125 results match your criteria uncoated amorphous


Elastic Behavior of NbO/AlO Core-Shell Nanowires in Terms of Short-Range-Order Structures.

ACS Appl Mater Interfaces 2021 May 14;13(20):24238-24249. Epub 2021 May 14.

Department of Materials Physics, Institute for Materials Science, University of Stuttgart, Stuttgart 70569, Germany.

Single-crystalline niobium pentoxide nanowires (NWs) of length 10-15 μm and diameter 100-200 nm are synthesized by thermal oxidation of niobium substrates in a mild vacuum (3-10 mbar). Amorphous AlO shells of varying thicknesses (10, 30, 40, and 50 nm) are deposited on top of the wires using atomic layer deposition. Bending tests of the uncoated NbO NWs and the NbO/AlO core-shell NWs are carried out inside a scanning electron microscope using a micromanipulator with a force measurement tip. Read More

View Article and Full-Text PDF

Structural insight into transmissive mutant huntingtin species by correlative light and electron microscopy and cryo-electron tomography.

Biochem Biophys Res Commun 2021 Jun 10;560:99-104. Epub 2021 May 10.

Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA; Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. Electronic address:

Aggregates of mutant huntingtin (mHTT) containing an expanded polyglutamine (polyQ) tract are hallmarks of Huntington's Disease (HD). Studies have shown that mHTT can spread between cells, leading to the propagation of misfolded protein pathology. However, the structure of transmissive mHTT species, and the molecular mechanisms underlying their transmission remain unknown. Read More

View Article and Full-Text PDF

Silicon Oxynitrophosphide Nanoscale Coating Enhances Antioxidant Marker-Induced Angiogenesis During in vivo Cranial Bone-Defect Healing.

JBMR Plus 2021 Apr 18;5(4):e10425. Epub 2021 Mar 18.

Bone-Muscle Research Center University of Texas at Arlington Arlington TX USA.

Critical-sized bone defects are challenging to heal because of the sudden and large volume of lost bone. Fixative plates are often used to stabilize defects, yet oxidative stress and delayed angiogenesis are contributing factors to poor biocompatibility and delayed bone healing. This study tests the angiogenic and antioxidant properties of amorphous silicon oxynitrophosphide (SiONPx) nanoscale-coating material on endothelial cells to regenerate vascular tissue in vitro and in bone defects. Read More

View Article and Full-Text PDF

Optimized anti-reflection core-shell microspheres for enhanced optical trapping by structured light beams.

Sci Rep 2021 Mar 2;11(1):4996. Epub 2021 Mar 2.

Department of Physics, Institute for Advanced Studies in Basic Sciences (IASBS), 45137-66731, Zanjan, Iran.

In this paper, we study the optical trapping of anti-reflection core-shell microspheres by regular Gaussian beam and several structured beams including radially polarized Gaussian, petal, and hard-aperture-truncated circular Airy beams. We show that using an appropriate anti-reflection core-shell microsphere for the optical trapping by several structured light beams can dramatically enhance the strength of the trap compared to the trapping by the common Gaussian beam. The optimal core-shell thickness ratio that minimizes the scattering force is obtained for polystyrene-silica and anatase-amorphous titania microspheres, such that the core-shells act as anti-reflection coated microspheres. Read More

View Article and Full-Text PDF

Long-Term Assessment of the In Vitro Corrosion Resistance of Biomimetic ACP Coatings Electrodeposited from an Acetate Bath.

J Funct Biomater 2021 Feb 7;12(1). Epub 2021 Feb 7.

Faculty of Science and Technology, Institute of Materials Engineering, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland.

Calcium phosphate coatings are able to improve the osseointegration process due to their chemical composition, which is similar to that of bone tissues. In this work, to increase the long-term corrosion resistance and to improve the osseointegration process of commercially pure titanium Grade 4 (CpTi G4), biomimetic amorphous calcium phosphate (ACP) coatings were electrodeposited for the first time from an acetate bath with a pH level of 7.0 and a Ca:P ratio of 1. Read More

View Article and Full-Text PDF
February 2021

Stabilisation of hollow colloidal TiO particles by partial coating with evenly distributed lobes.

Soft Matter 2021 Feb;17(6):1480-1486

Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK.

