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Perspectives on natural compounds in chemoprevention and treatment of cancer: an update with new promising compounds.

Eur J Cancer 2021 Apr 14;149:165-183. Epub 2021 Apr 14.

Department of Pharmaceutical Sciences and Research, School of Pharmacy, Marshall University, Huntington, WV, 25701, USA. Electronic address:

Cancer is the second deadliest disease worldwide. Although recent advances applying precision treatments with targeted (molecular and immune) agents are promising, the histological and molecular heterogeneity of cancer cells and huge mutational burdens (intrinsic or acquired after therapy) leading to drug resistance and treatment failure are posing continuous challenges. These recent advances do not negate the need for alternative approaches such as chemoprevention, the pharmacological approach to reverse, suppress or prevent the initial phases of carcinogenesis or the progression of premalignant cells to invasive disease by using non-toxic agents. Read More

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An AIS-based emission inventory and the impact on air quality in Tianjin port based on localized emission factors.

Sci Total Environ 2021 Apr 6;783:146869. Epub 2021 Apr 6.

Tianjin Key Laboratory of Urban Transport Emission Research & State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China. Electronic address:

Ship pollution has become a hot global issue. This study established a basic information database of Tianjin Port ship emissions and used it to screen representative ship types and perform real-world ship measurements by a portable emission measurement system (PEMS), which generated localized emission factors. The results show that the localized emission factors are significantly higher than those recommended in recommended in Chinese guidelines, which will lead to lower calculation results of the previous inventory. Read More

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Brain Metastases: An Update on Multi-disciplinary Approach of Clinical Management.

Neurochirurgie 2021 Apr 14. Epub 2021 Apr 14.

Department of Neurosurgery, University of Wisconsin School of Medicine & Public Health, UW Carbone Cancer Center, Madison, WI, USA. Electronic address:

Importance: Brain metastasis (BM) is the most common malignant intracranial neoplasm in adults with over 100,000 new cases annually in the United States and outnumbering primary brain tumors 10:1.

Observations:  The incidence of BM in adult cancer patients ranges from 10-40%, and is increasing with improved surveillance, effective systemic therapy, and an aging population. The overall prognosis of cancer patients is largely dependent on the presence or absence of brain metastasis, and therefore, a timely and accurate diagnosis is crucial for improving long-term outcomes, especially in the current era of significantly improved systemic therapy for many common cancers. Read More

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The Gut Microbiome: a New Frontier in Musculoskeletal Research.

Curr Osteoporos Rep 2021 Apr 17. Epub 2021 Apr 17.

Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Purpose Of The Review: The human gut harbors a complex community of microbes that influence many processes regulating musculoskeletal development and homeostasis. This review gives an update on the current knowledge surrounding the impact of the gut microbiota on musculoskeletal health, with an emphasis on research conducted over the last three years.

Recent Findings: The gut microbiota and their metabolites are associated with sarcopenia, osteoporosis, osteoarthritis, and rheumatoid arthritis. Read More

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Cardiovascular toxicity of breast cancer treatment: an update.

Cancer Chemother Pharmacol 2021 Apr 17. Epub 2021 Apr 17.

Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528, Athens, Greece.

Novel chemotherapeutic agents have marked a new era in oncology during the past decade, prolonging significantly the overall survival of breast cancer patients. Nevertheless, contemporary antineoplastic treatments can frequently cause adverse cardiovascular side effects. Common manifestations of chemotherapy-induced cardiotoxicity include cardiomyopathy, ischemia, conduction disturbances, hypertension and thromboembolic events, while the type of the treatment regimen administered crucially determines clinical outcome. Read More

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Complications of Botulinum toxin A: An Update Review.

J Cosmet Dermatol 2021 Apr 17. Epub 2021 Apr 17.

Department of Dermatology, University Medical Center Mainz, Mainz, Germany.

Cosmetic surgery procedures have increased manifolds all over the world owing to the ever-increasing demand of people to look beautiful and young. Injectable treatments like botulinum toxin are becoming more popular owing to their rapid, well defined and lasting results for the reduction of facial fine lines, wrinkles and facial rejuvenation. These emerging treatments are quite safe but can have certain adverse effects. Read More

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Professional development training preferences of occupational therapists working with older adults in Australia: A discrete choice experiment.

