7,321 results match your criteria univariate multivariable


The documentation of pain intensity and its influences on care in the emergency department.

Int Emerg Nurs 2021 Jun 21;57:101015. Epub 2021 Jun 21.

Emergency and Trauma Centre, Royal Brisbane and Women's Hospital, Brisbane, Australia; Facility of Medicine, The University of Queensland, Brisbane, Australia.

Background: Assessment and reassessment of self reported pain intensity scores form the basis of acute pain care in the emergency deprtment (ED), however are frequently undocumented. The effects of not documenting pain assessments on time to first analgesic medication (TTA) and ED length of stay (EDLOS) are unknown.

Methods: This is a retrospective cross-sectional study to investigate the association between documented evidence of pain intensity scores, TTA and EDLOS in the ED. Read More

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Analytic Morphomics Are Related to Outcomes After Lung Volume Reduction Surgery.

Semin Thorac Cardiovasc Surg 2021 Jun 21. Epub 2021 Jun 21.

Division of Acute Care Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Lung volume reduction surgery continues to have a high morbidity despite National Emphysema Treatment Trial selection criteria. This study evaluated the association between analytic morphomics on chest computed tomography scans and outcomes after lung volume reduction surgery. In a retrospective review of 85 lung volume reduction surgery patients from 1998-2013, dorsal muscle group area, subcutaneous and visceral fat area, and bone mineral density were assessed using analytic morphomics. Read More

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Impact of Anti-anaerobic Antibiotic Activity on Graft-versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients at an Institution that Utilizes Antibiotic Cycling.

Transpl Infect Dis 2021 Jun 24:e13676. Epub 2021 Jun 24.

+Department of Pharmacy, West Virginia University Hospital.

Background: At our institution, antibiotic cycling for febrile neutropenia is utilized to increase heterogeneity of antibiotic exposure in patients who have undergone an allogeneic hematopoietic stem cell transplantation (allo-HSCT). Development of acute graft-versus-host disease (aGVHD) has been associated with low diversity within stool microbiota. To date, discordant outcomes have been reported implicating anti-anaerobic antibiotic use with the development of aGVHD, and there is currently a lack of published data available in an antibiotic cycled environment. Read More

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Neutralizing Antibody Responses to SARS-CoV-2 in Korean Patients Who Have Recovered from COVID-19.

Yonsei Med J 2021 Jul;62(7):584-592

Department of Microbiology, Institute for Viral Diseases, College of Medicine, Korea University, Seoul, Korea.

Purpose: Neutralizing antibodies (NAbs) have been considered effective in preventing and treating viral infections. However, until now, the duration and clinical implications of antibody-mediated nature immunity in Koreans have remained unknown. Therefore, we examined NAbs levels and clinical characteristics in recovered coronavirus disease 2019 (COVID-19) patients. Read More

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Contrast-enhanced CT longitudinal tail sign as a marker of positive resection margins in adenoid cystic carcinoma of the central airway.

J Thorac Dis 2021 May;13(5):2803-2811

Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, China.

Background: Due to submucosal infiltration's biological nature along the airway, adenoid cystic carcinoma (ACC) frequently leaves positive surgical margins. This study evaluated the clinicopathologic, and computed tomography (CT) features for predicting surgical margin status in central airway ACC.

Methods: We retrospectively analyzed the files of 71 patients with ACC of the central airway proven by histopathology and surgery who had presented between January 2010 and December 2018. Read More

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Effect of type 2 diabetic mellitus in the prognosis of acute-on-chronic liver failure patients in China.

World J Gastroenterol 2021 Jun;27(23):3372-3385

Department of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian Province, China.

Background: Acute-on-chronic liver failure (ACLF) patients have a high short-term mortality rate, and the severity evaluation of ACLF is necessary for prognostication. Therefore, it was meaningful to evaluate the association between type 2 diabetic mellitus (DM) and ACLF and further explore the feasibility of using DM as a prognostic indicator in ACLF patients. The association between type 2 DM and the prognosis of patients with severe liver disease remains unclear. Read More

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Increased Risk of Incident Heart Failure and Death Is Associated With Insulin Resistance in People With Newly Diagnosed Type 2 Diabetes: UKPDS 89.

Diabetes Care 2021 Jun 23. Epub 2021 Jun 23.

Diabetes Trials Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.

Objective: Insulin resistance (IR) may mediate heart failure (HF) development. We examined whether IR in people with newly diagnosed type 2 diabetes (T2D) increased their risk of a composite outcome of HF or death or of HF alone.

