5,507 results match your criteria uptake parallel

A mixed methods study to evaluate participatory mapping for rural water safety planning in western Kenya.

PLoS One 2021 28;16(7):e0255286. Epub 2021 Jul 28.

School of Geography and Environmental Science, University of Southampton, Highfield, Southampton, United Kingdom.

Water safety planning is an approach to ensure safe drinking-water access through comprehensive risk assessment and water supply management from catchment to consumer. However, its uptake remains low in rural areas. Participatory mapping, the process of map creation for resource management by local communities, has yet to be used for rural water safety planning. Read More

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A compact integrated microfluidic oxygenator with high gas exchange efficiency and compatibility for long-lasting endothelialization.

Lab Chip 2021 Jul 26. Epub 2021 Jul 26.

Université Paris-Saclay, CNRS, Centre de Nanosciences et Nanotechnologies C2N, UMR9001, Palaiseau 91120, France.

We have developed and tested a novel microfluidic device for blood oxygenation, which exhibits a large surface area of gas exchange and can support long-term sustainable endothelialization of blood microcapillaries, enhancing its hemocompatibility for clinical applications. The architecture of the parallel stacking of the trilayers is based on a central injection for blood and a lateral injection/output for gas which allows significant reduction in shear stress, promoting sustainable endothelialization since cells can be maintained viable for up to 2 weeks after initial seeding in the blood microchannel network. The circular design of curved blood capillaries allows covering a maximal surface area at 4 inch wafer scale, producing high oxygen uptake and carbon dioxide release in each single unit. Read More

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Coping strategies in response to different levels of elevated water hardness in channel catfish (Ictalurus punctatus): Insight into ion-regulatory and histopathological modulations.

Comp Biochem Physiol A Mol Integr Physiol 2021 Jul 20;260:111040. Epub 2021 Jul 20.

Department of Aquaculture and Fisheries, University of Arkansas at Pine Bluff, 1200 North University Drive, Pine Bluff 71601, AR, USA. Electronic address:

Water hardness above the optimal level can incite toxic effects in fish, which are often species specific. Hence, we aimed at obtaining insights on the potential effects of elevated water hardness as well as coping strategies in channel catfish (Ictalurus punctatus). First, a toxicity assay was performed where the 96 h-LC was calculated as 4939 mg/L CaCO. Read More

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Cardiorespiratory fitness assessed by cardiopulmonary exercise testing between different stages of pre-dialysis chronic kidney disease: A systematic review and meta-analysis.

Nephrology (Carlton) 2021 Jul 20. Epub 2021 Jul 20.

Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Aim: The burden of several cardiovascular risk factors increases in parallel to renal function decline. Exercise intolerance is common in patients with chronic kidney disease (CKD) and has been associated with increased risk of adverse outcomes. Whether indices of cardiorespiratory capacity deteriorate with advancing CKD stages is unknown. Read More

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Concomitant oral intake of purified clinoptilolite tuff (G-PUR) reduces enteral lead uptake in healthy humans.

Sci Rep 2021 07 20;11(1):14796. Epub 2021 Jul 20.

Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Lead exposure can cause substantial organ damage. Enteral lead absorption may be reduced by concomitant intake of clinoptilolite tuff, a zeolite from natural sources. This study aimed to assess the effect of purified clinoptilolite tuff (G-PUR) on enteral lead uptake in adults using stable lead isotope Pb as a tracer. Read More

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Challenging traditional carbohydrate intake recommendations for optimizing performance at high altitude.

Curr Opin Clin Nutr Metab Care 2021 Jul 23. Epub 2021 Jul 23.

Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.

Purpose Of Review: To highlight emerging evidence challenging traditional recommendations to increase carbohydrate intake to optimize performance at high altitude.

Recent Findings: Several studies have now clearly demonstrated that, compared with sea level, exogenous carbohydrate oxidation during aerobic exercise is blunted in lowlanders during initial exposure to high altitude. There is also no apparent ergogenic effect of ingesting carbohydrate during aerobic exercise on subsequent performance at high altitude, either initially after arriving or even after up to 22 days of acclimatization. Read More

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F-fluorodeoxyglucose positron emission tomography-based prediction for splenectomy in patients with suspected splenic lymphoma.

