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APE1 facilitates PD-L1-mediated progression of laryngeal and hypopharyngeal squamous cell carcinoma.

Int Immunopharmacol 2021 May 5;97:107675. Epub 2021 May 5.

Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China. Electronic address:

Laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HSCC) seriously affect the life quality of patients. Nowadays, immunotherapy is widely used in the treatment of cancer. Tumor-infiltrating lymphocytes (TILs), programmed cell death 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) play key roles in the immunotherapy of cancer. Read More

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Prediction of human-Streptococcus pneumoniae protein-protein interactions using logistic regression.

Comput Biol Chem 2021 Apr 24;92:107492. Epub 2021 Apr 24.

Faculty of Biology, Universitas Nasional, Jakarta, 12520, Indonesia. Electronic address:

Streptococcus pneumoniae is a major cause of mortality in children under five years old. In recent years, the emergence of antibiotic-resistant strains of S. pneumoniae increases the threat level of this pathogen. Read More

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Using a central venous pressure sensor for continuous monitoring of endotracheal tube cuff pressure.

J Clin Anesth 2021 May 5;73:110300. Epub 2021 May 5.

Department of Anesthesiology, Zigong Fourth People's Hospital, Zigong 643000, China.. Electronic address:

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Automated detection of hippocampal sclerosis: Comparison of a composite MRI-based index with conventional MRI measures.

Epilepsy Res 2021 Apr 9;174:106638. Epub 2021 Apr 9.

Department of Radiology, Sanbo Brain Hospital, Capital Medical University, China. Electronic address:

Purpose: This study aims to compare the performance of an MRI-based composite index (HSI) with conventional MRI-based measures in hippocampal sclerosis (HS) detection and postoperative outcome estimation.

Methods: Seventy-two temporal lobe epilepsy (TLE) patients with pathologically confirmed HS and fifteen TLE patients without HS were included retrospectively. The T1-weighted and FLAIR images of these patients were processed with AccuBrain to quantify the hippocampal volume (HV) and the hippocampal FLAIR signal. Read More

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A consistent deep registration network with group data modeling.

Comput Med Imaging Graph 2021 Mar 26;90:101904. Epub 2021 Mar 26.

Shanghai United Imaging Intelligence Co. Ltd, Shanghai, China; School of Biomedical Engineering, ShanghaiTech University, Shanghai, China; Department of Artificial Intelligence, Korea University, Seoul 02841, Republic of Korea. Electronic address:

Medical image registration is a critical process for automated image computing, and ideally, the deformation field from one image to another should be smooth and inverse-consistent in order to bidirectionally align anatomical structures and to preserve their topology. Consistent registration can reduce bias caused by the order of input images, increase robustness, and improve reliability of subsequent quantitative analysis. Rigorous differential geometry constraints have been used in traditional methods to enforce the topological consistency but require comprehensive optimization and are time consuming. Read More

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Automated assessment of glomerulosclerosis and tubular atrophy using deep learning.

Comput Med Imaging Graph 2021 May 2;90:101930. Epub 2021 May 2.

Politecnico di Torino, PoliToBIOMed Lab, Biolab, Department of Electronics and Telecommunications, Corso Duca degli Abruzzi 24, Turin, 10129, Italy.

In kidney transplantations, pathologists evaluate the architecture of both glomeruli, interstitium and tubules to assess the nephron status. An accurate assessment of glomerulosclerosis and tubular atrophy is crucial for determining kidney acceptance, which is currently based on the pathologists' histological evaluations on renal biopsies in addition to clinical data. In this work, we present an automated algorithm, called RENTAG (Robust EvaluatioN of Tubular Atrophy & Glomerulosclerosis), for the segmentation and classification of glomerular and tubular structures in histopathological images. Read More

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Comparison in detection of prodromal Parkinson's disease patients using original and updated MDS research criteria in two independent cohorts.

Parkinsonism Relat Disord 2021 Apr 30;87:48-55. Epub 2021 Apr 30.

Department of Neurology, P. J. Safarik University, Trieda SNP 1, 04011, Kosice, Slovak Republic; Department of Neurology, University Hospital L. Pasteur, Rastislavova 43, 04190, Kosice, Slovak Republic.

Introduction: MDS research criteria for prodromal Parkinson's disease (pPD) were published in 2015 and updated in 2019. We aimed to determine the difference in pPD patient detection rates in two cohorts recruited via gastrointestinal symptoms (PARCAS study) and the presence of a probable REM sleep behaviour disorder (PDBIOM study) using the original and updated criteria.

