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Universal Detection of Mi Antigen and Frequencies of Glycophorin Hybrids among Blood Donors in Taiwan by Human Monoclonal Antibodies against Mi (MNS7), Mur (MNS10), and MUT (MNS35) Antigens.

Diagnostics (Basel) 2021 Apr 29;11(5). Epub 2021 Apr 29.

Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.

Glycophorin hybrids such as GP.Mur are common in Southeast Asians. In Taiwan, clinically significant alloantibodies to the GP. Read More

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Epidemiology, outcomes, and utilization of intensive care unit resources for critically ill COVID-19 patients in Libya: A prospective multi-center cohort study.

PLoS One 2021 30;16(4):e0251085. Epub 2021 Apr 30.

Faculty of Medicine University of Tripoli, Tripoli, Libya.

Background: The coronavirus disease (COVID-19) pandemic has severely affected African countries, specifically the countries, such as Libya, that are in constant conflict. Clinical and laboratory information, including mortality and associated risk factors in relation to hospital settings and available resources, about critically ill patients with COVID-19 in Africa is not available. This study aimed to determine the mortality and morbidity of COVID-19 patients in intensive care units (ICU) following 60 days after ICU admission, and explore the factors that influence in-ICU mortality rate. Read More

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Tranexamic acid to reduce head injury death in people with traumatic brain injury: the CRASH-3 international RCT.

Health Technol Assess 2021 Apr;25(26):1-76

Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.

Background: Tranexamic acid safely reduces mortality in traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury and can cause brain herniation and death. We assessed the effects of tranexamic acid in traumatic brain injury patients. Read More

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Hydroxyl-Terminated Saponified Natural Rubber Based on the HO/P25-TiO Powder/UVC-Irradiation System.

Polymers (Basel) 2021 Apr 17;13(8). Epub 2021 Apr 17.

Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Nakhon Pathom 73170, Thailand.

Natural rubber (NR), a long-chain hydrocarbon polymer mostly consisting of -1,4-polyisoprene units, has a high molecular weight (MW) and viscosity, enabling it to show excellent physical properties. However, NR has no reactive functional group, making it difficult to react with other molecules, especially in manufacturing processes. The functionalized low-molecular-weight NR (FLNR) is a requirement to disperse ingredients into the rubber adequately. Read More

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SARS-CoV-2 Renal Impairment in Critical Care: An Observational Study of 42 Cases (Kidney COVID).

J Clin Med 2021 Apr 8;10(8). Epub 2021 Apr 8.

Department of Anesthesiology and Intensive Care, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, 75012 Paris, France.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to 5% to 16% hospitalization in intensive care units (ICU) and is associated with 23% to 75% of kidney impairments, including acute kidney injury (AKI). The current work aims to precisely characterize the renal impairment associated to SARS-CoV-2 in ICU patients. Forty-two patients consecutively admitted to the ICU of a French university hospital who tested positive for SARS-CoV-2 between 25 March 2020, and 29 April 2020, were included and classified in categories according to their renal function. Read More

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The Emerging Role of the Interplay Among Astrocytes, Microglia, and Neurons in the Hippocampus in Health and Disease.

Front Aging Neurosci 2021 6;13:651973. Epub 2021 Apr 6.

Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.

For over a century, neurons have been considered the basic functional units of the brain while glia only elements of support. Activation of glia has been long regarded detrimental for survival of neurons but more it appears that this is not the case in all circumstances. In this review, we report and discuss the recent literature on the alterations of astrocytes and microglia during inflammaging, the low-grade, slow, chronic inflammatory response that characterizes normal brain aging, and in acute inflammation. Read More

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Safety aspects of kraft lignin fractions: Discussions on the in chemico antioxidant activity and the induction of oxidative stress on a cell-based in vitro model.

Int J Biol Macromol 2021 Apr 19;182:977-986. Epub 2021 Apr 19.