Ann Transl Med 2021 Jun;9(12):1009

Department of Hematology, Huadong Hospital, Fudan University, Shanghai, China.

Background: Diagnostic splenectomy is often performed on patients with suspected splenic lymphoma. However, unnecessary splenectomy entails more harm than benefit for patients. Therefore, a preliminary screening method for patients with suspected splenic lymphoma that has high sensitivity and specificity is urgently needed. Read More

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Dosimetric quantities of neuroendocrine tumors over treatment cycles with Lu-DOTA-TATE.

J Nucl Med 2021 Jul 16. Epub 2021 Jul 16.

Department of Medical Radiation Physics, Clinical Sciences Lund, Lund University, Sweden.

Tumor dosimetry was performed for Lu-DOTA-TATE with the aims of better understanding i) the range and variation of the tumor absorbed doses (ADs), ii) how different dosimetric quantities evolve over the treatment cycles, and iii) whether this evolution differs depending on the tumor grade. Such information is important for radiobiological interpretation and may inform the design of alternative administration schemes. Data come from 41 patients with neuroendocrine tumors (NETs) of grade 1 ( = 23) or 2 ( = 18), that had received between 2 and 9 treatment cycles. Read More

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When Engagement Leads to Action: Understanding the Impact of Cancer (Mis)information among Latino/a Facebook Users.

Health Commun 2021 Jul 13:1-13. Epub 2021 Jul 13.

Department of Health, Behavior & Society, Johns Hopkins School of Public Health.

Latinos/as - the largest minority group in the U.S. - are avid Facebook users, making this an opportune tool to educate on the uptake of cancer prevention and screening behaviors. Read More

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A Randomized Crossover Trial on the Acute Cardiovascular Demands During Flywheel Exercise.

Front Physiol 2021 25;12:665462. Epub 2021 Jun 25.

Science and Research Center Koper, Institute for Kinesiology Research, Koper, Slovenia.

In a randomized crossover trial, we examined whether age plays a role in the mean arterial pressure (MAP) response during a vigorous flywheel exercise of varying load. We hypothesized that the magnitude of increase in the MAP during the flywheel exercise would increase in proportion to advancing age, thereby imposing a significant challenge to the cardiovascular system. A total of 30 participants of both sexes (age range from 20-55 y, 37% women) underwent a detailed medical examination, and their maximal oxygen uptake was determined. Read More

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The effects of flipped classroom characterized by situational and collaborative learning in a community nursing course: A quasi-experimental design.

Nurse Educ Today 2021 Jun 30;105:105037. Epub 2021 Jun 30.

School of Nursing, Nanjing University of Chinese Medicine, 138 Xianlin RD, Nanjing, Jiangsu Province, China.

Background: Since traditional teaching could not help to develop competences, flipped classroom has caught the sight of researchers. Despite the uptake of flipped classroom in other disciplines, there is a dearth of evidence available about the use in nursing curricula. In addition, there is no consensus on how to best implement a flipped classroom. Read More

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Multichannel gas-uptake/evolution reactor for monitoring liquid-phase chemical reactions.

Rev Sci Instrum 2021 Apr;92(4):044103

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA.

The design of a headspace pressure-monitoring reactor for measuring the uptake/evolution of gas in gas-liquid chemical transformations is described. The reactor features a parallel setup with ten-reactor cells, each featuring a low working volume of 0.2-2 ml, a pressure capacity from 0 to 150 PSIa, and a high sensitivity pressure transducer. Read More

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Retrofusion of intralumenal MVB membranes parallels viral infection and coexists with exosome release.

Curr Biol 2021 Jul 1. Epub 2021 Jul 1.

Oncode Institute, Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands. Electronic address:

The endosomal system constitutes a highly dynamic vesicle network used to relay materials and signals between the cell and its environment. Once internalized, endosomes gradually mature into late acidic compartments and acquire a multivesicular body (MVB) organization through invagination of the limiting membrane (LM) to form intraluminal vesicles (ILVs). Cargoes sequestered into ILVs can either be delivered to lysosomes for degradation or secreted following fusion of the MVB with the plasma membrane. Read More

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Parallel Screening Using the Chloroalkane Penetration Assay Reveals Structure-Penetration Relationships.

