32,282 results match your criteria undergoing chronic

Variations in natural polyphenols determine the anti-inflammatory potential of virgin coconut oils.

J Food Sci 2021 Apr 16. Epub 2021 Apr 16.

Department of Biochemistry, Amala Cancer Research Centre, Thrissur, Kerala, India.

Virgin coconut oil (VCO), an edible oil prepared from fresh coconut kernel by natural or mechanical means without undergoing chemical refining, has been in the limelight of research as functional food oil. The phenolic components in VCO have been accredited with these pharmacological benefits. The present study compared the phenolic constituents of freshly prepared fermentation processed (FVCO) and hot-pressed VCO (HVCO) and their anti-inflammatory efficacies. Read More

View Article and Full-Text PDF

Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD.

Sci Rep 2021 Apr 16;11(1):8359. Epub 2021 Apr 16.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Chronic obstructive pulmonary disease (COPD), an established risk factor for lung cancer, remains largely undiagnosed and untreated before lung cancer surgery. We evaluated the effect of perioperative bronchodilator therapy on lung function changes in COPD patients who underwent surgery for non-small cell lung cancer (NSCLC). From a database including NSCLC patients undergoing lung resection, COPD patients were identified and divided into two groups based on the use of bronchodilator during the pre- and post-operative period. Read More

View Article and Full-Text PDF

CD52/GPI- T-Cells Are Enriched for Alloreactive Specificity and Predict Acute Graft-Versus-Host-Disease After Stem Cell Transplantation.

Transplant Cell Ther 2021 Feb 25. Epub 2021 Feb 25.

Institute of Immunology and Immunotherapy, College of Medical and Dental Studies, University of Birmingham and Birmingham Health Partners, Birmingham, United Kingdom; Centre for Clinical Haematology, Queen Elizabeth NHS Foundation Trust and Birmingham Health Partners, Birmingham, United Kingdom.

Alemtuzumab is a CD52-specific lympho-depleting antibody. CD52- T cells emerge under alemtuzumab selection pressure. We sought to investigate the phenotype and function of the CD52- T cell fraction and related their presence to clinical outcome. Read More

View Article and Full-Text PDF
February 2021

Management of peri-prosthetic joint infection and severe bone loss after total hip arthroplasty using a long-stemmed cemented custom-made articulating spacer (CUMARS).

BMC Musculoskelet Disord 2021 Apr 16;22(1):358. Epub 2021 Apr 16.

Brighton and Sussex University Hospitals, Brighton, UK.

Background: There is little evidence on techniques for management of peri-prosthetic infection (PJI) in the context of severe proximal femoral bone loss. Custom-made articulating spacers (CUMARS) utilising cemented femoral stems as spacers was described providing better bone support and longer survival compared to conventional articulating spacers. We retrospectively report our experience managing PJI by adaptation of this technique using long cemented femoral stems where bone loss precludes use of standard stems. Read More

View Article and Full-Text PDF

Reducing Superfluous Opioid Prescribing Practices After Brain Surgery: It Is Time to Talk About Drugs.

Neurosurgery 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA.

Background: Opioids are prescribed routinely after cranial surgery despite a paucity of evidence regarding the optimal quantity needed. Overprescribing may adversely contribute to opioid abuse, chronic use, and diversion.

Objective: To evaluate the effectiveness of a system-wide campaign to reduce opioid prescribing excess while maintaining adequate analgesia. Read More

View Article and Full-Text PDF

Brain stimulation effects on serum BDNF, VEGF and TNFα in treatment resistant psychiatric disorders.

Eur J Neurosci 2021 Apr 16. Epub 2021 Apr 16.

Republican Vilnius Psychiatric Hospital, Parko str. 21, LT-11205, Vilnius, Lithuania.

Resistance to pharmacological treatment poses a notable challenge for psychiatry. Such cases are usually treated with brain stimulation techniques, including repetitive transcranial magnetic stimulation (rTMS) and electroconvulsive therapy (ECT). Empirical evidence links treatment resistance to insufficient brain plasticity and chronic inflammation. Read More

View Article and Full-Text PDF

Long-term pulmonary rehabilitation progressively reduces hospitalizations and mortality in a cohort of patients with severe and very severe copd: a 5-year follow up.

Eur J Phys Rehabil Med 2021 Apr 16. Epub 2021 Apr 16.

