4,622,820 results match your criteria united states

Genome-wide Association and Meta-analysis of Age-at-Onset in Parkinson Disease: Evidence From COURAGE-PD Consortium.

Neurology 2022 May 26. Epub 2022 May 26.

Sorbonne Université (SU) Unité Mixte de Recherche (UMR) 1127, INSERM U1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.

Background And Objectives: Considerable heterogeneity exists in the literature concerning genetic determinants of the age of onset (AAO) of Parkinson's disease (PD), which could be attributed to lack of well-powered replication cohorts. The previous largest GWAS identified nd loci on chromosome (Chr) 4 with a significant influence on AAO of PD, these have not been independently replicated. The present study aims to conduct a meta-analysis of GWAS of PD AAO and validate previously observed findings in worldwide populations. Read More

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Adult Neurology Rotations for Child Neurology Residents: A Survey of Program Directors.

Neurology 2022 May 26. Epub 2022 May 26.

Division of Child Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH.

Background And Objectives: We aimed to identify how child neurology and neurodevelopmental disabilities residency program directors (PDs) implemented revised Accreditation Council for Graduate Medical Education requirements for adult neurology training for child neurology residents. Prior to 2014, American Board of Psychiatry and Neurology certification for child neurology required an "adult year," with no specified rotation requirements. At that point, programs scheduled a median of 10 months of adult neurology rotations during the third postgraduate year (PGY-3). Read More

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Patterns of preschool educators' beliefs and practices over the course of a coaching intervention.

Emily C Hanno

J Sch Psychol 2022 Jun 29;92:96-120. Epub 2022 Mar 29.

Graduate School of Education, Harvard University, United States of America. Electronic address:

This study used person-centered approaches to examine whether educator beliefs and practices transformed as a result of a randomized coaching intervention focused on the quality of teacher-child interactions. It also considers whether educators' beliefs and practices at the end of the intervention were in turn jointly associated with children's development. Latent profile analysis with a sample of 281 preschool educators working primarily in public school prekindergarten and Head Start programs across nine U. Read More

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Early career Black women in school-based mental health fields: Understanding their experiences of workplace discrimination.

J Sch Psychol 2022 Jun 8;92:49-65. Epub 2022 Mar 8.

William and Mary, United States of America.

This study aimed to understand school mental health providers' experiences with racism and other forms of discrimination (i.e., gendered-based discrimination) at work, with an exclusive focus on early career Black women. Read More

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Exploring profiles of coaches' fidelity to Double Check's Motivational Interviewing-embedded coaching: Outcomes associated with fidelity.

J Sch Psychol 2022 Jun 30;92:285-298. Epub 2022 Apr 30.

University of Virginia, School of Education and Human Development, United States of America.

Motivational interviewing (MI) is applied in a variety of clinical and coaching models to promote behavior change, with increasing interest in its potential to optimize school-based implementation fidelity. Yet there has been less consideration of fidelity indicators for MI-embedded coaching and their associations with outcomes. We leveraged exisiting data from 151 teachers across 18 schools, who were part of a larger 39 middle school randomized controlled trial of a teacher coaching model, to explore profiles of fidelity and the associations between fidelity and outcomes. Read More

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A cost-effectiveness analysis of four approaches to universal screening for reading risk in upper elementary and middle school.

J Sch Psychol 2022 Jun 27;92:246-264. Epub 2022 Apr 27.

Gibson Consulting Group, Austin, TX, United States of America.

Research on universal screening in reading has primarily focused on the psychometric adequacy of screening procedures without critically considering costs and value. Educators in upper elementary and middle school have access to a great deal of extant student achievement data, which makes the evaluation of the costs associated with collecting new data for screening purposes paramount. We conducted a retrospective analysis of four approaches to reading screening using cost-effectiveness analysis. Read More

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The academic benefits of maintaining friendships across the transition to high school.

J Sch Psychol 2022 Jun 13;92:136-147. Epub 2022 Apr 13.

University of California, Los Angeles, 502 Portola Plaza, Los Angeles, CA 90095, United States of America.

Extending past research on the social and academic disruption associated with the transition from middle to high school, this study examined the role of friendship stability. Specifically, the goal was to investigate how friendships maintained from middle school and perceived (academic and emotional) support from friends at ninth grade contributed to school-related affect (e.g. Read More

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Becoming a Parent During Cardiovascular Training.

J Am Coll Cardiol 2022 May;79(21):2119-2126

Division of Cardiovascular Medicine, University of Florida College of Medicine, Malcom Randall VA Medical Center, Gainesville, Florida, USA.

Background: Specialty training in cardiovascular diseases is consistently perceived to have adverse job conditions and interfere with family life. There is a dearth of universal workforce support for trainees who become parents during training.

