84,107 results match your criteria universities osteoarthritis

Novel photosensitive dual-anisotropic conductive Janus film endued with magnetic-luminescent properties and derivative 3D structures.

J Colloid Interface Sci 2021 May 26;601:899-914. Epub 2021 May 26.

Key Laboratory of Applied Chemistry and Nanotechnology at Universities of Jilin Province, Changchun University of Science and Technology, Changchun 130022, China.

A new photosensitive dual-anisotropic conductive Janus film (PDCJF) is proposed for the first time. It is rationally designed and manufactured by facile electrospinning. PDCJF is firstly constructed using 2,7-dibromo-9-fluorenone (DBF) with photoconductive and luminescent properties. Read More

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In vitro generation of oxidized standards for lipidomics. Application to major membrane lipid components.

J Chromatogr A 2021 May 19;1651:462254. Epub 2021 May 19.

Centre for Metabolomics and Bioanalysis (CEMBIO), Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, 28660 Boadilla del Monte, Madrid. Spain. Electronic address:

Membrane lipids (sphingolipids, glycerophospholipids, cardiolipins, and cholesteryl esters) are critical in cellular functions. Alterations in the levels of oxidized counterparts of some of these lipids have been linked to the onset and development of many pathologies. Unfortunately, the scarce commercial availability of chemically defined oxidized lipids is a limitation for accurate quantitative analysis, characterization of oxidized composition, or testing their biological effects in lipidomic studies. Read More

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The squirrel monkey model in clinical neuroscience.

Neurosci Biobehav Rev 2021 Jun 9. Epub 2021 Jun 9.

Brain Connectivity and Behaviour Laboratory, Sorbonne Universities, Paris, France; Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of Bordeaux, Bordeaux, France. Electronic address:

Clinical neuroscience research relying on animal models brought valuable translational insights into the function and pathologies of the human brain. The anatomical, physiological, and behavioural similarities between humans and mammals have prompted researchers to study cerebral mechanisms at different levels to develop and test new treatments. The vast majority of biomedical research uses rodent models, which are easily manipulable and have a broadly resembling organisation to the human nervous system but cannot satisfactorily mimic some disorders. Read More

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Incidence and risk factors of late-onset hemorrhagic cystitis after single umbilical cord blood transplantation with myeloablative conditioning regimen.

Int J Hematol 2021 Jun 12. Epub 2021 Jun 12.

Department of Hematology of Anhui Provincial Hospital, Anhui Medical University, Hefei, China.

Objective: To explore the incidence and risk factors of late-onset hemorrhagic cystitis (LOHC) in patients undergoing single umbilical cord blood transplantation for hematological malignancies.

Methods: Clinical data from 234 patients who consecutively underwent single UCBT using a myeloablative conditioning regimen without antithymocyte globulin in our center were retrospectively analyzed.

Results: In total, 64 (27. Read More

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Identification of key genes in the tumor microenvironment of lung adenocarcinoma.

Med Oncol 2021 Jun 12;38(7):83. Epub 2021 Jun 12.

Key Laboratory of Medical Imaging and Artifical Intelligence of Hunan Province, 423000, Chenzhou, P. R. China.

The tumor microenvironment plays an important role in tumor development and progression, but the role of immune and stromal cells in this environment has not been sufficiently studied. In this study, we aimed to identify key genes associated with the microenvironment of lung adenocarcinoma (LUAD). Raw data for stromal and immune cells in malignant tumors were downloaded from The Cancer Genome Atlas (TCGA). Read More

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Cr-Doped CoP Nanorod Arrays as High-Performance Hydrogen Evolution Reaction Catalysts at High Current Density.

Small 2021 Jun 12:e2100832. Epub 2021 Jun 12.

State Key Lab of Organic-Inorganic Composites and Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.