Graduate Program in Genetics, Department of Genetics - Federal University of Paraná (UFPR), Curitiba, PR, Brazil. Electronic address:

Lignin is a complex phenolic biopolymer present in plant cell walls and a by-product of the cellulose pulping industry. Lignin has functional properties, such as antioxidant activity, that make it a potential natural active ingredient for health-care products. However, not all safety aspects of lignin fractions have been adequately investigated. Read More

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Rapid, highly sensitive and quantitative detection of interleukin 6 based on SERS magnetic immunoassay.

Anal Methods 2021 04;13(15):1823-1831

College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi, Xinjiang 830054, China.

Sepsis is a systemic inflammatory response syndrome caused by infection, and is a common disease in intensive care units (ICUs), whereby the mortality rate is as high as 30% to 50%. Early diagnosis and treatment can significantly reduce the mortality rate of patients with sepsis. We have developed a method based on SERS for the rapid and quantitative detection of IL-6. Read More

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Nonattendance to gastroenterologist follow-up after discharge is associated with a thirty-days re-admission in patients with inflammatory bowel disease: a multicenter study.

Minerva Med 2021 Apr 21. Epub 2021 Apr 21.

Gastroenterology and Hepatology Institute, The Nazareth Hospital, EMMS, Nazareth, Isarel -

Background: Inflammatory bowel disease (IBD) is a set of chronic inflammatory diseases associated with significant morbidity and high hospitalization rate. IBD patients are particularly prone to re-hospitalization resulting in high medical cost and morbidity. The aim of this study is to assess laboratory and clinical predictors of re-admission in patients who were hospitalized with IBD flare. Read More

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Transcranial Doppler in Acute COVID-19 Infection: Unexpected Associations.

Stroke 2021 Apr 21:STROKEAHA120032150. Epub 2021 Apr 21.

Dvision of Stroke, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD. (M.C.J., M.N.B.).

Background And Purpose: Stroke may complicate coronavirus disease 2019 (COVID-19) infection based on clinical hypercoagulability. We investigated whether transcranial Doppler ultrasound has utility for identifying microemboli and clinically relevant cerebral blood flow velocities (CBFVs) in COVID-19.

Methods: We performed transcranial Doppler for a consecutive series of patients with confirmed or suspected COVID-19 infection admitted to 2 intensive care units at a large academic center including evaluation for microembolic signals. Read More

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Electron stimulated desorption of vanadyl-groups from vanadium oxide thin films on Ru(0001) probed with STM.

Phys Chem Chem Phys 2021 Apr 25;23(14):8439-8445. Epub 2021 Mar 25.

Carl von Ossietzky Universität Oldenburg, Institut für Physik, D-26111 Oldenburg, Germany.

Low-temperature scanning tunnelling microscopy (STM) is employed to study electron-stimulated desorption of vanadyl groups from an ultrathin vanadium oxide film. The vanadia patches are prepared by reactive vapour deposition of V onto a Ru(0001) surface and comprise a highly ordered network of six and twelve membered V-O rings, some of them terminated by upright V[double bond, length as m-dash]O groups. The vanadyl units can be desorbed via electron injection from the STM tip in a reliable fashion. Read More

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The effects of alcohol consumption and its associations with disease activity among 979 patients with inflammatory arthritis.

RMD Open 2021 Apr;7(2)

The Centre for Arthritis and Rheumatic Disease, St Vincent's University Hospital, Dublin, Ireland

Objective: The role of alcohol in inflammatory disease remains debated. This study explores the relationship between alcohol and disease activity in patients with inflammatory arthritis.

Methods: Patients attending a rheumatology clinic between 2010 and 2020 were prospectively followed. Read More

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Neurological Manifestations of COVID-19 Within the Intensive Care Unit During a Military Deployment for the Early Pandemic Surge in New York City.

Cureus 2021 Mar 12;13(3):e13858. Epub 2021 Mar 12.

Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, USA.