Methods: We evaluated all risk and prodromal markers, except genetic testing, plasma urate and physical inactivity, in both cohorts and DaT scan, diabetes mellitus type II and cognitive deficit in the PARCAS cohort. Read More

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Insecticide fipronil and its transformation products in human blood and urine: Assessment of human exposure in general population of China.

Sci Total Environ 2021 Apr 24;786:147342. Epub 2021 Apr 24.

Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China. Electronic address:

Fipronil (FP) is widely used as a highly effective insecticide worldwide, thereby raising concern about environmental contamination and risk for human health. However, data on the occurrence of FP and its transformation products (FPs) in human blood and urine are limited. In this study, 39 pairs of serum, plasma, blood cells (BCs), and urine samples were collected from adults in Wuhan, central China (2020), in order to characterize the concentration profiles of FPs in different matrices. Read More

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LCA and economic study on the local oxygen supply in Central Europe during the COVID-19 pandemic.

Sci Total Environ 2021 Apr 29;786:147401. Epub 2021 Apr 29.

AGH University of Science and Technology, Faculty of Energy and Fuels, Department of Coal Chemistry and Environmental Sciences, Al. Mickiewicza 30, 30-059 Kraków, Poland. Electronic address:

Medical oxygen is the key to survival for COVID-19 patients. To meet the pandemic-driven oxygen demand spike, local hospitals began searching for a suitable medical oxygen delivery system. Among the studies published on the impact of COVID-19 on a range of aspects, including the global economy and the environment, no study has been conducted on the environmental impact of medical oxygen supply to hospitals under epidemic conditions. Read More

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Cumulative tea consumption is inversely associated with colorectal adenomas in adults: A cross-sectional study in a Taiwanese population.

Cancer Epidemiol 2021 May 5;73:101945. Epub 2021 May 5.

Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Division of Family Medicine, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin, Taiwan; Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Purpose: This study examined the association between cumulative tea consumption over time and various colorectal adenomas as well as their pathology, number, and size.

Methods: 7355 eligible subjects who underwent health check-ups with colonoscopies were recruited. They were classified into three groups: polyp-free, having low-risk colorectal adenomas, and having high-risk colorectal adenomas. Read More

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Longitudinal changes in HRV across pregnancy and postpartum: Effect of negative partner relationship qualities.

Psychoneuroendocrinology 2021 Apr 21;129:105216. Epub 2021 Apr 21.

Department of Psychiatry & Behavioral Health and the Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

During pregnancy, there are significant physiological changes to support a healthy fetus. Parasympathetic activity normatively decreases across pregnancy, and psychological stress can promote even further decreased heart rate variability (HRV). This study evaluated (1) changes in vagally-mediated HRV from pregnancy to postpartum, (2) changes in vagally-mediated HRV from pregnancy to postpartum based on negative partner relationship qualities, and (3) changes in depressive symptoms from pregnancy to postpartum based on negative partner relationship qualities. Read More

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A transfer learning with structured filter pruning approach for improved breast cancer classification on point-of-care devices.

Comput Biol Med 2021 Apr 30;134:104432. Epub 2021 Apr 30.

Missouri University of Science and Technology, Rolla, MO, 65409, USA. Electronic address:

Background And Objective: A significant progress has been made in automated medical diagnosis with the advent of deep learning methods in recent years. However, deploying a deep learning model for mobile and small-scale, low-cost devices is a major bottleneck. Further, breast cancer is more prevalent currently, and ductal carcinoma being its most common type. Read More

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A novel compartmental model to capture the nonlinear trend of COVID-19.

Comput Biol Med 2021 Apr 30;134:104421. Epub 2021 Apr 30.

Computer Science and Engineering, Mississippi State University, Starkville, MS, USA.

The COVID-19 pandemic took the world by surprise and surpassed the expectations of epidemiologists, governments, medical experts, and the scientific community as a whole. The majority of epidemiological models failed to capture the non-linear trend of the susceptible compartment and were unable to model this pandemic accurately. This study presents a variant of the well-known SEIRD model to account for social awareness measures, variable death rate, and the presence of asymptomatic infected individuals. Read More

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Shorter outpatient wait-times for buprenorphine are associated with linkage to care post-hospital discharge.

Drug Alcohol Depend 2021 Apr 20;224:108703. Epub 2021 Apr 20.

Department of Medicine, Boston University School of Medicine, 801 Massachusetts Ave, Boston, MA, 02118, USA.

Background: Inpatient addiction consult services (ACS) lower barriers to accessing medications for opioid use disorder (MOUD), however not every patient recommended for MOUD links to outpatient care. We hypothesized that fewer days between discharge date and outpatient appointment date was associated with improved linkage to buprenorphine treatment among patients evaluated by an ACS.