Developing highly efficient, low-cost electrocatalysts with long-time stability at high current density working conditions for hydrogen evolution reaction (HER) remains a great challenge for the large-scale commercialization of hydrogen production from water electrolysis. Herein, the Cr-doped CoP nanorod arrays on carbon cloth (Cr-CoP-NR/CC) is reported as high performance HER catalysts with overpotentials of 38 and 209 mV at the HER current densities of 10 and 500 mA cm , respectively, outperforming the performance of the commercial Pt/C at high current density. And its HER performance shows almost no loss after 20 h working at 500 mA cm . Read More

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Edible Materials in Tissue Regeneration.

Macromol Biosci 2021 Jun 12:e2100114. Epub 2021 Jun 12.

School of Biomedical Engineering, Sun Yat-sen University, Shenzhen, 518057, China.

Edible materials have attracted increasing attention because of their excellent properties including availability, biocompatibility, biological activity, and biodegradability. Natural polysaccharides, phenolic compounds, and proteins are widely used in tissue regeneration. To better characterize their healing effect, this review article describes the applications of edible materials in tissue regeneration including wound healing and bone tissue regeneration. Read More

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Clean and Affordable Hydrogen Fuel from Alkaline Water Splitting: Past, Recent Progress, and Future Prospects.

Adv Mater 2021 Jun 12:e2007100. Epub 2021 Jun 12.

Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Institute of Energy, Hefei Comprehensive National Science Center, CAS Center for Excellence in Nanoscience, Department of Chemistry, Institute of Biomimetic Materials & Chemistry, University of Science and Technology of China, Hefei, 230026, China.

Hydrogen economy has emerged as a very promising alternative to the current hydrocarbon economy, which involves the process of harvesting renewable energy to split water into hydrogen and oxygen and then further utilization of clean hydrogen fuel. The production of hydrogen by water electrolysis is an essential prerequisite of the hydrogen economy with zero carbon emission. Among various water electrolysis technologies, alkaline water splitting has been commercialized for more than 100 years, representing the most mature and economic technology. Read More

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Confinement of Zinc Salt in Ultrathin Heterogeneous Film to Stabilize Zinc Metal Anode.

Small 2021 Jun 12:e2100722. Epub 2021 Jun 12.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.

Aqueous zinc metal batteries (AZMBs) have drawn great attention due to the high theoretical capacity, low redox potential, and abundance reserves. However, the practical application of rechargeable AZMBs are hindered by the poor reversibility of Zn metal anode, owing to easy dendrite growth and serious side reactions. Herein, the preparation of heterogeneous interfacial film with highly dispersed and confined zinc salt in a 2D channel by coassembling polyamide 6, zinc trifluoromethanesulfonate, and layered double hydroxides, which significantly suppresses the dendrite formation, H evolution reaction as well as O corrosion is reported. Read More

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Patients with stage II of the knee osteoarthritis most likely benefit from the intra-articular injections of autologous adipose tissue-from 2 years of follow-up studies.

Arch Orthop Trauma Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of Orthopedic Surgery, Rehasport Clinic, Poznan, Poland.

Background: Knee osteoarthritis (OA) is a common, chronic, progressive and degenerative disease which affects patients' quality of life and may cause disability and social isolation. OA is a huge economic burden for the patient and a large strain for the whole healthcare system. Articular cartilage has a small potential to repair, with progressively more clinicians emphasizing cellular therapy. Read More

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Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity.

Signal Transduct Target Ther 2021 Jun 11;6(1):231. Epub 2021 Jun 11.

Key Laboratory for Experimental Teratology of Ministry of Education and Dept. Immunology, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong, China.

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Cross-national comparison of psychosocial well-being and diabetes outcomes in adults with type 1 diabetes during the COVID-19 pandemic in US, Brazil, and Iran.

Diabetol Metab Syndr 2021 Jun 11;13(1):63. Epub 2021 Jun 11.

Department of Family and Community Medicine, University of California, 500 Parnassus Avenue, San Francisco, CA, 94117, USA.

Background: The COVID-19 pandemic is a global public health emergency, which presents wide-ranging negative impacts on individuals with diabetes. To examine psychosocial well-being and diabetes outcomes in individuals with type 1 diabetes during the COVID-19 pandemic, and investigate how these factors vary in different countries.