ACS Chem Biol 2021 Jul 5;16(7):1184-1190. Epub 2021 Jul 5.

Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155 United States.

The efficiency with which polycationic peptides penetrate the cytosol depends on the number and overall patterning of arginine residues. While general trends and unusually penetrant patterns of arginine residues have been discovered, prior work has not effectively leveraged high-throughput screens to measure cytosolic penetration rather than total cell uptake. In this work, we adapted the chloroalkane penetration assay, which exclusively measures cytosolic penetration, to screen peptide libraries in a high-throughput, quantitative, and automation-ready manner. Read More

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Effects of imatinib on vascular insulin sensitivity and free fatty acid transport in early weight gain.

PLoS One 2021 2;16(7):e0250442. Epub 2021 Jul 2.

Department of Physiology, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Center, Amsterdam, The Netherlands.

Background: Vascular endothelial dysfunction is an essential part of the pathophysiology of type 2 diabetes and its complications. In type 2 diabetes, endothelial dysfunction is characterized by reduced insulin signaling and increased transendothelial transport of fatty acids (FA). As the Abl kinase inhibitor imatinib was previously shown to reverse type 2 diabetes and to inhibit VEGF signaling via Abl kinases, we studied the effect of imatinib on vascular insulin sensitivity and fatty acid transport in vivo and in vitro. Read More

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Amelioration potential of β-pinene on Cr(VI)-induced toxicity on morphology, physiology and ultrastructure of maize.

Environ Sci Pollut Res Int 2021 Jul 1. Epub 2021 Jul 1.

Department of Botany, Panjab University, Chandigarh, 160 014, India.

Heavy metals' amassment in the soil environment is a threat to crop and agricultural sustainability and consequentially the global food security. For achieving enhancement of crop productivity in parallel to reducing chromium (Cr) load onto food chain demands continuous investigation and efforts to develop cost-effective strategies for maximizing crop yield and quality. In this context, we investigated the amelioration of Cr(VI) toxicity through β-pinene in experimental dome simulating natural field conditions. Read More

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The Magnetic Couples Study: protocol for a mixed methods prospective cohort study of HIV-serodifferent heterosexual couples' perspectives and use of pre-exposure prophylaxis (PrEP).

BMJ Open 2021 Jul 1;11(7):e048993. Epub 2021 Jul 1.

School of Pharmacy and Pharmaceutical Sciences, University of Colorado - Anschutz Medical Campus, Aurora, Colorado, USA.

Introduction: HIV transmission within serodifferent heterosexual couples plays a key role in sustaining the global HIV pandemic. In the USA, transmission within established mixed-status couples accounts for up to half of all new HIV infections among heterosexuals. Oral HIV pre-exposure prophylaxis (PrEP) is a highly effective prevention method, although underutilised among serodifferent couples. Read More

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ASC-1 transporter-dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation.

FEBS Lett 2021 Jul 1. Epub 2021 Jul 1.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Hungary.

Brown and beige adipocytes dissipate energy by uncoupling protein 1 (UCP1)-dependent and UCP1-independent thermogenesis, which may be utilized to develop treatments against obesity. We have found that mRNA and protein expression of the alanine/serine/cysteine transporter-1 (ASC-1) was induced during adipocyte differentiation of human brown-prone deep neck and beige-competent subcutaneous neck progenitors, and SGBS preadipocytes. cAMP stimulation of differentiated adipocytes led to elevated uptake of serine, cysteine, and glycine, in parallel with increased oxygen consumption, augmented UCP1-dependent proton leak, increased creatine-driven substrate cycle-coupled respiration, and upregulation of thermogenesis marker genes and several respiratory complex subunits; these outcomes were impeded in the presence of the specific ASC-1 inhibitor, BMS-466442. Read More

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Pre-ischemic Lactate Levels Affect Post-ischemic Recovery in an Isolated Rat Heart Model of Donation After Circulatory Death (DCD).

Front Cardiovasc Med 2021 14;8:669205. Epub 2021 Jun 14.

Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, Bern, Switzerland.

