64 results match your criteria unreported comorbidity

Sleep Quality and Associated Factors Among Diabetes Mellitus Patients in a Follow-Up Clinic at the University of Gondar Comprehensive Specialized Hospital in Gondar, Northwest Ethiopia: A Cross-Sectional Study.

Diabetes Metab Syndr Obes 2020 9;13:4859-4868. Epub 2020 Dec 9.

Department of Medical Nursing, School of Nursing, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.

Introduction: Diabetic mellitus has a negative impact on the quality of sleep. It is one of the leading public health conditions which can result in poor sleep quality. Poor sleep quality is an unreported and unrecognized problem which can affect the prognosis of diabetes patients. Read More

View Article and Full-Text PDF
December 2020

A case of failure to thrive secondary to primary hyperoxaluria type 1.

Radiol Case Rep 2020 Oct 5;15(10):1806-1808. Epub 2020 Aug 5.

Department of Radiology, Jacobi Medical Center, 1400 Pelham Parkway, Bronx, NY 10461, USA.

Primary hyperoxaluria type 1 is a rare genetic condition characterized by oxalate deposition in the kidneys. We report findings of an 8-month old female presenting with failure to thrive, poor oral intake, and kidney stones resulting in the diagnosis of primary hyperoxaluria type 1. The patient exhibits a unique presentation without renal failure at the time of diagnosis suggesting a previously unreported comorbidity in early stages of disease. Read More

View Article and Full-Text PDF
October 2020

Multicentre study of risk factors for mortality in patients with Acinetobacter bacteraemia receiving colistin treatment.

Int J Antimicrob Agents 2020 Jun 9;55(6):105956. Epub 2020 Apr 9.

Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address:

Colistin remains a last-line antibiotic for the treatment of infections by multidrug-resistant Acinetobacter species. However, mortality rates are high in patients with Acinetobacter infection receiving colistin treatment. This multicentre study evaluated whether colistin susceptibility, additional antimicrobial agents or other prognostic factors influenced the clinical outcomes of patients receiving colistin treatment for Acinetobacter bacteraemia. Read More

View Article and Full-Text PDF

Compliance and Utility of a Smartphone App for the Detection of Exacerbations in Patients With Chronic Obstructive Pulmonary Disease: Cohort Study.

JMIR Mhealth Uhealth 2020 03 19;8(3):e15699. Epub 2020 Mar 19.

Pulmonology Department, Hospital Clínico San Carlos, Madrid, Spain.

Background: In recent years, mobile health (mHealth)-related apps have been developed to help manage chronic diseases. Apps may allow patients with a chronic disease characterized by exacerbations, such as chronic obstructive pulmonary disease (COPD), to track and even suspect disease exacerbations, thereby facilitating self-management and prompt intervention. Nevertheless, there is insufficient evidence regarding patient compliance in the daily use of mHealth apps for chronic disease monitoring. Read More

View Article and Full-Text PDF

Readmissions to an alternate hospital in patients undergoing vascular intervention for claudication and critical limb ischemia associated with significantly higher mortality.

J Vasc Surg 2019 12 29;70(6):1960-1972. Epub 2019 May 29.

Department of Surgery, University of Miami Miller School of Medicine, Miami, Fla.

Background: Hospital readmissions with 30 days after vascular surgical interventions have been associated with increased morbidity, mortality, and cost. Readmission rates, now a Centers for Medicare and Medicaid Services quality measure, have been studied in databases that have excluded certain payer types and states and have not accounted for readmission to a hospital different from that of the index admission. More accurate and nationally representative data are needed, because this fragmentation of care could lead to flawed conclusions. Read More

View Article and Full-Text PDF
December 2019

Phenotypic and genetic analysis of an adult cohort with extreme obesity.

Int J Obes (Lond) 2019 10 21;43(10):2057-2065. Epub 2018 Sep 21.

Department of Medicine and Endocrinology, University of Toronto, Toronto, ON, Canada.

Context: Adult extreme obesity (EO) is a growing health concern. The prevalence of known obesity associated co-morbidities namely cardio-metabolic and neuro-psychiatric disease in EO is not fully established. The contribution of pathogenic genetic variants, previously implicated in early childhood onset obesity, to adult EO is also not established. Read More

View Article and Full-Text PDF
October 2019

TSC-associated neuropsychiatric disorders (TAND): findings from the TOSCA natural history study.