Methods: We extracted appointment and demographic data from electronic medical records and conducted retrospective chart review of adults diagnosed with opioid use disorder (OUD) evaluated by an ACS in Boston, MA between July 2015 and August 2017. Read More

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The association between treatment and systemic inflammation in acromegaly.

Growth Horm IGF Res 2021 Apr 30;57-58:101391. Epub 2021 Apr 30.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

Objective: Acromegaly is characterized by an excess of growth hormone (GH) and insulin like growth-factor 1 (IGF1), and it is strongly associated with cardiovascular diseases (CVD). Both acute and long-lasting pro-inflammatory effects have been attributed to IGF1. Previous results suggest the presence of systemic inflammation in treated patients. Read More

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Outcomes in intervention and management of multiple pregnancies trials: A systematic review.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 24;261:178-192. Epub 2021 Apr 24.

Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Birmingham Women's and Children's Hospital, Birmingham, UK. Electronic address:

Objectives: Twin pregnancy has risks of adverse outcomes for mother and baby. Data synthesis is required to gain evidence to aid recommendations but may be hampered by variations in outcome reporting.

Study Design: Systematically review outcomes reported in twin pregnancy trials (PROSPERO - CRD42019133805). Read More

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Xanthogranulomatous pyelonephritis in an eight year old male child: A case report and review of the literature.

Int J Surg Case Rep 2021 Apr 30;82:105943. Epub 2021 Apr 30.

Faculty of Medicine, Kilimanjaro Christian Medical University College, Box 2240, Moshi, Tanzania; Department of Urology, Kilimanjaro Christian Medical Centre, Box 3010, Moshi, Tanzania.

Introduction And Importance: Xanthogranulomatous pyelonephritis is an extremely rare but known form of chronic pyelonephritis resulting from prolonged suppuration of the kidney. Pre-operatively, it may mimic renal tuberculosis or neoplastic lesions including renal cell carcinoma due to its vague clinical presentation, equivocal laboratory and radiological investigations. Due to its rarity and academic interest, herein we report such a rare case we recently encountered in our clinical practice. Read More

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Rare case report of anorectal malformation and intestinal atresia.

Int J Surg Case Rep 2021 Apr 30;82:105945. Epub 2021 Apr 30.

Division of Pediatric Surgery, Department of Surgery, Loma Linda University Medical Center, United States of America. Electronic address:

Introduction: Intestinal malformations, such as intestinal atresia, malrotation, and anorectal malformation, are rare events, but concurrent intestinal atresia and anorectal malformation are rare in combination. These anomalies have similar in utero and perinatal symptoms, which can make the diagnosis of both defects prenatally challenging.

Presentation Of Case: We present a case of a male infant with a prenatal diagnosis of truncus arteriosus who on a 32-week routine prenatal ultrasound was suspected to have an intestinal malformation. Read More

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Jejunal GIST masquerading as an ovarian mass: A case report.

Int J Surg Case Rep 2021 May 3;82:105960. Epub 2021 May 3.

Department of GI and General Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Introduction And Importance: Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors originating in the wall of the gastrointestinal tract. Jejunal GIST is the rarest subtype. Large GIST can present with an abdominopelvic mass which can be preoperatively misdiagnosed as a gynecological tumor. Read More

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Pancreaticoduodenectomy for hepatic portal lymph node metastasis after hepatic resection for hepatocellular carcinoma: A clinical case report.

Int J Surg Case Rep 2021 Apr 27;82:105921. Epub 2021 Apr 27.

Center for Pathology and Cytology, Bach Mai Hospital, Viet Nam.

Introduction: In 2018, Hepatocellular carcinoma (HCC) was predicted to be the sixth most commonly diagnosed cancer. Extra-hepatic metastasis due to HCC is a poor prognostic factor, depending on the stage of the disease.

Presentation Of Case: We report a case of a 52-years old male who had undergone Segment 5 (S5) hepatectomy for HCC of 4. Read More

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Communication and empathy skills: Essential requisites for patient-centered radiology care.

Eur J Radiol 2021 May 3;140:109754. Epub 2021 May 3.

Department of Radiology, Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:

Purpose: To investigate how patients value radiologists, using data from the Dutch healthcare assessment website.

Method: The Dutch healthcare assessment website was searched for patient reviews about radiologists in The Netherlands. The scores (scale of 1-10) assigned to the most recent review of each radiologist were extracted. Read More

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The impact on health outcomes of implementing electronic health records to support the care of older people in residential aged care: A scoping review.

Int J Med Inform 2021 Apr 24;151:104471. Epub 2021 Apr 24.