Donation after circulatory death (DCD) could substantially improve donor heart availability. In DCD, the heart is not only exposed to a period of warm ischemia, but also to a damaging pre-ischemic phase. We hypothesized that the DCD-relevant pre-ischemic lactate levels negatively affect the post-ischemic functional and mitochondrial recovery in an isolated rat heart model of DCD. Read More

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Modeling Cervical Cancer Screening Strategies With Varying Levels of Human Papillomavirus Vaccination.

JAMA Netw Open 2021 Jun 1;4(6):e2115321. Epub 2021 Jun 1.

Department of Gynaecological Oncology, Mater Misericordiae University Hospital, Dublin, Ireland.

Importance: Cervical cancer screening is a lifesaving intervention, with an array of approaches, including liquid-based cytology (LBC), molecular testing for human papillomavirus (HPV) infection, and combinations via parallel cotesting or sequential triage. Maximizing screening efficacy while minimizing overtreatment is vital, especially when considering how the HPV vaccine will affect the interpretation of results.

Objectives: To estimate the likely outcomes of different screening modalities and to model how the increasing uptake of the HPV vaccine could affect the interpretation of screening results. Read More

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Effect of Liraglutide on Arterial Inflammation Assessed as [F]FDG Uptake in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial.

Circ Cardiovasc Imaging 2021 Jul 30;14(7):e012174. Epub 2021 Jun 30.

Department of Clinical Physiology, Nuclear Medicine and PET and Cluster for Molecular Imaging, Department of Biomedical Sciences, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark (R.S.R., J.K.J., T.B., A.K.).

Background: The mechanism behind the cardiovascular protection observed with human GLP-1 RA (glucagon-like peptide-1 receptor agonists) in type 2 diabetes is unknown. We hypothesized that treatment with the GLP-1 RA liraglutide had a positive effect on vascular inflammation.

Methods: LIRAFLAME (Effect of liraglutide on vascular inflammation in type-2 diabetes: A randomized, placebocontrolled, double-blind, parallel clinical PET/CT trial) was a double-blind, randomized controlled trial performed at a single university hospital clinic in Denmark. Read More

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DNA-stable isotope probing (DNA-SIP) identifies marine sponge-associated bacteria actively utilizing dissolved organic matter (DOM).

Environ Microbiol 2021 Jun 22. Epub 2021 Jun 22.

Department of Freshwater and Marine Ecology, Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, P.O. Box 94240, 1090 GE Amsterdam, Netherlands.

Sponges possess exceptionally diverse associated microbial communities and play a major role in (re)cycling of dissolved organic matter (DOM) in marine ecosystems. Linking sponge-associated community structure with DOM utilization is essential to understand host-microbe interactions in the uptake, processing, and exchange of resources. We coupled, for the first time, DNA-stable isotope probing (DNA-SIP) with 16S rRNA amplicon sequencing in a sponge holobiont to identify which symbiotic bacterial taxa are metabolically active in DOM uptake. Read More

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Comparison of Vaccine Acceptance Between COVID-19 and Seasonal Influenza Among Women in China: A National Online Survey Based on Health Belief Model.

Front Med (Lausanne) 2021 4;8:679520. Epub 2021 Jun 4.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Influenza could circulate in parallel with COVID-19. Studies focusing on the comparison of vaccine acceptance between COVID-19 and seasonal influenza are lacking. The aim of the study was to assess and compare vaccine acceptance of COVID-19 and influenza among reproductive women in China, in order to better understand and address factors associated with vaccine acceptance and to provide guidance for targeted measures to promote vaccination. Read More

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Comparative Assessment of Autogenous Cancellous Bone Graft and Bovine-Derived Demineralized Bone Matrix for Secondary Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate.

Cleft Palate Craniofac J 2021 Jun 17:10556656211025197. Epub 2021 Jun 17.

Department of Paediatric Surgery, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Objective: Comparison between bovine-derived demineralized bone matrix (DMBM) and iliac crest graft over long term for secondary alveolar bone grafting (SABG) in patients with unilateral cleft lip and palate (UCLP) in terms of radiological and clinical outcomes.

Design: Prospective, randomized, parallel groups, double-blind, controlled trial.

Setting: Unit of Oral and Maxillofacial Surgery, Oral Health Science Centre, Postgraduate Institute of Medical Education & Research, Chandigarh. Read More

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Using stable isotope probing and fluorescence spectroscopy to examine the roles of substrate and soluble microbial products in extracellular polymeric substance formation in activated sludge process.

