6,326 results match your criteria units injectable


A systematic review and meta-analysis of technical aspects and clinical outcomes of botulinum toxin prior to abdominal wall reconstruction.

Hernia 2021 Sep 21. Epub 2021 Sep 21.

Department of Surgery, Amsterdam Gastroenterology and Metabolism, Amsterdam Infection and Immunity, Amsterdam University Medical Centers, Location AMC, Suite J1A-228, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.

Purpose: To systematically review technical aspects and treatment regimens of botulinum toxin A (BTA) injections in the lateral abdominal wall musculature. We also investigated the effect of BTA on abdominal muscle- and hernia dimensions, and clinical outcome.

Methods: PubMed, EMBASE, CENTRAL, and CINAHL were searched for studies that investigate the injection of BTA in the lateral abdominal wall muscles. Read More

View Article and Full-Text PDF
September 2021

Analgesic potential of different available commercial brands of botulinum neurotoxin-A in formalin-induced orofacial pain in mice.

Toxicon X 2021 Nov 2;12:100083. Epub 2021 Sep 2.

Post-Graduated Program Genetics and Biochemistry, Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, MG, Brazil.

The use of botulinum neurotoxin-A (BoNT-A) is an alternative for the management of orofacial pain disorders. Although only Botox has labeled, there are other commercial brands available for use, among them: Dysport, Botulift, Prosigne, and Xeomin. The objective of the present study was to evaluate the possible differences in the antinociceptive effect evoked by different commercially available formulations of BoNT-A in an animal model of inflammatory orofacial pain induced by formalin injection. Read More

View Article and Full-Text PDF
November 2021

Hyperbranched anion exchangers prepared from polyethylene polyamine modified polymeric substrates for ion chromatography.

J Chromatogr A 2021 Aug 28;1655:462508. Epub 2021 Aug 28.

Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, China. Electronic address:

High hydrophilic anion stationary phases play a crucial role in the separation behavior of ion chromatography. Herein, we report novel polymeric anion exchangers grafted with polyethylene polyamines, including ethylenediamine, diethylenetriamine, triethylenetetramine and tetraethylene pentaamine, via a facile epoxy-amine polymerization method. The anion exchangers were characterized by scanning electron microscopy, thermogravimetry, Fourier transform infrared spectrometry and elemental analysis. Read More

View Article and Full-Text PDF

Cosmetic Filler Blindness: Recovery After Repeated Hyaluronidase Injections.

Aesthet Surg J 2021 Sep 4. Epub 2021 Sep 4.

Department of Oculoplastics, Sydney Eye Hospital, Sydney, Australia.

Background: The rise of cosmetic injectables has seen new clinical scenarios related to complications. The scenario of hyaluronic acid (HA) aesthetic interventional induced visual loss (AIIVL) has become more recognized. While this complication is rare, there can be delayed recognition and treatment, with limited opportunity to evaluate potential treatments and establish best practice guidelines. Read More

View Article and Full-Text PDF
September 2021

High Dose Cabergoline in Management of Bilateral Ovarian Hyperstimulation Syndrome: A Case Report.

Int Med Case Rep J 2021 24;14:557-561. Epub 2021 Aug 24.

Department of Epidemiology, Kabul University of Medical Sciences, Kabul, Afghanistan.

Ovarian hyperstimulation syndrome (OHSS) is an exaggerated response to excess hormones and is also one of the life-threatening iatrogenic complications which is associated with ovulation induction. This syndrome usually occurs in women who receive injectable hormones for the stimulation of egg development in the ovaries. This study describes a rare case of moderate ovarian hyperstimulation syndrome which has been managed and treated with high-dose cabergoline. Read More

View Article and Full-Text PDF

What Do We Know about Thromboprophylaxis and Its Monitoring in Critically Ill Patients?

Biomedicines 2021 Jul 22;9(8). Epub 2021 Jul 22.

Intensive Care, CHU de Charleroi, Université Libre de Bruxelles, 6042 Charleroi, Belgium.

Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is an important complication in patients hospitalized in intensive care units (ICU). Thromboprophylaxis is mainly performed with Low Molecular Weight Heparin (LMWH) and, in some specific patients, with Unfractionated Heparin (UFH). These intensive units are an environment where individual patient variability is extreme and where traditional antithrombotic protocols are frequently ineffective. Read More

View Article and Full-Text PDF

miR-93-5p knockdown repressed hepatocellular carcinoma progression via increasing ERBB4 and TETs-dependent DNA demethylation.

