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Georgian Med News 2021 Mar(312):7-14

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of the Russian Federation.

The aim of the study was to study the effectiveness of complex treatment of decompensated chronic venous insufficiency (CVI) using innovative techniques and proteolysis inhibitors with a wide spectrum of activity in patients with SARS-CoV-2 (COVID-19) in COVID hospital. This study was performed in the surgical department of COVID hospital on the basis of the Clinical Hospital No. 4 of the First Moscow State Medical University named I. Read More

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Benign cystic mesothelioma: A case report on the presentation of an unusual tumor.

Int J Surg Case Rep 2021 Apr 30;82:105918. Epub 2021 Apr 30.

King Hamad University Hospital, Bahrain.

Introduction: Benign cystic mesothelioma of the peritoneum is a rare, benign abdominal tumor. It can present with vague signs and symptoms and is often found on imaging or incidentally during surgery.

Presentation Of Case: We report the case of a 30-year-old man presenting with acute abdominal pain that radiated to the right iliac fossa. Read More

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Concomitant valve-sparing aortic root replacement with tetralogy of Fallot repair in a 30-year-old patient: A case report.

Int J Surg Case Rep 2021 Apr 29;82:105930. Epub 2021 Apr 29.

Adult Cardiac Surgical Intensive Care Unit, Hanoi Heart Hospital, Hanoi, Viet Nam.

Introduction And Importance: Aortic regurgitation and aortic root dilatation are common features in adults with both repaired and unrepaired tetralogy of Fallot (TOF). Valve-sparing aortic root replacement (VSARR) is an effective repair for aortic regurgitation due to progressive aortic root dilatation with TOF after repair. However, the effectiveness of this technique for unrepaired patients has rarely been reported. Read More

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Vestibular disorders in children: A retrospective analysis of vestibular function test findings.

Int J Pediatr Otorhinolaryngol 2021 Apr 29;146:110751. Epub 2021 Apr 29.

Acibadem Maslak Hospital ENT Department, Istanbul, Turkey.

Objective: This study was designed to describe the most common vestibular disorders in children and their associated findings on vestibular function testing.

Method: Data from 203 children with a mean age of 11.16 ± 3. Read More

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The Venous Occlusion Image Score: A Novel Quantitative Scoring Instrument for Cerebral Venous Sinus Thrombosis.

J Stroke Cerebrovasc Dis 2021 May 5;30(7):105845. Epub 2021 May 5.

Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, P R China. Electronic address:

Purpose: This study aims to test the validity of a new quantitative scoring instrument-the Venous Occlusion Image Score (VOIS), and assess the diagnostic and prognostic value of VOIS for cerebral venous sinus thrombosis (CVST).

Methods: The VOIS divided the major cerebral venous sinuses and internal jugular veins into nine parts of interest. CT venography and DSA source images and reconstruction were extracted from the database, then interpreted and scored independently according to VOIS by a panel of three reviewers. Read More

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A review of the Turned-down Onto Pericapsular-tissue Hemisectioned Amputated Toe (TOPHAT) flap for wound coverage during ray amputations of the toes.

Foot (Edinb) 2021 Apr 20;47:101803. Epub 2021 Apr 20.

Department of Vascular and Endovascular Surgery, Singapore General Hospital, Academia Level 5, Outram Road, 169608, Singapore. Electronic address:

Introduction: Exposure of the adjacent Metatarsal-Phalangeal Joint (MTPJ) commonly occurs after application of Topical Negative Pressure Wound Therapy (TNPWT) for a ray amputation wound. This is due to mechanical soft tissue erosion or trauma to the adjacent digital artery from direct pressure effect. This results in toe gangrene requiring a ray amputation and ultimately a larger wound bed. Read More

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Outcomes of hematopoietic cell transplantation (HCT) in patients with mixed response to treatment of confirmed or suspected invasive fungal infection before HCT.

Transplant Cell Ther 2021 May 5. Epub 2021 May 5.