Methods: Between April and June 2020 we employed a cross national comparative research study in the United States (US), Brazil, and Iran to collect data from 1788 adults with type 1 diabetes using web-based survey. Read More

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Therapeutic potential of targeting Tfr/Tfh cell balance by low-dose-IL-2 in active SLE: a post hoc analysis from a double-blind RCT study.

Arthritis Res Ther 2021 Jun 11;23(1):167. Epub 2021 Jun 11.

Department of Rheumatology & Immunology, Peking University People's Hospital, Beijing, 100044, China.

Objective: To investigate the regulation of T follicular regulatory (Tfr) and T follicular (Tfh) cell subtypes by low-dose IL-2 in systemic lupus erythematosus (SLE) in a randomized, double-blind, placebo-controlled clinical trial.

Methods: A post hoc analysis was performed in a randomized cohort of SLE patients (n=60) receiving low-dose IL-2 therapy (n=30) or placebo (n=30), along with the standard of care treatment. The primary endpoint was the attainment of SLE responder index-4 (SRI-4) at week 12 in the trial. Read More

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H3.3 kinetics predicts chromatin compaction status of parental genomes in early embryos.

Reprod Biol Endocrinol 2021 Jun 11;19(1):87. Epub 2021 Jun 11.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, Hubei, China.

Background: After fertilization, the fusion of gametes results in the formation of totipotent zygote. During sperm-egg fusion, maternal factors participate in parental chromatin remodeling. H3. Read More

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h-FBN assisted negative ion paper spray for the sensitive detection of small molecules.

Chem Commun (Camb) 2021 Jun 12. Epub 2021 Jun 12.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, People's Republic of China.

Negative ion mode paper spray mass spectrometry (PS-MS) suffers from intense background noise and unstable MS signal. For the first time, we reported fluorinated boron nitride nanosheet (h-FBN) assisted negative ion PS-MS for the detection of a series of molecules. We demonstrated that the introduction of h-FBN can greatly improve the detection sensitivity and signal stability in the negative ion mode. Read More

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Anti-Protozoal and Anti-Fungal Evaluation of 3,5-Disubstituted 1,2-Dioxolanes.

Bioorg Med Chem Lett 2021 Jun 8:128196. Epub 2021 Jun 8.

BioCIS, CNRS, Université Paris-Saclay, Châtenay-Malabry, 92290, France.

Endoperoxides are a class of compounds, which is well-known for their antimalarial properties, notably, but few reports exist about 3,5-disubstituted 1,2-dioxolanes. After having designed a new synthetic route for the preparation of these substances, they were evaluated against 4 different agents of infectious diseases, protozoa (Plasmodium, Leishmania) and Fungi (Candida and Aspergillus). Whereas moderate antifungal activity was found for our products, potent antimalarial and antileishmanial activities were observed for a few compounds. Read More

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The Minimal Clinically Important Difference (MCID) for the WOMAC and Factors Related to Achievement of the MCID After Medial Opening Wedge High Tibial Osteotomy for Knee Osteoarthritis.

Am J Sports Med 2021 Jun 11:3635465211016853. Epub 2021 Jun 11.

Department of Orthopedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: Many approaches have been used to determine the minimal clinically important difference (MCID) in patients undergoing total knee arthroplasty, but the MCID for outcome measures after medial opening wedge high tibial osteotomy (MOWHTO) for the treatment of medial compartment knee osteoarthritis (OA) has not been reported.

Purpose: To define the MCID for the Western Ontario and McMaster Universities Arthritis Index (WOMAC) after MOWHTO and to identify risk factors for not achieving the MCID.

Study Design: Case-control study; Level of evidence, 3. Read More

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Rare Self-Luminous Mixed-Valence Eu-MOF with a Self-Enhanced Characteristic as a Near-Infrared Fluorescent ECL Probe for Nondestructive Immunodetection.

Anal Chem 2021 Jun 11. Epub 2021 Jun 11.

Collaborative Innovation Centre for Green Chemical Manufacturing and Accurate Detection School of Chemistry and Chemical Engineering, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022 Shandong, China.