Autoimmunity 2021 Aug 26:1-14. Epub 2021 Aug 26.

Department of Intensive Care Units, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Background: microRNAs (miRNAs) are involved in hepatocellular carcinoma (HCC) development and can control gene expression directly targeting or regulating DNA methylation. This research aims to analyse the mechanism of miR-93-5p on HCC progression.

Methods: miR-93-5p, Erb-B2 receptor tyrosine kinase 4 (ERBB4) and ten-eleven translocation methyl-cytosine dioxygenases (TET1, TET2 and TET3) abundances were measured quantitative reverse transcription polymerase chain reaction and Western blotting. Read More

View Article and Full-Text PDF

Combined Therapy of Ciclosporin Plus Favipiravir in the Management of Patients with Severe COVID-19, not Responding to Dexamethasone: A non-Controlled Prospective Trial.

Int Immunopharmacol 2021 Oct 4;99:108043. Epub 2021 Aug 4.

Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Regarding the COVID-19 pandemic, potential therapeutic agents are being evaluated almost every day. Ciclosporin, a calcineurin inhibitor, is characterized by beneficial antiviral and immunomodulatory effects. The present study aimed to evaluate the efficacy of ciclosporin in managing COVID-19. Read More

View Article and Full-Text PDF
October 2021

Utilization of traditional Chinese medicine in the intensive care unit.

Chin Med 2021 Aug 23;16(1):84. Epub 2021 Aug 23.

Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, China.

Previous studies showed that traditional Chinese medicine (TCM) may be effective for patients with critical conditions. However, the extent to which TCM is used in intensive care units (ICUs) remains less investigated. This study aimed to investigate the utilization of TCM among ICU patients. Read More

View Article and Full-Text PDF

Pronounced declines in dispensed licit fentanyl, but not fentanyl derivatives.

Res Social Adm Pharm 2021 Aug 3. Epub 2021 Aug 3.

Geisinger Commonwealth School of Medicine, Scranton, PA, USA; Center for Pharmacy Innovation and Outcomes, Forty Fort, PA, USA. Electronic address:

Background: Fentanyl and its derivatives are highly utilized opioid-based analgesics provided to patients in various formulations, but this agent has also been implicated in many overdoses when misused. The evolving opioid crisis has increased pressure on the healthcare industry to monitor opioid prescriptions. Different policies and procedures implemented to contain the crisis have impacted the utilization of some opioids. Read More

View Article and Full-Text PDF

Are radiopharmaceuticals self-sterilizing? Radiation effect of gallium-68 and lutetium-177 on bacillus pumilus and staphylococcus succinus.

Nuklearmedizin 2021 Aug 20. Epub 2021 Aug 20.

Department of Nuclear Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: For radiopharmaceuticals, aseptic preparation in combination with filtration is the most commonly used sterilizing method. In general, the production of radiopharmaceuticals needs to fulfil the requirements of good manufacturing practice. In the scope of this work, we focused on the positron emitter gallium-68 and on the therapeutically used beta- and gamma-emitter lutetium-177, as they are routinely used for in-house synthesis of radiopharmaceuticals in nuclear medicine departments. Read More

View Article and Full-Text PDF

Symptom control after different duration of triptorelin treatment following conservative surgery for deep infiltrating endometriosis: Post-hoc analysis of a multicentre, prospective, real-world study.

Medicine (Baltimore) 2021 Jul;100(30):e26753

Gynaecology Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Abstract: Triptorelin has been used after surgery in deep infiltrating endometriosis. This post-hoc analysis aimed to evaluate symptom control between patients receiving 1-3 triptorelin injections and those receiving 4-6 injections within 24 months of conservative surgery for deep infiltrating endometriosis, in the real-world.Included patients were divided into two groups (received up to 3 months injections in group A, 4-6 injections in group B) based on the numbers of triptorelin (Diphereline, 3. Read More

View Article and Full-Text PDF

Predicting the epidemic curve of the coronavirus (SARS-CoV-2) disease (COVID-19) using artificial intelligence: An application on the first and second waves.