Orphanet J Rare Dis 2018 09 10;13(1):157. Epub 2018 Sep 10.

UZ Brussel Vrije Universiteit Brussel, Brussels, Belgium.

Background: Most evidence for TSC-associated neuropsychiatric disorders (TAND) to date have come from small studies and case reports, and very little is known about TAND in adults. We explored baseline TAND data from the large-scale international TOSCA natural history study to compare childhood and adult patterns, describe age-based patterns, and explore genotype-TAND correlations.

Results: The study enrolled 2216 eligible participants with TSC from 170 sites across 31 countries at the data cut-off for the third interim analysis (data cut-off date: September 30, 2015). Read More

View Article and Full-Text PDF
September 2018

Variation in National Readmission Patterns After Burn Injury.

J Burn Care Res 2018 08;39(5):670-675

DeWitt Daughtry Family Department of Surgery, Miller School of Medicine, University of Miami, Florida.

A significant proportion of readmissions occurs at a different hospital than the index admission, and is thus missed by current quality metrics. No study has examined all-hospital adult 30-day readmission rates, including different hospitals, following burn injury across the United States. The purpose of this study was to evaluate nationwide readmission rates, potential risk factors, and ultimately the burden of burn injury readmission, including readmission to a different hospital. Read More

View Article and Full-Text PDF

Seroprevalence of dengue among healthy adults in a rural community in Southern Malaysia: a pilot study.

Infect Dis Poverty 2018 Jan 16;7(1). Epub 2018 Jan 16.

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500, Petaling Jaya, Malaysia.

Background: The frequency and magnitude of dengue epidemics continue to increase exponentially in Malaysia, with a shift in the age range predominance toward adults and an expansion to rural areas. Despite this, information pertaining to the extent of transmission of dengue virus (DENV) in the rural community is lacking. This community-based pilot study was conducted to establish DENV seroprevalence amongst healthy adults in a rural district in Southern Malaysia, and to identify influencing factors. Read More

View Article and Full-Text PDF
January 2018

Brief Report: Major Depressive Disorder with Psychotic Features in Williams Syndrome: A Case Series.

J Autism Dev Disord 2018 03;48(3):947-952

Lurie Center for Autism, Massachusetts General Hospital, One Maguire Road, Lexington, MA, 02421-3114, USA.

Descriptions of individuals with Williams syndrome (WS) and co-morbid major depressive disorder (MDD) with psychotic features have not appeared in the literature. In addition to reviewing previous reports of psychotic symptoms in persons with WS, this paper introduces clinical histories and therapeutic management strategies for three previously unreported adults with WS diagnosed with co-morbid MDD with psychotic features. Co-morbid medical disorders common in WS are highlighted with regard to safe and appropriate pharmacological treatment. Read More

View Article and Full-Text PDF

Polyploidy and Mitotic Cell Death Are Two Distinct HIV-1 Vpr-Driven Outcomes in Renal Tubule Epithelial Cells.

J Virol 2018 01 2;92(2). Epub 2018 Jan 2.

Department of Pathology, Duke University, Durham, North Carolina, USA

Prior studies have found that HIV, through the Vpr protein, promotes genome reduplication (polyploidy) in infection-surviving epithelial cells within renal tissue. However, the temporal progression and molecular regulation through which Vpr promotes polyploidy have remained unclear. Here we define a sequential progression to Vpr-mediated polyploidy in human renal tubule epithelial cells (RTECs). Read More

View Article and Full-Text PDF
January 2018

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.

Nat Genet 2017 Oct 4;49(10):1450-1457. Epub 2017 Sep 4.

Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). Read More

View Article and Full-Text PDF
October 2017

The Turner syndrome life course project: Karyotype-phenotype analyses across the lifespan.

Clin Endocrinol (Oxf) 2017 Nov 24;87(5):532-538. Epub 2017 Jul 24.

Reproductive Medicine Unit, University College London Hospital, London, UK.

