2,996 results match your criteria unique scaffolds

Chiral Triarylborane-based Small Organic Molecules for Circularly Polarized Luminescence.

Chem Rec 2021 Sep 24. Epub 2021 Sep 24.

School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China.

Circularly polarized luminescence (CPL) has shown promising application potentials in 3D display, optical data storage, smart sensors/probers, CPL lasers, and light source for asymmetric photosynthesis. In the last decade, the CPL-active small organic molecules (CPL-SOMs) have attracted rapidly increasing research interest owing to the great advantages of SOMs, such as high luminescence efficiency, facile modification of chemical structure, fine emission wavelength tuning, precise relationships between structure and properties, and as well as easy fabrication. Promoted by the unique effects of boryl group, such as strong electron-accepting ability, great steric effect, and Lewis acidity to bind with Lewis bases, we herein summarized our recent research results about the creation of CPL-SOMs by modification of chiral scaffolds, such as [2. Read More

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September 2021

Biomorphic Transformations: A Leap Forward in Getting Nanostructured 3-D Bioceramics.

Front Chem 2021 7;9:728907. Epub 2021 Sep 7.

Institute of Science and Technology for Ceramics, Italian National Research Council, Faenza, Italy.

Obtaining 3-D inorganic devices with designed chemical composition, complex geometry, hierarchic structure and effective mechanical performance is a major scientific goal, still prevented by insurmountable technological limitations. With particular respect to the biomedical field, there is a lack in solutions ensuring the regeneration of long, load-bearing bone segments such as the ones of limbs, due to the still unmet goal of converging, in a unique device, bioactive chemical composition, multi-scale cell-conducive porosity and a hierarchically organized architecture capable of bearing and managing complex mechanical loads in a unique 3D implant. An emerging, but still very poorly explored approach in this respect, is given by biomorphic transformation processes, aimed at converting natural structures into functional 3D inorganic constructs with smart mechanical performance. Read More

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September 2021

A blueprint of the topology and mechanics of the human ovary for next-generation bioengineering and diagnosis.

Nat Commun 2021 Sep 23;12(1):5603. Epub 2021 Sep 23.

Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.

Although the first dissection of the human ovary dates back to the 17 century, the biophysical characteristics of the ovarian cell microenvironment are still poorly understood. However, this information is vital to deciphering cellular processes such as proliferation, morphology and differentiation, as well as pathologies like tumor progression, as demonstrated in other biological tissues. Here, we provide the first readout of human ovarian fiber morphology, interstitial and perifollicular fiber orientation, pore geometry, topography and surface roughness, and elastic and viscoelastic properties. Read More

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September 2021

Repairing of Subchondral Defect and Articular Cartilage of Knee Joint of Rabbit by Gadolinium Containing Bio-Nanocomposites.

J Biomed Nanotechnol 2021 Aug;17(8):1584-1597

Department of Orthopedics, The Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, Heilongjiang, China.

A variety of gadolinium (Gd) based nanoparticles (NPs) were synthesized due to the unique magnetic properties of Gd-containing rare earth compounds and the particularity of micro/nano-materials, which were then incorporated into hydroxyapatite (HA) to obtain inorganic-organic composite materials. Then, HA/Gd NPs containing slow-release transforming growth factor (TGF-β1) were harvested. Adipose-derived stem cells (ADSCs) were extracted from the adipose tissue of a four-month-old New Zealand white rabbit. Read More

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Fluorinated peptide biomaterials.

Pept Sci (Hoboken) 2021 Mar 28;113(2). Epub 2020 Jul 28.

Department of Biomedical Engineering, Penn State University, University Park, Pennsylvania, USA.

Fluorinated compounds, while rarely used by nature, are emerging as fundamental ingredients in biomedical research, with applications in drug discovery, metabolomics, biospectroscopy, and, as the focus of this review, peptide/protein engineering. Leveraging the fluorous effect to direct peptide assembly has evolved an entirely new class of organofluorine building blocks from which unique and bioactive materials can be constructed. Here, we discuss three distinct peptide fluorination strategies used to design and induce peptide assembly into nano-, micro-, and macrosupramolecular states that potentiate high-ordered organization into material scaffolds. Read More

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Heparin Microislands in Microporous Annealed Particle Scaffolds for Accelerated Diabetic Wound Healing.

Adv Funct Mater 2021 Aug 18;31(35). Epub 2021 Jun 18.

Department of Biomedical Engineering, University of Virginia, 415 Lane Rd, Charlottesville, VA 22908.