Department of Medicine, University of Washington, Seattle, WA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Background: Patients with hematologic malignancy or bone marrow failure are typically required to achieve radiographic improvement or stabilization of invasive fungal infection (IFI) prior to hematopoietic cell transplant (HCT) due to concern for progression prior to engraftment. Refractory IFI with a mixture of improvement and progression on serial imaging (or a "mixed response") poses a clinical dilemma, as delay in HCT may allow hematologic relapse or other complications. Further, HCT itself may yield the immune reconstitution necessary for clearance of infection. Read More

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Mechanical thrombectomy in distal residual occlusions of the middle cerebral artery after large vessel recanalization in acute stroke: 2b or not 2b? A pragmatic approach in real-life scenarios.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Hopital Foch, Department of Diagnostic and Interventional Neuroradiology, Suresnes, Île-de-France, FR.

Background: AND PURPOSE: Recent studies have suggested that a recanalization grade of modified thrombolysis in cerebral infarction (mTICI) ≥2c is strongly related with good clinical outcome rather than the current therapeutic angiography target ≥2b. In order to achieve better recanalization, additional further maneuvers on distal residual vessel occlusion may be required. The aim of this paper was to evaluate the safety and efficacy of rescue treatment in residual vessel occlusions (RVOs) after recanalization of large vessel occlusions in the anterior circulation. Read More

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Prognostic value of preoperative psoas muscle index as a measure of nutritional status in patients with esophageal cancer receiving neoadjuvant therapy.

Nutrition 2021 Mar 6;90:111232. Epub 2021 Mar 6.

First Department of Surgery, Faculty of Medicine University of Yamanashi, Yamanashi, Japan.

Objectives: It has been reported that preoperative nutritional status in some gastrointestinal cancers has a significant effect on postoperative prognosis. However, there are few reports on esophageal cancer, especially for esophageal cancer patients who have undergone neoadjuvant therapy and surgery. Psoas muscle index (PMI) is widely known as an index for assessing preoperative nutritional status, and has recently been reported for its prognostic value in many malignancies. Read More

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The Fate of Sutures Post Rotator Cuff Repair.

J Shoulder Elbow Surg 2021 May 5. Epub 2021 May 5.

Department/ Institution: Orthopaedic Research Institute, St. George Hospital Campus, University of New South Wales, Sydney, NSW, Australia. Electronic address:

Background: Ultrasound imaging has been widely used as a diagnostic tool for rotator cuff tears. Several studies have explored the changes in rotator cuff tendon morphology after arthroscopic cuff repair, however none have addressed the fate of sutures. The aim of this study was to determine: (1) if the sutures migrate through the tendon during the postoperative healing period in patients who have had arthroscopic rotator cuff repair, (2) if the sutures do migrate, the time point at which it does and, (3) if the quality of the tendon, in terms of tendon stiffness, modulus of elasticity, bursal thickness and anatomical footprint, affects suture migration. Read More

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ENB-guided microwave ablation combined with uniportal VATS for multiple ground glass opacities.

Ann Thorac Surg 2021 May 5. Epub 2021 May 5.

Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China. Electronic address:

Background: An increasing number of patients are being diagnosed with multiple ground glass opacities (GGOs), but a consensus on the treatment of these patients is still lacking. The aim of this study was to investigate the safety and feasibility of a novel technique, electromagnetic navigation bronchoscopy (ENB)-guided microwave ablation combined with uniportal video-assisted thoracoscopic surgery (Uni-VATS), in patients with multiple GGOs.

Methods: The clinical, radiographic, surgical, and pathological data of patients with multiple GGOs who underwent ENB-guided microwave ablation combined with Uni-VATS from October 2018 to December 2019 were reviewed. Read More

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Is Outpatient Management of Mandibular Fractures Associated With Inflammatory Complications? An ACS-NSQIP Study.

J Oral Maxillofac Surg 2021 Mar 26. Epub 2021 Mar 26.

Assistant Professor, Oral & Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA. Electronic address:

Purpose: Timing of mandibular fracture repair has long been debated. The purpose of the present study was to assess the incidence of postoperative inflammatory complications (POICs) following open repair of mandibular fractures managed non-urgently in the outpatient setting versus urgently in the inpatient setting.

