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Irritant-Induced Chronic Cough Triggers: A Scoping Review and Clinical Checklist.

Am J Speech Lang Pathol 2021 May 14:1-31. Epub 2021 May 14.

Department of Speech, Language, and Hearing Sciences, Auburn University, AL.

Purpose The primary aim of this review was to identify environmental irritants known to trigger chronic cough through the life span and develop a comprehensive clinically useful irritant checklist. Method A scoping review was conducted using the Preferred Reporting Items for Systematic Review and Meta-Analysis Extension for Scoping Reviews, checklist, and explanation. English-language, full-text resources were identified through Medline, PsycINFO, SPORTDiscus, Web of Science, and ProQuest Dissertations and Theses Global. Read More

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Cross-linguistic influence of phonological awareness and phonological recoding skills in Chinese reading acquisition among early adolescent students.

J Gen Psychol 2021 May 14:1-22. Epub 2021 May 14.

East China Normal University.

This study investigated crosslinguistic phonological awareness and phonological recoding skills in Chinese reading acquisition among early Chinese adolescent students. 76 Chinese children participated in this study and finished a series of reading measurements over 1 year (from Grade 5 to Grade 6). In Grade 5, they were assessed by Chinese phonological awareness (syllable, onset, rhyme, phoneme, and tone awareness), English phonological awareness (syllable, onset, and rime, phoneme awareness) as well as English and Chinese phonological recoding skills. Read More

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Aerosol characterization in a city in central China plain and implications for emission control.

J Environ Sci (China) 2021 Jun 22;104:242-252. Epub 2020 Dec 22.

State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China; College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters, Nanjing University of Information Science and Technology, Nanjing 210044, China. Electronic address:

Extensive studies on aerosol chemistry have been carried out in megacities in China, however, aerosol characterization in Central China Plain (CCP) is limited. Here we conducted real-time measurements of fine particle composition with a time-of-flight aerosol chemical speciation monitor in Kaifeng, Henan province in October 2019. Our results showed that nitrate and organics constituted the major fraction of non-refractory PM for the entire study, on average accounting for 34% and 33%, respectively. Read More

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Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds.

PLoS Genet 2021 May 13;17(5):e1009543. Epub 2021 May 13.

Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

Histiocytic sarcoma is an aggressive hematopoietic malignancy of mature tissue histiocytes with a poorly understood etiology in humans. A histologically and clinically similar counterpart affects flat-coated retrievers (FCRs) at unusually high frequency, with 20% developing the lethal disease. The similar clinical presentation combined with the closed population structure of dogs, leading to high genetic homogeneity, makes dogs an excellent model for genetic studies of cancer susceptibility. Read More

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Effect of Hurricane Irma on daily direct-care nurse staffing in nursing homes.

J Am Geriatr Soc 2021 May 12. Epub 2021 May 12.

Florida Policy Exchange Center of Aging, School of Aging Studies, University of South Florida, Tampa, Florida, USA.

Objectives: To examine the effect of Hurricane Irma on staff-related financial expenditures and daily direct-care nurse staffing levels.

Design: Retrospective cohort study.

Setting: September 3-24, 2017 in the state of Florida, United States. Read More

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Individual red blood cell nitric oxide production in sickle cell anemia: nitric oxide production is increased and sickle shaped cells have unique morphologic change compared to discoid cells.

Free Radic Biol Med 2021 May 8. Epub 2021 May 8.

Division of Cardiology, Children's Hospital of Los Angeles; Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California. Electronic address:

Sickle cell anemia (SCA) is characterized by decreased red blood cell (RBC) deformability due to polymerization of deoxygenated hemoglobin, leading to abnormal mechanical properties of RBC, increased cellular adhesion, and microcirculatory obstruction. Prior work has demonstrated that NO• influences RBC hydration and deformability and is produced at a basal rate that increases under shear stress in normal RBC. Nevertheless, the origin and physiological relevance of nitric oxide (NO•) production and scavenging in RBC remains unclear. Read More

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Patient perspectives on the need for implanted device information: Implications for a post-procedural communication framework.