Mimicking growth factor-ECM interactions for promoting cell migration is a powerful technique to improve tissue integration with biomaterial scaffolds for the regeneration of damaged tissues. This has been attempted by scaffold-mediated controlled delivery of exogenous growth factors; however, the predetermined nature of this delivery can limit the scaffold's ability to meet each wound's unique spatiotemporal regenerative needs and presents translational hurdles. To address this limitation, we present a new approach to growth factor presentation by incorporating heparin microislands, which are spatially isolated heparin-containing microparticles that can reorganize and protect endogenous local growth factors via heterogeneous sequestration at the microscale and result in functional improvements in wound healing. Read More

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Structural characterization of NrnC identifies unifying features of dinucleotidases.

Elife 2021 Sep 17;10. Epub 2021 Sep 17.

Deutsches Elektronen-Synchrotron DESY, Centre for Structural Systems Biology (CSSB), Hamburg, Germany.

RNA degradation is fundamental for cellular homeostasis. The process is carried out by various classes of endolytic and exolytic enzymes that together degrade an RNA polymer to mono-ribonucleotides. Within the exoribonucleases, nano-RNases play a unique role as they act on the smallest breakdown products and hence catalyze the final steps in the process. Read More

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September 2021

Stapled β-Hairpins Featuring 4-Mercaptoproline.

J Am Chem Soc 2021 Sep 13;143(37):15039-15044. Epub 2021 Sep 13.

Department of Chemistry, Tufts University, Medford, Massachusetts 02155, United States.

Peptides constrained by intramolecular cross-links, especially stapled α-helices, have emerged as versatile scaffolds for drug development. However, there are fewer examples of similarly constrained scaffolds for other secondary structures. Here, we used a novel computational strategy to identify an optimal staple for antiparallel β-strands, and then we incorporated that staple within a β-hairpin peptide. Read More

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September 2021

Injectable Lignin--Gelatin Cryogels with Antioxidant and Antibacterial Properties for Biomedical Applications.

Biomacromolecules 2021 Sep 13. Epub 2021 Sep 13.

Center of Nanotechnology, King Abdulaziz University, Jeddah 21569, Saudi Arabia.

For several biomedical applications, it is essential to develop novel bioactive materials. Such biomaterials could potentially improve wound healing, prevent infections, or be used in immunoengineering. For example, bioactive materials that reduce oxidative stress without relying on antibiotics and other drugs could be beneficial. Read More

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September 2021

Inflammatory and regenerative processes in bioresorbable synthetic pulmonary valves up to two years in sheep: Spatiotemporal insights augmented by Raman microspectroscopy.

Acta Biomater 2021 Sep 9. Epub 2021 Sep 9.

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands; Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands. Electronic address:

In situ heart valve tissue engineering is an emerging approach in which resorbable, off-the-shelf available scaffolds are used to induce endogenous heart valve restoration. Such scaffolds are designed to recruit endogenous cells in vivo, which subsequently resorb polymer and produce and remodel new valvular tissue in situ. Recently, preclinical studies using electrospun supramolecular elastomeric valvular grafts have shown that this approach enables in situ regeneration of pulmonary valves with long-term functionality in vivo. Read More

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September 2021

Tunable metacrylated hyaluronic acid-based hybrid bioinks for stereolithography 3D bioprinting.

Biofabrication 2021 Sep 10. Epub 2021 Sep 10.

Mechanical and Manufacturing Engineering, University of Calgary, 2500 University Drive NW, MEB 405, Calgary, Alberta, T2N 1N4, CANADA.

Hyaluronic acid (HA) is a native extra-cellular matrix derivative that promises unique properties, such as anti-inflammatory response and cell-signaling with tissue-specific applications under its bioactive properties. Here, we evaluated the importance of the duration of synthesis to obtain photocrosslinkable methacrylated hyaluronic acid (MeHA) with a high degree of substitution to be used as a bioink for stereolithographic (SLA) 3D bioprinting. Our findings show that a 10-day synthesis results in an 88% degree of methacrylation (DM), whereas 3-day and 5-day syntheses result in 32% and 42% DM, respectively. Read More

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September 2021

The role of tendon derived stem/progenitor cells and extracellular matrix components in the bone tendon junction repair.

Bone 2021 Sep 14;153:116172. Epub 2021 Sep 14.

