411,544 results match your criteria uptake


68Ga-DOTA-FAPI-04 PET/CT Imaging in a Case of SAPHO Syndrome.

Clin Nucl Med 2021 Sep 22. Epub 2021 Sep 22.

From the Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China; and Academician (Expert) Workstation of Sichuan Province, PR China.

Abstract: A 66-year-old woman presented with anterior chest wall and knee joints pain and multiple skin lesions. 99mTc-MDP bone scintigraphy showed increased bone density in the sternal angle with abnormal bone metabolism. The patient was enrolled in a 68Ga-DOTA-FAPI-04 PET/CT tumor clinical trial, and it showed increased tracer uptake in the sternum and right knee joint. Read More

View Article and Full-Text PDF
September 2021

18F-FDG-Detected Brown Tumor Confined to the Maxillary Bone With Parathyroid Adenoma.

Clin Nucl Med 2021 Sep 22. Epub 2021 Sep 22.

From the Department of Diagnostic Radiology, Tokyo Medical and Dental University, Tokyo, Japan Department of Head and Neck Surgery, Tokyo Medical and Dental University, Tokyo, Japan Division of Surgical Pathology, Tokyo Medical and Dental University Hospital, Tokyo, Japan.

Abstract: Brown tumor is a reactive osteolytic lesion associated with hyperparathyroidism and an extremely rare form of a single lesion in the maxilla. We report the case of a 57-year-old woman with renal dysfunction, nasal obstruction, and hypercalcemia. MRI and CT revealed a huge osteolytic lesion in the maxilla. Read More

View Article and Full-Text PDF
September 2021

Effect of Climbing Speed on Pulmonary Oxygen Uptake and Muscle Oxygen Saturation Dynamics in the Finger Flexors.

Int J Sports Physiol Perform 2021 Sep 24:1-9. Epub 2021 Sep 24.

Purpose: Although sport climbing is a self-paced whole-body activity, speed varies with climbing style, and the effect of this on systemic and localized oxygen responses is not well understood. Therefore, the aim of the present study was to determine muscle and pulmonary oxygen responses during submaximal climbing at differing speeds of ascent.

Methods: Thirty-two intermediate and advanced sport climbers completed three 4-minute-long ascents of the same route at 4, 6, and 9 m·min-1 on a motorized climbing ergometer (treadwall) on separate laboratory visits. Read More

View Article and Full-Text PDF
September 2021

Peer Presence Increases Session Ratings of Perceived Exertion.

Int J Sports Physiol Perform 2021 Sep 24:1-5. Epub 2021 Sep 24.

Purpose: This study aimed to examine the effect of peer presence on session rating of perceived exertion (RPE) responses.

Method: Fourteen males, with mean (SD) age 22.4 (3. Read More

View Article and Full-Text PDF
September 2021

Comparison of Physiological Responses and Muscle Activity During Incremental and Decremental Cycling Exercise.

Int J Sports Physiol Perform 2021 Sep 24:1-8. Epub 2021 Sep 24.

Objective: To investigate whether a cycling test based on decremental loads (DEC) could elicit higher maximal oxygen uptake (V˙O2max) values compared with an incremental test (INC).

Design: Nineteen well-trained individuals performed an INC and a DEC test on a single day, in randomized order.

Methods: During INC, the load was increased by 20 W·min-1 until task failure. Read More

View Article and Full-Text PDF
September 2021

"That was quick, simple, and easy": Patient perceptions of acceptability of point-of-care hepatitis C RNA testing at a reception prison.

Int J Drug Policy 2021 Sep 21;99:103456. Epub 2021 Sep 21.

The Kirby Institute, UNSW Sydney, Level 6, Wallace Wurth Building, Sydney, NSW, 2052, Australia.

Introduction: Current diagnostic pathways require multiple healthcare provider visits and lead to a drop-off in the hepatitis C virus (HCV) testing and treatment care cascade. In prison settings, frequent transitioning between prisons and the community further reduces uptake of testing and treatment. The PIVOT study evaluated a 'one-stop-shop' intervention integrating point-of-care HCV RNA testing, Fibroscan®-based liver disease assessment, and treatment prescription at a reception prison in Australia. Read More

View Article and Full-Text PDF
September 2021

Vaccine uptake and constrained decision making: The case of Covid-19.

Soc Sci Med 2021 Sep 17;289:114410. Epub 2021 Sep 17.

