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DNA identification of species of the Anopheles maculipennis complex and first record of An. daciae in Belgium.

Med Vet Entomol 2021 May 5. Epub 2021 May 5.

The Unit of Entomology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

The present study aimed at identifying the members of the Anopheles maculipennis complex (Diptera: Culicidae) occurring in Belgium. Therefore, the second internal transcribed spacer of nuclear ribosomal DNA (ITS2) and the mitochondrial cytochrome oxidase subunit I (COI) loci were sequenced in 175 and 111 specimens, respectively, collected between 2007 and 2019. In parallel, the suitability of two species-diagnostic PCR-RFLP assays was tested. Read More

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Validation of Oxford Cognitive Screen: Executive Function (OCS-EF), a tablet-based executive function assessment tool amongst adolescent females in rural South Africa.

Int J Psychol 2021 May 5. Epub 2021 May 5.

Department of Psychiatry, University of Oxford, Oxford, UK.

Short, reliable, easily administered executive function (EF) assessment tools are needed to measure EF in low- and middle-income countries, particularly in sub-Saharan Africa given the prevalence of human immunodeficiency virus (HIV)-associated neurocognitive disorder. We administered Oxford Cognitive Screen-Executive Function (OCS-EF) to 932 rural South African females (mean age 19.7 years). Read More

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How to manage endings in unsuccessful therapy: A qualitative comparison of youth and clinician perspectives.

Psychother Res 2021 May 5:1-14. Epub 2021 May 5.

Research Department for Clinical, Educational and Health Psychology, University College London, London, UK.

Approximately half of those who access child and adolescent mental health services do not show measurable improvement in symptoms. This study aimed to provide practice recommendations for managing treatment endings, particularly when outcomes have not improved. Semi-structured interviews were carried out with 26 young people with a history of anxiety and/or depression along with 7 roundtable sessions with 52 mental health clinicians. Read More

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Developing eHealth in neonatal care to enhance parents' self-management.

Scand J Caring Sci 2021 May 5. Epub 2021 May 5.

Department of Health Science, Faculty of Medicine, Lund University, Lund, Sweden.

Background: Discharge from a neonatal care unit is often experienced as a vulnerable time for parents. By communicating through digital technology, it may be possible to improve the support for parents and thereby make the transition from hospital to home less stressful.

Aim: To develop an eHealth device supporting the transition from hospital to home for parents with a preterm-born child in Sweden using participatory design. Read More

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In vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease.

EJNMMI Res 2021 May 5;11(1):45. Epub 2021 May 5.

Nuclear Medicine Department, University Hospital of Bordeaux, 33076, Bordeaux, France.

Background: Inflammatory vascular disease of the arteries, such as inflamed atheromatous plaques or arteritis, may cause aneurysms or ischemic strokes. In this context, using positron emission tomography (PET) to image inflammation may help select patients who would benefit from appropriate therapeutic interventions. This study sought to assess the usefulness of the 18 kDa translocator protein (TSPO) tracers [C]-PBR28 and [F]-PBR06 for imaging inflammatory vascular disease in vitro and in vivo. Read More

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Monitoring fetal well-being in labor in late fetal growth restriction.

Minerva Obstet Gynecol 2021 May 5. Epub 2021 May 5.

Department of Medicine and Surgery, Obstetrics and Gynecology Unit, University of Parma, Parma, Italy.

Late-onset fetal growth restriction (FGR) accounts for approximately 70-80% of all cases of FGR secondary to uteroplacental insufficiency and is associated with an increased risk of adverse antepartum and perinatal events, which in most instances result from hypoxic insults either present at the onset of labour or supervening during labour as a result of uterine contractions. Labour represents a stressful event for the fetoplacental unit being uterine contractions associated with an up-to 60% reduction of the uteroplacental perfusion. Intrapartum fetal heart rate monitoring by means of cardiotocography (CTG) currently represents the mainstay for the identification of fetal hypoxia during labour and is recommended for the fetal surveillance in the case of FGR or other conditions associated with an increased risk of hypoxia during labour. Read More

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Inpatient Care Costs of COVID-19 in South Africa's Public Healthcare System.

Int J Health Policy Manag 2021 Apr 25. Epub 2021 Apr 25.

SAMRC Centre for Health Economics and Decision Science-PRICELESS SA, School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Coronavirus disease 2019 (COVID-19) has had a devastating impact globally, with severe health and economic consequences. To prepare health systems to deal with the pandemic, epidemiological and cost projection models are required to inform budgets and efficient allocation of resources. This study estimates daily inpatient care costs of COVID-19 in South Africa, an important input into cost projection and economic evaluation models. Read More

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Comparison of adaptive multiple phenotype association tests using summary statistics in genome-wide association studies.