Center for Health Services Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Aim: The implementation of electronic health records (EHRs) in the aged care sector has been shown to improve efficiency and quality of care, administrative and funding processes. The aim of this study was to examine whether implementing EHRs and/or interventions leveraging EHRs in residential aged care facilities has any impact on health outcomes for residents and to review and summarise any published evidence.

Methods: Using the Joanna Briggs Institute guidelines for conducting scoping reviews, we searched PubMed, CINAHL, Embase, Cochrane and Scopus databases for articles describing the impact of EHRs and/or EHR-based interventions on health outcomes for residents in residential aged care. Read More

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One-pot synthesis of a self-reinforcing cascade bioreactor for combined photodynamic/chemodynamic/starvation therapy.

J Colloid Interface Sci 2021 Apr 2;599:543-555. Epub 2021 Apr 2.

Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong Special Administrative Region. Electronic address:

The combination of photodynamic therapy (PDT) and chemodynamic therapy (CDT) have attracted a great deal of interest, but tumor hypoxia and glutathione (GSH) overproduction still limit their further applications. Herein, an intelligent reactive oxygen species (ROS) nanogenerator Ce6/GOx@ZIF-8/PDA@MnO (denoted as CGZPM; Ce6, GOx, ZIF-8, PDA, MnO are chlorin e6, glucose oxidase, zeolitic imidazolate framework-8, polydopamine and manganese dioxide respectively) with O-generating and GSH-/glucose-depleting abilities was constructed by a facile and green one-pot method. After intake by tumor cells, the outer MnO was rapidly degraded by the acidic pH, and the overexpression of hydrogen peroxide (HO) and GSH with abundant Mn and O produced would eventually achieve multifunctionality. Read More

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Forecasting emergency department hourly occupancy using time series analysis.

Am J Emerg Med 2021 Apr 29;48:177-182. Epub 2021 Apr 29.

Department of Statistics and Operations Research, University of North Carolina at Chapel Hill (UNC), NC, USA. Electronic address:

Study Objective: To develop a novel predictive model for emergency department (ED) hourly occupancy using readily available data at time of prediction with a time series analysis methodology.

Methods: We performed a retrospective analysis of all ED visits from a large academic center during calendar year 2012 to predict ED hourly occupancy. Due to the time-of-day and day-of-week effects, a seasonal autoregressive integrated moving average with external regressor (SARIMAX) model was selected. Read More

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Risk assessment of vertebral compressive fracture using bone mass index and strength predicted by computed tomography image based finite element analysis.

Clin Biomech (Bristol, Avon) 2021 Apr 23;85:105365. Epub 2021 Apr 23.

Inazawa Municipal Hospital, Department of Neurosurgery, Inazawa, Aichi 492-8510, Japan.

Background: A main purpose of osteoporosis diagnosis is to evaluate the bone fracture risk. Some bone mass indices evaluated using bone mineral density has been utilized clinically to assess the degree of osteoporosis. On the other hand, Computed tomography image based finite element analysis has been developed to evaluate bone strength of vertebral bodies. Read More

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Letter to the Editor: Targeting adverse stress-related consequences of the COVID-19 crisis in individuals with psychotic disorders and childhood maltreatment.

J Psychiatr Res 2021 Apr 30;138:453-455. Epub 2021 Apr 30.

Department of Psychiatry, Biomedical Research Institute, University Hospital 12 de Octubre (imas12), Faculty of Medicine, Complutense University of Madrid (UCM), Madrid, Spain; CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain.

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Investigation of the skin lesions in lightning strike death.

Leg Med (Tokyo) 2021 Apr 30;52:101896. Epub 2021 Apr 30.

Section Legal Medicine, Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Via del Vespro, 129, 90127, Italy. Electronic address:

Lightning strike-related deaths are unusual, and the victim bodies can present different lesions due to the different injury mechanisms associated with this event. Since the post mortem assessment can be challenging, the evaluation of the characteristics of the skin lesions becomes fundamental to reconstruct the event. Due to the paucity of literature on this topic, the authors report the case of a 59-year-old man found dead near his home after a thunderstorm. Read More

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A pitfall in targeted Sanger sequencing of BRCA splicing variants in at-risk individuals.

Pathol Res Pract 2021 Apr 28;222:153456. Epub 2021 Apr 28.

Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, China. Electronic address:

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Vestibular disorders in children: A retrospective analysis of vestibular function test findings.

Int J Pediatr Otorhinolaryngol 2021 Apr 29;146:110751. Epub 2021 Apr 29.

Acibadem Maslak Hospital ENT Department, Istanbul, Turkey.

Objective: This study was designed to describe the most common vestibular disorders in children and their associated findings on vestibular function testing.

Method: Data from 203 children with a mean age of 11.16 ± 3. Read More

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