Inform Med Unlocked 2021 8;25:100691. Epub 2021 Aug 8.

Department of Health Systems Management and Quality Management in Health Care, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.

Objectives: The COVID-19 pandemic is considered a major threat to global public health. The aim of our study was to use the official epidemiological data to forecast the epidemic curves (daily new cases) of the COVID-19 using Artificial Intelligence (AI)-based Recurrent Neural Networks (RNNs), then to compare and validate the predicted models with the observed data.

Methods: We used publicly available datasets from the World Health Organization and Johns Hopkins University to create a training dataset, then we employed RNNs with gated recurring units (Long Short-Term Memory - LSTM units) to create two prediction models. Read More

View Article and Full-Text PDF

Case report: risk of skin necrosis related to injectable vancomycin in critically ill newborn infants.

BMC Pediatr 2021 08 13;21(1):343. Epub 2021 Aug 13.

Univ. Lille, CHU Lille, ULR 2694- METRICS: Evaluation des technologies de santé et des pratiques médicales, F-59000, Lille, France.

Background: Vancomycin is commonly used as part of empiric antibiotic therapy in the preterm infants who develop signs and symptoms of infection. Although skin necrosis has been noted to occur following injection of vancomycin into a peripheral vein in an adult patient, this complication has not been previously described in a preterm infant.

Case Presentation: We report the case of a very low birthweight male infant born at 30 weeks gestational age who developed skin necrosis, most likely as a complication of vancomycin administration via a peripheral venous catheter. Read More

View Article and Full-Text PDF

Do gait parameters improve after botulinum toxin injections in post stroke patients? A prospective study.

Toxicon 2021 Sep 10;200:189-197. Epub 2021 Aug 10.

Department of Physical Medicine and Rehabilitation, University of Ioannina, S. Niarchos Ave, Ioannina, 45110, Greece. Electronic address:

The intramuscular injection of botulinum toxin is one of the most efficient ways to treat localized spasticity in patients suffering from Central Nervous System lesions like stroke, cerebral palsy and multiple sclerosis. The gait analysis based on kinetics and kinematics is a recognized way of measurement of the effect of intramuscular injection of botulinum toxin in spastic patients suffering from chronic stroke. The aim of this study is to provide evidence of the beneficial effect of botulinum toxin on characteristics of gait pattern on patients suffering from chronic stroke. Read More

View Article and Full-Text PDF
September 2021

Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration.

Commun Biol 2021 08 11;4(1):956. Epub 2021 Aug 11.

Department of Bioengineering, George Mason University, Fairfax, VA, USA.

Lipid Nanoparticles (LNPs) are used to deliver siRNA and COVID-19 mRNA vaccines. The main factor known to determine their delivery efficiency is the pKa of the LNP containing an ionizable lipid. Herein, we report a method that can predict the LNP pKa from the structure of the ionizable lipid. Read More

View Article and Full-Text PDF

Quantitative gait analysis of patients with severe sacroiliac joint dysfunction: a prospective clinical study.

J Neurosurg Sci 2021 Aug 3. Epub 2021 Aug 3.

Neurosurgical Department, Masaryk Hospital Krajská Zdravotní a.s., J. E. Purkyně University, Ústí nad Labem, Czech Republic.

Background: Sacroiliac joint (SIJ) dysfunction is a chronic painful condition responsible for up to 30% of back pain. Treatment modalities include physiotherapy, intraarticular analgesic injections, ablation techniques or SIJ fusion. The severity of SIJ dysfunction is commonly assessed via subjective pain or disability scales. Read More

View Article and Full-Text PDF

Impact of the COVID-19 pandemic on the management of cancer patients: the experience of the cancer outpatients department of a university hospital in Paris.

Clin Med (Lond) 2021 Sep 2;21(5):e552-e555. Epub 2021 Aug 2.

Cochin Hospital, Paris, France.

Cancer patients are a highly vulnerable group in the COVID-19 pandemic and it has been necessary for oncology units to adapt to this unexpected situation. We present our management of outpatients with cancer during the pandemic. We applied two major adaptations: extending the intervals between injections for maintenance therapy and protocol adaptation for patients with comorbidities. Read More

View Article and Full-Text PDF
September 2021

Synthesis of poly(2-methacryloyloxyethyl phosphorylcholine)-conjugated lipids and their characterization and surface properties of modified liposomes for protein interactions.