Hum Mol Genet 2021 May 5. Epub 2021 May 5.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516 USA.

Genome-wide association studies have been successful mapping loci for individual phenotypes, but few studies have comprehensively interrogated evidence of shared genetic effects across multiple phenotypes simultaneously. Statistical methods have been proposed for analyzing multiple phenotypes using summary statistics, which enables studies of shared genetic effects while avoiding challenges associated with individual-level data sharing. Adaptive tests have been developed to maintain power against multiple alternative hypotheses because the most powerful single-alternative test depends on the underlying structure of the associations between the multiple phenotypes and a single nucleotide polymorphism (SNP). Read More

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Sex, ethnic and socioeconomic inequalities and trajectories in child and adolescent mental health in Australia and the UK: findings from national prospective longitudinal studies.

J Child Psychol Psychiatry 2021 May 5. Epub 2021 May 5.

Centre for Longitudinal Studies, UCL Institute of Social Research, University College London, London, UK.

Background: This study investigates the sex, ethnic and socioeconomic inequalities in emotional difficulties over childhood and adolescence using longitudinal cohort studies in the UK and Australia. Estimating cross-national differences contributes to understanding of the consistency of inequalities in mental health across contexts.

Methods: Data from 19,748 participants in two contemporary representative samples in Australia (Growing Up in Australia: The Longitudinal Study of Australian Children, n = 4,975) and UK (Millennium Cohort Study, n = 14,773) were used. Read More

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Analysis of Brugada syndrome loci reveals that fine-mapping clustered GWAS hits enhances the annotation of disease-relevant variants.

Cell Rep Med 2021 Apr 20;2(4):100250. Epub 2021 Apr 20.

Department of Medical Sciences, School of Medicine, Universitat de Girona, Girona, Spain.

Genome-wide association studies (GWASs) are instrumental in identifying loci harboring common single-nucleotide variants (SNVs) that affect human traits and diseases. GWAS hits emerge in clusters, but the focus is often on the most significant hit in each trait- or disease-associated locus. The remaining hits represent SNVs in linkage disequilibrium (LD) and are considered redundant and thus frequently marginally reported or exploited. Read More

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A near miss: subclinical saddle pulmonary embolism diagnosed by handheld ultrasound.

Oxf Med Case Reports 2021 Apr 28;2021(4):omab011. Epub 2021 Apr 28.

Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.

Introduction: Pulmonary embolism (PE) is a life-threatening condition characterized by occlusive disease of the pulmonary vasculature. Point-of-care ultrasound (POCUS) of right ventricular strain patterns have high specificity and low sensitivity for diagnosis. Here, we describe a patient with a saddle PE and low pre-test probability who was diagnosed primarily by handheld POCUS. Read More

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Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome.

mSystems 2021 May 4;6(3). Epub 2021 May 4.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea

Identification of transcriptional regulatory elements in the GC-rich genome is essential for the production of novel biochemicals from secondary metabolite biosynthetic gene clusters (smBGCs). Despite many efforts to understand the regulation of transcription initiation in smBGCs, information on the regulation of transcription termination and posttranscriptional processing remains scarce. In this study, we identified the transcriptional regulatory elements in β-lactam antibiotic-producing ATCC 27064 by determining a total of 1,427 transcript 3'-end positions (TEPs) using the term-seq method. Read More

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Boundary spanning and identity work in the clinical research delivery workforce: a qualitative study of research nurses, midwives and allied health professionals in the National Health Service, United Kingdom.

Health Res Policy Syst 2021 May 4;19(1):74. Epub 2021 May 4.

The Healthcare Improvement Studies Institute, University of Cambridge, Cambridge, United Kingdom.

Background: Research nurses, midwives and allied health professionals are members of an important emergent profession delivering clinical research and, in the United Kingdom, have been the focus of considerable investment by the National Institute for Health Research (NIHR). This paper considers the experiences of research nurses, midwives and allied health professionals in relation to professional identity work, recognizing these are coproduced alongside others that they interact with (including patients, clinical staff and other research staff).

Methods: Semi-structured interviews were conducted with 45 nurses, midwives and allied health professionals in the UK about their experiences of working in research delivery. Read More

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Investigation of Mitochondrial Adaptations to Modulation of Carbohydrate Supply during Adipogenesis of 3T3-L1 Cells by Targeted H-NMR Spectroscopy.