Aust Occup Ther J 2021 Apr 16. Epub 2021 Apr 16.

College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.

Introduction: Members of the public expect occupational therapists to provide evidence-based practice. Participation in professional development activities is essential to update knowledge and acquire skills to enable delivery of evidence-based assessment and intervention. Therapists commonly choose to participate in professional development through attending training workshops. Read More

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Biopsychosocial Model Social Anxiety and Substance Use Revised.

Curr Psychiatry Rep 2021 Apr 17;23(6):35. Epub 2021 Apr 17.

Department of Psychology, Louisiana State University, 236 Audubon Hall, Baton Rouge, LA, 70803, USA.

Purpose Of Review: To review data published in the past 5 years to evaluate the utility of our biopsychosocial model of social anxiety's relation to substance misuse to evaluate the model's utility and update it.

Recent Findings: Data support the utility of our revised model-e.g. Read More

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Evaluation of the Mawid mobile healthcare application in delivering services during the COVID-19 pandemic in Saudi Arabia.

Int Health 2021 Apr 16. Epub 2021 Apr 16.

College of Business Administration, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Purpose: The purpose of this study is to evaluate MAWID mobile application developed by the Ministry of Health, Saudi Arabia, which is used for primary care hospitals appointments management and for tracking and tracing COVID-19.

Participants And Methods: An online questionnaire-based survey was used for collecting data related to three major factors including Ease of Use, Satisfaction, and Benefits of MAWID application among its users. Out of total 2542 participants, 345 participants completed only a part of the survey, and 204 participants did not use the application. Read More

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Update in imaging of cancer therapy-related cardiac toxicity in adults.

Open Heart 2021 Apr;8(1)

Pediatric Cardiology, Wilhelmina Children's Hospital University Medical Centre, Utrecht, The Netherlands

Over the past decades, prognosis of patients with cancer has strongly improved and the number of cancer survivors is rapidly growing. Despite this success, cancer treatment is associated with development of serious cardiovascular diseases including left ventricular (LV) systolic dysfunction, heart failure, valvular disease, myocardial infarction, arrhythmias or pericardial diseases. Serial non-invasive cardiac imaging is an important tool to detect early signs of cardiotoxicity, to allow for timely intervention and provide optimal circumstances for long-term prognosis. Read More

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Update on B-cell lymphoproliferative disorders of the gastrointestinal tract.

Semin Diagn Pathol 2021 Mar 26. Epub 2021 Mar 26.

Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, 420 Delaware St. SE, Minneapolis, MN 55455, USA. Electronic address:

The gastrointestinal (GI) tract is home to a significant portion of the immune system, which interacts daily with the antigenic milieu of its contents. Therefore, the presence of white blood cells within the walls of the GI tract upon histologic examination is a familiar sight on GI biopsies-both in health and disease. The GI tract is the most common site of extranodal lymphomas, most of which are B-cell neoplasms. Read More

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Measuring Psychological Load in Sport.

Int J Sports Med 2021 Apr 16. Epub 2021 Apr 16.

Premier Rugby Limited, Twickenham, United Kingdom of Great Britain and Northern Ireland.

Monitoring the physical load undertaken by athletes and examining the subsequent relationship with performance and injury and illness risk is common practice in high performance sport. Less attention has been paid to the psychological factors contributing to the overall load experienced and the impact upon health status and performance. This paper discusses considerations for the conceptualization and measurement of psychological load in sport. Read More

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Towards an updated ESTRO-EFOMP core curriculum for education and training of medical physics experts in radiotherapy - A survey of current education and training practice in Europe.

Phys Med 2021 Apr 13;84:65-71. Epub 2021 Apr 13.

Servei de Radiofisica i Radioprotecció, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain.

Purpose: ESTRO-EFOMP intend to update the core curriculum (CC) for education and training of medical physicists in radiotherapy in line with the European Commission (EC) guidelines on Medical Physics Experts (MPE), the CanMEDS methodology and recent developments in radiotherapy. As input, a survey of the current structure of radiotherapy MPE national training schemes (NTS) in Europe was carried out.