Sci Total Environ 2021 Sep 20;788:147875. Epub 2021 May 20.

Department of Environment and Energy, Sejong University, Seoul 05006, South Korea. Electronic address:

In this study, we used stable isotope-labeled soluble microbial products (SMP) and substrates to explore their assimilation into the formation of new biological products (i.e., extracellular polymeric substances and biomass) in two adjacent sequencing batch reactors. Read More

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September 2021

Do assessments of cardiorespiratory and muscular fitness influence subsequent reported physical activity? A randomized controlled trial.

BMC Sports Sci Med Rehabil 2021 Jun 15;13(1):69. Epub 2021 Jun 15.

Department of Medicine, Division of General Internal Medicine, University of Minnesota, 420 Delaware St SE, MMC 784, Minneapolis, MN, 55455, USA.

Background: Regular physical activity and exercise provide many health benefits. These health benefits are mediated in large part through cardiorespiratory fitness and muscular strength. As most individuals have not had an assessment of their personal cardiorespiratory fitness or muscular strength we investigated if measurements of cardiorespiratory fitness and muscular strength would influence an individual's subsequent self-reported exercise and physical activity. Read More

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Electroacupuncture alleviates spatial memory deficits in METH withdrawal mice by enhancing astrocyte-mediated glutamate clearance in the dCA1.

Addict Biol 2021 Jun 14:e13068. Epub 2021 Jun 14.

Department of Human Anatomy and Histoembryology, Nanjing University of Chinese Medicine, Nanjing, China.

Methamphetamine (METH) elicits endogenous glutamate (Glu) in the brain, which could partially explain METH-induced memory deficits. Here, we investigated the therapeutic effects of electroacupuncture (EA) on spatial memory deficits in METH withdrawal mice and its potential synaptic mechanisms. We found that EA at acupoints 'Baihui' and 'Yintang' ameliorated the impaired spatial memory in METH withdrawal mice. Read More

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Influences of the hydrophilic components of two anthropogenic dissolved organic nitrogen groups on phytoplankton growth in Jiaozhou Bay, China.

Mar Pollut Bull 2021 Aug 16;169:112551. Epub 2021 Jun 16.

Frontiers Science Center for Deep Ocean Multispheres and Earth System, and Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao 266100, China; Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China. Electronic address:

Increasing human activities have caused the accumulation of dissolved organic nitrogen (DON) in the ocean, which can alter dominant coastal phytoplankton species. However, insights into DON's effects on marine phytoplankton growth are insufficient compared with those of dissolved inorganic nitrogen (DIN), especially regarding the role of specific DON components. Therefore, in this study, the effects of the hydrophilic (Hic) and low molecular weight (LMW) components of two anthropogenic DON sources on the growth and bioavailable nitrogen uptake of phytoplankton were studied using in situ cultural experiments conducted in Jiaozhou Bay, China. Read More

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Live Imaging of Mitochondria in Kidney Tissue.

Methods Mol Biol 2021 ;2275:393-402

Institute of Anatomy, University of Zurich, Zurich, Switzerland.

Kidneys are highly aerobic organs and their function is tightly coupled to mitochondrial energy production. Renal tubular cells, particularly the proximal tubule (PT), require an abundance of mitochondria to provide sufficient energy for regulating fluid and electrolyte balance. Meanwhile, mitochondrial defects are implicated in a range of different kidney diseases. Read More

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January 2021

Silicon elevated cadmium tolerance in wheat (Triticum aestivum L.) by endorsing nutrients uptake and antioxidative defense mechanisms in the leaves.

Plant Physiol Biochem 2021 May 31;166:148-159. Epub 2021 May 31.

Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Numerous abiotic stressors including heavy metal stresses, specifically cadmium (Cd) stress in agricultural bio-system hinder the plant adequate growth. The present study was aimed to reveal the protective role of silicon (Si) application with two levels and to recognize the optimum level of Si for wheat plants grown hydroponically under three different levels of Cd toxicities. In methodology, we used nine treatments with three levels of Si (0, 1, and 3 mmol L; NaSiO) against three levels of Cd (0, 50, 200 μmol L; CdCl) with three biological replicates. Read More

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