Biomater Sci 2021 Sep 20;9(17):5854-5867. Epub 2021 Jul 20.

Department of Immunology, Genetics and Pathology (IGP), Uppsala University, Dag Hammarskjölds väg 20, SE-751 85, Uppsala, Sweden.

Poly(ethylene glycol) (PEG) is frequently used for liposomal surface modification. However, as PEGylated liposomes are cleared rapidly from circulation upon repeated injections, substitutes of PEG are being sought. We focused on a water-soluble polymer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) units, and synthesized poly(MPC) (PMPC)-conjugated lipid (PMPC-lipid) with degrees of MPC polymerization ranging from 10 to 100 (calculated molecular weight: 3 to 30 kDa). Read More

View Article and Full-Text PDF
September 2021

Botulinum toxin injection of the inferior oblique muscles for V-pattern strabismus and primary position hypertropia.

Am J Ophthalmol 2021 Jul 17. Epub 2021 Jul 17.

Department of Ophthalmology, Boston Children's Hospital, Boston, MA, USA; Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address:

Purpose: To evaluate outcomes of botulinum toxin (BTX) injection of the inferior oblique (IO) muscles.

Design: Retrospective case series.

Methods Setting: Single center, ophthalmology department at Boston Children's Hospital STUDY POPULATION: All patients treated with IO muscle injection of BTX (onabotulinumtoxinA) between 2010 and 2020. Read More

View Article and Full-Text PDF

The Use of Botulinum Toxin in a Case of Acquired Periodic Alternating Nystagmus.

Br Ir Orthopt J 2021 15;17(1):85-90. Epub 2021 Apr 15.

Moorfields Eye Hospital, GB.

Aim: To describe a case of acquired Periodic Alternating Nystagmus (PAN) with oscillopsia treated with botulinum toxin injections into four horizontal rectus muscles.

Method: A 22-year-old woman presented with sudden onset PAN. The only abnormality found following extensive investigations was bilateral superior cerebellar peduncle atrophy on MRI. Read More

View Article and Full-Text PDF

Injections and infections: understanding syringe service program utilization in a rural state.

Harm Reduct J 2021 Jul 17;18(1):74. Epub 2021 Jul 17.

Center for Outcomes Research and Evaluation/Maine Medical Center Research Institute, 509 Forest Ave, Portland, ME, USA.

Background: Increasing rates of injection drug use (IDU) associated-infections suggest significant syringe service program (SSP) underutilization. Our study objective was to assess practices of safe injection techniques and to determine predictors of SSP utilization in a rural state.

Patients And Methods: This was a fifteen-month cross-sectional study of participants hospitalized with IDU-associated infections in Maine. Read More

View Article and Full-Text PDF

Does botulinum toxin have any role in the management of chronic pain associated with bruxism?

Cranio 2021 Jul 14:1-8. Epub 2021 Jul 14.

Department of Oral Maxillofacial Surgery, Regional Dental College, Guwahati, Assam, India.

Objective: To determine the efficacy of injectable botulinum toxin (BTA) in the management of pain associated with nocturnal bruxism.

Methods: The study subjects consisted of 40 male and female volunteers who complained of chronic pain in the masseter muscles bilaterally due to bruxism. Twenty units of BTA were injected bilaterally into the masseter muscles. Read More

View Article and Full-Text PDF

A supramolecular host-guest interaction-mediated injectable hydrogel system with enhanced stability and sustained protein release.

Acta Biomater 2021 09 8;131:286-301. Epub 2021 Jul 8.

Research Institute of Advanced Materials (RIAM), Department of Materials Science and Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Electronic address:

Injectable hydrogels have been studied as drug delivery systems because of their minimal invasiveness and sustained drug release properties. Pluronic F127, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers, exhibits thermo-responsive properties and hence is injectable due to its rapid sol-gel transition. Unmodified Pluronic F127-based hydrogels, however, have limited long-term stability and controllable release of drugs entrapped within them. Read More

View Article and Full-Text PDF
September 2021

Lower Critical Solution Temperature Phase Transition of Poly(PEGMA) Hydrogel Thin Films.