Health Expect 2021 May 11. Epub 2021 May 11.

Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA, USA.

Background: Shared decision making and patient-centred communication have become part of pre-procedural decisions and perioperative care across medical specialties. However, gaps exist in patient communication about the implanted device received and the benefits in sharing information about their procedure and device.

Objective: To understand the patients' knowledge of identifying information for their implanted devices and perspectives on sharing their implanted device information. Read More

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Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice.

Acta Neuropathol Commun 2021 May 10;9(1):83. Epub 2021 May 10.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, Rm. 4KD481, 60 Leonard Ave., Toronto, ON, M5T 0S8, Canada.

When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer's disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-like fashion. Within the brain, Aβ exists as a pool of distinct C-terminal variants with lengths ranging from 37 to 43 amino acids, yet the relative contribution of individual C-terminal Aβ variants to the seeding behavior of Aβ aggregates remains unknown. Here, we have investigated the relative seeding activities of Aβ aggregates composed exclusively of recombinant Aβ38, Aβ40, Aβ42, or Aβ43. Read More

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Pan-cancer analysis reveals tumor-associated macrophage communication in the tumor microenvironment.

Exp Hematol Oncol 2021 May 10;10(1):31. Epub 2021 May 10.

Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Background: Tumor-associated macrophages (TAMs) are abundant in the tumor microenvironment (TME). However, their contribution to the immunosuppressive status of the TME remains unclear.

Methods: We integrated single-cell sequencing and transcriptome data from different tumor types to uncover the molecular features of TAMs. Read More

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The effect of microstructure on mechanical properties of corn cob.

Micron 2021 Apr 20;146:103070. Epub 2021 Apr 20.

Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, 130025, China; College of Biological and Agricultural Engineering, Jilin University, Changchun, 130025, China.

As a natural biomass resource, corn cob has excellent mechanical properties and a special layered structure. To investigate the relationship between the mechanical properties and microstructure of corn cob, the ultra-deep field 3D microscope was used to characterize the macro geometric parameters, and the scanning electron microscopy (SEM) was observe the microstructure of the corn cob. The Fourier transform infrared spectrometer was used to analyze the fiber composition, revealing the contribution of fiber composition to the mechanical properties. Read More

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Achieving High Pseudocapacitance Anode by An Nanocrystallization Strategy for Ultrastable Sodium-Ion Batteries.

ACS Appl Mater Interfaces 2021 May 10. Epub 2021 May 10.

Department of Electrical Engineering and Computer Science, South Dakota State University, Brookings, South Dakota 57007, United States.

Conversion/alloying type anodes have shown great promise for sodium-ion batteries (SIBs) because of their high theoretical capacity. However, the poor structural stability derived from the large volume expansion and short lifetime impedes their further practical applications. Herein, we report a novel anode with a pomegranate-like nanostructure of SnPO particles homogeneously dispersed in the robust N-doped carbon matrix. Read More

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Electrosteric stabilization of oil/water emulsions by adsorption of chitosan oligosaccharides-An electrokinetic study.

Authors:
Viktoria Milkova

Carbohydr Polym 2021 Aug 16;265:118072. Epub 2021 Apr 16.

Institute of Physical Chemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria; Institut für Biology und Biotechnologie der Pflanzen, Westfälische Wilhems-Universität Münster, Schlossgarten 3, Münster, 48149, Germany. Electronic address:

The present study was focused on investigation of electrokinetic behaviour of lecithin-stabilized oil/water emulsions in the presence of chitosan oligosaccharides (COS). The oligosaccharides give unique opportunity for precisely characterization of the properties of chitosan as a function of the degree of acetylation (DA) and degree of polymerization (DP) of the polymer. For the study were chosen well characterized ultra pure COS molecules with completely acetylated monomers and mixture of COS molecules with acetylated and deacetylated monomers. Read More

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A Novel Jumbo Phage PhiMa05 Inhibits Harmful sp.

