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TEVAR and periscope graft technique to treatment of huge aneurysm of aortic isthmus: Case report.

Int J Surg Case Rep 2021 Jun 19;84:106129. Epub 2021 Jun 19.

Vascular Surgery Unit - AOmUP Policlinico 'P. Giaccone', Palermo, Italy; Department of Surgical, Oncological and Oral Sciences, University of Palermo, Italy.

Introduction: Thoracic endovascular aortic repair (TEVAR) has revolutionized the treatment of thoracic aortic aneurysms. Innovative techniques as chimney and periscope grafts can improve the outcomes of procedure. Herein, we report a case in emergency of huge Thoracic aortic aneurism. Read More

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Willingness of youth without disabilities to have romantic love and marital relationships with persons with disabilities.

Life Sci Soc Policy 2021 Jun 21;17(1). Epub 2021 Jun 21.

Department of Sociology, Wolaita Sodo University, Sodo, Ethiopia.

People with disabilities face attitudinal barriers including prejudice, stereotypes, and low expectations. Many young people without disabilities may doubt that people with disabilities can be fulfilling partners in any loving adult relationship. The objective of the present research was to assess the willingness of non-disabled youth to engage in conjugal relationships with persons with disabilities in Wolaita Sodo town, Ethiopia. Read More

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Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (Telomelysin) with radiotherapy in oesophageal cancer patients unfit for standard treatments.

Eur J Cancer 2021 Jun 18;153:98-108. Epub 2021 Jun 18.

Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan. Electronic address:

Purpose: OBP-301 (Telomelysin) is an attenuated type-5 adenovirus that contains the human telomerase reverse transcriptase promoter to regulate viral replication. OBP-301 sensitises human cancer cells to ionising radiation by inhibiting DNA repair, and radiation enhances coxsackievirus and adenovirus receptor-mediated OBP-301 infection on the contrary. We assessed OBP-301 with radiotherapy in oesophageal cancer patients unfit for standard chemoradiation treatments. Read More

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Laser in situ Fenestration in Thoracic Endovascular Aortic Repair: A Single-Center Analysis.

Ann Vasc Surg 2021 Jun 18. Epub 2021 Jun 18.

Medical University of South Carolina, Ashley River Tower, 25 Courtenay Drive, Charleston, SC 29425, United States of America. Electronic address:

Introduction And Objectives: Laser in situ fenestration (LISF) is an expanding technique for arch vessel revascularization in thoracic endovascular aortic repair (TEVAR). We present a single center's early and midterm outcomes using adjunctive LISF with TEVAR for treatment of various arch pathologies.

Methods: 24 patients underwent TEVAR with LISF (2017 - 2020). Read More

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Fitness vs. fatness as determinants of survival in non-institutionalized older adults: The EXERNET multi-center study.

J Gerontol A Biol Sci Med Sci 2021 Jun 21. Epub 2021 Jun 21.

GENUD (Growth, Exercise, NUtrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain.

Background: Physical fitness and body composition are important health indicators, nevertheless their combined pattern inter-relationships and their association with mortality are poorly investigated.

Methods: This longitudinal study is part of the Spanish EXERNET-Elder project. Person-months follow-up were calculated from the interview date, performed between June 2008 and November 2009, until date of death or censoring on March 2018 (whichever came first). Read More

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Anti-thymocyte globulin with CsA and MMF as GVHD prophylaxis in nonmyeloablative HLA-mismatched allogeneic HCT.

Bone Marrow Transplant 2021 Jun 19. Epub 2021 Jun 19.

Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands.

Nonmyeloablative regimens are used for allogeneic hematopoietic cell transplantation (HCT) of older or medically unfit patients, but successful outcome is still hindered by graft-versus-host disease (GVHD), especially in the setting of HLA-mismatched HCT. New GVHD prophylaxis strategies are emerging, including the triple drug strategy, that improve the GVHD-free and relapse-free survival (GRFS). Because the impact of ATG in HLA-mismatched Flu-TBI-based nonmyeloablative HCT has not been investigated, we did a retrospective analysis in three Dutch centers. Read More

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The recurrent urinary tract infection health and functional impact questionnaire (RUHFI-Q): design and feasibility assessment of a new evaluation scale.

