9,637 results match your criteria unsuspected


Prevalence, interpretation, and management of unexpected positive cultures in revision TKA: a systematic review.

Knee Surg Sports Traumatol Arthrosc 2022 Jan 15. Epub 2022 Jan 15.

Department of Orthopaedic Surgery, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

Purpose: Unexpected positive intraoperative cultures (UPIC) found in revision total knee arthroplasty (TKA) are difficult to interpret. Management goes along with risks for both over- and undertreating a potential periprosthetic joint infection (PJI). The objective of this systematic review was to determine the prevalence of UPIC in revision TKA surgery, evaluate the diagnostic workup process and the postoperative treatment, and assess outcome regarding re-revision rates. Read More

View Article and Full-Text PDF
January 2022

Unsuspected Central Vision Decrease from Macular Ganglion Cell Loss after Posterior Segment Surgery.

Authors:
Richard F Spaide

Retina 2022 Jan 12. Epub 2022 Jan 12.

From the Vitreous, Retina, Macula Consultants of New York.

Purpose: To describe a novel post-surgical complication of circumscribed macula ganglion cell loss as an apparent cause of unsuspected vision loss following posterior segment surgery.

Methods: Patients were seen in referral and were evaluated with comprehensive examination to include optical coherence tomography (OCT) and microperimetry.

Results: All 8 patients had a sudden central vision loss following vitrectomy and many patients suspected the central loss was present even before the eye patch was removed on the first postoperative day. Read More

View Article and Full-Text PDF
January 2022

Pleomorphic Appearance of Breast Cancer Cutaneous Metastases.

Authors:
Philip R Cohen

Cureus 2021 Dec 9;13(12):e20301. Epub 2021 Dec 9.

Dermatology, University of California, Davis Medical Center, Sacramento, USA.

Cutaneous metastases occur in approximately 10% of oncology patients as a feature of a persistent solid tumor or the harbinger of recurrent neoplastic disease. However, they can be the presenting manifestation of an unsuspected visceral malignancy in one percent of previously cancer-free individuals. Metastatic skin lesions from breast carcinoma are diverse in their appearance. Read More

View Article and Full-Text PDF
December 2021

Cardiac arrest following unsuspected self-poisoning with doxylamine.

Ther Drug Monit 2022 Jan 11. Epub 2022 Jan 11.

Clinical Toxicology Unit, Clinical Analysis Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Intensive Care Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Intensive Care Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Intensive Care Department. Hospital Universitari Son Llàtzer. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Cardiology Department. Hospital Universitari Son Llàtzer. Department of Medicine, Faculty of Medicine, University of the Balearic Islands. Research Institute of Health Sciences (IdISBa). Palma de Mallorca, Spain. Institute of Legal Medicine of the Balearic Islands. Ministry of Justice. Department of Medicine, Faculty of Medicine, University of the Balearic Islands. Palma de Mallorca, Spain. Institute of Legal Medicine of the Balearic Islands. Ministry of Justice. Department of Medicine, Faculty of Medicine, University of the Balearic Islands. Palma de Mallorca, Spain.

View Article and Full-Text PDF
January 2022

Resurgence of intestinal ascariasis among adults: radiological diagnosis and clinical implications.

Abdom Radiol (NY) 2022 Jan 11. Epub 2022 Jan 11.

Department of Radiology, University of California-San Diego Medical Center, 200 West Arbor Drive, San Diego, CA, 92103, USA.

To report the radiological features of intestinal ascariasis and to review the clinical implications of this re-emerging disease for adult population of the USA. This retrospective observational study involved 12 adult patients, whose radiological examinations disclosed unsuspected presence of ascaris in their intestinal tract. They were evaluated by computed tomography of the abdomen with oral contrast, small bowel series with barium, and magnetic resonance enterography. Read More

View Article and Full-Text PDF
January 2022

Physical Forces and Transient Nuclear Envelope Rupture during Metastasis: The Key for Success?

Cancers (Basel) 2021 Dec 24;14(1). Epub 2021 Dec 24.

Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía-University of Pablo de Olavide-University of Seville-CSIC, 41092 Seville, Spain.

During metastasis, invading tumor cells and circulating tumor cells (CTC) face multiple mechanical challenges during migration through narrow pores and cell squeezing. However, little is known on the importance and consequences of mechanical stress for tumor progression and success in invading a new organ. Recently, several studies have shown that cell constriction can lead to nuclear envelope rupture (NER) during interphase. Read More

View Article and Full-Text PDF
December 2021

Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research.