Methods: The authors utilized the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database to enroll a sample of patients with mandibular fractures who underwent open repair. Read More

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Impact of the first surge of the COVID-19 pandemic on a tertiary referral centre for kidney cancer.

BJU Int 2021 May 8. Epub 2021 May 8.

Specialist Centre for Kidney Cancer, Royal Free London NHS Foundation Trust, UK.

Objectives: To analyse the impact of the COVID-19 pandemic on a centralised specialist kidney cancer care pathway.

Materials & Methods: Retrospective analysis of patient and pathway characteristics including prioritisation strategies at the Specialist Centre for Kidney Cancer (SCKC) located at the Royal Free London NHS Foundation Trust (RFH) before and during the surge of COVID-19.

Results: On March 18, 2020 all elective surgery was halted at RFH to redeploy resources and staff for the COVID-19 surge. Read More

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Epidemiology of Tongue Squamous Cell Carcinoma: A Retrospective Cohort Study.

Oral Dis 2021 May 8. Epub 2021 May 8.

Clinical Research Division, National Cancer Institute, Rio de Janeiro (RJ), Brazil.

Objective: Analyze the epidemiological profile and the specific survival of patients diagnosed with tongue squamous cell carcinoma at the National Cancer Institute (INCA).

Materials And Methods: Hospital Cancer Registry System Data and Mortality Information from 2007 to 2009 were retrieved in a retrospective cohort study of patients diagnosed with tongue squamous cell carcinoma. Specific survival was estimated using the Kaplan-Meier method. Read More

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Effect of the local probiotics in the therapy of periodontitis A randomised prospective study.

Int J Dent Hyg 2021 May 8. Epub 2021 May 8.

Department of Periodontology and Oral medicine, Medical faculty, University of Nis, Serbia.

Objectives: The use of local probiotics in the therapy of periodontitis is reflected in their ability to antagonize periodontopathogens and modulate the immune response of the host to the presence of pathogenic microorganisms. The aim of this study was to investigated the use of local probiotics in the treatment of periodontitis as an adjunctive therapy to scaling and root planning (SRP).

Methods: The study involved 80 patients diagnosed with periodontitis. Read More

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Association with clinic risk factors of Percheron artery infarction and magnetic resonance imaging involvement patterns.

Acta Neurol Belg 2021 May 8. Epub 2021 May 8.

Department of Radiology, Medical Faculty, Ataturk University, Erzurum, Turkey.

Radiological imaging is important in the diagnosis of the artery of Percheron (AOP) infarction. This study aimed to discuss the magnetic resonance imaging (MRI) findings of this abnormal variant of arterial supply. Patients who presented to our hospital with stroke symptoms between 2010 and 2019 and underwent brain MRI were evaluated retrospectively. Read More

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Stapleless vs Stapled Gastric Bypass vs Hypocaloric Diet: a Three-Arm Randomized Controlled Trial of Body Mass Evolution with Secondary Outcomes for Telomere Length and Metabolic Syndrome Changes.

Obes Surg 2021 May 8. Epub 2021 May 8.

Research Group of the University Medical Center, Nur-Sultan, Kazakhstan.

Background: Obesity and metabolic syndrome (MetS) reduce life expectancy and are challenging to resolve. This randomized controlled trial (RCT) of patients with obesity and MetS undergoing surgical vs nonsurgical treatment compared changes in BMI, and secondarily, telomere length (as a biomarker of life expectancy) and changes in MetS components (insulin resistance, dyslipidemia, hypertension).

Methods: Study design was a single-center, prospective, three-arm RCT. Read More

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Gastrointestinal and oncologic outcomes of pediatric gastrointestinal lymphoma following upfront resection or biopsy of bowel masses.

Pediatr Surg Int 2021 May 8. Epub 2021 May 8.

Department of Paediatric Surgery, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.