Can J Urol 2021 Jun;28(3):10729-10732

Department of Urology, University Hospital Limerick, Dooradoyle, Co. Limerick, Ireland.

Introduction: We aim to design a tool to assess the impact of recurrent urinary tract infection (rUTI) on quality of life (QoL) in adult women, given the notable absence of an established instrument for this purpose.

Materials And Methods: Best practice guidelines in health-related survey design were reviewed. A literature review informed creation of an interview guide. Read More

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The Ontario Forensic Mental Health System: A Population-based Review: Le système ontarien de services psychiatriques médico-légaux: Une étude dans la population.

Can J Psychiatry 2021 Jun 10:7067437211023103. Epub 2021 Jun 10.

228603Forensic Psychiatry Program, St. Joseph's Healthcare Hamilton, Ontario, Canada.

Objective: The purpose of this study was to increase the understanding of the Canadian forensic psychiatry system by providing a population-based overview of the Ontario forensic mental health system.

Methods: Data were collected on 1,240 accused adults who were subject to the jurisdiction of the Ontario Review Board (ORB) between 2014 and 2015. Archival data were retrieved from annual ORB hearing hospital reports for accused supervised by all nine adult forensic psychiatry facilities across Ontario. Read More

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Evaluating Factors Associated with the Cancellation and Delay of Elective Surgical Procedures: A Systematic Review.

Int J Qual Health Care 2021 Jun 8. Epub 2021 Jun 8.

Department of Management, Otago Business School, University of Otago, New Zealand.

Background: Elective surgery cancellation is considered a fundamental problem in health care services-it causes considerable disruption to patient flow, further eroding often already stretched operating capacity, and consequentially reduces both hospital performance and patient satisfaction. This research presents a systematic review (SR) of the reasons for surgery cancellation among different hospitals and countries. By highlighting these causes, we identify how to reduce cancellations thereby improving the use of surgical capacity and resources and create a more predicable patient flow. Read More

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[Elderly Glioma].

No Shinkei Geka 2021 May;49(3):647-659

Department of Neurosurgery, Hiroshima University Hospital.

Treatment of elderly glioma patients is a challenge in neurosurgery/neuro-oncology. The International Society of Geriatric Oncology(SIOG)recommends that elderly cancer patients undergo comprehensive geriatric assessment(CGA). The CGA score proved to be a significant predictor of mortality in this cohort, and it could be a useful treatment decision tool. Read More

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Endoscope-assisted techniques for evacuation of acute subdural haematoma in the elderly: The lesser of two evils? A scoping review of the literature.

Clin Neurol Neurosurg 2021 May 29;207:106712. Epub 2021 May 29.

Department of Neurosurgery, University Hospital of Wales, Cardiff, UK. Electronic address:

Introduction: Surgical evacuation of acute subdural haematoma (ASDH) in the elderly remains a point of contention due to the significant associated mortality. Therefore, there is a dire need for alternative treatment options. Endoscope-assisted techniques (EAT) have been increasingly reported over the last decade with variable outcomes. Read More

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Review of Venetoclax in CLL, AML and Multiple Myeloma.

J Pers Med 2021 May 24;11(6). Epub 2021 May 24.

Department of Haematology, Peter MacCallum Cancer Centre, Melbourne 3000, Australia.

Venetoclax is a highly selective and effective B-cell lymphoma-2 (BCL-2) inhibitor, which is able to reinstate the apoptotic potential of cancer cells. With its full repertoire yet to be explored, it has changed the therapeutic landscape in haematological malignancies, and most particularly chronic lymphocytic leukaemia (CLL), acute myeloid leukaemia (AML) and multiple myeloma (MM). In CLL, it has shown remarkable efficacy both as monotherapy and in combination therapy. Read More

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Compositional Changes in Grapes and Leaves as a Consequence of Smoke Exposure of Vineyards from Multiple Bushfires across a Ripening Season.

Molecules 2021 May 26;26(11). Epub 2021 May 26.