Front Neuroendocrinol 2022 Jan 7;65:100977. Epub 2022 Jan 7.

Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), 14004 Cordoba, Spain; Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Cordoba, Spain; Hospital Universitario Reina Sofia, 14004 Cordoba, Spain; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 14004 Cordoba, Spain; Institute of Biomedicine, University of Turku, FIN-20520 Turku, Finland. Electronic address:

In late 2003, a major breakthrough in our understanding of the mechanisms that govern reproduction occurred with the identification of the reproductive roles of kisspeptins, encoded by the Kiss1 gene, and their receptor, Gpr54 (aka, Kiss1R). The discovery of this unsuspected reproductive facet attracted an extraordinary interest and boosted an intense research activity, in human and model species, that, in a relatively short period, established a series of basic concepts on the physiological roles of kisspeptins. Such fundamental knowledge, gathered in these early years of kisspeptin research, set the scene for the more recent in-depth dissection of the intimacies of the neuronal networks involving Kiss1 neurons, their precise mechanisms of regulation and the molecular underpinnings of the function of kisspeptins as pivotal regulators of all key aspects of reproductive function, from puberty onset to pulsatile gonadotropin secretion and the metabolic control of fertility. Read More

View Article and Full-Text PDF
January 2022

MYC, mitochondrial metabolism and O-GlcNAcylation converge to modulate the activity and subcellular localization of DNA and RNA demethylases.

Leukemia 2022 Jan 8. Epub 2022 Jan 8.

Division of Hematology and Medical Oncology, Department of Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, 78229, USA.

Mitochondria can function as signaling organelles, and part of this output leads to epigenetic remodeling. The full extent of this far-reaching interplay remains undefined. Here, we show that MYC transcriptionally activates IDH2 and increases alpha-ketoglutarate (αKG) levels. Read More

View Article and Full-Text PDF
January 2022

Cancer Diagnoses Following Abnormal Noninvasive Prenatal Testing: A Case Series, Literature Review, and Proposed Management Model.

JCO Precis Oncol 2021 Nov;5:1001-1012

Department of Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.

Noninvasive prenatal testing (NIPT) is a screening test for fetal chromosomal aneuploidy using cell-free DNA derived from maternal blood. It has been rapidly accepted into obstetric practice because of its application from 10-weeks' gestation, and its high sensitivity and specificity. NIPT results can be influenced by several factors including placental or maternal mosaicism and co-twin demise; cell-free DNA from a maternal origin can also complicate interpretation, with evidence that NIPT can detect previously unsuspected malignancies. Read More

View Article and Full-Text PDF
November 2021

Can routine MRI spine T1 sequences be used for prediction of decreased bone density?

Acta Radiol 2022 Jan 6:2841851211063008. Epub 2022 Jan 6.

Department of Radiology, 81558Kokilaben Dhirubhai Ambani Hospital, Mumbai, India.

Background: Bone marrow signal is ideally evaluated with magnetic resonance imaging (MRI) due to its high tissue contrast. While advanced MRI quantitative methods can be used for estimating bone density, there are no readily available parameters on routine clinical MRI sequences of the lumbar spine.

Purpose: To evaluate whether T1 signal intensity (SI) ratio of lumbar vertebral body (VB)/cerebrospinal fluid (CSF) may predict decreased bone density. Read More

View Article and Full-Text PDF
January 2022

A Rare Case of Unsuspected Extra-Adrenal Pheochromocytoma in a Patient Undergoing Excision for Vagal Schwannoma.

Neurol India 2021 Nov-Dec;69(6):1863-1864

Department of Ophthalmology, Armed Forces Medical College, Pune, Maharashtra, India.

View Article and Full-Text PDF
January 2022

CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing.

Mol Metab 2021 Dec 30:101428. Epub 2021 Dec 30.

Centre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, 400016 Chongqing, China. Electronic address:

Objective: Enhanced de novo lipogenesis (DNL) in hepatocytes is a major contributor to nonalcoholic fatty liver disease (NAFLD). Fatty acid translocase (FAT/CD36) is involved in the pathogenesis of NAFLD through facilitating free fatty acids uptake. Here, we explored the effects of CD36 on DNL and elucidated the underlying mechanisms. Read More

View Article and Full-Text PDF
December 2021

Rosai-Dorfman Disease of Bone and Soft Tissue.