Purpose: Complete upfront resection of pediatric gastrointestinal lymphomas is recommended over biopsy whenever feasible, but either approach may have adverse sequelae. We sought to compare gastrointestinal and oncological outcomes of pediatric gastrointestinal lymphomas who underwent attempted upfront resection or biopsy of the presenting bowel mass.

Methods: We retrospectively reviewed charts of children with gastrointestinal lymphomas treated on LMB89 and LMB96 protocols from 2000 to 2019 who underwent upfront gastrointestinal surgery, and compared resection and biopsy groups. Read More

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Surgical repair techniques, functional outcome, and return to sports after apophyseal avulsion fractures of the ischial tuberosity in adolescents.

Int Orthop 2021 May 8. Epub 2021 May 8.

Department Orthopeadic and Sports Trauma Surgery, Sportklinik Stuttgart GmbH, Taubenheimstrasse 8, 70372, Stuttgart, Germany.

Purpose: Among juvenile apophyseal avulsion injuries of the pelvis in adolescents, fractures of the ischial tuberosity are rare but sustainably debilitating. Also because informations on surgical repair options are very sparse and so far limited to general reviews, reports of individual cases or heterogeous small case series, practitioners, patients and their parental environment still feel a comprehensible hesitation regarding operative treatment. Therefore we intended to investigate patient related outcome measurements and return to sports rates after different types of surgical intervention in an own case series, so far unprecendented in its size. Read More

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Preserved thenar muscles in non-ambulant Duchenne muscular dystrophy patients.

J Cachexia Sarcopenia Muscle 2021 May 8. Epub 2021 May 8.

Duchenne Center, Leiden, Netherlands.

Background: Clinical trials in Duchenne muscular dystrophy (DMD) focus primarily on ambulant patients. Results cannot be extrapolated to later disease stages due to a decline in targeted muscle tissue. In non-ambulant DMD patients, hand function is relatively preserved and crucial for daily-life activities. Read More

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High spectral and spatial resolution MRI of prostate cancer: a pilot study.

Magn Reson Med 2021 May 8. Epub 2021 May 8.

Department of Radiology, University of Chicago, Chicago, Illinois, USA.

Purpose: High spectral and spatial resolution (HiSS) MRI is a spectroscopic imaging method focusing on water and fat resonances that has good diagnostic utility in breast imaging. The purpose of this work was to assess the feasibility and potential utility of HiSS MRI for the diagnosis of prostate cancer.

Methods: HiSS MRI was acquired at 3 T from six patients who underwent prostatectomy, yielding a train of 127 phase-coherent gradient echo (GRE) images. Read More

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Use of a Tumor Bed Boost in the Radiotherapy after Oncoplastic Breast Conserving Surgery.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):110-119

Aim Of The Study: Use of a radiotherapy (RT) tumor bed boost in addition to whole breast irradiation (WBI) after oncoplastic breast conserving surgery (OBCS) can be very challenging due to the massive tissue displacements. The aim of our study is to present relevant RT data regarding the use of a boost RT in patients who underwent OBCS and received adjuvant RT at Neolife Medical Center Bucharest. 12 patients treated with intensity modulated radiotherapy (IMRT), after OBCS, using conventional or hypofractionated schedules, between 10/2018 and 12/2020 were included in the study. Read More

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6 Years of Breast Reconstruction in One Center - An Objective Analysis.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):98-104

Breast cancer represents the most common type of neoplasm in women around the world. Breast reconstruction following mastectomy has become a demanding procedure in the treatment of patients suffering from breast cancer. Their major role is to improve the quality of life of women, leading to better aesthetic outcomes. Read More

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Contralateral Prophylactic Mastectomy in Patients with Breast Cancer.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):73-83

The rate of contralateral prophylactic mastectomy (CPM) increased within the recent years. The main reasons are: genetic testing, availability of breast reconstruction, more often use of preoperative breast MRI, improvement of postoperative aesthetic results and reimbursement of breast reconstruction. The purpose of this study was to analyze the indication of CPM, it's evolution and the surgical techniques used for this type of surgery. Read More