Introduction: Turner syndrome (TS) is associated with a variety of morbidities affecting nearly every body system, some of which increase in prevalence in adult life. The severity of clinical features in TS is roughly in parallel with the magnitude of the deficit of X-chromosome material. The aim of this study was to extend the established karyotype-phenotype relationships using data from a large adult cohort. Read More

View Article and Full-Text PDF
November 2017

Serious fungal infections in Thailand.

Eur J Clin Microbiol Infect Dis 2017 Jun 4;36(6):931-935. Epub 2017 Feb 4.

The National Aspergillosis Centre in association with the LIFE program at www.LIFE-worldwide.org, The University of Manchester, Manchester, UK.

The burden of serious fungal infection in Thailand is increasing but data regarding its incidence and prevalence are lacking. In this study we aimed to estimate the burden of serious fungal diseases in Thailand based on the size of the populations at risk and available epidemiological databases. Data derived from The Bureau of Epidemiology, Department of Disease Control, Thai Ministry of Public Health, World Health Organisation, international and local reports, and some unreported data were used. Read More

View Article and Full-Text PDF

Vesicourethral reflux-induced renal failure in a patient with ICF syndrome due to a novel DNMT3B mutation.

Am J Med Genet A 2016 12 8;170(12):3253-3257. Epub 2016 Sep 8.

Division of Immunology and Allergy, Department of Pediatrics, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.

ICF syndrome is a primary immunodeficiency disease characterized by hypo- or agammaglobulinemia, centromeric instability mainly on chromosomes 1, 9, and 16 and facial anomalies. ICF syndrome presents with frequent respiratory tract infections in infancy. A 20-month-old female patient was referred to our clinic due to frequent lower respiratory tract infections. Read More

View Article and Full-Text PDF
December 2016

Risk factors associated with treatment discontinuation and down-titration in type 2 diabetes patients treated with sulfonylureas.

Curr Med Res Opin 2016 09 13;32(9):1567-75. Epub 2016 Jun 13.

e MSD Portugal , Paço de Arcos , Portugal.

Objectives: Sulfonylurea therapy among patients with type 2 diabetes mellitus (T2DM) can be disrupted due to adverse events, including hypoglycemia. A retrospective study using the MarketScan claims database quantified the frequency of sulfonylurea discontinuation or down-titration and identified associated risk factors.

Research Design And Methods: Adult patients with an index sulfonylurea prescription between 2008 and 2012 and 1 year continuous enrollment pre- and post-index were included. Read More

View Article and Full-Text PDF
September 2016

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.

Nat Genet 2016 05 14;48(5):510-8. Epub 2016 Mar 14.

Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.

We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between these clinically related diseases. Using high-density genotype data from more than 86,000 individuals of European ancestry, we identified 244 independent multidisease signals, including 27 new genome-wide significant susceptibility loci and 3 unreported shared risk loci. Complex pleiotropy was supported when contrasting multidisease signals with expression data sets from human, rat and mouse together with epigenetic and expressed enhancer profiles. Read More

View Article and Full-Text PDF

Mortality in Rheumatoid Arthritis (RA): factors associated with recording RA on death certificates.

BMC Musculoskelet Disord 2015 Oct 5;16:277. Epub 2015 Oct 5.

University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA.

Background: Death certificates can be used to assess disease prevalence and incidence; however, rheumatoid arthritis (RA) often remains unreported in death certificates. We sought to determine to what extent RA is underreported and what demographic and clinical characteristics could predict mention of RA in the death certificate.

Methods: We recruited 1328 patients with RA from private, public and military rheumatology practices and followed them prospectively for yearly evaluations. Read More

View Article and Full-Text PDF
October 2015

Correlates of major medication side effects interfering with daily performance: results from a cross-sectional cohort study of older psychiatric patients.

Int Psychogeriatr 2016 Feb 28;28(2):331-40. Epub 2015 Sep 28.

Center for Psychopharmacology,Diakonhjemmet Hospital,Oslo,Norway.

Background: Polypharmacy is common among older persons who are also vulnerable to side effects. We aimed to characterize patients who on admission to a geriatric psychiatric hospital had major medication side effects interfering with daily performance.