Methods: A 35-question survey was sent to all European medical physics national societies (NS) with a focus on existence of an NTS, its format and duration, required entry-level education, and financial support for trainees. Read More

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Synchronization for stochastic coupled networks with Lévy noise via event-triggered control.

Neural Netw 2021 Mar 24;141:40-51. Epub 2021 Mar 24.

Department of Mathematics, Southern Illinois University, Carbondale, Illinois 62901, USA. Electronic address:

This paper addresses the realization of almost sure synchronization problem for a new array of stochastic networks associated with delay and Lévy noise via event-triggered control. The coupling structure of the network is governed by a continuous-time homogeneous Markov chain. The nodes in the networks communicate with each other and update their information only at discrete-time instants so that the network workload can be minimized. Read More

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Updated estimates of eligibility for and response to genome-targeted oncology drugs among US cancer patients, 2006-2020.

Ann Oncol 2021 Apr 13. Epub 2021 Apr 13.

University of California San Francisco, 550 16th St, 2nd Fl, San Francisco, CA 94158.

Background: Prior studies have evaluated the percentage of cancer patients with advanced or metastatic cancer who are eligible for and respond to genome-targeted therapy, but since that publication, the number of FDA approvals for drugs targeting genetic indications has grown rapidly. We sought to update the estimates of both eligibility for and response to genome-targeted and informed therapies in US cancer patients for FDA-approved drugs to reflect estimates as of 2020.

Methods: We used mortality data from the American Cancer Society to estimate eligibility for these drugs, based on prevalence statistics from the published literature. Read More

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Occupational exposure to glass wool fibers: an update.

J Occup Environ Hyg 2021 Apr 16:1-15. Epub 2021 Apr 16.

Johns Manville Corporation, Environmental, Health, Safety and Risk, Denver, Colorado, USA.

In the decade since the last published comprehensive report of occupational exposures in the glass wool insulation industry, many process and regulatory changes have occurred in the glass wool manufacturing sector. This paper assesses whether any significant changes in worker exposures to glass wool fibers have resulted from these process and regulatory changes. The analysis compares worker exposures to glass wool overall and across different product and job categories in the manufacturing sector prior to and after 2007, the data cutoff period for the last comprehensive update of occupational exposures in this industry. Read More

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[Dilated cardiomyopathy in children].

Authors:
Gonzalo Urcelay

Rev Chil Pediatr 2020 Dec 8;91(6):860-866. Epub 2020 Oct 8.

Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Pediatric cardiomyopathies are infrequent diseases of the cardiac muscle, with an annual inciden ce of 1.1 to 1.2 per 100,000 children. Read More

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December 2020

Treatment of renal lower pole stones: an update.

Int Braz J Urol 2022 Jan 20;48. Epub 2022 Jan 20.

Seção de Endourologia - Divisão de Urologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, SP, Brasil.

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January 2022

Biologic Treatment Algorithms for Moderate-to-Severe Psoriasis with Comorbid Conditions and Special Populations: A Review.

Am J Clin Dermatol 2021 Apr 16. Epub 2021 Apr 16.

Dermatology Research and Education Foundation, Irvine, CA, USA.

The emergence of data from clinical trials of biologics, the approval of new biologics, and our improved understanding of psoriasis pathogenesis have increased the therapeutic possibilities for the treatment of moderate-to-severe psoriasis. Biologics currently approved for the treatment of psoriasis include tumor necrosis factor inhibitors, interleukin (IL)-17 inhibitors, ustekinumab (an IL-12/23 inhibitor), and IL-23 inhibitors. Data from clinical trials and studies of the safety and efficacy of biologics provide essential information for the personalization of patient care. Read More

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Management of neurogenic bladder dysfunction in children update and recommendations on medical treatment.

Int Braz J Urol 2021 Feb 28;47. Epub 2021 Feb 28.

Service of Urology, Italian Hospital, Buenos Aires, Argentina.

Introduction: Defective closure of the neural tube affects different systems and generates sequelae, such as neurogenic bladder (NB). Myelomeningocele (MMC) represents the most frequent and most severe cause of NB in children. Damage of the renal parenchyma in children with NB acquired in postnatal stages is preventable given adequate evaluation, follow-up and proactive management. Read More

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February 2021

[Chronic obstructive pulmonary disease: the right treatment for the right patient].