Institute for Global Health, University College London, United Kingdom. Electronic address:

Policy makers require support in conceptualizing and assessing the impact that vaccination policies can have on the proportion of the population being vaccinated against COVID-19. To this purpose, we propose a behavioural economics-based framework to model vaccination choices. We calibrate our model using up-to-date surveys on people attitudes toward vaccination as well as estimates of COVID-19 infection and mortality rates and vaccine efficacy for the UK population. Read More

View Article and Full-Text PDF
September 2021

Regulation of dendritic cell function by Fc-γ-receptors and the neonatal Fc receptor.

Mol Immunol 2021 Sep 21;139:193-201. Epub 2021 Sep 21.

Department of Biochemistry and Pharmacology, The University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Rd, Parkville, Victoria, 3010, Australia. Electronic address:

Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to communicate with other immune cells. Among those receptors, Fc receptors (FcRs) are triggered by the Fc region of antibodies produced during adaptive immunity. In this review, the role of FcγR and neonatal Fc receptor (FcRn) in DC immunity will be discussed. Read More

View Article and Full-Text PDF
September 2021

Toxic effects of cyanotoxins in teleost fish: A comprehensive review.

Aquat Toxicol 2021 Sep 17;240:105971. Epub 2021 Sep 17.

Integrative Biology Research Unit, Department of Life Sciences, Presidency University, 86/1, College Street, Kolkata 700073, India. Electronic address:

The phenomenon of eutrophication leads to the global occurrence of algal blooms. Cyanotoxins as produced by many cyanobacterial species can lead to detrimental effects to the biome due to their stability and potential biomagnification along food webs. Therefore, understanding of the potential risks these toxins pose to the most susceptible organisms is an important prerequisite for ecological risks assessment of cyanobacteria blooms. Read More

View Article and Full-Text PDF
September 2021

"My husband is my family." The culture of pregnancy disclosure and its implications on early pregnancy registration in a child nutrition intervention in rural Maharashtra, India.

Midwifery 2021 Sep 14;103:103141. Epub 2021 Sep 14.

International Public Health, School of Public Health, University of Sydney, Australia. Electronic address:

Less than seventeen percent pregnant women in rural India had full antenatal check-ups. Early uptake to maternal and child healthcare services is strongly associated with cultural beliefs and practices around pregnancy and childbirth. This study aims to assess the cultural elements that influence women's behaviours of disclosure of their pregnancy in rural setting in Maharashtra state of India. Read More

View Article and Full-Text PDF
September 2021

In vitro Fourier transform infrared spectroscopic study of the effect of glycerol on the uptake of beclomethasone dipropionate in living respiratory cells.

Int J Pharm 2021 Sep 21:121118. Epub 2021 Sep 21.

Institute of Pharmaceutical Science, King's College London, London SE1 9NH, United Kingdom. Electronic address:

The quantification of drug in living cells is of increasing interest in pharmaceutical research because of its importance in understanding drug efficacy and toxicity. Label-free in situ measurement methods are advantageous for their ability to obtain chemical and time profiles without the need of labelling or extraction steps. We have previously shown that Fourier transform infrared (FTIR) spectroscopy has the potential to quantify drug in situ within living cells at micromolar level when a simple solution of drug was added to the medium. Read More

View Article and Full-Text PDF
September 2021

Matrix tablets based on a novel poly (magnesium acrylate) hydrogel for the treatment of inflammatory bowel diseases.

Int J Pharm 2021 Sep 21:121121. Epub 2021 Sep 21.

Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain; Institute of Industrial Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain. Electronic address:

The objective of this work was to evaluate the potential use of a new polymer (PAMgA) in the development sustained release matrix tablets for the treatment of bowel inflammatory diseases. For this purpose, budesonide, a highly lipophilic compound, was used as model drug. Tablets with two reticulation grades of PAMgA (PAMgA 5 and 40) and with 9 mg of budesonide were developed and characterized. Read More

View Article and Full-Text PDF
September 2021

The poorly conducted orchestra of steroid hormones, oxidative stress and inflammation in frailty needs a maestro: Regular physical exercise.

Exp Gerontol 2021 Sep 21:111562. Epub 2021 Sep 21.

