Exp Neurol 2021 Jun 5:113781. Epub 2021 Jun 5.
Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Advanced Platform Technology Center, Research Service, Louis Stokes Veterans Affairs Medical Center, Cleveland, OH, USA; Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:
Objective: Stress urinary incontinence (SUI) is prevalent among older women and can result from insufficient regeneration of the pudendal nerve (PN). Electrical stimulation (ES) of the PN upregulates brain derived neurotrophic factor (BDNF) and accelerates regeneration. Using tyrosine kinase B (TrkB) to reduce the availability of free BDNF, the aim of this study was to determine if BDNF is necessary for accelerated recovery via ES in a model of SUI. Read More