Methods: Cross-sectional cohort study of patients consecutively admitted to a geriatric psychiatric hospital from 2006, 06 December to 2008, 24 October. Read More

View Article and Full-Text PDF
February 2016

Adverse reactions to antipsychotics in Parkinson disease: an analysis of the Spanish pharmacovigilance database.

Clin Neuropharmacol 2015 May-Jun;38(3):69-84

*Pharmacy Service, Araba's Mental Health Network; †Pharmacokinetics, Nanotechnology, and Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, and ‡Centro de Investigación Lascaray Ikergunea, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Araba/Álava; §Pharmacy Service, Alto Deba Integrated Health Organization, Arrasate, Gipuzkoa; ║Basque Pharmacovigilance Unit, and ¶Department of Neurology, Hospital Galdakao-Usánsolo, Galdakao, Vizcaya, Spain.

Purpose: Although antipsychotics are well known for causing a plethora of adverse drug reactions (ADRs), the main concern when used to treat psychosis in Parkinson disease (PD) has traditionally been motor function worsening. The limited number of patients included in clinical trials contributes to underreport less common ADR. The aims of this study were to describe ADR to antipsychotics occurring in patients with PD notified to the Spanish Pharmacovigilance System and to contrast them with published reports. Read More

View Article and Full-Text PDF

Phenotypic modifications of patients with full chromosome aneuploidies and concurrent suspected or confirmed second diagnoses.

Am J Med Genet A 2015 Sep 25;167A(9):2168-75. Epub 2015 Apr 25.

Section of Genetics and Metabolism, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

The coexistence of two or more distinct genetic conditions is known to be a rare phenomenon. Full chromosome aneuploidies can be associated with a broad variety of cytogenetic abnormalities or single gene disorders resulting in phenotypic modifications that confuse the diagnostic process. We present six patients with primary aneuploidies and a suspected or confirmed secondary genetic diagnosis or unusual birth defect. Read More

View Article and Full-Text PDF
September 2015

Breast cancer characteristics and survival differences between Maori, Pacific and other New Zealand women included in the Quality Audit program of Breast Surgeons of Australia and New Zealand.

Asian Pac J Cancer Prev 2015 ;16(6):2465-72

Waikato Clinical School, Faculty of Medical and Health Sciences, University of Auckland, New Zealand E-mail :

Background: The Quality Audit (BQA) program of the Breast Surgeons of Australia and New Zealand (NZ) collects data on early female breast cancer and its treatment. BQA data covered approximately half all early breast cancers diagnosed in NZ during roll-out of the BQA program in 1998-2010. Coverage increased progressively to about 80% by 2008. Read More

View Article and Full-Text PDF
February 2016

Copy number variations in children with brain malformations and refractory epilepsy.

Am J Med Genet A 2015 Mar;167A(3):512-23

Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.

Brain malformations are a major cause of therapy-refractory epilepsy as well as neurological and developmental disabilities in children. This study examined the frequency and the nature of copy number variations among children with structural brain malformations and refractory epilepsy. The medical records of all children born between 1990 and 2009 in the epilepsy registry at the Astrid Lindgren's Children's Hospital were reviewed and 86 patients with refractory epilepsy and various brain malformations were identified. Read More

View Article and Full-Text PDF

[Sexual dysfunctions, psychiatric diseases and quality of life: a review].

Psychiatr Pol 2014 Jul-Aug;48(4):715-26

Sexual dysfunctions may have a significant effect on the quality of life, but are unreported and under-diagnosed. A review of recent literature highlights the correlation between dysfunction and a decreased quality of life in people with psychiatric comorbidity, and explores several aspects impacting care, from following the patient to pharmacological and non-pharmacological treatments. Sexual dysfunctions (SD) have been shown to be prevalent, but under-diagnosed and un-dertreated because of communication barriers between patients and physicians. Read More

View Article and Full-Text PDF
November 2014

Transcatheter closure of atrial septal defect associated with arrhythmogenic right ventricular cardiomyopathy: a case report and literature review.

Cardiol Young 2015 Mar 30;25(3):403-7. Epub 2014 Sep 30.

3Department of Cardiology,Shandong Provincial Qianfoshan Hospital,Shandong University,Jinan,Shandong Province,China.