Objectives: This study sought to identify parental policies across cardiovascular training programs internationally. Read More

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The association between race and place of death among persons with dementia.

J Pain Symptom Manage 2022 May 23. Epub 2022 May 23.

Department of Physiological Nursing, University of California, San Francisco, United States.

Context: Little is known about racial differences in place of death for persons with dementia (PWD), who may be especially vulnerable to receiving care at end of life that is not concordant with their goals or that places higher burden on caregivers.

Objective: To determine if there are racial and ethnic differences in place of death among PWD.

Method: We analyzed data from the nationally representative National Health and Aging Trends study. Read More

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Analysis of female enrollment in clinical trials for alcohol and substance use disorders: Is it time for sex-informed pharmacotherapy?

Contemp Clin Trials 2022 May 23:106784. Epub 2022 May 23.

Mary Horrigan Connors Center for Women's Health and Gender Biology, Department of Psychiatry, Brigham and Women's Hospital, United States of America; Harvard Medical School, Boston, MA, United States of America. Electronic address:

Background: Women represent an increasing number of individuals with alcohol and substance use disorders (ASUDs), and sex-differences might affect results of interventional clinical trials (CTs). We aim at assessing the proportion of women and the reporting of sex-stratified and female-specific data in CTs for ASUDs.

Methods: We extracted data from ClinicalTrials. Read More

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Harmonization of multi-site MRS data with ComBat.

Neuroimage 2022 May 23:119330. Epub 2022 May 23.

Department of Radiology, University of Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, AB, Canada; Alberta Children's Hospital Research Institute, University of Calgary, AB, Canada.

Magnetic resonance spectroscopy (MRS) is a non-invasive neuroimaging technique used to measure brain chemistry in vivo and has been used to study the healthy brain as well as neuropathology in numerous neurological disorders. The number of multi-site studies using MRS are increasing; however, non-biological variability introduced during data collection across multiple sites, such as differences in scanner vendors and site-specific acquisition implementations for MRS, can obscure detection of biological effects of interest. ComBat is a data harmonization technique that can remove non-biological sources of variance in multisite studies. Read More

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Clinical characteristics and outcome of infective endocarditis due to Abiotrophia and Granulicatella compared to Viridans group streptococci.

J Infect 2022 May 23. Epub 2022 May 23.

Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain. Electronic address:

Objective: To describe the clinical characteristics and outcome of Abiotrophia and Granulicatella infective endocarditis and compare them with Viridans group streptococci infective endocarditis.

Methods: All patients in the International Collaboration on Endocarditis (ICE) - prospective cohort study (PCS) and the ICE-PLUS cohort were included (n=8112). Data from patients with definitive or possible IE due to Abiotrophia species, Granulicatella species and Viridans group streptococci was analyzed. Read More

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QT-AMP: Sequencing PCR amplicons from Quanti-Tray wells to analyze enterococci communities.

Sci Total Environ 2022 May 23:156188. Epub 2022 May 23.

Lee County Environmental Laboratory, Fort Myers, FL 33907, United States.

Enterococcus is ubiquitous in human feces and has been adopted as a useful indicator of human fecal pollution in water. Although regular enterococci monitoring only examines their numbers, identifying human-specific Enterococcus species or genotypes could help discriminate human fecal contamination from other environmental sources. We documented a new approach to characterize enterococci using a high-throughput 16S rRNA gene amplicon sequencing platform from Quanti Trays after following the counting of the most probable numbers of enterococci. Read More

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Breast arterial calcification and Epicardial adipose tissue volume but not density are independently associated with cardiovascular risk.

Int J Cardiol 2022 May 23. Epub 2022 May 23.

Monash University, Melbourne, Victoria, Australia, Wellington Rd, Clayton, Australia, 3800; Monash Cardiovascular Research Centre, Monash Health, Melbourne, Victoria, Australia, 246 Clayton Rd, Clayton, Australia, 3168; Victorian Heart Institute, Melbourne, Victoria, Australia, Blackburn Rd, Clayton, Australia, 3800; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia, 75 Commercial Rd, Melbourne, Australia, 3004. Electronic address:

Background: Mammographically detected breast arterial calcification (BAC) has been proposed as surrogate marker for coronary artery disease (CAD) in women. Epicardial adipose tissue (EAT) and peri-coronary adipose tissue (PCAT) are inflammatory fat depots linked to atherogenesis. BAC has demonstrated association with inflammation, therefore we aimed to determine the association between BAC, EAT and PCAT. Read More

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Machine learning to refine prognostic and predictive nodal burden thresholds for post-operative radiotherapy in completely resected stage III-N2 non-small cell lung cancer.

Radiother Oncol 2022 May 23. Epub 2022 May 23.

Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA, United States. Electronic address:

Background: The role of post-operative radiotherapy (PORT) for completely resected N2 non-small-cell lung cancer (NSCLC) is controversial in light of recent randomized data. We sought to utilize machine learning to identify a subset of patients who may still benefit from PORT based on extent of nodal involvement.

Materials/methods: Patients with completely resected N2 NSCLC were identified in the National Cancer Database. Read More

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Blockade of the mineralocorticoid receptors in the medial prefrontal cortex prevents the acquisition of one-trial tolerance in mice.

Behav Brain Res 2022 May 23:113938. Epub 2022 May 23.

Psychobiology Group/Department of Psychology/CECH-UFSCar, São Carlos, SP, 13565-905, Brazil; Joint Graduate Program in Physiological Sciences UFSCar/UNESP. Rod. Washington Luís, Km 235, São Carlos, SP, 13565-905, Brazil; Graduate Program in Psychology UFSCar, Rod. Washington Luís, Km 235, São Carlos, SP, 13565-905, Brazil; Neuroscience and Behavioral Institute, Av. do Café, 2.450, 14050-220 Ribeirão Preto, SP, Brazil. Electronic address:

One-trial tolerance (OTT) is characterized by the lack of anxiolytic-like effects of benzodiazepines in animals submitted to a trial 2 in the elevated plus-maze (EPM) and is described to be influenced by learning mechanisms. Mineralocorticoid receptors (MR) in the infralimbic subregion (IL) of the medial prefrontal cortex (mPFC) are important modulators of emotional learning, but the MR involvement in the establishment of OTT remains unclear. We investigated the effects of intra-IL infusions of RU 28318 (an MR antagonist) on the OTT to the anxiolytic effects of midazolam (MDZ, GABA-benzodiazepine agonist) in mice exposed to a two-trial protocol in the EPM. Read More

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Impact of reduced anthropogenic emissions on chemical characteristics of urban aerosol by individual particle analysis.

Chemosphere 2022 May 23:135013. Epub 2022 May 23.

Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, 100029, China. Electronic address:

A single particle aerosol mass spectrometer was deployed in a heavily polluted area of China during a coronavirus lockdown to explore the impact of reduced anthropogenic emissions on the chemical composition, size distributions, mixing state, and secondary formation of urban aerosols. Ten particle groups were identified using an adaptive resonance network algorithm. Increased atmospheric oxidation during the lockdown period (LP) resulted in a 42. Read More

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Current vaccine strategies against SARS-CoV-2 - Promises and Challenges.

J Allergy Clin Immunol 2022 May 23. Epub 2022 May 23.

Department of Microbiology and Immunology, Thomas Jefferson University, Sidney Kimmel Medical College, Philadelphia, PA-19107, United States; Jefferson Vaccine Center, Thomas Jefferson University, Philadelphia, PA 19107, United States. Electronic address:

In the years since the SARS-CoV-2 pandemic began and spread across the globe, lessons have been learned about the challenges and opportunities a pandemic brings to humankind. Researchers have produced many vaccines at unprecedented speed to protect people but have also been cognizant of the challenges presented by a new and unexpected infectious disease. The scope of this review is to examine the path of vaccine discovery so far and identify potential targets. Read More

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The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats.

Toxicol Appl Pharmacol 2022 May 23:116085. Epub 2022 May 23.

Public Health and Integrated Toxicology Division, Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, United States of America. Electronic address:

Ozone-induced lung injury/inflammation dissipates despite continued exposure for 3 or more days; however, the mechanisms of adaptation/habituation remain unclear. Since ozone effects are mediated through adrenal-derived stress hormones, which also regulate longevity of centrally-mediated stress response, we hypothesized that ozone-adaptation is linked to diminution of neuroendocrine stress-axes activation and glucocorticoid levels. Male Wistar-Kyoto-rats (12-week-old) were injected with vehicle or a therapeutically-relevant dexamethasone dose (0. Read More

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Gender Representation Among Presenters in Ophthalmology Subspecialties in 2019: A Retrospective Review.

Am J Ophthalmol 2022 May 23. Epub 2022 May 23.

University of Utah Health John A Moran Eye Center, Salt Lake City, Utah, United States.

Purpose: To describe gender representation at eight national ophthalmology conferences, stratified by role, session category, and sub-specialty.

Design: Retrospective cross-sectional study.

Study Population: 3,817 presenters at the 2019 American Academy of Ophthalmology subspecialty days, American Society of Cataract and Refractive Surgery, American Glaucoma Society, American Society of Retina Specialists, American Society of Ophthalmic Plastic and Reconstructive Surgery, American Association for Pediatric Ophthalmology and Strabismus, North American Neuro-Ophthalmology Society, and American Uveitis Society meetings. Read More

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Modeling polycyclic aromatic hydrocarbons in India: Seasonal variations, sources and associated health risks.

Environ Res 2022 May 23:113466. Epub 2022 May 23.