The Australian Wine Research Institute, Glen Osmond, SA 5064, Australia.

The negative effects of smoke exposure of grapes in vineyards that are close to harvest are well documented. Volatile phenols in smoke from forest and grass fires can contaminate berries and, upon uptake, are readily converted into a range of glycosylated grape metabolites. These phenolic glycosides and corresponding volatile phenols are extracted into the must and carried through the winemaking process, leading to wines with overtly smoky aromas and flavours. Read More

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A Space-Time Analysis of Rural Older People's Outdoor Mobility and Its Impact on Self-Rated Health: Evidence from a Taiwanese Rural Village.

Int J Environ Res Public Health 2021 May 31;18(11). Epub 2021 May 31.

Department of Urban Planning, College of Planning and Design, National Cheng Kung University, Tainan City 70101, Taiwan.

With the aggravation of rural aging, the well-being and self-rated health level of older people in rural communities are significantly lower than those in urban communities. Past studies hold that mobility is essential to the quality of life of the elderly, and well-being depends on their own adaptation strategies in the built environment. Therefore, this study combines three key factors related to active aging: environment, health and mobility, and assumes that the elderly with good health status will have environmental proactivity and a wider range of daily mobility in a poor rural built environment. Read More

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FLT3 Tyrosine Kinase Inhibitors for the Treatment of Fit and Unfit Patients with FLT3-Mutated AML: A Systematic Review.

Int J Mol Sci 2021 May 30;22(11). Epub 2021 May 30.

Service d'Hématologie Clinique, Centre Hospitalier Universitaire de Nice, 06200 Nice, France.

FLT3-mutated acute myeloid leukemia accounts for around 30% of acute myeloid leukemia (AML). The mutation carried a poor prognosis until the rise of tyrosine kinase inhibitors (TKIs). New potent and specific inhibitors have successfully altered the course of the disease, increasing the complete response rate and the survival of patients with FLT3-mutated AML. Read More

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Physiological Fitness and the Pathophysiology of Chronic Lymphocytic Leukemia (CLL).

Cells 2021 May 11;10(5). Epub 2021 May 11.

Division of Medical Oncology, Duke University School of Medicine, Durham, NC 27710, USA.

Chronic lymphocytic leukemia (CLL) is associated with physical dysfunction and low overall fitness that predicts poor survival following the commencement of treatment. However, it remains unknown whether higher fitness provides antioncogenic effects. We identified ten fit (CLL-FIT) and ten less fit (CLL-UNFIT) treatment-naïve CLL patients from 144 patients who completed a set of physical fitness and performance tests. Read More

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Therapeutic Use of Valproic Acid and All-Trans Retinoic Acid in Acute Myeloid Leukemia-Literature Review and Discussion of Possible Use in Relapse after Allogeneic Stem Cell Transplantation.

Pharmaceuticals (Basel) 2021 May 2;14(5). Epub 2021 May 2.

Department of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway.

Even though allogeneic stem cell transplantation is the most intensive treatment for acute myeloid leukemia (AML), chemo-resistant leukemia relapse is still one of the most common causes of death for these patients, as is transplant-related mortality, i.e., graft versus host disease, infections, and organ damage. Read More

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Type 1A endoleak detachable coil embolization after endovascular aneurysm sealing: Case report.

Int J Surg Case Rep 2021 May 26;83:106024. Epub 2021 May 26.

Vascular Surgery Unit, AOUP Policlinico 'P. Giaccone', Palermo, Italy; Department of Surgical, Oncological and Oral Sciences, University of Palermo, Italy.

Introduction: Endovascular aneurysm sealing (EVAS) with the Nellix system was introduced to reduce endovascular aneurysm repair (EVAR) perioperative complications, especially endoleaks. Herein we report a case of successful type 1A endoleak managed with detachable coils embolization after EVAS.

Presentation Of Case: A 77-year-old male was referred for abdominal pain. Read More

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Giant Myxoid Spindle Cell Neoplasm Presenting with Abdominal Swelling and Concurrent Weight Loss.

World Neurosurg 2021 May 28;152:1-2. Epub 2021 May 28.