Steady and efficient sensitized emission of Eu to Eu can be achieved through a rare mixed-valence Eu-MOF (LEuEu). Compared with the sensitization of other substances, the similar ion radius and configuration of the extranuclear electron between Eu and Eu make sensitization easier and more efficient. The sensitization of Eu to Eu is of great assistance for the self-enhanced luminescence of LEuEu, the longer luminous time, and the more stable electrochemiluminescence (ECL) signal. Read More

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Ovarian dysgerminoma with pseudo-Meigs syndrome: A case report.

Medicine (Baltimore) 2021 Jun;100(23):e26319

Forensic and Pathology Laboratory, Jiaxing University Medical College, Jiaxing, ZJ, China.

Rationale: Dysgerminoma is a rare malignant tumor of the ovary, more frequently occurring in young women. The main signs of pseudo-Meigs syndrome (PMS) are ascites and hydrothorax accompanying benign or malignant ovarian tumors (no fibroma or fibroma-like tumor).

Patient Concerns: A 19-year-old woman with fever and chest tightness for 2 days. Read More

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Associations and interaction effects of maternal smoking and genetic polymorphisms of cytochrome P450 genes with risk of congenital heart disease in offspring: A case-control study.

Medicine (Baltimore) 2021 Jun;100(23):e26268

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University.

Abstract: To assess associations and interactions of maternal smoking and cytochrome P450 (CYP450) genetic variants with the developments of congenital heart disease (CHD) and specific subtypes.A case-control study of 654 cases and 666 controls was conducted from November 2017 to March 2020. The exposures of interest were maternal active and passive smoking before/in the early pregnancy and CYP450 genetic polymorphisms. Read More

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Rational emotive education for reducing stress of undergraduate students of religious education program: An experimental study.

Medicine (Baltimore) 2021 Jun;100(23):e26177

Department of Educational Foundations, University of Nigeria, P.M.B 410001, Nsukka, Enugu State.

Background: Rational emotive education (REE) program aims to improve the behavioral and mental health of students. This study objective was to evaluate the effect of an REE program on stress among undergraduate students of religious education program in Nigerian Universities.

Method: One hundred and fifty (150) religious education undergraduates who had high level of stress participated in the study. Read More

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A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.

Elife 2021 Jun 11;10. Epub 2021 Jun 11.

The School of Medicine, Nankai University, Tianjin, China.

Transcoelomic spread of cancer cells across the peritoneal cavity occurs in most initially diagnosed ovarian cancer (OC) patients and accounts for most cancer-related death. However, how OC cells interact with peritoneal stromal cells to evade the immune surveillance remains largely unexplored. Here, through an in vivo genome-wide CRISPR/Cas9 screen, we identified IL20RA, which decreased dramatically in OC patients during peritoneal metastasis, as a key factor preventing the transcoelomic metastasis of OC. Read More

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COVID-19 and Undergraduates with Disabilities: Challenges Resulting from the Rapid Transition to Online Course Delivery for Students with Disabilities in Undergraduate STEM at Large-Enrollment Institutions.

CBE Life Sci Educ 2021 Sep;20(3):ar36

Research for Inclusive STEM Education Center, School of Life Sciences, Arizona State University, Tempe, AZ 85281.

The COVID-19 pandemic caused nearly all colleges and universities to transition in-person courses to an online format. In this study, we explored how the rapid transition to online instruction during the COVID-19 pandemic affected students with disabilities. We interviewed 66 science, technology, engineering, and math (STEM) undergraduates with disabilities at seven large-enrollment institutions during Spring 2020. Read More

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September 2021

Mitigating SARS-CoV-2 in the Deployed Environment.

Mil Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery, US Army Institute of Surgical Research, Sam Houston, TX 78234, USA.

Introduction: Unlike other communal living environments (universities, boarding schools, and camps) that have been suspended during the COVID-19 pandemic, the deployed military force must continue its mission. Early challenges in the 2020 deployed environment included limited availability of living and quarantine space and limited testing capacity. This is a brief report of stringent quarantine strategies employed to newly arriving cohorts at a NATO and U. Read More

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Embryonic stem cells are devoid of macropinocytosis, a trafficking pathway for activin a in differentiated cells.