Health Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra (ESEnfC), Coimbra, Portugal; Institute Polytechnic of Maia, Porto, Portugal; University of Coimbra, Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019) at Faculty of Sport Science and Physical Education, (FCDEF-UC), Portugal. Electronic address:

This review outlines the various factors associated with unhealthy aging which includes becoming frail and dependent. With many people not engaging in recommended exercise, facilitators and barriers to engage with exercise must be investigated to promote exercise uptake and adherence over the lifespan for different demographics, including the old, less affluent, women, and those with different cultural-ethnic backgrounds. Governmental and locally funded public health messages and environmental facilitation (gyms, parks etc. Read More

View Article and Full-Text PDF
September 2021

Flavonoid-statin interactions causing myopathy and the possible significance of OATP transport, CYP450 metabolism and mevalonate synthesis.

Life Sci 2021 Sep 21:119975. Epub 2021 Sep 21.

Adelaide Medical School, The University of Adelaide, Adelaide, SA 5005, Australia.

3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors, statins, are a primary treatment for hyperlipidemic cardiovascular diseases which are a leading global cause of death. Statin therapy is life saving and discontinuation due to adverse events such as myotoxicity may lead to unfavourable outcomes. There is no known mechanism for statin-induced myotoxicity although it is theorized that it is due to inhibition of downstream products of the HMG-CoA pathway. Read More

View Article and Full-Text PDF
September 2021

Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming.

Cell Metab 2021 Sep 17. Epub 2021 Sep 17.

Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, USA; Division of Immunotherapy, The Hiram C. Polk, Jr., MD Department of Surgery, Immuno-Oncology Program, Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA. Electronic address:

One of the defining characteristics of a pre-metastatic niche, a fundamental requirement for primary tumor metastasis, is infiltration of immunosuppressive macrophages. How these macrophages acquire their phenotype remains largely unexplored. Here, we demonstrate that tumor-derived exosomes (TDEs) polarize macrophages toward an immunosuppressive phenotype characterized by increased PD-L1 expression through NF-kB-dependent, glycolytic-dominant metabolic reprogramming. Read More

View Article and Full-Text PDF
September 2021

Redundant roles of four ZIP family members in zinc homeostasis and seed development in Arabidopsis thaliana.

Plant J 2021 Sep 24. Epub 2021 Sep 24.

Department of Biological Sciences, Dartmouth College, Hanover, NH, 03755, USA.

Zinc (Zn) is essential for normal plant growth and development. The ZIP (ZRT, IRT-like Protein) family members are involved in Zn transport and cellular Zn homeostasis throughout the domains of life. In this study, we have characterized four ZIP transporters from Arabidopsis thaliana (IRT3, ZIP4, ZIP6 and ZIP9) to better understand their functional roles. Read More

View Article and Full-Text PDF
September 2021

ZmCTLP1 is required for the maintenance of lipid homeostasis and the basal endosperm transfer layer in maize kernels.

New Phytol 2021 Sep 24. Epub 2021 Sep 24.

State Key Laboratory of Plant Physiology and Biochemistry and National Maize Improvement Center, Department of Plant Genetics and Breeding, China Agricultural University, Beijing, 100193, P. R. China.

Maize kernel weight is influenced by the unloading of nutrients from the maternal placenta and their passage through the transfer tissue of the basal endosperm transfer layer (BETL) and the basal intermediate zone (BIZ) to the upper part of the endosperm. Here, we show that Small kernel 10 (Smk10) encodes a choline transporter-like protein 1 (ZmCTLP1) that facilitates choline uptake and is located in the trans-Golgi network (TGN). Its loss-of-function results in reduced choline content, leading to smaller kernels with a lower starch content. Read More

View Article and Full-Text PDF
September 2021

Examining the impact of a community-based exercise intervention on cardiorespiratory fitness, cardiovascular health, strength, flexibility and physical activity among adults living with HIV: A three-phased intervention study.

PLoS One 2021 24;16(9):e0257639. Epub 2021 Sep 24.

Institute of Health Policy, Management and Evaluation (IHPME), University of Toronto, Toronto, Ontario, Canada.

Purpose: Our aim was to examine the impact of a community-based exercise (CBE) intervention on cardiorespiratory fitness, cardiovascular health, strength, flexibility, and physical activity outcomes among adults living with HIV.

Methods: We conducted a longitudinal intervention study with community-dwelling adults living with HIV in Toronto, Canada. We measured cardiopulmonary fitness (V̇O2peak (primary outcome), heart rate, blood pressure), strength (grip strength, vertical jump, back extension, push-ups, curl ups), flexibility (sit and reach test), and self-reported physical activity bimonthly across three phases. Read More

View Article and Full-Text PDF
September 2021

Exploring menstrual products: A systematic review and meta-analysis of reusable menstrual pads for public health internationally.