Research Design And Methods: Insulin resistance (HOMA2-IR) values for UKPDS participants were derived from paired fasting plasma glucose (FPG) and insulin measures. Read More

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Tobacco use among urban slum dwellers attending a cancer screening clinic in the National Capital Region of India: a cross-sectional study.

Ecancermedicalscience 2021 11;15:1230. Epub 2021 May 11.

Chief Executive Officer, ICMR - India Cancer Research Consortium, IRCS Building, Red Cross Road, Delhi 110003, India.

Background: Tobacco consumption in India varies based on the place of residence (urban/rural). Minimal, exclusive information exists regarding the same for 'urban slum' dwellers. The current study determines the tobacco use pattern among such individuals in Noida, Uttar Pradesh (India). Read More

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HER2 positivity as a biomarker for poor prognosis and unresponsiveness to anti-EGFR therapy in colorectal cancer.

J Cancer Res Clin Oncol 2021 Jun 22. Epub 2021 Jun 22.

Department of General Surgery, Colorectal Cancer Center, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, People's Republic of China.

Purpose: To investigate the role of HER2 positivity in prognosis and unresponsiveness to anti-EGFR therapy for colorectal cancer.

Methods: Patients who underwent primary CRC tumor resection were included. HER2 status of CRC was confirmed by immunohistochemistry and fluorescence in situ hybridization tests. Read More

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A Retrospective Study of 52 Patients With Primary Small Cell Carcinoma of the Esophagus Treated With Radical Surgery.

Cancer Control 2021 Jan-Dec;28:10732748211027147

Department of Thoracic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 71067Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.

Background: Primary small cell carcinoma of the esophagus (SCCE) is a rare and extremely fatal disease. We aim to evaluate the efficacy of radical surgery for resectable SCCE and to explore potential prognostic factors.

Methods: We retrospectively reviewed 52 consecutive SCCE patients who underwent radical surgery from February 1993 to November 2014 at a single institution. Read More

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Late preterm births: neonatal mortality and morbidity in twins vs. singletons.

J Matern Fetal Neonatal Med 2021 Jun 21:1-6. Epub 2021 Jun 21.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Oregon Health and Science University, Portland, OR, USA.

Objective: To examine the outcomes of twins and singletons in the late preterm period.

Materials And Methods: This is a retrospective cohort study of data obtained for 165,894 births in California who delivered between 34 + 0 and 36 + 6 weeks. The primary outcome was neonatal and infant mortality. Read More

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High Mortality and Venous Thromboembolism Risk Following Major Penetrating Abdominal Venous Injuries.

Ann Vasc Surg 2021 Jun 18. Epub 2021 Jun 18.

Division of Vascular Surgery, University of Massachusetts Medical Center, Worcester, MA. Electronic address:

Introduction: Penetrating injuries to the inferior vena cava (IVC) and/or iliac veins are a source of hemorrhage but may also predispose patients to venous thromboembolism (VTE). We sought to determine the relationship between iliocaval injury, VTE and mortality.

Methods: The National Trauma Data Bank was queried for penetrating abdominal trauma from 2015-2017. Read More

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Health-related quality of life outcomes and influencing factors in patients with unruptured intracranial aneurysms after endovascular treatment.

Qual Life Res 2021 Jun 21. Epub 2021 Jun 21.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, China.

Background: Health-related quality of life (HRQoL) is an important indicator when evaluating prognosis and disease-related treatments. Our current knowledge of the HRQoL outcomes of unruptured intracranial aneurysm (UIA) patients treated by the endovascular intervention appeared to be very limited. To fill this gap, the present study investigated the HRQoL outcomes and identified the influencing factors in UIA patients treated by endovascular intervention. Read More

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Serum Anti-Müllerian Hormone Levels Were Negatively Associated With Body Fat Percentage in PCOS Patients.

Front Endocrinol (Lausanne) 2021 4;12:659717. Epub 2021 Jun 4.

Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, China.

Background: Obesity is a state of excess body fat accumulation, and appears to be closely associated with polycystic ovary syndrome (PCOS). Notably, plausible biological pathways through which obesity can regulate anti-Müllerian hormone (AMH) production have been proposed, and women with PCOS characteristically have an increased AMH level. Body fat accumulation can be described by body fat percentage (BFP). Read More

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Elevated Preoperative CA125 Levels Predicts Poor Prognosis of Hilar Cholangiocarcinoma Receiving Radical Surgery.

Clin Res Hepatol Gastroenterol 2021 Jun 17:101695. Epub 2021 Jun 17.

Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Electronic address:

Background: Preoperative serum carbohydrate antigen 125 (CA125) is used to judge the diagnosis and prognosis of various tumors. However, the relationship between preoperative serum CA125 and prognosis of hilar cholangiocarcinoma (HCCA) has not been proven. This study aims to evaluate preoperative serum CA125 in predicting the prognosis of HCCA after resection. Read More

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Evaluating the impact of social deprivation on Press Ganey® Outpatient Medical Practice Survey Scores.

Health Qual Life Outcomes 2021 Jun 19;19(1):167. Epub 2021 Jun 19.

Department of Orthopaedics, University of Utah, 590 Wakara Way, Salt Lake City, UT, 84108, USA.

Background: Social deprivation has been shown to affect access to health care services, and influences outcomes for a variety of physical and psychological conditions. However, the impact on patient satisfaction remains less clear. The objective of this study was to determine if social deprivation is an independent predictor of patient satisfaction, as measured by the Press Ganey® Outpatient Medical Practice Survey (PGOMPS). Read More

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Idiopathic scoliosis and associated factors among school children: a school-based screening in Ethiopia.

Arch Public Health 2021 Jun 18;79(1):107. Epub 2021 Jun 18.

Department of Physiotherapy, School of Medicine, College of Medicine and Health Sciences, University of Gondar comprehensive specialized hospital, P.O. Box: 196, Gondar, Ethiopia.

Background: Early detection of scoliosis is a preface to prevent progression. In resource-constrained countries like Ethiopia, there is a need for a cost-effective reliable solution for screening. The surprising fact is that there is neither idiopathic scoliosis screening nor reporting of data from Ethiopia. Read More

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RTOG-0129 risk groups are reproducible in a prospective multicenter heterogeneously treated cohort.

Cancer 2021 Jun 18. Epub 2021 Jun 18.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Background: Recursive partitioning analysis (RPA) from the Radiation Therapy Oncology Group (RTOG)-0129 has identified a low-risk group of patients with oropharynx cancer (OPC) who might benefit from therapeutic de-intensification. These risk groups have not yet been reproduced in an independent cohort treated heterogeneously. Therefore, the objective of this analysis was to validate the RPA risk groups and examine the prognostic impact of novel factors. Read More

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Depressive Symptoms and Associated Health-Related Variables in Older Adult Breast Cancer Survivors and Non-Cancer Controls.

Oncol Nurs Forum 2021 Jul;48(4):412-422

Wake Forest Baptist Health.

Objectives: To examine the prevalence of depressive symptoms and associated risk factors in older adult breast cancer survivors (BCS) and age-matched non-cancer controls.

Sample & Setting: Using the Surveillance, Epidemiology, and End Results-Medicare Health Outcome Survey linked dataset from 1998 to 2012, BCS and non-cancer controls aged 65 years or older were identified.

Methods & Variables: Depressive symptoms, comorbidities, functional limitations, socio-demographics, and health-related information were examined. Read More

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Elevated neutrophil to lymphocyte ratio is associated with decreased amputation-free survival after femoropopliteal percutaneous revascularization.

Int Angiol 2021 Jun 18. Epub 2021 Jun 18.

Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, Case Western Reserve University, Cleveland, OH, USA -

Background: An elevated neutrophil-lymphocyte ratio (NLR) is a biomarker associated with adverse outcomes after cardiovascular surgery. This study evaluates the association of preoperative NLR with clinical outcomes after peripheral vascular intervention (PVI) of the femoropopliteal segments.

Methods: A retrospective review identified 488 patients who underwent percutaneous interventions of femoropopliteal arteries between 2011 and 2018 and had a pre-procedural complete blood count with differential with normal white blood cell count within 30 days prior to intervention. Read More

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Prevalence and risk factors for left ventricular diastolic dysfunction in systemic sclerosis: a multi-center study of CRDC cohort in China.

Clin Rheumatol 2021 Jun 17. Epub 2021 Jun 17.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Objective: Left ventricular diastolic dysfunction (LVDD) is a common manifestation of cardiac involvement in systemic sclerosis (SSc), which is associated with increased mortality, but little is known about the risk factors. The aim is to determine the frequency and potential predictors of SSc-LVDD.

Methods: We conducted a prospective multi-center cohort study, enrolling 784 SSc patients assessed by echocardiography between April 2008 and June 2019. Read More

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Clinical Characteristics and Survival Outcomes in Neuroblastoma With Bone Metastasis Based on SEER Database Analysis.

Front Oncol 2021 1;11:677023. Epub 2021 Jun 1.

Department of Orthopedic Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.

Purpose: Clinical features and survival analysis of neuroblastoma (NB) are well explored. However, clinical research of NB patients with bone metastasis is rarely reported. Thus, the current study was performed to analyze the clinical features, survival outcome, and risk factors in those patients. Read More

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Perineural invasion as a risk factor for locoregional recurrence of invasive breast cancer.