Arch Pathol Lab Med 2022 01;146(1):40-46

From the Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York.

Context.—: Rosai-Dorfman disease is a rare histiocytic proliferative disorder of unknown pathogenesis that may be diagnostically difficult in extranodal sites. It is commonly an unsuspected diagnosis when arising in bone and soft tissue, especially when it presents without associated lymphadenopathy. Read More

View Article and Full-Text PDF
January 2022

Toward Modeling Psychomotor Performance in Karate Combats Using Computer Vision Pose Estimation.

Sensors (Basel) 2021 Dec 15;21(24). Epub 2021 Dec 15.

aDeNu Research Group, Artificial Intelligence Department, Computer Science School, Universidad Nacional de Educación a Distancia (UNED), 28040 Madrid, Spain.

Technological advances enable the design of systems that interact more closely with humans in a multitude of previously unsuspected fields. Martial arts are not outside the application of these techniques. From the point of view of the modeling of human movement in relation to the learning of complex motor skills, martial arts are of interest because they are articulated around a system of movements that are predefined, or at least, bounded, and governed by the laws of Physics. Read More

View Article and Full-Text PDF
December 2021

Cerebral amyloidomas: Perspective on unusual morphological features.

Clin Neuropathol 2021 Dec 27. Epub 2021 Dec 27.

Aims: Cerebral amyloidomas (CAs) are mass-producing congophilic lesions most commonly due to λ light chain deposits, contrasting them with light chain deposition disease (LCDD) which has non-polarizable, often κ light chain deposition.

Materials And Methods: Although usual histological features are well known, we detail 3 recent CAs with unusual morphological findings and review the literature specifically for these features.

Results: Two women, aged 56 and 58 years, had right cerebral white matter CAs. Read More

View Article and Full-Text PDF
December 2021

Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-λ/ι and Nuclear Factor κ-B.

Curr Alzheimer Res 2021 ;18(12):941-955

Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida, FL, USA | Research Service, James A. Haley Veterans Medical Center, Tampa, Florida, FL, USA.

Βackground: β-Amyloid precursor protein-cleaving enzyme-1 (BACE1) initiates the production of Aβ-peptides that form Aβ-plaque in Alzheimer's disease.

Methods: Reportedly, acute insulin treatment in normal mice, and hyperinsulinemia in high-fat-fed (HFF) obese/diabetic mice, increase BACE1 activity and levels of Aβ-peptides and phospho- -thr-231-tau in the brain; moreover, these effects are blocked by PKC-λ/ι inhibitors. However, as chemical inhibitors may affect unsuspected targets, we presently used knockout methodology to further examine PKC-λ/ι requirements. Read More

View Article and Full-Text PDF
January 2021

Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma.

Elife 2021 12 23;10. Epub 2021 Dec 23.

Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, Canada.

Different melanoma subtypes exhibit specific and non-overlapping sets of oncogene and tumor suppressor mutations, despite a common cell of origin in melanocytes. For example, activation of the Gα signaling pathway is a characteristic initiating event in primary melanomas that arise in the dermis, uveal tract, or central nervous system. It is rare in melanomas arising in the epidermis. Read More

View Article and Full-Text PDF
December 2021

Unsuspected mobility of Arctic hares revealed by longest journey ever recorded in a lagomorph.

Ecology 2021 Dec 22:e3620. Epub 2021 Dec 22.

Canada Research Chair on Northern Biodiversity, Centre for Northern Studies and Quebec Center for Biodiversity Science, Université du Québec à Rimouski, 300 Allée des Ursulines, Rimouski, Quebec, Canada.

View Article and Full-Text PDF
December 2021

Fuel for emotion: how mitophagy in the BLA can mediate increased anxiety in stressful social situations.

Autophagy 2021 Dec 19:1-2. Epub 2021 Dec 19.

Section on Synapse Development Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Psychosocial stress is a common risk factor for anxiety disorders. The cellular mechanism for the anxiogenic effect of psychosocial stress is largely unclear. We recently showed that chronic social defeat (CSD) stress in mice causes mitochondrial impairment, which triggers the PINK1-PRKN/parkin mitophagy pathway selectively in the amygdala. Read More

View Article and Full-Text PDF
December 2021

COVID-19 induced aorto duodenal fistula following evar in the so called "negative" patient.