School of Biomedical Sciences, The University of Western Australia, Perth, Australia. Electronic address:

Fibrocartilage enthesis is the junction between bone and tendon with a typical characteristics of fibrocartilage transition zones. The regeneration of this transition zone is the bottleneck for functional restoration of bone tendon junction (BTJ). Biomimetic approaches, especially decellularized extracellular matrix (ECM) materials, are strategies which aim to mimic the components of tissues to the utmost extent, and are becoming popular in BTJ healing because of their ability not only to provide scaffolds to allow cells to attach and migrate, but also to provide a microenvironment to guide stem/progenitor cells lineage-specific differentiation. Read More

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September 2021

Docking to a Basic Helix Promotes Specific Phosphorylation by G1-Cdk1.

Int J Mol Sci 2021 Sep 1;22(17). Epub 2021 Sep 1.

Institute of Technology, Faculty of Science and Technology, University of Tartu, 50411 Tartu, Estonia.

Cyclins are the activators of cyclin-dependent kinase (CDK) complex, but they also act as docking scaffolds for different short linear motifs (SLiMs) in CDK substrates and inhibitors. According to the unified model of CDK function, the cell cycle is coordinated by CDK both via general CDK activity thresholds and cyclin-specific substrate docking. Recently, it was found that the G1-cyclins of have a specific function in promoting polarization and growth of the buds, making the G1 cyclins essential for cell survival. Read More

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September 2021

Bioactivity and Antibacterial Behaviors of Nanostructured Lithium-Doped Hydroxyapatite for Bone Scaffold Application.

Int J Mol Sci 2021 Aug 26;22(17). Epub 2021 Aug 26.

Department of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran P.O. Box 19919-43344, Iran.

The material for bone scaffold replacement should be biocompatible and antibacterial to prevent scaffold-associated infection. We biofunctionalized the hydroxyapatite (HA) properties by doping it with lithium (Li). The HA and 4 Li-doped HA (0. Read More

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Extracellular Matrix-Mimetic Hydrogels for Treating Neural Tissue Injury: A Focus on Fibrin, Hyaluronic Acid, and Elastin-Like Polypeptide Hydrogels.

Adv Healthc Mater 2021 Sep 8:e2101329. Epub 2021 Sep 8.

Department of Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 8th St, Troy, NY, 12180, USA.

Neurological and functional recovery is limited following central nervous system injury and severe injury to the peripheral nervous system. Extracellular matrix (ECM)-mimetic hydrogels are of particular interest as regenerative scaffolds for the injured nervous system as they provide 3D bioactive interfaces that modulate cellular response to the injury environment and provide naturally degradable scaffolding for effective tissue remodeling. In this review, three unique ECM-mimetic hydrogels used in models of neural injury are reviewed: fibrin hydrogels, which rely on a naturally occurring enzymatic gelation, hyaluronic acid hydrogels, which require chemical modification prior to chemical crosslinking, and elastin-like polypeptide (ELP) hydrogels, which exhibit a temperature-sensitive gelation. Read More

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September 2021

High contiguity de novo genome assembly and DNA modification analyses for the fungus fly, Sciara coprophila, using single-molecule sequencing.

BMC Genomics 2021 Sep 6;22(1):643. Epub 2021 Sep 6.

Department of Molecular Biology, Cell Biology and Biochemistry, Brown University Division of Biology and Medicine, Sidney Frank Hall for Life Sciences, 185 Meeting Street, Providence, RI, 02912, USA.

Background: The lower Dipteran fungus fly, Sciara coprophila, has many unique biological features that challenge the rule of genome DNA constancy. For example, Sciara undergoes paternal chromosome elimination and maternal X chromosome nondisjunction during spermatogenesis, paternal X elimination during embryogenesis, intrachromosomal DNA amplification of DNA puff loci during larval development, and germline-limited chromosome elimination from all somatic cells. Paternal chromosome elimination in Sciara was the first observation of imprinting, though the mechanism remains a mystery. Read More

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September 2021

Total synthesis of the pseudoindoxyl class of natural products.

Org Biomol Chem 2021 Sep 6. Epub 2021 Sep 6.

Organic Chemistry Division, CSIR-National Chemical Laboratory Dr Homi Bhabha Road, Pune-411008, India.

The pseudoindoxyl sub-structural motif, amongst the large set of the indole class of alkaloids, represents a unique subset of the oxygenated indole class of the alkaloid family. A majority of this class of natural products contains complex bridged/polycyclic scaffolds with interesting biological profiles. They are thus attractive synthetic targets. Read More

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September 2021

The use of a novel deer antler decellularized cartilage-derived matrix scaffold for repair of osteochondral defects.

J Biol Eng 2021 Sep 3;15(1):23. Epub 2021 Sep 3.