Coronavirus disease 2019 (COVID-19) resulted in a worldwide pandemic that at the time of this writing has caused over 400,000 deaths within the United States. During the pandemic surge in New York City, NY, a number of military Medical Corps (MC) and Nurse Corps (NC) providers were mobilized in direct support of critical care capabilities through expansion intensive care units. In the course of the deployment, high rates of neurological-related manifestations associated with COVID-19 infection were directly observed by our military provider teams which will be described and supporting literature highlighted. Read More

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Autoantibodies Against Methylglyoxal-Modified Apolipoprotein B100 and ApoB100 Peptide Are Associated With Less Coronary Artery Atherosclerosis and Retinopathy in Long-Term Type 1 Diabetes.

Diabetes Care 2021 Apr 15. Epub 2021 Apr 15.

Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.

Objective: Methylglyoxal (MGO), a reactive aldehyde forming advanced glycation end products (AGEs), is increased in diabetes and recognized by the immune system, resulting in anti-AGE-specific autoantibodies. The association of these immune responses with macro- and microvascular complications in type 1 diabetes remains unclarified. We investigated associations between MGO-modified apolipoprotein B100 (apoB100) and apoB100 peptide 5 (MGO-p5) autoantibodies and coronary atherosclerosis and retinopathy in type 1 diabetes. Read More

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Comparative study of not from concentrate and reconstituted from concentrate of pomegranate juices on nutritional and sensory profile.

Food Sci Technol Int 2021 Apr 14:10820132211003707. Epub 2021 Apr 14.

ITC Limited, ITC Life Sciences & Technology Centre, Bengaluru, India.

Pomegranate juice is popular due to its unique health benefits, sensory characteristics and also a good source of bioactive compounds. Comparative study on processing effect of Not from Concentrate (NFC) and Reconstituted from concentrate (RFC) pomegranate juice on the nutritional and sensory characteristics of 'Ganesh' variant was conducted. Results showed that not much differences observed in parameters like pH, acidity, essential elements, protein, total sugars and polyphenol content between NFC and RFC. Read More

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Serum glucose, lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of COVID-19.

Endocrinol Diabetes Metab 2021 04 16;4(2):e00215. Epub 2021 Feb 16.

NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK.

Background: COVID-19 has a broad clinical spectrum. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity.

Methods: Clinical and laboratory data from 610 COVID-19 cases hospitalized in the province of Zheijang, China were investigated as risk factors for severe COVID-19 (assessed by respiratory distress) compared to mild or common forms using logistic regression methods. Read More

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Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke.

IBRO Neurosci Rep 2021 Jun 5;10:18-30. Epub 2021 Jan 5.

Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, United States.

Background: The absolute number of new stroke patients is annually increasing and there still remains only a few Food and Drug Administration (FDA) approved treatments with significant limitations available to patients. Tanshinone IIA (Tan IIA) is a promising potential therapeutic for ischemic stroke that has shown success in pre-clinical rodent studies but lead to inconsistent efficacy results in human patients. The physical properties of Tan-IIA, including short half-life and low solubility, suggests that Poly (lactic-co-glycolic acid) (PLGA) nanoparticle-assisted delivery may lead to improve bioavailability and therapeutic efficacy. Read More

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The PaO2/FiO2 ratio on admission is independently associated with prolonged hospitalization in COVID-19 patients.

J Infect Dev Ctries 2021 Mar 31;15(3):353-359. Epub 2021 Mar 31.

Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Introduction: The early identification of factors that predict the length of hospital stay (HS) in patients affected by coronavirus desease (COVID-19) might assist therapeutic decisions and patient flow management.

Methodology: We collected, at the time of admission, routine clinical, laboratory, and imaging parameters of hypoxia, lung damage, inflammation, and organ dysfunction in a consecutive series of 50 COVID-19 patients admitted to the Respiratory Disease and Infectious Disease Units of the University Hospital of Sassari (North-Sardinia, Italy) and alive on discharge.

Results: Prolonged HS (PHS, >21 days) patients had significantly lower PaO2/FiO2 ratio and lymphocytes, and significantly higher Chest CT severity score, C-reactive protein (CRP) and lactic dehydrogenase (LDH) when compared to non-PHS patients. Read More

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Modelling intensive care unit capacity under different epidemiological scenarios of the COVID-19 pandemic in three Western European countries.