J Cell Sci 2021 Jun 11. Epub 2021 Jun 11.

Foundation for Research & Technology-Hellas (FORTH), Institute of Molecular Biology and Biotechnology (IMBB), Department of Biomedical Research, Ioannina, Greece.

Ligand/receptor complexes formed at the plasma membrane are internalised via various endocytic pathways that influence the ultimate signalling output by regulating the complex's selection of interaction partners along the trafficking route. We report that in differentiated cells Activin A/receptor complexes are internalised via Clathrin-mediated endocytosis (CME) and macropinocytosis (MP), whereas in human embryonic stem cells (hESCs) internalisation occurred via CME. We further show that hESCs are devoid of MP, which becomes functional upon differentiation towards endothelial cells through mesoderm mediators. Read More

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Association of serum levels of inflammatory markers and adipokines with joint symptoms and structures in participants with knee osteoarthritis.

Rheumatology (Oxford) 2021 Jun 11. Epub 2021 Jun 11.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.

Objective: To investigate the longitudinal associations of serum inflammatory markers and adipokines with joint symptoms and structures in participants with knee osteoarthritis (OA).

Methods: Two hundred participants (46.5% female, mean age 63. Read More

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A "double-locked" probe for the detection of hydrogen sulfide in a viscous system.

Chem Commun (Camb) 2021 Jun 11. Epub 2021 Jun 11.

College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institutes of Biomedical Sciences, Shandong Normal University, Jinan 250014, People's Republic of China.

A novel "double-locked" probe, DCO-H2S-V, was prepared for detecting hydrogen sulfide in a highly viscous system. Experiments demonstrated that only when H2S and a high viscosity environment coexist in a cell, can the probe be activated effectively and emit fluorescence. This has been successfully used for detecting the changes in viscosity and H2S in a Parkinson's disease model, PC-12 cells treated with glutamate. Read More

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miR-498 inhibits autophagy and M2-like polarization of tumor-associated macrophages in esophageal cancer via MDM2/ATF3.

Epigenomics 2021 Jun 11. Epub 2021 Jun 11.

Department of Anatomy, School of Basic Medicine, North Sichuan Medical College, Nanchong, 637000, Sichuan, PR China.

Structured abstract To elucidate the effect of miRNA (miR)-498 on autophagy and M2-like macrophage polarization in esophageal cancer. Autophagy was evaluated in esophageal cancer. Macrophage markers specific for M1- or M2-like phenotype were determined. Read More

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Liquid-Phase Exfoliated Few-Layer Iodine Nanosheets for High-Rate Lithium-Iodine Batteries.

Chempluschem 2021 Jun;86(6):865-869

College of Applied Science and Technology, Beijing Union University, Beijing, 100012, P. R. China.

Rechargeable lithium-iodine (Li-iodine) batteries attract significant attention owning to their high energy density, wide abundance and low cost of iodine resources. However, iodine suffers from low electrical conductivity and high solubility in aprotic electrolyte, leading to fast capacity degradation, low columbic efficiency, as well as poor rate capability. Herein, we propose a simple method for the large-scale production of two-dimensional (2D) few-layer iodine nanosheets (FLINs) via liquid-phase exfoliation of iodine in deionized water. Read More

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Manipulation of the Magnetic Properties of Janus WSSe Monolayer by the Adsorption of Transition Metal Atoms.

Nanoscale Res Lett 2021 Jun 10;16(1):104. Epub 2021 Jun 10.

Department of Physics, OSED, Fujian Provincial Key Laboratory of Semiconductors Materials and Applications, Xiamen University, Xiamen, 361005, People's Republic of China.

Two-dimensional Janus materials have great potential for the applications in spintronic devices due to their particular structures and novel characteristics. However, they are usually non-magnetic in nature. Here, different transition metals (TMs: Co, Fe, Mn, Cr, and V) adsorbed WSSe frameworks are constructed, and their structures and magnetic properties are comprehensively investigated by first-principles calculations. Read More

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