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Neurosurgery, Zucker School of Medicine at Hofstra, Long Island Jewish Medical Center and North Shore University Hospital, Northwell Health, Manhasset, New York, USA. Electronic address:

Retroperitoneal sarcomas may grow extremely large before becoming clinically symptomatic, and curative resection often has high associated morbidity. An 83-year-old man presented with insidious-onset abdominal pain and weight loss owing to a 16.3 × 13. Read More

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Health-related quality of life with fixed-duration venetoclax-obinutuzumab for previously untreated chronic lymphocytic leukemia: Results from the randomized, phase 3 CLL14 trial.

Am J Hematol 2021 May 29. Epub 2021 May 29.

Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Duesseldorf; German CLL Study Group, University of Cologne, Cologne, Germany.

Chronic lymphocytic leukemia (CLL)-related symptoms impair the well-being of patients, making improvement of health-related quality of life (QoL) a goal of treatment. The CLL14 trial demonstrated higher efficacy of fixed-duration venetoclax-obinutuzumab (Ven-Obi) compared to chlorambucil-obinutuzumab (Clb-Obi) in patients with previously untreated CLL. To assess patients' QoL, the following patient-reported outcomes (PRO) measures were assessed: the M. Read More

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Physician-modified fenestrated Navion endograft for the treatment of a symptomatic postdissection thoracoabdominal aneurysm.

J Vasc Surg Cases Innov Tech 2021 Jun 15;7(2):344-349. Epub 2021 Apr 15.

Unit of Vascular Surgery, Department of Surgical Sciences, University of Turin, AOU Citta' della Salute e della Scienza, Turin, Italy.

We report the case of a physician-modified four-fenestration endograft for the emergent treatment of a 65-year-old patient with postdissection thoracoabdominal aneurysm deemed unfit for open surgery. The patient, after elective thoracic endovascular aneurysm repair as the first stage of a preplanned two-stage total thoracoabdominal endovascular repair, presented acute onset of dyspnea and thoracic pain. Computed tomography angiography (CTA) showed signs of contained rupture. Read More

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Antibody Therapies for Large B-Cell Lymphoma.

Biologics 2021 18;15:153-174. Epub 2021 May 18.

Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS, Torino, Italy.

Large B-cell lymphomas (LBCLs) constitute a subgroup of aggressive but highly curable lymphoproliferative diseases. Treatment of relapsed/refractory (R/R) patients still represents an unmet clinical need, and novel drugs and combinations are in continuous development. The pan-B cell panel of surface antigens that characterizes LBCL leads to a large umbrella of druggable targets. Read More

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Long-Term Outcomes of Thoracic Endovascular Repair for Aortic Arch Dissection Using Customized Single-Branched Fenestrated Stent-Graft.

Vasc Endovascular Surg 2021 May 26:15385744211010446. Epub 2021 May 26.

Department of Vascular Surgery, 12520Changhai Hospital, Naval Medical University, Shanghai, China.

Objectives: To report outcomes of thoracic endovascular repair using customized single-branched fenestrated stent-grafts in treatment of aortic arch dissections.

Materials And Methods: Between November 2009 and November 2011, 16 patients with aortic arch dissections underwent thoracic endovascular aortic repair utilizing customized unibody single-branched fenestrated stent-graft (UBFSG) in our institution.

Results: All 16 patients were male with mean age of 54. Read More

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Impact of the COVID-19 Pandemic on Radiotherapy Supply.

Radiol Res Pract 2021 5;2021:5550536. Epub 2021 May 5.

Section of Radiology and Radiation Oncology, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, Bari 70124, Italy.

Background: The impetuous entrance of the COVID-19 pandemic in Italy in March 2020, after the onset and diffusion in China, found the health system widely unfit to face the large amount of infected patients. The matter of this investigation was to evaluate how pandemic fear and guidelines for limiting the diffusion of SARS-CoV-2 virus could have impacted the regular supply of radiotherapy (RT) and the outcome of the treatments.