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Advanced Oncoplastic Breast Conserving Surgery: Single Institution Experience with 823 Patients.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):59-72

Oncoplastic breast conserving surgery (BCS) becomes the standard of care in multidisciplinary breast cancer treatment. From our perspective, the aim of oncoplastic BCS is the best oncological, aesthetic and functional surgical treatment results. The study's objective is to present our approaches to the selection of surgical techniques and determine operative and oncological outcomes of oncoplastic surgery. Read More

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Diagnostic Accuracy of Axillary Ultrasound for Prediction of Axillary Pathologic Response after Neoadjuvant Treatment in Breast Cancer.

Chirurgia (Bucur) 2021 Mar-Apr;116(2 Suppl):45-58

In the era of NAT, to accurately predict pathologic response is a great challenge, which might influence surgical approach for breast and axilla. Axillary staging via imaging methods as an adjunct have long been used with various reported accuracy rates. However, the role of preoperative axillary ultrasonography (AUS) in clinical N0 patients after NAT is still controversial. Read More

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Selective Laser Trabeculoplasty Versus MIGS: Forgotten Art or First-Step Procedure in Selected Patients with Open-Angle Glaucoma.

Ophthalmol Ther 2021 May 7. Epub 2021 May 7.

Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin Institute of Health, Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Introduction: To evaluate the long-term effect on intraocular pressure (IOP) and glaucoma medication of selective laser trabeculoplasty (SLT) compared to minimally invasive glaucoma surgery (MIGS) in primary open-angle glaucoma (POAG) and its potential in clinical practice.

Methods: A total of 342 consecutive patients (stand-alone procedures) were included. One hundred and five patients underwent SLT treatment (360° SLT, 95-105 spots, Trabeculas SLT ARCLaser, Nürnberg, DE), 107 patients had an ab interno-derived trabeculotomy (Trabectome, NeoMedix, Tustin, USA), and 130 patients received iStent inject implantation (2 implants-Glaukos, CA, USA). Read More

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Hepatic Arterioportal Fistula Is Associated with Decreased Future Liver Remnant Regeneration after Stage-I ALPPS for Hepatocellular Carcinoma.

J Gastrointest Surg 2021 May 7. Epub 2021 May 7.

Department of Hepatobiliary Surgery and Liver transplantation, the First Affiliated Hospital of Guangxi Medical University, Shuangrong Raod 6, Nanning, 530021, China.

Background: Hepatocellular carcinoma (HCC) patients often developed hepatic arterioportal fistula (APF). The aim of this study is to evaluate the impact of APF on future liver remnant (FLR) regeneration and surgical outcomes after the first stage of associating liver partition and portal vein ligation for staged hepatectomy (stage-I ALPPS).

Methods: Consecutive HCC patients who underwent ALPPS at our center between March 2017 and May 2019 were retrospectively studied. Read More

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Long-term fasting improves lipoprotein-associated atherogenic risk in humans.

Eur J Nutr 2021 May 7. Epub 2021 May 7.

Buchinger Wilhelmi Clinic, Wilhelm-Beck-Straße 27, 88662, Überlingen, Germany.

Purpose: Dyslipidemia is a major health concern associated with an increased risk of cardiovascular mortality. Long-term fasting (LF) has been shown to improve plasma lipid profile. We performed an in-depth investigation of lipoprotein composition. Read More

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A modified surgical technique for aortopexy in tracheobronchomalacia.

Interact Cardiovasc Thorac Surg 2021 May 8. Epub 2021 May 8.

Department of Cardiothoracic Surgery, Amsterdam University Medical Center location AMC, Amsterdam, Netherlands.

Objectives: Tracheobronchomalacia (TBM) is characterized by collapse of trachea, bronchi or both, leading to dyspnoea, expiratory stridor, coughing or recurrent airway infections. Surgical treatment with aortopexy is warranted for severe TBM. We describe a modified aortopexy technique with aortic wall strap sutures that evenly distributes the traction force over the full width of the aortic arch. Read More

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