Vascular 2021 Dec 17:17085381211053695. Epub 2021 Dec 17.

Department of Translational Medicine for Romagna, and Vascular Diseases Center, University of Ferrara, Ferrara, Italy.

Objectives: Since October 2019, SARS-CoV-2 pandemic represents a challenge for the international healthcare system and for the treatment and survival of patients. We normally focus on symptomatic patients, and symptoms can range from the respiratory to the gastrointestinal system. In addition, we consider patients without fever and respiratory symptoms, with both a negative RT nasopharyngeal swab and lung CT, as a "Covid-19 negative patient. Read More

View Article and Full-Text PDF
December 2021

Deep vein thrombosis in the thigh: MR imaging in two cases with atypical presentations.

Skeletal Radiol 2021 Dec 14. Epub 2021 Dec 14.

Department of Orthopedic Surgery, Daejeon St. Mary's Hospital, The Catholic University of Korea, Daejeon, Republic of Korea.

Deep vein thrombosis (DVT) is a common clinical problem affecting the lower extremities. Prompt imaging of suspected DVT is helpful for rapid diagnosis and proper treatment. However, patients without clear predisposing factors for DVT may be directed to alternative diagnoses of a musculoskeletal disorder. Read More

View Article and Full-Text PDF
December 2021

Exposures to IARC Carcinogenic Agents in Work Settings Not Traditionally Associated with Sinonasal Cancer Risk: The Experience of the Italian National Sinonasal Cancer Registry.

Int J Environ Res Public Health 2021 11 29;18(23). Epub 2021 Nov 29.

Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Istituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro, 00100 Roma, Italy.

The aim of this study is to highlight tasks and jobs not commonly considered at high risk for sinonasal cancer (SNC) identified by Regional Operating Centers currently active in the Italian National Sinonasal Cancer Registry (ReNaTuNS), which retrieve occupational histories through a standardized questionnaire. Data on exposures to IARC carcinogenic agents in work settings unknown to be associated with SNC risk were collected and analyzed. Out of 2,208 SNC cases recorded in the ReNaTuNS database, 216 cases and their worked exposure periods were analyzed. Read More

View Article and Full-Text PDF
November 2021

Lipopeptide Interplay Mediates Molecular Interactions between Soil Bacilli and Pseudomonads.

Microbiol Spectr 2021 12 8;9(3):e0203821. Epub 2021 Dec 8.

Microbial Processes and Interactions Laboratory, Terra Teaching and Research Centre, Gembloux Agro-Bio Tech, University of Liègegrid.4861.b, Gembloux, Belgium.

Some species, such as B. velezensis, are important members of the plant-associated microbiome, conferring protection against phytopathogens. However, our knowledge about multitrophic interactions determining the ecological fitness of these biocontrol bacteria in the competitive rhizosphere niche is still limited. Read More

View Article and Full-Text PDF
December 2021

Incidence of unplanned excisions of soft tissue sarcomas in the Netherlands: A population-based study.

Eur J Surg Oncol 2021 Nov 19. Epub 2021 Nov 19.

Department of Research & Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands. Electronic address:

Introduction: Timely recognition of soft tissue sarcomas (STS) remains challenging, potentially leading to unplanned excisions (also known as 'whoops procedures'). This population-based study charted the occurrence of unplanned excisions and identified associated patient, tumour, and treatment-related characteristics. Furthermore, it presents an overview of the outcomes and clinical management following an unplanned excision. Read More

View Article and Full-Text PDF
November 2021

Nutrigenomic Effect of Hydroxytyrosol in Vascular Endothelial Cells: A Transcriptomic Profile Analysis.

Nutrients 2021 Nov 9;13(11). Epub 2021 Nov 9.

Cardiology Division, Pisa University Hospital, 56124 Pisa, Italy.

Hydroxytyrosol (HT), a peculiar olive and olive oil phenolic antioxidant, plays a significant role in the endothelial and cardiovascular protection associated with olive oil consumption. However, studies examining the effects of HT on the whole-genome expression of endothelial cells, which are prominent targets for vasculo-protective effects of olive oil polyphenols, have been lacking. This study aims to comprehensively evaluate the genomic effects exerted by HT, at the transcriptional level, in endothelial cells under resting or proinflammatory conditions. Read More

View Article and Full-Text PDF
November 2021

Heart as a Model for Cardiac Development and Diseases.