Internal Medicine, Institute of Thoracic Diseases School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Backgroud: Pulmonary rehabilitation (PR) is recognized as a multidisciplinary intervention designed to reduce symptoms, improve functional status, and prevent acute exacerbations in patients with chronic obstructive pulmonary disease (COPD).

Aim: This study was aimed at evaluating the effects of a long-term PR program on the hospitalization rate and mortality of patients with severe and very severe COPD.

Materials And Methods: This was a prospective study where cohorts of 195 patients undergoing a PR program were followed up for 5 years. Read More

View Article and Full-Text PDF

Posterior cruciate ligament repair with suture tape augmentation: a case series with minimum 2-year follow-up.

J Exp Orthop 2021 Apr 15;8(1):28. Epub 2021 Apr 15.

University of Stirling, Stirling, UK.

Purpose: The posterior cruciate ligament (PCL) is an important stabilizer of the knee and can be damaged in up to 20% of ligamentous injuries. Numerous techniques for surgical treatment have been described in the literature with none shown to be clearly superior. The aim of this study was to assess the 2-year outcomes of PCL repair with suture tape augmentation. Read More

View Article and Full-Text PDF

A Simple Nomogram to Predict Contrast-Induced Acute Kidney Injury in Patients with Congestive Heart Failure Undergoing Coronary Angiography.

Cardiol Res Pract 2021 23;2021:9614953. Epub 2021 Mar 23.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.

Background: Patients with congestive heart failure (CHF) are vulnerable to contrast-induced kidney injury (CI-AKI), but few prediction models are currently available. Therefore, we aimed to establish a simple nomogram for CI-AKI risk assessment for patients with CHF undergoing coronary angiography.

Methods: A total of 1876 consecutive patients with CHF (defined as New York Heart Association functional class II-IV or Killip class II-IV) were enrolled and randomly (2:1) assigned to a development cohort and a validation cohort. Read More

View Article and Full-Text PDF

Eye amputation following lifitegrast treatment for ocular graft-versus-host disease: First case report.

J Fr Ophtalmol 2021 Apr 12. Epub 2021 Apr 12.

Ophthalmology department, University Hospital of Nice, 30, voie Romaine, 06000 Nice, France. Electronic address:

Graft-versus-host disease (GVHD) is a common complication in patients undergoing allogeneic stem cell transplantation for acute myeloblastic leukemia that could be very difficult to treat. Lifitegrast 5% (Xiidra@, Novartis), a new immunosuppressive eye drop, was recently approved by the FDA for the treatment of severe dry eye and is currently under review by the European Medicines Agency. In France, lifitegrast has been approved by the French authorities for temporary use in refractory dry eye syndrome resistant to tear substitutes and topical cyclosporine. Read More

View Article and Full-Text PDF

Screening for the early detection of pulmonary arterial hypertension in patients with systemic sclerosis: A systematic review and meta-analysis of long-term outcomes.

Semin Arthritis Rheum 2021 Apr 4;51(3):495-512. Epub 2021 Apr 4.

The University of Melbourne, Victoria, Australia; The University of Melbourne, St. Vincent's Hospital, Level 3, 35 Victoria Pde, Fitzroy, Melbourne, Victoria 3065, Australia. Electronic address:

Background: Systemic sclerosis (scleroderma, SSc) is a chronic multisystem autoimmune disease characterised by fibrosis of the skin and internal organs and vasculopathy. One of the major contributors to mortality in patients with SSc is pulmonary arterial hypertension (PAH). International recommendations advise annual screening for the early detection of PAH in asymptomatic patients with SSc. Read More

View Article and Full-Text PDF

Association of acute kidney injury with outcomes in patients undergoing percutaneous left atrial appendage closure.

Catheter Cardiovasc Interv 2021 Apr 15. Epub 2021 Apr 15.

Section of Cardiology, Baylor College of Medicine, Houston, Texas.

Objectives: Using a large nationally representative database, we aimed to examine risk factors for acute kidney injury (AKI) and its association with outcomes in patients undergoing percutaneous left atrial appendage closure (LAAC).

Background: Previous small-scale studies have reported poor outcomes with AKI following percutaneous LAAC.