Arrhythmogenic right ventricular cardiomyopathy is characterised by progressive, fibrofatty replacement of myocardium, and ventricular arrhythmias, and its prognosis is usually poor. Arrhythmogenic right ventricular cardiomyopathy associated with atrial septal defect is very rare, and this combination may make the diagnosis, treatment, and prognosis difficult. We present a case of a patient with this association who underwent interventional treatment with a septal defect occluder. Read More

View Article and Full-Text PDF

Impaired 6-min walk test, heart rate recovery and cardiac function post pulmonary embolism in long-term survivors.

Respir Med 2014 Oct 13;108(10):1556-65. Epub 2014 Aug 13.

ANZAC Research Institute, Sydney, Australia; Department of Cardiology, Concord Repatriation General Hospital and The University of Sydney, Sydney, Australia. Electronic address:

Background: The functional capacity of long-term survivors of submassive pulmonary embolism (PE) is unreported. A six-minute walk distance (6MWD) <350 m and reduced heart rate recovery (HRR) indicate adverse prognosis in various chronic diseases.

Methods: Long-term survivors of acute PE (January 2000-June 2005) were invited to undergo prospectively planned six-minute walk test (6MWT), transthoracic echocardiogram (TTE), clinical and biochemical evaluation with cardiac biomarkers. Read More

View Article and Full-Text PDF
October 2014

First report of the Hyper-IgM syndrome Registry of the Latin American Society for Immunodeficiencies: novel mutations, unique infections, and outcomes.

J Clin Immunol 2014 Feb 9;34(2):146-56. Epub 2014 Jan 9.

Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, 1730 Lineu Prestes Avenue, São Paulo, SP, ZIP 05508-000, Brazil.

Hyper-IgM (HIGM) syndrome is a heterogeneous group of disorders characterized by normal or elevated serum IgM levels associated with absent or decreased IgG, IgA and IgE. Here we summarize data from the HIGM syndrome Registry of the Latin American Society for Immunodeficiencies (LASID). Of the 58 patients from 51 families reported to the registry with the clinical phenotype of HIGM syndrome, molecular defects were identified in 37 patients thus far. Read More

View Article and Full-Text PDF
February 2014

GAPO syndrome associated with pyoderma vegetans: an unreported co-existence.

Genet Couns 2013 ;24(2):133-9

Department of Dermatology, Yuzuncu Yil University, Faculty of Medicine, Van, Turkey.

GAPO syndrome is a rare autosomal recessive disease and an acronym composed of growth retardation, alopecia, pseudoanodontia, optic atrophy. Approximately 38 cases have been reported in literature until now. Pyoderma vegetans is a chronic inflammatory disease characterized with vesicopustular, exudative and vegetative lesions usually localized on face, scalp, axilla and genitalia. Read More

View Article and Full-Text PDF
October 2013

Prevalence of associated disorders in Indian patients with celiac disease.

Indian J Gastroenterol 2013 Sep 30;32(5):330-4. Epub 2013 Jul 30.

Department of Gastroenterology, Sawai Man Singh Medical College, J L N Marg, Jaipur 302 004, India.

Celiac disease (CD) is an immune-mediated disorder that may be associated with various diseases that share a similar pathogenic immune mechanism. This study reports on the prevalence of various diseases in a cohort of CD patients in northern India. Patients diagnosed with CD based on modified ESPGHAN criteria were prospectively evaluated for associated concomitant diseases. Read More

View Article and Full-Text PDF
September 2013

Epstein-Barr virus-associated smooth muscle tumor-report of 3 tumors including 1 intracerebral case with a prominent intratumoral B-lymphocytic component and plasma cells.

Ann Diagn Pathol 2013 Feb 27;17(1):91-8. Epub 2012 Sep 27.

Department of Pathology, National University Health System, Singapore.

Three Epstein-Barr virus-associated smooth muscle tumors (intracranial, endobronchial, and paraspinal) in 2 patients are presented. The patient with the intracranial tumor had no concurrent or previous manifestation of this neoplasm and was immunosuppressed because of a renal transplant. The other patient had AIDS and radiologic evidence of involvement of multiple other sites. Read More

View Article and Full-Text PDF
February 2013