Int J Epidemiol 2021 Apr 9. Epub 2021 Apr 9.

MRC Centre for Global Infectious Disease Analysis & WHO Collaborating Centre for Infectious Disease Modelling, Abdul Latif Jameel Institute for Disease and Emergency Analytics, Imperial College London, St Mary's Campus, Norfolk Place, London, UK.

Background: The coronavirus disease 2019 (COVID-19) pandemic has placed enormous strain on intensive care units (ICUs) in Europe. Ensuring access to care, irrespective of COVID-19 status, in winter 2020-2021 is essential.

Methods: An integrated model of hospital capacity planning and epidemiological projections of COVID-19 patients is used to estimate the demand for and resultant spare capacity of ICU beds, staff and ventilators under different epidemic scenarios in France, Germany and Italy across the 2020-2021 winter period. Read More

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[Combined prognostic value of serum lactic acid, procalcitonin and severity score for short-term prognosis of septic shock patients].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):281-285

Department of Critical Care Medicine, Affiliated Hospital of Jining Medical University, Jining 272030, Shandong, China. Corresponding author: Hu Qinghe, Email:

Objective: To explore the value of lactic acid (Lac), procalcitonin (PCT), sequential organ failure assessment (SOFA) score and acute physiology and chronic health evaluation II (APACHE II) score in assessing the severity and predicting the prognosis in sepsis shock.

Methods: A retrospectively study was conducted. Patients with septic shock hospitalized in the department of critical care medicine of the Affiliated Hospital of Jining Medical University from April 2015 to June 2019 were enrrolled. Read More

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Comparison of a one-step real-time RT-PCR and a nested real-time RT-PCR for a genogroup II norovirus reveals differences in sensitivity depending upon assay design and visualization.

PLoS One 2021 8;16(4):e0248581. Epub 2021 Apr 8.

Department of Food, Nutrition, and Bioprocessing Sciences, North Carolina State University, Raleigh, NC, United States of America.

Human norovirus (NoV) is the leading cause of acute viral gastroenteritis and a major source of foodborne illness. Detection of NoV in food and environmental samples is typically performed using molecular techniques, including real-time reverse transcription polymerase chain reaction (RT-PCR) and less frequently, nested real-time PCR. In this study, we conducted a controlled comparison of two published NoV detection assays: a broadly reactive one-step real-time RT-PCR and a two-step nested real-time PCR assay. Read More

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Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design?

Chembiochem 2021 Apr 7. Epub 2021 Apr 7.

Swiss Federal Institute of Technology in Lausanne (EPFL), 1015, Lausanne, Switzerland.

For several years, drugs with reactive electrophilic appendages have been developed. These units typically confer prolonged residence time of the drugs on their protein targets, and may assist targeting shallow binding sites and/or improving the drug-protein target spectrum. Studies on natural electrophilic molecules have indicated that, in many instances, natural electrophiles use similar mechanisms to alter signaling pathways. Read More

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Clinical features and predictors of severity in COVID-19 patients with critical illness in Singapore.

Sci Rep 2021 04 5;11(1):7477. Epub 2021 Apr 5.

Tan Tock Seng Hospital, Singapore, Singapore.

We aim to describe a case series of critically and non-critically ill COVID-19 patients in Singapore. This was a multicentered prospective study with clinical and laboratory details. Details for fifty uncomplicated COVID-19 patients and ten who required mechanical ventilation were collected. Read More

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Characterization of Natural and Alkaline-Oxidized Proanthocyanidins in Plant Extracts by Ultrahigh-Resolution UHPLC-MS/MS.

Molecules 2021 Mar 26;26(7). Epub 2021 Mar 26.

Natural Chemistry Research Group, Department of Chemistry, University of Turku, FI-20014 Turku, Finland.