Biomolecules 2021 Apr 29;11(5). Epub 2021 Apr 29.

Human Biology and Toxicology Unit, Faculty of Medicine and Pharmacy, Research Institute for Health Sciences and Technology, UMONS, 20 Place du Parc, 7000 Mons, Belgium.

(1) Background: White adipose tissue (WAT) is a dynamic and plastic tissue showing high sensitivity to carbohydrate supply. In such a context, the WAT may accordingly modulate its mitochondrial metabolic activity. We previously demonstrated that a partial replacement of glucose by galactose in a culture medium of 3T3-L1 cells leads to a poorer adipogenic yield and improved global mitochondrial health. Read More

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Environmental Impact of Food Preparations Enriched with Phenolic Extracts from Olive Oil Mill Waste.

Foods 2021 Apr 29;10(5). Epub 2021 Apr 29.

Department of Agricultural and Environmental Sciences (DiSAA), Università degli Studi di Milano, 20133 Milan, Italy.

Reducing food waste as well as converting waste products into second-life products are global challenges to promote the circular economy business model. In this context, the aim of this study is to quantify the environmental impact of lab-scale food preparations enriched with phenolic extracts from olive oil mill waste, i.e. Read More

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Older Adults' Experiences of a Physical Activity and Sedentary Behaviour Intervention: A Nested Qualitative Study in the SITLESS Multi-Country Randomised Clinical Trial.

Int J Environ Res Public Health 2021 Apr 29;18(9). Epub 2021 Apr 29.

Fundació Salut i Envelliment (Foundation on Health and Ageing)-UAB, Universitat Autònoma de Barcelona, 08041 Barcelona, Spain.

Background: The SITLESS programme comprises exercise referral schemes and self-management strategies and has been evaluated in a trial in Denmark, Spain, Germany and Northern Ireland. The aim of this qualitative study was to understand the implementation and contextual aspects of the intervention in relation to the mechanisms of impact and to explore the perceived effects.

Methods: Qualitative methodologies were nested in the SITLESS trial including 71 individual interviews and 12 focus groups targeting intervention and control group participants from postintervention to 18-month follow-up in all intervention sites based on a semi-structured topic guide. Read More

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ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Institute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, Russia.

COVID-19 is a highly contagious new infection caused by the single-stranded RNA Sars-CoV-2 virus. For the first time, this infection was recorded in December 2019 in the Chinese province of Wuhan. The virus presumably crossed the interspecies barrier and passed to humans from a bat. Read More

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ECMO Support and Operator Safety in the Context of COVID-19 Outbreak: A Regional Center Experience.

Membranes (Basel) 2021 Apr 30;11(5). Epub 2021 Apr 30.

Department of Surgical Sciences, University of Turin, 10126 Turin, Italy.

Since the beginning of the COVID-19 emergency, the referral Intensive Care Unit for the Extracorporeal Membrane Oxygenation (ECMO) support of Piedmont Region (Italy), in cooperation with infectious disease specialists, perfusionists and cardiac surgeons, developed a protocol to guarantee operator safety during invasive procedures, among which the ECMO positioning or inter-hospital transport. The use of powered air-purifying respirators, filtering facepiece particles (FFP) 2-3 masks, protective suits, disposable sterile surgical gowns, and two pairs of sterile gloves as a part of a protocol seemed effective and feasible for trained healthcare workers and allow all the complex activities connected with the positioning of the ECMO support to be completed effectively. The simulation training on donning and doffing procedures and the presence of a dedicated team member to verify the compliance with the safety procedure effectively reassured operators and likely reduced the risk of self-contamination. Read More

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Heat Unit Requirements of "Flame Seedless" Table Grape: A Tool to Predict Its Harvest Period in Protected Cultivation.

Plants (Basel) 2021 Apr 30;10(5). Epub 2021 Apr 30.

Department of Agronomy, ceiA3, University of Almería, 04120 Almería, Almería, Spain.

Greenhouse cultivation of table grapes is a challenge due to difficulties imposed by their perennial habit and chilling requirements. Despite difficulties, greenhouse cultivation allows ripening long before that in the open field. Nonetheless, for harvesting "Flame Seedless" in the most profitable periods, a cultural practices timetable has to be established. Read More

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Caregiver presence and involvement in a Canadian neonatal intensive care unit: An observational cohort study.

J Pediatr Nurs 2021 May 1;60:123-129. Epub 2021 May 1.

IWK Health Centre, Halifax, Nova Scotia, Canada.