Cells 2021 11 8;10(11). Epub 2021 Nov 8.

Genetics Reproduction and Development Institute (iGReD), INSERM U1103, CNRS UMR6293, University of Clermont Auvergne, 28 Place Henri-Dunant, 63000 Clermont-Ferrand, France.

The heart, also referred to as the dorsal vessel, pumps the insect blood, the hemolymph. The bilateral heart primordia develop from the most dorsally located mesodermal cells, migrate coordinately, and fuse to form the cardiac tube. Though much simpler, the fruit fly heart displays several developmental and functional similarities to the vertebrate heart and, as we discuss here, represents an attractive model system for dissecting mechanisms of cardiac aging and heart failure and identifying genes causing congenital heart diseases. Read More

View Article and Full-Text PDF
November 2021

Nesprin-1 Isoforms Differentially Contribute to Muscle Function.

Cells 2021 11 6;10(11). Epub 2021 Nov 6.

Institut NeuroMyoGène, CNRS UMR5310, INSERM U1217, Université Claude Bernard Lyon 1, 69008 Lyon, France.

Nesprin-1 is a large scaffold protein connecting nuclei to the actin cytoskeleton via its KASH and Calponin Homology domains, respectively. Nesprin-1 disconnection from nuclei results in altered muscle function and myonuclei mispositioning. Furthermore, Nesprin-1 mutations are associated with muscular pathologies such as Emery Dreifuss muscular dystrophy and arthrogryposis. Read More

View Article and Full-Text PDF
November 2021

High Density of CD16+ Tumor-Infiltrating Immune Cells in Recurrent Ovarian Cancer Is Associated with Enhanced Responsiveness to Chemotherapy and Prolonged Overall Survival.

Cancers (Basel) 2021 Nov 18;13(22). Epub 2021 Nov 18.

Institute of Pathology, Kantonsspital Baden AG, 5404 Baden, Switzerland.

Background: Ovarian cancer (OC) is the most aggressive and fatal malignancy of the female reproductive system. Debulking surgery with adjuvant chemotherapy represents the standard treatment, but recurrence rates are particularly high. Over the past decades, the association between the immune system and cancer progression has been extensively investigated. Read More

View Article and Full-Text PDF
November 2021

SDHI Fungicide Toxicity and Associated Adverse Outcome Pathways: What Can Zebrafish Tell Us?

Int J Mol Sci 2021 Nov 16;22(22). Epub 2021 Nov 16.

Inserm U1141, NeuroDiderot, Université de Paris, F-75019 Paris, France.

Succinate dehydrogenase inhibitor (SDHI) fungicides are increasingly used in agriculture to combat molds and fungi, two major threats to both food supply and public health. However, the essential requirement for the succinate dehydrogenase (SDH) complex-the molecular target of SDHIs-in energy metabolism for almost all extant eukaryotes and the lack of species specificity of these fungicides raise concerns about their toxicity toward off-target organisms and, more generally, toward the environment. Herein we review the current knowledge on the toxicity toward zebrafish () of nine commonly used SDHI fungicides: bixafen, boscalid, fluxapyroxad, flutolanil, isoflucypram, isopyrazam, penthiopyrad, sedaxane, and thifluzamide. Read More

View Article and Full-Text PDF
November 2021

Real-world deployment of lateral flow SARS-CoV-2 antigen detection in the emergency department to provide rapid, accurate and safe diagnosis of COVID-19.

Infect Prev Pract 2021 Dec 18;3(4):100186. Epub 2021 Nov 18.

Emergency Department, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Background: Point-of-care (POC) SARS-CoV-2 lateral-flow antigen detection (LFD) testing in the emergency department (ED) could inform rapid infection control decisions but requirements for safe deployment have not been fully defined.

Methods: Review of LFD test results, laboratory and POC-RT-PCR results and ED-performance metrics during a two-week high SARS-CoV-2 prevalence period followed by several months of falling prevalence.

Aim: Determine whether LFD testing can be safely deployed in ED to provide an effective universal SARS-CoV-2 testing capability. Read More

View Article and Full-Text PDF
December 2021