Langmuir 2021 07 8;37(28):8585-8593. Epub 2021 Jul 8.

Soft Matter Sciences and Engineering, ESPCI Paris, PSL University, Sorbonne Université, CNRS, F-75005 Paris, France.

Surface-attached hydrogel films with well-controlled chemistry are a new approach of polymer thin layers and an actual alternative to polymer brushes and layer-by-layer assemblies. The advantage is that the thickness of hydrogel films can widely range from a few nanometers to several micrometers. Hydrogel films can also remarkably respond to stimuli such as temperature: (i) the thickness change is of great amplitude, fourfold and more, which could not be reached with the geometry of polymer brushes or layer-by-layer assemblies, (ii) the time response is very short (less than 1 s), and (iii) the swelling-to-collapse transition is narrow (a small temperature change of a few degrees may be enough). Read More

View Article and Full-Text PDF

Rush immunotherapy in two cats with atopic skin syndrome.

JFMS Open Rep 2021 Jan-Jun;7(1):20551169211023327. Epub 2021 Jun 21.

Allergy, Skin and Ear Clinic for Pets, Livonia, MI, USA.

Case Series Summary: Two cats with feline atopic skin syndrome (FASS) were included in this case series. They were diagnosed with FASS by a combination of history, physical examination and exclusion of other pruritic diseases. They underwent rush immunotherapy (RIT) after determination of offending environmental allergens by either serum IgE or intradermal testing. Read More

View Article and Full-Text PDF

Post-Event Application of Neurotropin Protects against Ischemic Insult toward Better Outcomes in a Murine Model of Subarachnoid Hemorrhage.

Biomedicines 2021 Jun 10;9(6). Epub 2021 Jun 10.

Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University, Koriyama, Fukushima 963-8611, Japan.

Early brain injury (EBI) is closely linked to the development of delayed cerebral ischemia and poor outcomes after aneurysmal subarachnoid hemorrhage (SAH). This study aimed to evaluate the neuroprotective effect of neurotropin on EBI in a murine model of SAH. Twenty-four C57BL/6N mice were treated with intraperitoneal injections of either saline or 2. Read More

View Article and Full-Text PDF

Unfractionated Heparin TID Dosing Regimen Is Associated With a Lower Rate of Pulmonary Embolism When Compared With BID Dosing in Patients Undergoing Craniotomy.

World Neurosurg 2021 Sep 21;153:e147-e152. Epub 2021 Jun 21.

Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address:

Background: Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), and intracranial hemorrhage (ICH) may complicate the post-operative course of patients undergoing craniotomy. While prophylaxis with unfractionated heparin (UFH) has been shown to reduce VTE rates, twice-daily (BID) and three-times-daily (TID) UFH dosing regimens have not been compared in neurosurgical procedures. The objective of this study was to explore the association between UFH dosing regimen and rates of VTE and ICH in craniotomy patients. Read More

View Article and Full-Text PDF
September 2021

Practical guidance on the initiation, titration, and switching of basal insulins: a narrative review for primary care.

Ann Med 2021 12;53(1):998-1009

University of Florida, Gainesville, USA.

Many patients with type 2 diabetes will ultimately require the inclusion of basal insulin in their treatment regimen. Since most people with type 2 diabetes are managed in the community, it is important that primary care providers understand and correctly manage the initiation and titration of basal insulins, and help patients to self-manage insulin injections. Newer, long-acting basal insulins provide greater stability and flexibility than older preparations and improved delivery systems. Read More

View Article and Full-Text PDF
December 2021

Case Report: Metreleptin and SGLT2 Inhibitor Combination Therapy Is Effective for Acquired Incomplete Lipodystrophy.

Front Endocrinol (Lausanne) 2021 31;12:690996. Epub 2021 May 31.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.

Childhood cancer survivors (CCSs) who have undergone bone marrow transplantation with systemic chemotherapy and whole-body irradiation often experience impaired glucose tolerance with marked insulin resistance. Incomplete acquired diabetic lipodystrophy should be considered as a late complication of bone marrow transplantation. A 24-year-old Japanese female patient with incomplete acquired lipodystrophy, a CCS of acute lymphocytic leukemia at the age of 3 years, was treated for diabetes mellitus and dyslipidemia at our hospital. Read More

View Article and Full-Text PDF