Front Microbiol 2021 20;12:660351. Epub 2021 Apr 20.

Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai, Thailand.

poses a concern because of its potential contribution to eutrophication and production of microcystins (MCs). Phage treatment has been proposed as a novel biocontrol method for . Here, we isolated a lytic cyanophage named PhiMa05 with high efficiency against MCs-producing strains. Read More

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Individuals at risk for rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential.

Cell Host Microbe 2021 May 5;29(5):726-739.e5. Epub 2021 May 5.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address:

Rheumatoid arthritis (RA) is an autoimmune disease characterized in seropositive individuals by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked to the intestinal microbiota, yet the association of microbes with CCP serology and their contribution to RA is unclear. We describe intestinal phage communities of individuals at risk for developing RA, with or without anti-CCP antibodies, whose first-degree relatives have been diagnosed with RA. Read More

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Does peer relationship matter? A multilevel investigation of the effects of peer and supervisory relationships on group supervision outcomes.

J Couns Psychol 2021 May 6. Epub 2021 May 6.

Department of Educational Psychology, The Chinese University of Hong Kong.

Research in clinical supervision has primarily focused on the contribution of supervisors to training outcome. However, peers may also play a significant role in trainees' development, particularly during group supervision. Fifty-three trainees from 10 supervision groups completed measures of peer relationship, supervisory working alliance (SWA), supervision satisfaction (SAT), and counseling self-efficacy (CSE) at three time points during a 20-week counseling practicum at a department clinic in Hong Kong. Read More

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The maternal health study: Study design update for a prospective cohort of first-time mothers and their firstborn children from birth to age ten.

Paediatr Perinat Epidemiol 2021 May 6. Epub 2021 May 6.

Intergenerational Health, Murdoch Children's Research Institute, Melbourne, Vic., Australia.

Background: Maternal health is critical to the health and well-being of children and families, but is rarely the primary focus of pregnancy and birth cohort studies. Globally, poor maternal health and the exposure of women and children to family violence contribute to the perpetuation and persistence of intergenerational health inequalities.

Objectives: The Maternal Health Study was designed to investigate the contribution of social and obstetric risk factors to common maternal physical and psychological morbidities. Read More

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Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas.

Leukemia 2021 May 5. Epub 2021 May 5.

University of Duesseldorf, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Center for Child and Adolescent Health, Düsseldorf, Germany.

B cells have the unique property to somatically alter their immunoglobulin (IG) genes by V(D)J recombination, somatic hypermutation (SHM) and class-switch recombination (CSR). Aberrant targeting of these mechanisms is implicated in lymphomagenesis, but the mutational processes are poorly understood. By performing whole genome and transcriptome sequencing of 181 germinal center derived B-cell lymphomas (gcBCL) we identified distinct mutational signatures linked to SHM and CSR. Read More

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Unique Considerations for Complete Surgical Analgesia for Below-the-Knee Amputations.

Cureus 2021 Mar 31;13(3):e14224. Epub 2021 Mar 31.

Department of Anesthesiology, Harbor-University of California, Los Angeles Medical Center, Torrance, USA.

Recent cadaver studies have suggested that posterior femoral cutaneous nerve (PFCN) may contribute to the sensory innervation of the posterior lower leg. Whether this is clinically relevant may be revealed in patients who underwent below-the-knee amputation (BKA) with monitored anesthesia care (MAC) and peripheral nerve blocks. We performed femoral and sciatic nerve blocks for a 55-year-old male patient who underwent BKA and subsequent formalization surgeries as the main surgical analgesia while providing MAC in the operating room. Read More

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A Phylogeny-Informed Analysis of the Global Coral-Symbiodiniaceae Interaction Network Reveals that Traits Correlated with Thermal Bleaching Are Specific to Symbiont Transmission Mode.

mSystems 2021 May 4;6(3). Epub 2021 May 4.