Background: Presence in the neonatal intensive care unit (NICU) is a vital step for caregivers initiating involvement, such as skin-to-skin contact, holding or singing/reading to their newborn. Little is known about caregiver presence and involvement in Canadian NICU's context by caregiver type (mother, father, other), and the association between maternal presence and key maternal and newborn characteristics.

Purpose: The primary objective was to examine the presence and involvement of family caregivers in the NICU. Read More

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Some brief personal reflections on the 100th Anniversary Conference papers. Where are we? Where have we come from? Where might we go?

David Tuckett

Int J Psychoanal 2019 Dec 23;100(6):1455-1464. Epub 2019 Dec 23.

The Psychoanalysis Unit and Centre for the Study of Decision-Making Uncertainty, University College London (UCL), London, UK.

This contribution is a personal reflection on the papers presented at the New York and London anniversary conferences, in which the author takes stock to consider what they might tell us about where the discipline is now, where it has come from and where it might go. Taking the clinical contributions as evidence of the way many leading analysts in the field now proceed, it is suggested that there is an increasing and more and more subtle use of the analyst's behaviour, thoughts, fantasies, feelings and experiences, inside and outside the session, as core sources for constructing the patient's unconscious. Placing this observation in the context of issues of evidence raised in the 50th and 75th anniversary volumes, the author argues that a possible future agenda for the field may be to think more plainly about the basis of an analyst's knowledge claims, whether made implicitly or explicitly to patients in sessions. Read More

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December 2019

Updated APLAR consensus statements on care for patients with rheumatic diseases during the COVID-19 pandemic.

Int J Rheum Dis 2021 May 4. Epub 2021 May 4.

Department of Rheumatology, BSM Medical University, Dhaka, Bangladesh.

Aim: To update previous guidance of the Asia Pacific League of Associations for Rheumatology (APLAR) on the management of patients with rheumatic and musculoskeletal diseases (RMD) during the coronavirus disease 2019 (COVID-19) pandemic.

Methods: Research questions were formulated focusing on diagnosis and treatment of adult patients with RMD within the context of the pandemic, including the management of RMD in patients who developed COVID-19. MEDLINE was searched for eligible studies to address the questions, and the APLAR COVID-19 task force convened 2 meetings through video conferencing to discuss its findings and integrate best available evidence with expert opinion. Read More

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Comparing Critical Care Admissions Among Urban Populations Before and During the COVID-19 Pandemic.

Health Secur 2021 Apr 30. Epub 2021 Apr 30.

Panagis Galiatsatos, MD, MHS, and Souvik Chatterjee, MD, are Assistant Professors and Edward S. Chen, MD, is an Associate Professor, Division of Pulmonary and Critical Care Medicine; Kathleen R. Page, MD, is an Associate Professor, Division of Infectious Diseases; Felicia Hill-Briggs, PhD, is a Professor, Division of General Internal Medicine; and Sherita H. Golden, MD, MHS, is a Professor, Division of Endocrinology, Diabetes, and Metabolism; all in the Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Panagis Galiatsatos and Felicia Hill-Briggs are Co-Chairs, Johns Hopkins Health Equity Steering Committee, Office of Diversity, Inclusion, and Health Equity; and Sherita H. Golden is Director, Office of Diversity, Inclusion, and Health Equity, and Lead, Armstrong Institute for Patient Safety and Quality; all at Johns Hopkins Medicine, Baltimore, MD. Panagis Galiatsatos is Co-Director, Medicine for the Greater Good; and Joyce Maygers, DNP, RN, is a Senior Clinical Outcomes Coordinator, Department of Care Management; both at Johns Hopkins Bayview Medical Center, Baltimore, MD. Sauradeep Sarker, MD, is an Internal Medicine Resident, Department of Medicine, Sinai Hospital, Baltimore, MD. Vanya Jones, PhD, is an Associate Professor, Health, Behavior, and Society; Felicia Hill-Briggs and Sherita H. Golden are Professors of Medicine, Welch Center for Prevention, Epidemiology, and Clinical Research; and Sherita H. Golden is a Professor, Department of Epidemiology; all at the Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Tina Tolson, RN, is Director, Johns Hopkins Medicine Language Services, Johns Hopkins Health System, Baltimore, MD.