Methods: We queried the Nationwide Readmission Database to identify LAAC procedures performed from 2016 to 2017. Read More

View Article and Full-Text PDF

Excellent overall and chronic graft-versus-host-disease-free event-free survival in Fanconi anaemia patients undergoing matched related- and unrelated-donor bone marrow transplantation using alemtuzumab-Flu-Cy: the UK experience.

Br J Haematol 2021 Apr 14. Epub 2021 Apr 14.

Department of Bone Marrow Transplant and Haematology, Great Ormond Street Hospital for Children, London, UK.

Haematopoietic stem cell transplantation (HSCT) remains the only curative option in Fanconi anaemia (FA). We analysed the outcome of children transplanted for FA between 1999 and 2018 in the UK. A total of 94 transplants were performed in 82 patients. Read More

View Article and Full-Text PDF

Differences in the quality of life of chronic kidney disease patients undergoing hemodialysis and continuous ambulatory peritoneal dialysis.

J Public Health Res 2021 Apr 14;10(2). Epub 2021 Apr 14.

School of Nursing, Faculty of Medicine, Universitas Brawijaya, Malang.

Background: Chronic kidney disease (CKD) is defined as a progressive disease that causes renal failure and requires extended and long-term therapies. CKD patients need to choose one of these therapies to improve their quality of life. This study aims to investigate differences in the quality of life of chronic kidney disease patients undergoing hemodialysis and continuous ambulatory peritoneal dialysis (CAPD). Read More

View Article and Full-Text PDF

Characterizing chronological accumulation of comorbidities in healthy veterans: a computational approach.

Sci Rep 2021 Apr 14;11(1):8104. Epub 2021 Apr 14.

Cooperative Studies Program Epidemiology Center-Durham, Durham VA Health Care System, Durham, NC, USA.

Understanding patient accumulation of comorbidities can facilitate healthcare strategy and personalized preventative care. We applied a directed network graph to electronic health record (EHR) data and characterized comorbidities in a cohort of healthy veterans undergoing screening colonoscopy. The Veterans Affairs Cooperative Studies Program #380 was a prospective longitudinal study of screening and surveillance colonoscopy. Read More

View Article and Full-Text PDF

Risk Factors For Prolonged Opioid Use After Spine Surgery.

Global Spine J 2021 Apr 15:21925682211003854. Epub 2021 Apr 15.

Department of Orthopaedics & Rehabilitation, 12311Penn State Milton S. Hershey Medical Center, Hope Drive, Hershey, PA, USA.

Study Design: Retrospective review.

Objective: Our purpose was to evaluate factors associated with increased risk of prolonged post-operative opioid pain medication usage following spine surgery, as well as identify the risk of various post-operative complications that may be associated with pre-operative opioid usage.

Methods: The MarketScan commercial claims and encounters database includes approximately 39 million patients per year. Read More

View Article and Full-Text PDF

Efferocytosis by Paneth cells within the intestine.

Curr Biol 2021 Apr 8. Epub 2021 Apr 8.

Center for Cell Clearance, University of Virginia, Jeanette Lancaster Way, Charlottesville, VA 22908, USA; Department of Microbiology, Immunology, and Cancer Biology, Jefferson Park Avenue, University of Virginia, Charlottesville, VA 22908, USA; VIB-UGent Center for Inflammation Research, Technologiepark 71, Ghent 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium. Electronic address:

Apoptotic cells are quickly and efficiently engulfed and removed via the process of efferocytosis by either professional phagocytes, such as macrophages, or non-professional phagocytes, including epithelial cells. In addition to debris removal, a key benefit of efferocytosis is that phagocytes engulfing apoptotic cells release anti-inflammatory mediators that help reduce local tissue inflammation; conversely, accumulation of uncleared apoptotic cells predisposes to a pro-inflammatory tissue milieu. Due to their high proliferative capacity, intestinal epithelial cells (iECs) are sensitive to inflammation, irradiation, and chemotherapy-induced DNA damage, leading to apoptosis. Read More

View Article and Full-Text PDF

[Covid-19 vaccination and renal patients: overcoming unwarranted fears and re-establishing priorities].

G Ital Nefrol 2021 Apr 14;38(2). Epub 2021 Apr 14.

U.O. Nefrologia e Dialisi, Ospedale di Desio - ASST - Brianza, Desio, Italia.