Integrative Research Center, Field Museum of Natural History, Chicago, Illinois, USA

The complex network of associations between corals and their dinoflagellates (family Symbiodiniaceae) are the basis of coral reef ecosystems but are sensitive to increasing global temperatures. Coral-symbiont interactions are restricted by ecological and evolutionary determinants that constrain partner choice and influence holobiont response to environmental stress; however, little is known about how these processes shape thermal resilience of the holobiont. Here, we built a network of global coral-Symbiodiniaceae associations, mapped species traits (e. Read More

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One-Sided Chronic Intervillositis of Unknown Etiology in Dizygotic Twins: A Description of 3 Cases.

Int J Mol Sci 2021 Apr 30;22(9). Epub 2021 Apr 30.

Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Chronic intervillositis of unknown etiology (CIUE) is a rare, poorly understood, histopathological diagnosis of the placenta that is frequently accompanied by adverse pregnancy outcomes including miscarriage, fetal growth restriction, and intrauterine fetal death. CIUE is thought to have an immunologically driven pathophysiology and may be related to human leukocyte antigen mismatches between the mother and the fetus. Dizygotic twins with one-sided CIUE provide an interesting context to study the influence of immunogenetic differences in such cases. Read More

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Modeling pancreatic cancer in mice for experimental therapeutics.

Biochim Biophys Acta Rev Cancer 2021 May 1:188554. Epub 2021 May 1.

Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is characterized by early metastasis, low resectability, high recurrence, and therapy resistance. The experimental mouse models have played a central role in understanding the pathobiology of PDAC and in the preclinical evaluation of various therapeutic modalities. Different mouse models with targetable pathological hallmarks have been developed and employed to address the unique challenges associated with PDAC progression, metastasis, and stromal heterogeneity. Read More

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Mimicking the Human Tympanic Membrane: The Significance of Scaffold Geometry.

Adv Healthc Mater 2021 May 4:e2002082. Epub 2021 May 4.

Department of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.

The human tympanic membrane (TM) captures sound waves from the environment and transforms them into mechanical motion. The successful transmission of these acoustic vibrations is attributed to the unique architecture of the TM. However, a limited knowledge is available on the contribution of its discrete anatomical features, which is important for fabricating functional TM replacements. Read More

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An Intravital Microscopy Toolbox to Study Mammary Gland Dynamics from Cellular Level to Organ Scale.

J Mammary Gland Biol Neoplasia 2021 May 4. Epub 2021 May 4.

VIB-KULeuven Center for Cancer Biology, Herestraat 49, 3000, Leuven, Belgium.

The architecture of the mouse mammary gland is highly dynamic and constantly remodeled during pubertal development and estrous cycle-driven sprouting and regression of alveolar side branches. During each of these developmental stages, turnover is driven by distinct subsets of mammary epithelial cells. Extensive previous research has shed light on the unique morphological and cell biological characteristics of each stage. Read More

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Environmental and sex-specific molecular signatures of glioma causation.

Neuro Oncol 2021 May 4. Epub 2021 May 4.

Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut.

Background: The relative importance of genetic and environmental risk factors in gliomagenesis remains uncertain.

Methods: Using whole-exome sequencing data from 1105 adult gliomas, we evaluate the relative contribution to cancer cell lineage proliferation and survival of single-nucleotide mutations in tumors by IDH mutation subtype and sex. We also quantify the contributions of COSMIC cancer mutational signatures to these tumors, identifying possible risk exposures. Read More

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Impact of Air Pollution on Allergic Rhinitis and Asthma: Consensus Statement by Indian Academy of Pediatrics.

Indian Pediatr 2021 May 3. Epub 2021 May 3.