In the context of the COVID-19 pandemic, reassessing intensive care unit (ICU) use by population should be a priority for hospitals planning for critical care resource allocation. In our study, we reviewed the impact of COVID-19 on a community hospital serving an urban region, comparing the sociodemographic distribution of ICU admissions before and during the pandemic. We executed a time-sensitive analysis to see if COVID-19 ICU admissions reflect the regional sociodemographic populations and ICU admission trends before the pandemic. Read More

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Assessment toolbox for Indian medical graduate competencies.

J Postgrad Med 2021 Apr-Jun;67(2):80-90

Department of Pharmacology, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.

The new competency-based medical education curriculum for Bachelor of Medicine and Bachelor of Surgery is being implemented in a phased manner in medical colleges across India since the year 2019. The Graduate Medical Education Regulations enlist a total of 35 global competencies for the five roles expected of an Indian medical graduate, the roles being clinician, communicator, leader, professional, and life-long learner. Along with an effective implementation of the new curriculum, both in spirit and in action, it is imperative to assess the listed competencies. Read More

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Diagnostic value of [18F]FDG-PET/CT for treatment monitoring in large vessel vasculitis: a systematic review and meta-analysis.

Eur J Nucl Med Mol Imaging 2021 May 3. Epub 2021 May 3.

Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Purpose: Monitoring disease activity in patients with large vessel vasculitis (LVV) can be challenging. [18F]FDG-PET/CT is increasingly used to evaluate treatment response in LVV. In this systematic review and meta-analysis, we aimed to summarize the current evidence on the value of [18F]FDG-PET/CT for treatment monitoring in LVV. Read More

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Appraising research policy instrument mixes: a multicriteria mapping study in six European countries of diagnostic innovation to manage antimicrobial resistance.

Res Policy 2021 May;50(4):104140

Brighton and Sussex Medical School, Falmer, Brighton, United Kingdom.

This article provides prospective appraisal of key policy instruments intended to stimulate innovation to combat antimicrobial resistance (AMR). AMR refers to the ability of microbes to evolve resistance to those treatments designed to kill them, and is associated with the overuse or misuse of medicines such as antibiotics. AMR is an emerging global challenge with major implications for healthcare and society as a whole. Read More

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Staff perceptions of military chemical-biological-radiological-nuclear (CBRN) air-purifying masks during a simulated clinical task in the context of SARS-CoV-2.

Anaesth Intensive Care 2021 May 3:310057X20984787. Epub 2021 May 3.

Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Herston, Australia.

Air-purifying full-face masks, such as military chemical-biological-radiological-nuclear masks, might offer superior protection against severe acute respiratory syndrome coronavirus 2 compared to disposable polypropylene P2 or N95 masks. In addition, disposable masks are in short supply, while military chemical-biological-radiological-nuclear masks can be disinfected then reused. It is unknown whether such masks might be appropriate for civilians with minimal training in their use. Read More

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Multiple stressors shape invertebrate assemblages and reduce their trophic niche: A case study in a regulated stream.

Sci Total Environ 2021 Jun 4;773:145061. Epub 2021 Feb 4.

Univ Lyon, Université Claude Bernard Lyon 1, CNRS, ENTPE, UMR 5023 LEHNA, F-69622 Villeurbanne, France.

Few studies have addressed how the diversity of basal resources change with stream regulation and the potential consequences on river biota. We sampled invertebrates above and below a series of dams, over two years, at both downwelling and upwelling zones. In each zone, we recorded the daily temperature and flow variations, estimated the algal development, measured the available resources, and analysed carbon and nitrogen stable isotope compositions of the invertebrate community. Read More

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Risk Factors for Nosocomial Methicillin Resistant Staphylococcus aureus (MRSA) Colonization in a Neonatal Intensive Care Unit: A Case-Control Study.

Am J Infect Control 2021 Apr 30. Epub 2021 Apr 30.

Cohen Children's Medical Center of New York, New York, NY; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.

Aim: To determine risk factors for MRSA colonization in a Level IV Neonatal Intensive Care Unit (NICU) independent of length of stay and gestational age in the context of a persistently circulating MRSA clone.

Design: Retrospective matched case-control study.

Setting: Level IV NICU PATIENTS: Infants admitted between April 4,2017- March 31,2018. Read More

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Behavioural mimicry as an indicator of affiliation.

PLoS One 2021 3;16(5):e0250105. Epub 2021 May 3.

Aston University, Birmingham, United Kingdom.

Previous research has shown that behavioural mimicry fosters affiliation, and can be used to infer whether people belong to the same social unit. However, we still know very little about the generalizability of these findings and the individual factors involved. The present study intends to disentangle two important variables and assess their importance for affiliation: the matching in time of the behaviours versus their matching in form. Read More

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