Materials And Methods: From March 9, 2020, to May 29, 2020, a register has been established to record patients that cancelled or postponed the RT appointment. Read More

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Large cell neuroendocrine carcinoma arising from the anterior mediastinum.

BMJ Case Rep 2021 May 25;14(5). Epub 2021 May 25.

Gastroenterology, Mater Dei Hospital, Msida, Malta.

Anterior mediastinal large cell neuroendocrine carcinomas (LCNECs) are extremely rare, extremely aggressive malignancies that carry a dismal prognosis. We discuss a woman aged 60 years who presented with a 2-month history of recurrent severe constant epigastric pain. Abdominal examination revealed massive hepatomegaly and a CT scan of the liver confirmed coarse liver lesions. Read More

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Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: Comparison in younger and older adults.

Brain Behav 2021 May 25:e02126. Epub 2021 May 25.

Centre for Human Brain Health, University of Birmingham, Birmingham, UK.

Introduction: Resting cerebral blood flow (CBF) and perfusion measures have been used to determine brain health. Studies showing variation in resting CBF with age and fitness level using different imaging approaches have produced mixed findings. We assess the degree to which resting CBF measures through transcranial Doppler (TCD) and arterial spin labeling (ASL) MRI provide complementary information in older and younger, fit and unfit cohorts. Read More

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131I Ablation of an Entire Thyroid Gland in Locally Invasive Differentiated Thyroid Cancer Without Surgery.

Clin Nucl Med 2021 May 12. Epub 2021 May 12.

From the Department of Nuclear Medicine, Concord Hospital, Concord Faculty of Medicine and Health, University of Sydney, New South Wales Department of Endocrinology, Concord Hospital, Concord, Australia.

Abstract: A 79-year-old man with locally metastatic papillary thyroid cancer to left-sided cervical lymph nodes was referred for radioiodine therapy. He was considered unfit for thyroidectomy due to extensive local involvement and severe interstitial lung disease requiring continuous oxygen. The patient was treated with low doses of radioiodine (approximately 30 mCi) every 6 months with corticosteroid cover for 3 years with good effect. Read More

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Venetoclax-based combinations for the treatment of newly diagnosed acute myeloid leukemia.

Future Oncol 2021 May 24. Epub 2021 May 24.

Department of Internal Medicine, Division of Hematology & Oncology, University of California Davis School of Medicine, Sacramento, CA 95817, USA.

Elderly and/or unfit patients with acute myeloid leukemia have historically been challenging to manage as they were ineligible for what was considered standard of care treatment with induction chemotherapy. The emergence of venetoclax with hypomethylating agents or low-dose cytarabine has substantially improved outcomes in the frontline setting with manageable toxicity. However, this regimen can be challenging to deliver given its differences from standard intensive chemotherapy. Read More

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Distribution and health risk assessment of trace elements in ground/surface water of Kot Addu, Punjab, Pakistan: a multivariate analysis.

Environ Monit Assess 2021 May 22;193(6):351. Epub 2021 May 22.

Department of Environmental Sciences, COMSATS University Islamabad, Vehari-Campus, Vehari, 61100, Pakistan.

Water is a key component for living beings to sustain life and for socio-economic development. Anthropogenic activities contribute significantly to ground/surface water contamination particularly with trace elements. The present study was designed to evaluate distribution and health risk assessment of trace elements in ground/surface water of the previously unexplored area, Tehsil Kot Addu, Southern-Punjab, Pakistan. Read More

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Proportional meta-analysis of open surgery or fenestrated-endograft repair for post-dissection thoracoabdominal aneurysms.

J Vasc Surg 2021 May 18. Epub 2021 May 18.

Unit of Vascular Surgery, Department of Surgical Sciences, University of Turin, AOU Città della Salute e della Scienza, Turin, Italy.

Objective: To determine outcomes of post-dissection thoracoabdominal aneurysms (pD-TAAAs) by either open or endovascular repair with fenestrated or branched endografts (F/B-TEVAR).

Methods: A systematic review was conducted for open or endovascular repair of pD-TAAAs, between January 2009 and February 2020. A meta-analysis was performed for post-operative complications and both early and late mortality and re-interventions. Read More

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