PLoS One 2021 24;16(9):e0257610. Epub 2021 Sep 24.

Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Background: Girls and women need effective, safe, and affordable menstrual products. Single-use menstrual pads and tampons are regularly provided by agencies among resource-poor populations. Reusable menstrual pads (RMPs: fabric layers sewn together by an enterprise for manufacture of menstrual products) may be an effective alternative. Read More

View Article and Full-Text PDF
September 2021

The PUPPY Study: Protocol for a Longitudinal Mixed Methods Study Exploring Problems Coordinating and Accessing Primary Care for Attached and Unattached Patients Exacerbated During the COVID-19 Pandemic Year.

JMIR Res Protoc 2021 Sep 9. Epub 2021 Sep 9.

Queen's University, Kingston, CA.

Background: The COVID-19 pandemic significantly disrupted primary care in Canada, with many walk-in clinics and family practices initially closing or being perceived as inaccessible, pharmacies remaining open with restrictions on patient interactions, rapid uptake of virtual care, and reduced referrals for lab tests, diagnostics, and specialist care. The PUPPY Study (Problems Coordinating and Accessing Primary Care for Attached and Unattached Patients Exacerbated During the COVID-19 Pandemic Year) seeks to understand the impact of COVID-19 across the quadruple aim of primary care, with particular focus on the impacts on patients without attachment to a regular provider and those with chronic health conditions.

Objective: The PUPPY Study objective is to understand the impact of COVID-19 across the quadruple aim of primary care. Read More

View Article and Full-Text PDF
September 2021

Peatland microhabitat heterogeneity drives phototrophic microbes distribution and photosynthetic activity.

Environ Microbiol 2021 Sep 24. Epub 2021 Sep 24.

Laboratoire Ecologie Fonctionnelle et Environnement, Université de Toulouse, UPS, CNRS, Toulouse, France.

Phototrophic microbes are widespread in soils but their contribution to soil carbon (C) uptake remains underexplored in most terrestrial systems, including C-accreting systems such as peatlands. Here, by means of metabarcoding and ecophysiological measurements, we examined how microbial photosynthesis and its biotic (e.g. Read More

View Article and Full-Text PDF
September 2021

A Novel Low-Strain Phosphate Cathode for High-Rate and Ultralong Cycle-Life Potassium-Ion Batteries.

Angew Chem Int Ed Engl 2021 Sep 24. Epub 2021 Sep 24.

Nanjing Normal University, School of Chemistry and Materials Science, CHINA.

Most potassium-ion battery (PIB) cathode materials have deficient structural stability because of the huge radius of potassium ion, leading to inferior cycling performance. In this work, we report the controllable synthesis of a novel low-strain phosphate material K 3 (VO)(HV 2 O 3 )(PO 4 ) 2 (HPO 4 ) (denoted KVP) nanorulers as an efficient cathode for PIBs. The as-synthesized KVP nanoruler cathode can exhibit an initial reversible capacity of 80. Read More

View Article and Full-Text PDF
September 2021

Pulmonary rehabilitation for interstitial lung disease.

Cochrane Database Syst Rev 2021 Feb 1;2:CD006322. Epub 2021 Feb 1.

Institute for Breathing and Sleep, Melbourne, Australia.

Background: Interstitial lung disease (ILD) is characterised by reduced functional capacity, dyspnoea and exercise-induced hypoxia. Pulmonary rehabilitation is often used to improve symptoms, health-related quality of life and functional status in other chronic lung conditions. There is accumulating evidence for comparable effects of pulmonary rehabilitation in people with ILD. Read More

View Article and Full-Text PDF
February 2021

Management of phosphorus nutrient amidst climate change for sustainable agriculture.

J Environ Qual 2021 Sep 24. Epub 2021 Sep 24.

Xavier Research Foundation, St. Xavier's College, Palayamkottai, Tamil Nadu, 620002, India.

Nutrients are essential for plant growth and development; they influence the overall agricultural production. Phosphorus (P) is a major nutrient required for many physiological and biochemical functions of the plant. Phosphate rock is the major source of phosphate fertilizer which is becoming increasingly limited in both developing and developed countries. Read More

View Article and Full-Text PDF
September 2021

Assessment of intestinal macromolecular absorption in young piglets to pave the way to oral vaccination: preliminary results.

Vet Res Commun 2021 Sep 24. Epub 2021 Sep 24.

Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, 120 Veterinary Road, Saskatoon, SK, S7N 5E3, Canada.