Department of Environmental Science and Engineering, Fudan University, Shanghai, 200348, China; Department of Civil and Environmental Engineering, Louisiana State University, Baton Rouge, LA, 70803, United States. Electronic address:

Atmospheric polycyclic aromatic hydrocarbons (PAHs) are in high levels in developing countries like India. However, limited measurements are inadequate for better understanding of their ambient levels and health effects. This study predicted PAHs concentrations in atmosphere and estimated their sources and health risks in India in four representative months of winter, pre-monsoon, monsoon and post-monsoon in 2015 using an updated version of the Community Multiscale Air Quality model (CMAQ). Read More

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Current challenges of hydrothermal treated wastewater (HTWW) for environmental applications and their perspectives: A review.

Environ Res 2022 May 23:113532. Epub 2022 May 23.

Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB T6G 2W2, Canada. Electronic address:

Hydrothermal treatment (HT) is an emerged thermochemical approach for the utilization of biomass. In the last decade, intense research has been conducted on bio-oil and hydrochar, during which extensive amount of hydrothermal treated wastewater (HTWW) is produced, containing large amount of organic compounds along with several toxic chemicals. The composition of HTWW is highly dependent on the process conditions and organic composition of biomass, which determines its further utilization. Read More

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Heterogeneity of Drug Allergies and Reaction Lists in Two U.S. Healthcare Systems' Electronic Health Records.

Appl Clin Inform 2022 May 26. Epub 2022 May 26.

Medicine, Brigham and Women's Hospital, Boston, United States.

Background: Healthcare institutions have their own "picklist" for clinicians to document adverse drug reactions (ADRs) into the electronic health record (EHR) allergy list. Whether the lack of a nationally standardized picklist impacts clinician data entries is unknown.

Objectives: To assess the impact of defined reaction picklists on clinical documentation and, therefore, downstream analytics and clinical research using these data at two institutions. Read More

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Haploinsufficiency of PRRT2 Leading to Familial Hemiplegic Migraine in Chromosome 16p11.2 Deletion Syndrome.

Neuropediatrics 2022 May 26. Epub 2022 May 26.

Neurology, Children's National Health System, Washington, United States.

Microdeletion in the 16p11.2 loci lead to a distinct neurodevelopmental disorder with intellectual disability and autism spectrum disorder in addition to dysmorphia, macrocephaly and increased body mass index (BMI). One of the deleted genes in this region is PRRT2 which codes for Proline-rich transmembrane protein 2. Read More

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Video-assisted informed consent in a clinical trial of resuscitation of extremely preterm infants: Lessons learned.

Am J Perinatol 2022 May 26. Epub 2022 May 26.

Department of Pediatrics, Oregon Health & Science University, Portland, United States.

Objective: Obtaining informed consent for clinical trials is challenging in acute clinical settings. For the VentFirst randomized clinical trial (assisting ventilation during delayed cord clamping for infants <29 weeks' gestation), we created an informational video that sites could choose to use to supplement the standard in-person verbal and written consent. Using a post-consent survey, we sought to describe the impact of the video on subject recruitment, satisfaction with the consent process, and knowledge about the study. Read More

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Identifying Gaps in Resuscitation Practices Across Level IV Neonatal Intensive Care Units.

Am J Perinatol 2022 May 26. Epub 2022 May 26.

Division of Neonatal Perinatal Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, United States.

Objective: To describe resuscitation practices in level IV NICUs and identify possible areas of improvement.

Study Design: This study was a cross-sectional cohort survey of Children's Hospital Neonatal Consortium (CHNC) participating level IV NICUs. The survey was developed with consensus from resuscitation and education experts in the CHNC and pilot tested. Read More

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Energy density as a probe of band representations in photonic crystals.

J Phys Condens Matter 2022 May 26. Epub 2022 May 26.

Donostia International Physics Center, Ikerbasque Foundation of Science, Paseo Manuel de Lardizabal, 4, Donostia-San Sebastián, Gipuzkoa, 20018, SPAIN.

Topological Quantum Chemistry (TQC) has recently emerged as a instrumental tool to characterize the topological nature of both fermionic and bosonic band structures. TQC is based on the study of band representations and the localization of maximally localized Wannier functions. In this article, we study various two-dimensional photonic crystal structures analyzing their topological character through a combined study of TQC, their Wilson-loop spectra and the electromagnetic energy density. Read More

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Multi-label classification of reduced-lead ECGs using an interpretable deep convolutional neural network.

Physiol Meas 2022 May 26. Epub 2022 May 26.

Biomedical Engineering, Boston University, 44, Cummington Mall, Boston, Massachusetts, 02215-1300, UNITED STATES.

. We propose a model that can perform multi-label classification on 26 cardiac abnormalities from reduced lead Electrocardiograms (ECGs) and interpret the model.. Read More

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