiac scintigraphy) or F-fluoro-deoxyglucose (glucose metabolism) in combination with magnetic resonance imaging (MRI) and computed tomography (CT) for uptake anatomic definition. Read More

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Assessing the potential and kinetics of coupled nutrients uptake in mesotrophic streams in Chaohu Lake Basin, China.

Environ Sci Pollut Res Int 2021 Jul 3. Epub 2021 Jul 3.

College of Water Conservancy and Hydropower Engineering, Hohai University, Nanjing, China.

Interactions among multiple nutrients uptake certainly have a great effect on their retention in headwater streams, yet little research has been made to explore the quantitative characteristics of their interactions, especially in mesotrophic streams. In response, we conducted an identical series of instantaneous nutrient addition experiments, using ammonium nitrogen (NH-N) and phosphate phosphorus (PO-P) alone or together, in two mesotrophic agricultural headwater streams in Chaohu Lake Basin, China, to quantify the relationships between nutrient concentrations and uptake rates, and examine how NH-N and PO-P interact to affect their individual uptake. Both the Michaelis-Menten (M-M) equation and response surface model were utilized to analyze coupled NH-N and PO-P uptake patterns across a range of nutrient concentrations, by fitting the kinetic processes of NH-N and PO-P uptake in single- and dual-nutrient additions. Read More

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(S)-[F]THK5117 brain uptake is associated with Aβ plaques and MAO-B enzyme in a mouse model of Alzheimer's disease.

Neuropharmacology 2021 Jun 30;196:108676. Epub 2021 Jun 30.

Turku PET Centre, University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland; Medicity Research Laboratory, University of Turku, Tykistökatu 6 A, FI-20520, Turku, Finland. Electronic address:

The mouse model of beta-amyloid (Aβ) deposition, APP/PS1-21, exhibits high brain uptake of the tau-tracer (S)-[F]THK5117, although no neurofibrillary tangles are present in this mouse model. For this reason we investigated (S)-[F]THK5117 off-target binding to Aβ plaques and MAO-B enzyme in APP/PS1-21 transgenic (TG) mouse model of Aβ deposition. APP/PS1-21 TG and wild-type (WT) control mice in four different age groups (2-26 months) were imaged antemortem by positron emission tomography with (S)-[F]THK5117, and then brain autoradiography. Read More

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