In this study, we analyzed the proanthocyanidin (PA) composition of 55 plant extracts before and after alkaline oxidation by ultrahigh-resolution UHPLC-MS/MS. We characterized the natural PA structures in detail and studied the sophisticated changes in the modified PA structures and the typical patterns and models of reactions within different PA classes due to the oxidation. The natural PAs were A- and B-type PCs, PDs and PC/PD mixtures. Read More

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A Network of Pathways Controlling Cellular Homeostasis Affects the Onset of Senescence in .

J Fungi (Basel) 2021 Mar 31;7(4). Epub 2021 Mar 31.

Institute for Molecular Biosciences, Faculty of Biosciences, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.

Research on unraveled a network of molecular pathways affecting biological aging. In particular, a number of pathways active in the control of mitochondria were identified on different levels. A long-known key process active during aging of is the age-related reorganization of the mitochondrial DNA (mtDNA). Read More

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The Need of Enterococcal Coverage in Severe Intra-Abdominal Infection: Evidence from Animal Study.

J Clin Med 2021 Mar 2;10(5). Epub 2021 Mar 2.

Department of Emergency Medicine, CHA University School of Medicine, Seongnam 13497, Korea.

Intra-abdominal infection (IAI) is a common and important cause of infectious mortality in intensive care units. Adequate source control and appropriate antimicrobial regimens are key in the management of IAI. In community-acquired IAI, guidelines recommend the use of different antimicrobial regimens according to severity. Read More

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Assessing the risk of rapid radiographic progression in Hungarian rheumatoid arthritis patients.

BMC Musculoskelet Disord 2021 Apr 2;22(1):325. Epub 2021 Apr 2.

Department of Rheumatology, University of Debrecen, Faculty of Medicine, Nagyerdei str 98, Debrecen, 4032, Hungary.

Background: The outcome of rheumatoid arthritis (RA) should be determined early. Rapid radiological progression (RRP) is > or = 5 units increase according to the van der Heijde-Sharp score within a year. The risk of RRP can be estimated by a matrix model using non-radiographic indicators, such as C-reactive protein (CRP), rheumatoid factor (RF) and swollen joint count (SJC). Read More

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Clinical Characteristics and Short-Term Outcomes of Acute Kidney Injury Missed Diagnosis in Older Patients with Severe COVID-19 in Intensive Care Unit.

Q Li P Hu H Kang F Zhou

J Nutr Health Aging 2021 ;25(4):492-500

Feihu Zhou, Department of Critical Care Medicine, the First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China, Tel: +86 10 6693 8148; E-mail:

Objectives: Patients with severe or critical COVID-19 are at higher risk for developing acute kidney injury (AKI). However, whether AKI is diagnosed in all the patients and the correlation between the outcomes of COVID-19 are not well understood.

Patients And Methods: This cohort study was conducted from February 4, 2020 to April 16, 2020 in Wuhan, China. Read More

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Thousands of previously unknown phages discovered in whole-community human gut metagenomes.

Microbiome 2021 03 29;9(1):78. Epub 2021 Mar 29.

National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, USA.

Background: Double-stranded DNA bacteriophages (dsDNA phages) play pivotal roles in structuring human gut microbiomes; yet, the gut virome is far from being fully characterized, and additional groups of phages, including highly abundant ones, continue to be discovered by metagenome mining. A multilevel framework for taxonomic classification of viruses was recently adopted, facilitating the classification of phages into evolutionary informative taxonomic units based on hallmark genes. Together with advanced approaches for sequence assembly and powerful methods of sequence analysis, this revised framework offers the opportunity to discover and classify unknown phage taxa in the human gut. Read More

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The COVID-19 Epidemic: Management and Outcomes of Hemodialysis and Peritoneal Dialysis Patients in Stockholm, Sweden.

Kidney Blood Press Res 2021 26;46(2):250-256. Epub 2021 Mar 26.

Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.

Background: The COVID-19 outbreak has been associated with a high morbidity, mortality, and a risk of long-term sequelae, and patients with severe COVID-19 are at increased risk of acute kidney injury. CKD patients are at high risk of being exposed to COVID-19 and suffer complications and poor outcome. In Sweden, mitigation strategies did not include lockdown. Read More

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