Sci Rep 2021 Jun 17;11(1):12781. Epub 2021 Jun 17.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 22, New York, NY, 10044, USA.

Perineural invasion (PNI) is a pathologic finding observed across a spectrum of solid tumors, typically with adverse prognostic implications. Little is known about how the presence of PNI influences locoregional recurrence (LRR) among breast cancers. We evaluated the association between PNI and LRR among an unselected, broadly representative cohort of breast cancer patients, and among a propensity-score matched cohort. Read More

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Impact of Effective Dose to Immune Cells (EDIC) on Lymphocyte Nadir and Survival in Limited-Stage SCLC.

Radiother Oncol 2021 Jun 14. Epub 2021 Jun 14.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

Background: Effective dose to immune cell (EDIC), an estimated radiation dose to the circulating lymphocytes, is of significance for overall survival (OS) in non-small cell lung cancer. This study aimed to validate the EDIC's OS effect on limited-stage small cell lung cancer (LS-SCLC).

Method And Materials: This study included LS-SCLC patients received definitive chemo-radiation in one single center from 2012 to 2017. Read More

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Psychological stress among pregnant and puerperal women in Japan during the coronavirus disease 2019 pandemic.

J Obstet Gynaecol Res 2021 Jun 16. Epub 2021 Jun 16.

Department of Obstetrics and Gynecology, Teine Keijinkai Hospital, Sapporo, Japan.

Aim: To evaluate psychological stress among pregnant and puerperal women in Japan during the coronavirus disease 2019 (COVID-19) pandemic.

Methods: In this cross-sectional study, we recruited pregnant women and puerperal women who delivered between January and September 2020 in Japan, using an online questionnaire. Participants were divided into low, middle, and high groups according to the degree of the epidemic in their region of residence. Read More

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Does more testing in routine preoperative evaluation benefit the orthopedic patient? Case control study from a resource-constrained setting.

Ann Med Surg (Lond) 2021 Jun 28;66:102439. Epub 2021 May 28.

Department of Surgery, Section of Orthopedics, The Aga Khan University Hospital, Pakistan.

Background: Routine preoperative tests in healthy patients not only cause extra anxiety, but may delay treatment without influencing surgical plan. This has worse impact in resource-constrained settings where fee for service rather than health insurance is the usual norm. Investigators aim to determine if "routine" pre-operative tests are justified in healthy orthopedic patients. Read More

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Academic Productivity of United States Neurosurgeons Trained Abroad.

World Neurosurg 2021 Jun 13. Epub 2021 Jun 13.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Background: Previous research in neurosurgery has examined academic productivity for US medical graduates and residents. However, associations between scholarly output and international medical education, residency training, and fellowship training are scarcely documented.

Methods: 1671 US academic neurosurgeons were identified in 2020 using publicly available data along with their countries of medical school, residency, and fellowship training. Read More

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Abdominal Wall Thickness Predicts Surgical Site Infection in Emergency Colon Operations.

J Surg Res 2021 Jun 12;267:37-47. Epub 2021 Jun 12.

Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

Background: Body mass index (BMI) does not reliably predict Surgical site infections (SSI). We hypothesize that abdominal wall thickness (AWT) would serve as a better predictor of SSI for patients undergoing emergency colon operations.

Methods: We retrospectively evaluated our Emergency Surgery Database (2007-2018). Read More

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Comparative Analysis of Pediatric COVID-19 Infection in Southeast Asia, South Asia, Japan, and China.

Am J Trop Med Hyg 2021 Jun 15. Epub 2021 Jun 15.

Duke-NUS Medical School, Singapore.

There is a scarcity of data regarding coronavirus disease 2019 (COVID-19) infection in children from southeast and south Asia. This study aims to identify risk factors for severe COVID-19 disease among children in the region. This is an observational study of children with COVID-19 infection in hospitals contributing data to the Pediatric Acute and Critical Care COVID-19 Registry of Asia. Read More

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Does margin width impact breast cancer recurrence rates in women with breast conserving surgery for ductal carcinoma in situ?

Breast Cancer Res Treat 2021 Jun 15. Epub 2021 Jun 15.

Division of Surgical Oncology, Department of Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI, 53792, USA.

Purpose: Controversy remains regarding the optimal margin width for patients with ductal carcinoma in situ (DCIS) who undergo breast conserving surgery (BCS).

Methods: Women with a primary DCIS diagnosis were enrolled in a statewide population-based cohort from 1997 to 2006. Patients were surveyed every two years with follow-up data available through 2016. Read More

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