The SARS-CoV-2 (Covid-19) has infected about 124 million people worldwide and the total amount of casualties now sits at a staggering 2.7 million. One enigmatic aspect of this disease is the protean nature of the clinical manifestations, ranging from total absence of symptoms to extremely severe cases with multiorgan failure and death. Read More

View Article and Full-Text PDF

Anaemia and its impact on colorectal cancer patients: how can we better optimize surgical outcomes?

ANZ J Surg 2021 Apr 13. Epub 2021 Apr 13.

Department of Colorectal Surgery, Western Health, Melbourne, Victoria, Australia.

Background: Anaemia is a common manifestation of colorectal cancer (CRC). However, appropriate workup prior to surgery and the effect of anaemia on outcomes have not been well defined. This study aimed to describe preoperative anaemia incidence, investigations performed, treatment and associated complications in a CRC surgical population at a single large tertiary institution in Australia. Read More

View Article and Full-Text PDF

Alginates as food ingredients absorb extra salt in sodium chloride-treated mice.

Heliyon 2021 Mar 23;7(3):e06551. Epub 2021 Mar 23.

Department of Cell Pathology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Honjo 1-1-1, Kumamoto, 860-8556, Kumamoto, Japan.

Many patients with impaired renal function undergoing dialysis are subject to severe dietary restrictions. Especially overdose of salt is related to crisis of their life, so their meals are basically salt-free or low salt. Therefore, their quality of life is declined due to their yearning for salty taste. Read More

View Article and Full-Text PDF

Association between postsurgical pain and heart rate variability: protocol for a scoping review.

BMJ Open 2021 Apr 13;11(4):e044949. Epub 2021 Apr 13.

Anesthesiology and Perioperative Medicine, Queen's University, Kingston, Ontario, Canada

Introduction: Surgical interventions can elicit neuroendocrine responses and sympathovagal imbalance, ultimately affecting cardiac autonomic function. Cardiac complications account for 30% of postoperative complications and are the leading cause of morbidity and mortality following non-cardiac surgery. One cardiovascular parameter, heart rate variability (HRV), has been found to be predictive of postoperative morbidity and mortality. Read More

View Article and Full-Text PDF

Opioid-free anesthesia for patients with joint hypermobility syndrome undergoing craneo-cervical fixation: a case-series study focused on anti-hyperalgesic approach.

Orphanet J Rare Dis 2021 Apr 13;16(1):172. Epub 2021 Apr 13.

Servei Central D'Anestesiología (Anestalia), Centro Médico Teknon, Carrer Vilana 12, 08022, Barcelona, Spain.

Background: Patients with Ehlers-Danlos Syndrome/Hypermobility Type (EDS-HT/JHS) and Craneo-Cervical Instability frequently suffer from severe widespread pain which is difficult to control. Chronic neuroinflammation, opioid-induced hyperalgesia, and central sensitization may explain this painful condition. The aim of this study was to determine if opioid-free anesthesia plus the postoperative administration of lidocaine, ketamine and dexmedetomidine can reduce postoperative pain and the need of methadone rescues in comparison with opioid-based management in these patients undergoing Craneo-Cervical Fixation (CCF). Read More

View Article and Full-Text PDF

Sleep quality of chronic disease patients in Depok city public hospital.

Enferm Clin 2021 Apr;31 Suppl 2:S461-S466

Faculty of Nursing Universitas Indonesia, Depok, Indonesia. Electronic address:

This study identified sleep quality and assessed its determinants in 107 patients with chronic disease. The samples are patients who were undergoing in hospitalization and outpatient setting, they have taken by cross-sectional method and then analyzed by using Chi Square and Mann-Whitney test. Poor sleep quality experienced by patients with chronic disease. Read More

View Article and Full-Text PDF

Patient Reported Outcome Measures of Health-Related Quality of Life and Asthenia after Thyroidectomy.

J Surg Res 2021 Apr 10;264:394-401. Epub 2021 Apr 10.

Department of Surgery, Division of Surgical Oncology, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address:

Background: After thyroidectomy some patients experience a chronic fatigue syndrome called asthenia. The purpose of this study was to determine the post-operative health related quality of life (HRQOL) and risk of asthenia in patients undergoing thyroidectomy.