School of Life Science, Taizhou University, 1139 Shifu Avenue, Jiaojiang District, Zhejiang, 318000, Taizhou, China.

Background: The physiologic regenerative capacity of cartilage is severely limited. Current studies on the repair of osteochondral defects (OCDs) have mainly focused on the regeneration of cartilage tissues. The antler cartilage is a unique regenerative cartilage that has the potential for cartilage repair. Read More

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September 2021

Unified Approach to Imidodiphosphate-Type Brønsted Acids with Tunable Confinement and Acidity.

J Am Chem Soc 2021 Sep 3;143(36):14835-14844. Epub 2021 Sep 3.

Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.

We have designed and realized an efficient and operationally simple single-flask synthesis of imidodiphosphate-based Brønsted acids. The methodology proceeds consecutive chloride substitutions of hexachlorobisphosphazonium salts, providing rapid access to imidodiphosphates (IDP), iminoimidodiphosphates (IDP), and imidodiphosphorimidates (IDPi). These privileged acid catalysts feature a broad acidity range (p from ∼11 to <2 in MeCN) and a readily tunable confined active site. Read More

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September 2021

Fabrication of collagen with polyhexamethylene biguanide: A potential scaffold for infected wounds.

J Biomed Mater Res B Appl Biomater 2021 Sep 3. Epub 2021 Sep 3.

Department of Advance Zoology & Biotechnology, Guru Nanak College, Chennai, India.

Bacterial infection remains a great challenge in wound healing, especially in chronic wounds. Multidrug-resistant organisms are increasing in acute and chronic wound infections, which compromise the chance of therapeutics. Resistance to conventional antibiotics has created an urge to study new approach/system that can effectively control wound infection and enhance healing. Read More

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September 2021

Scaffold mediated delivery of dual miRNAs to transdifferentiate cardiac fibroblasts.

Mater Sci Eng C Mater Biol Appl 2021 Sep 15;128:112323. Epub 2021 Jul 15.

Graduate School of Interdisciplinary New Science, Toyo University, 2100 Kujirai, Kawagoe, Saitama 3508585, Japan; Bio-Nano Electronics Research Centre, Toyo University, 2100 Kujirai, Kawagoe, Saitama 3508585, Japan.

The standard scaffold-mediated delivery of drugs/biomolecules has been successful due to the unique attributes of scaffolds, specifically the electrospun polymeric scaffolds that mimic ECM are well suited for advanced regenerative applications. Cardiac tissue engineering includes the interpretation of cellular and molecular mechanisms concerning heart regeneration and identifying an efficient reprogramming strategy to overcome the limitation of delivery systems and enhance the reprogramming efficiency. This study is a step towards developing a functional scaffold through a parallel interpretation of electrospun PLLA scaffolds with two distinct topologies to achieve sustained delivery of two muscle-specific microRNAs (miR-1 and miR-133a) to directly reprogram the adult human cardiac fibroblasts into cardiomyocyte-like cells. Read More

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September 2021

Intrinsically fluorescent bioactive glass-poly(ester amide) hybrid microparticles for dual drug delivery and bone repair.

Mater Sci Eng C Mater Biol Appl 2021 Sep 1;128:112288. Epub 2021 Jul 1.

School of Biomedical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada; Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Ontario N6A 5B9, Canada. Electronic address:

The bone extracellular matrix (ECM) is a composite scaffold having inorganic hydroxyapatite and organic collagen fibers. Synthetic bone repair scaffolds that mimic the chemical composition of the native ECM and capable of delivering therapeutics are beneficial. In this study, we prepared intrinsically fluorescent organic-inorganic hybrid microparticle biomaterials by sol-gel process. Read More

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September 2021

Development of an in-situ forming, self-healing scaffold for dermal wound healing: in-vitro and in-vivo studies.

Mater Sci Eng C Mater Biol Appl 2021 Sep 18;128:112263. Epub 2021 Jun 18.

Department of Pharmacy, Birla Institute of Technology & Science, Pilani, Vidya Vihar, Rajasthan 333031, India. Electronic address:

The importance of the extra-cellular matrix (ECM) for wound healing has been extensively researched. Understanding its importance, multiple ECM mimetic scaffolds have been developed. However, the majority of such scaffolds are prefabricated. Read More

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September 2021

Distribution and diversity of dimetal-carboxylate halogenases in cyanobacteria.

BMC Genomics 2021 Aug 31;22(1):633. Epub 2021 Aug 31.

Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto, Matosinhos, Portugal.