The small intestine of the piglet has evolved to be permeable immediately after birth to facilitate the uptake of colostrum-derived immunoglobulins as well as other macromolecules, and cells. However, the precise timing of gut closure in today's precocious pig is not known. We gavaged piglets immediately after birth and at 1-h after birth with Cy5-labeled Ovalbumin (Cy5-Ova) then harvested their small intestine's 6-7 h later. Read More

View Article and Full-Text PDF
September 2021

Aceruloplasminemia: a multimodal imaging study in an Italian family with a novel mutation.

Neurol Sci 2021 Sep 24. Epub 2021 Sep 24.

Institute of Molecular Bioimaging and Physiology, National Research Council, Rome, Italy.

Objective: Structural abnormalities in thalami and basal ganglia, in particular the globus pallidus (GP), are a neuroimaging hallmark of hereditary aceruloplasminemia (HA), yet few functional imaging data exit in HA carriers. This study investigated the iron-related structural and functional abnormalities in an Italian HA family.

Methods: Multimodal imaging was used including structural 3 T MRI, functional imaging (SPECT imaging with I-ioflupane (DAT-SPECT), cardiac I metaiodobenzylguanidine (I-MIBG) scintigraphy, and F-fluorodeoxyglucose (F-FDG)-PET imaging). Read More

View Article and Full-Text PDF
September 2021

Radiochemical Evidence for the Contribution of Chemotyped Siderophore Producing Bacteria Towards Plant Iron Nutrition.

Curr Microbiol 2021 Sep 24. Epub 2021 Sep 24.

Division of Microbiology, ICAR-Indian Agricultural Research Institute (IARI), New Delhi, 110012, India.

Fe deficiency is a major challenge that limits agricultural productivity and is a serious human health concern worldwide. Under iron-limiting conditions soil microorganisms produce siderophores, that chelates Fe (ferric) and make it available to the plants. Selection of efficient siderophore producing bacteria and establishing their role in enhancing iron uptake is a strategic approach for improving plant nutrition. Read More

View Article and Full-Text PDF
September 2021

PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the "Cancer Integrin" αvβ6 with Ga-68-Trivehexin.

Eur J Nucl Med Mol Imaging 2021 Sep 24. Epub 2021 Sep 24.

Institute of Pathology, Technische Universität München, Munich, Germany.

Purpose: To develop a new probe for the αvβ6-integrin and assess its potential for PET imaging of carcinomas.

Methods: Ga-68-Trivehexin was synthesized by trimerization of the optimized αvβ6-integrin selective cyclic nonapeptide Tyr2 (sequence: c[YRGDLAYp(NMe)K]) on the TRAP chelator core, followed by automated labeling with Ga-68. The tracer was characterized by ELISA for activities towards integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1, as well as by cell binding assays on H2009 (αvβ6-positive) and MDA-MB-231 (αvβ6-negative) cells. Read More

View Article and Full-Text PDF
September 2021

Effect of the Histone Deacetylase Inhibitor FRM-0334 on Progranulin Levels in Patients With Progranulin Gene Haploinsufficiency: A Randomized Clinical Trial.

JAMA Netw Open 2021 Sep 1;4(9):e2125584. Epub 2021 Sep 1.

FORUM Pharmaceuticals Incorporated, Waltham, Massachusetts.

Importance: Histone deacetylase inhibitors have been repeatedly shown to elevate progranulin levels in preclinical models. This report describes the first randomized clinical trial of a histone deacetylase inhibitor in frontotemporal dementia (FTD) resulting from progranulin (GRN) gene variations.

Objective: To characterize the safety, tolerability, plasma pharmacokinetics, and pharmacodynamic effects of oral FRM-0334 on plasma progranulin and other exploratory biomarkers, including fluorodeoxyglucose (FDG)-positron emission tomography (PET), in individuals with GRN haploinsufficiency. Read More

View Article and Full-Text PDF
September 2021

Longitudinal Pathways to Influenza Vaccination Vary With Socio-Structural Disadvantages.

Ann Behav Med 2021 Sep 24. Epub 2021 Sep 24.

University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA.

Background: Although influenza vaccination can prevent influenza-related deaths, uptake remains low, particularly in disadvantaged populations.

Purpose: A theoretical model of psychological pathways to vaccination accounting for the direct and moderating role of socio-structural factors was tested. The study sought to understand the joint contributions of psychological (i. Read More

View Article and Full-Text PDF
September 2021