Methods: A single institution prospective observational cohort study of adults undergoing thyroidectomy from September 2016 to July 2019 with four HRQOL surveys: preoperative baseline, 2 wk-, 6 mo- and 12 mo-postoperatively. Read More

View Article and Full-Text PDF

Association of Psychosocial Factors and Hospital Complications with Risk for Readmission After Trauma.

J Surg Res 2021 Apr 10;264:334-345. Epub 2021 Apr 10.

Harborview Injury Prevention and Research Center, University of Washington, Seattle, Washington; Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, Washington; Division of General Pediatrics, Department of Pediatrics, University of Washington, Seattle, Washington.

Background: Unplanned hospital readmissions are associated with morbidity and high cost. Existing literature on readmission after trauma has focused on how injury characteristics are associated with readmission. We aimed to evaluate how psychosocial determinants of health and complications of hospitalization combined with injury characteristics affect risk of readmission after trauma. Read More

View Article and Full-Text PDF

Spectroscopic Photoacoustic Imaging of Cartilage Damage.

Osteoarthritis Cartilage 2021 Apr 10. Epub 2021 Apr 10.

PULS/e, Dept. of Biomedical Engineering, Eindhoven University of Technology, the Netherlands; Cardiovascular Biomechanics, Dept. of Biomedical Engineering, Eindhoven University of Technology, the Netherlands. Electronic address:

Objective: Osteoarthritis (OA) is a chronic joint disease characterized by progressive degradation of cartilage. It affects more than 10% of the people aged over 60 years-old worldwide with a rising prevalence due to the increasingly aging population. OA is a major source of pain, disability, and socioeconomic cost. Read More

View Article and Full-Text PDF

Sofosbuvir-based hepatitis C therapies in patients with chronic and end-stage kidney disease.

Nephrol Dial Transplant 2021 Apr 12. Epub 2021 Apr 12.

Miller School of Medicine, University of Miami, Miami, Florida, USA.

Sofosbuvir, a nucleotide inhibitor of the hepatitis C virus (HCV) polymerase, is a component of several all-oral HCV therapies. GS-331007, sofosbuvir's predominant metabolite, is renally eliminated and accumulates 5-fold to 20-fold in patients with advanced chronic kidney disease (CKD) or undergoing hemodialysis, respectively. Pre-clinical data did not determine whether these exposures represented a risk for toxicity. Read More

View Article and Full-Text PDF

Systematic Review and Meta-Analysis of the Impact of Bariatric Surgery on Lower Urinary Tract Symptoms in Males.

Obes Surg 2021 Apr 13. Epub 2021 Apr 13.

Department of Bariatric Surgery, St Richard's Hospital, Chichester, UK.

Background: Obesity is a chronic disease with multisystem morbidity. There are multiple studies reporting the effect of bariatric surgery on cardiovascular and metabolic disease, but few examine its impact on lower urinary tract symptoms. This article aims to perform a systematic review with meta-analysis, to determine the effects of bariatric surgery on lower urinary tract symptoms in male patients. Read More

View Article and Full-Text PDF

Dupilumab reduces systemic corticosteroid use and sinonasal surgery rate in CRSwNP.

Rhinology 2021 Apr 13. Epub 2021 Apr 13.

Ghent University, Ghent, Belgium.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease with a high symptom burden and poor quality of life. Treatment options include recurrent surgeries and/or frequent systemic corticosteroids (SCS). Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin-4 and interleukin-13, key drivers of type 2-mediated inflammation. Read More

View Article and Full-Text PDF

[Balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension:a paradigmatic case report].

G Ital Cardiol (Rome) 2021 Mar;22(3):12-16

Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università degli Studi, Bologna - U.O.C. Cardiologia, Dipartimento Cardio-Toraco-Vascolare, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola, Bologna.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a complex disease where organized pulmonary thrombi and progressive vascular remodeling of the pulmonary arterial tree act synergistically to increase pulmonary vascular resistance and cause pulmonary hypertension. Balloon pulmonary angioplasty (BPA) has gained a renewed interest for the treatment of patients with CTEPH who are not undergoing surgery with pulmonary endarterectomy (PEA) or with persistent/recurrent pulmonary hypertension after PEA and has shown promising results in several observational studies conducted to date. We describe the case of a 42-year-old man with inoperable CTEPH in NYHA functional class III who normalized functional capacity, hemodynamic profile and main hemodynamic parameters after three BPA sessions. Read More

View Article and Full-Text PDF