Background: Halogenation is a recurring feature in natural products, especially those from marine organisms. The selectivity with which halogenating enzymes act on their substrates renders halogenases interesting targets for biocatalyst development. Recently, CylC - the first predicted dimetal-carboxylate halogenase to be characterized - was shown to regio- and stereoselectively install a chlorine atom onto an unactivated carbon center during cylindrocyclophane biosynthesis. Read More

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Biofabrication of allogenic bone grafts using cellularized amniotic scaffolds for application in efficient bone healing.

Tissue Cell 2021 Aug 25;73:101631. Epub 2021 Aug 25.

Central Laboratory for Stem Cell Research & Translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, 500058, Telangana, India. Electronic address:

Introduction: The reconstruction/regeneration of human bone injuries/defects represents a crucial challenge due to the lack of suitable bio/immune compatible and implantable biological grafts. The available strategies represent implications of several types of grafting materials in the form of metals, synthetic, and various kinds of biological scaffolds; however, the lack of appropriate biological components required for activating and enhancing repair mechanisms at the lesion-site limits their wider applicability.

Methods: In this study, a unique approach for generating human osteogenic implantable grafts was developed using biofabrication technology. Read More

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Porphyrins and Polyoxometalate Scaffolds.

Chemistry 2021 Aug 30. Epub 2021 Aug 30.

Universite de Strasbourg, UMR 7177, 4 rue Blaise Pascal, 670080, Strasbourg, FRANCE.

Polyoxometalates (POMs) can act as unique reservoirs for multiple electron transfers. As POMs display only weak absorption in the visible spectrum, they can be associated with chromophores such as porphyrins and porphyrin antennae. In this review, the research dedicated to the combination of porphyrins and polyoxometalates is put in context and the state of the art identifying the challenges addressed in the optimization of hybrid materials for applications is detailed. Read More

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Harnessing cyclotides to design and develop novel peptide GPCR ligands.

RSC Chem Biol 2020 Oct 22;1(4):177-191. Epub 2020 Jul 22.

Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland Brisbane Queensland 4072 Australia

Cyclotides are plant-derived cyclic, disulfide-rich peptides with a unique cyclic cystine knot topology that confers them with remarkable structural stability and resistance to proteolytic degradation. Recently, cyclotides have emerged as promising scaffold molecules for designing peptide-based therapeutics. Here, we provide examples of how engineering cyclotides using molecular grafting may lead to the development of novel peptide ligands of G protein-coupled receptors (GPCRs), today's most exploited drug targets. Read More

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October 2020

Microfluidic Printing of Tunable Hollow Microfibers for Vascular Tissue Engineering.

Adv Mater Technol 2021 Aug 10;6(8). Epub 2021 Jun 10.

Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, 47405, United States.

Bioprinting of vascular tissues holds great potential in tissue engineering and regenerative medicine. However, challenges remain in fabricating biocompatible and versatile scaffolds for the rapid engineering of vascular tissues and vascularized organs. Here, we report novel bioink-enabled microfluidic printing of tunable hollow microfibers for the rapid formation of blood vessels. Read More

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Minimally invasive co-injection of modular micro-muscular and micro-vascular tissues improves in situ skeletal muscle regeneration.

Biomaterials 2021 Aug 20;277:121072. Epub 2021 Aug 20.

Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen, 361021, PR China; Fujian Provincial Key Laboratory of Biochemical Technology (Huaqiao University), Xiamen, 361021, PR China. Electronic address:

Various conventional treatment strategies for volumetric muscle loss (VML) are often hampered by the extreme donor site morbidity, the limited availability of quality muscle flaps, and complicated, as well as invasive surgical procedures. The conventional biomaterial-based scaffolding systems carrying myoblasts have been extensively investigated towards improving the regeneration of the injured muscle tissues, as well as their injectable forms. However, the applicability of such designed systems has been restricted due to the lack of available vascular networks. Read More

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Critical Review of Biodegradable and Bioactive Polymer Composites for Bone Tissue Engineering and Drug Delivery Applications.

Polymers (Basel) 2021 Aug 6;13(16). Epub 2021 Aug 6.

Research Centre for Sustainability Science and Governance (SGK), Institute for Environment and Development (LESTARI), Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Malaysia.

In the determination of the bioavailability of drugs administered orally, the drugs' solubility and permeability play a crucial role. For absorption of drug molecules and production of a pharmacological response, solubility is an important parameter that defines the concentration of the drug in systemic circulation. It is a challenging task to improve the oral bioavailability of drugs that have poor water solubility. Read More

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