President 2020, Indian Academy of Pediatrics.

Justification: Rising air pollution is an ever-growing threat to many human diseases. Poor air quality has been directly correlated with respiratory allergies with a disproportionate affection among the pediatric age group. A clear understanding of common air pollutants and their potential contribution in allergic rhinitis and asthma is lacking. Read More

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The impact of child health interventions and risk factors on child survival in Kenya, 1993-2014: a Bayesian spatio-temporal analysis with counterfactual scenarios.

BMC Med 2021 May 4;19(1):102. Epub 2021 May 4.

Population Health Unit, Kenya Medical Research Institute-Wellcome Trust Research Programme, Nairobi, Kenya.

Background: During the millennium development goals period, reduction in under-five mortality (U5M) and increases in child health intervention coverage were characterised by sub-national disparities and inequities across Kenya. The contribution of changing risk factors and intervention coverage on the sub-national changes in U5M remains poorly defined.

Methods: Sub-national county-level data on U5M and 43 factors known to be associated with U5M spanning 1993 and 2014 were assembled. Read More

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Advancing Semen Evaluation Using Lipidomics.

Front Vet Sci 2021 16;8:601794. Epub 2021 Apr 16.

Department of Animal and Dairy Sciences, Mississippi State University, Starkville, MS, United States.

Developing a deeper understanding of biological components of sperm is essential to improving cryopreservation techniques and reproductive technologies. To fully ascertain the functional determinants of fertility, lipidomic methods have come to the forefront. Lipidomics is the study of the lipid profile (lipidome) within a cell, tissue, or organism and provides a quantitative analysis of the lipid content in that sample. Read More

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Genome wide identification, phylogeny, and synteny analysis of family in common carp ().

Biotechnol Rep (Amst) 2021 Jun 16;30:e00607. Epub 2021 Mar 16.

Division of Fish Genetics and Biotechnology, Fauclty of Fisheries Rangil, Ganderbal, SKUAST-Kashmir, India.

Common carp () is a commercial fish species valuable for nutritious components and plays a vital role in human healthy nutrition. The SOX (SRY-related genes systematically characterized by a high-mobility group HMG-box) encoded important gene regulatory proteins, a family of transcription factors found in a broad range of animal taxa and extensively known for its contribution in multiple developmental processes including contribution in sex determination across phyla. In our current study, we initially accomplished a genome-wide analysis to report the SOX gene family in common carp fish based on available genomic sequences of zebrafish retrieved from gene repository databases, we focused on the global identification of the Sox gene family in Common carp among wide range of vertebrates and teleosts based on bioinformatics tools and techniques and explore the evolutionary relationships. Read More

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The difference in views of educators and students on Forced Online Distance Education can lead to unintentional side effects.

Educ Inf Technol (Dordr) 2021 Apr 28:1-27. Epub 2021 Apr 28.

Faculty of Natural Sciences and Mathematics, University of Maribor, SI-2000 Maribor, Slovenia.

The aim of the study was to investigate the different views of educators and students on Forced Online Distance Education during the Corona virus disease 2019 (COVID-19) lock-down. Such differences in views can be a source of misunderstanding, leading to unintended side effects. Online open-ended surveys resulted in 1341 comments received from 210 university educators and 347 students. Read More

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Protease-activated receptor 1 drives and maintains ductal cell fates in the premalignant pancreas and ductal adenocarcinoma.

Mol Oncol 2021 May 1. Epub 2021 May 1.

Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, The Netherlands.

Pancreatic acinar cells have high plasticity and can transdifferentiate into ductal-like cells. This acinar-to-ductal metaplasia (ADM) contributes to tissue maintenance but may also contribute to the premalignant transformation that can eventually progress to pancreatic ductal adenocarcinoma (PDAC). Macrophages are key players in ADM, and macrophage-secreted matrix metalloproteinase (MMP)-9 induces ADM through yet unknown mechanisms. Read More

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