Internist (Berl) 2021 Apr 16. Epub 2021 Apr 16.

Klinik für Innere Medizin, Pneumologie, Intensiv- und Schlafmedizin, Universitätsklinikum Gießen und Marburg, Standort Marburg, Baldingerstr. 1, 35033, Marburg, Deutschland.

In recent years, large treatment studies have been published in the field of chronic obstructive pulmonary disease (COPD) and were supplemented by several post-hoc analyses in 2020. The new evidence was incorporated into the 2021 update of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) report. This article describes the updated fundamentals of and recommendations for the treatment of COPD. Read More

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How orthodontic research can be enriched and advanced by the novel and promising evolutions in biomedicine.

J Orthod 2021 Apr 16:14653125211006116. Epub 2021 Apr 16.

Department of Dentistry, School of Medicine, European University Cyprus, Nicosia, Cyprus.

Recent advances in developmental, molecular and cellular biology as well as biomedical technologies show a promising future for crossing the gap between biomedical basic sciences and clinical orthodontics. Orthodontic research shall utilise the advances and technologies in biomedical fields including genomics, molecular biology, bioinformatics and developmental biology. This review provides an update on the novel and promising evolutions in biomedicine and highlights their current and likely future implementation to orthodontic practice. Read More

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Hong Kong Urological Association-Hong Kong Society of Uro-Oncology consensus statements on the management of advanced prostate cancer-2019 Updates.

Asia Pac J Clin Oncol 2021 Apr;17 Suppl 3:12-26

Department of Surgery, Princess Margaret Hospital, New Territories, Hong Kong.

Background: To update the Hong Kong Urological Association-Hong Kong Society of Uro-Oncology consensus statements on the management of advanced prostate cancer, the same panelists as in the previous consensus panel held a series of meetings to discuss updated clinical evidence and experiences.

Methods: The previous consensus statements were retained, deleted, or revised, and new statements were added. At the final meeting, all statements were reviewed and amended as appropriate, followed by panel voting. Read More

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Antidepressants for people with epilepsy and depression.

Cochrane Database Syst Rev 2021 Apr 16;4:CD010682. Epub 2021 Apr 16.

Department of Health Data Science, University of Liverpool, Liverpool, UK.

Background: Depressive disorders are the most common psychiatric comorbidity in people with epilepsy, affecting around one-third, with a significant negative impact on quality of life. There is concern that people may not be receiving appropriate treatment for their depression because of uncertainty regarding which antidepressant or class works best, and the perceived risk of exacerbating seizures. This review aimed to address these issues, and inform clinical practice and future research. Read More

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Smoking and stress in the general population in Denmark.

Tob Prev Cessat 2021 12;7:27. Epub 2021 Apr 12.

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.

Introduction: The social pressure placed on smokers today might potentially lead to an increasing level of stress. We investigated if the proportion of persons with high stress level had increased over time more in smokers than in non-smokers.

Methods: Data were obtained from repeated cross-sectional surveys of The Capital Region Health Survey conducted in 2010, 2013 and 2017. Read More

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Update on the Mechanisms of Tubular Cell Injury in Diabetic Kidney Disease.

Front Med (Lausanne) 2021 30;8:661076. Epub 2021 Mar 30.

Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Increasing evidence supports a role of proximal tubular (PT) injury in the progression of diabetic kidney disease (DKD), in patients with or without proteinuria. Research on the mechanisms of the PT injury in DKD could help us to identify potential new biomarkers and drug targets for DKD. A high glucose transport state and mismatched local hypoxia in the PT of diabetes patients may be the initiating factors causing PT injury. Read More

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Obese Adipose Tissue as a Driver of Breast Cancer Growth and Development: Update and Emerging Evidence.

Front Oncol 2021 30;11:638918. Epub 2021 Mar 30.

Department of Medicine, Weill Cornell Medicine, New York, NY, United States.

Obesity is an established risk factor for breast cancer growth and progression. A number of advances have been made in recent years revealing new insights into this link. Early events in breast cancer development involve the neoplastic transformation of breast epithelial cells to cancer cells. Read More

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update.

Environ Epigenet 2021 8;7(1):dvab001. Epub 2021 Apr 8.

Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236, USA.

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