Photo-catalytically active crystalline TiO2 has attracted special attention due to its relevance for renewable energy and is typically obtained by the calcination of amorphous TiO2. However, stabilising hollow colloidal TiO2 particles against aggregation during calcination without compromising their photocatalytic activity poses two conflicting demands: to be stable their surface needs to be coated, while efficient photocatalysis requires an exposed TiO2 surface. Here, this incompatibility is resolved by partially coating TiO2 shells with evenly distributed 3-trimethoxysilyl propyl methacrylate (TPM) lobes. Read More

View Article and Full-Text PDF
February 2021

A facile and low-cost AlO coating as an artificial solid electrolyte interphase layer on graphite/silicon composites for lithium-ion batteries.

Nanotechnology 2021 Apr;32(14):144001

School of Engineering, Faculty of Applied Science, University of British Columbia, Kelowna, BC, V1V 1V7, Canada.

Graphite/silicon (G/Si) composites are considered as possible alternative anode materials to commercial graphite anodes. However, the unstable solid electrolyte interphase (SEI) on G/Si particles results in rapid capacity decay, impeding practical applications. Herein, a facile and low-cost AlO coating was developed to fabricate stable artificial SEI layers on G/Si composites. Read More

View Article and Full-Text PDF

SiCNO Coatings Enhance Endothelialization and Bactericidal activity and Reduce Blood Cell Activation.

ACS Biomater Sci Eng 2020 10 21;6(10):5571-5587. Epub 2020 Sep 21.

Materials Research Center, Indian Institute of Science, Bangalore, Karnataka 560012, India.

For biomedical applications, a number of ceramic coatings have been investigated, but the interactions with the components of living system remain unexplored for oxycarbonitride coatings. While addressing this aspect, the present study aims to provide an understanding of the biocompatibility of novel SiCNO coatings that could validate the hypothesis that such coatings may not only enhance the cell-material interaction by re-endothelialization but also can help to reduce bacterial adhesion and activation of blood cells. This work reports the physicochemical properties, hemocompatibility, endothelialization, and antibacterial properties of novel amorphous SiCNO coatings deposited on commercial pure titanium (Ti) by radiofrequency (RF) magnetron sputtering at varied nitrogen (N) flow rates. Read More

View Article and Full-Text PDF
October 2020

Anion exchange and successive ionic layer adsorption and reaction-assisted coating of BiVO with BiS to produce nanostructured photoanode for enhanced photoelectrochemical water splitting.

J Colloid Interface Sci 2021 Mar 26;585:72-84. Epub 2020 Nov 26.

Department of Materials Science and Engineering, Chungnam National University, Daejeon 34134, Republic of Korea. Electronic address:

Photoelectrochemical water splitting is an environmentally benign way to store solar energy. Properties such as fast charge recombination and poor charge transport rate severely restrict the use of BiVO as a photoanode for photoelectrochemical water splitting and many attempts were made to improve the current performance limit of the photoanode. To address these disadvantages, a highly efficient BiVO/BiS heterojunction was fabricated applying facial anion-exchange (AE) and successive ionic layer adsorption and reaction (SILAR). Read More

View Article and Full-Text PDF

On the role of alginate coating on the mechanical and biological properties of 58S bioactive glass scaffolds.

Int J Biol Macromol 2021 Jan 10;167:947-961. Epub 2020 Nov 10.

Department of Materials Science and Engineering, Faculty of Engineering & Technology, Tarbiat Modares University, P. O. Box: 14115-143, Tehran, Iran. Electronic address:

In this study, novel 3D porous alginate-coated 58S bioactive glass scaffolds were fabricated through a foam replication method using a combination of amorphous 58S bioactive glass structure and sodium alginate. The formation of the alginate coating on the surface of the struts of BG scaffolds was confirmed. The effect of alginate coating on the microstructure, mechanical properties, biodegradability, biomineralization, adhesion, viability, and differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) on the 58S BG scaffolds were evaluated. Read More

View Article and Full-Text PDF
January 2021

The Development of Minitablets for a Pediatric Dosage Form for a Combination Therapy.

J Pharm Sci 2020 12 1;109(12):3590-3597. Epub 2020 Sep 1.

Department of Pharmaceutical Sciences, Merck & Co., Inc, Kenilworth, NJ 07033, USA. Electronic address:

Minitablets are an appealing option for an age-appropriate pediatric dosage form. In particular, for combination therapies where multiple active ingredients are dosed simultaneously, the use of minitablets will enable independent adjustments of each dose. The work presented describes the development of Compound A and Compound B minitablets for a combination therapy. Read More

View Article and Full-Text PDF
December 2020

Investigation of Ag/a-C:H Nanocomposite Coatings on Titanium for Orthopedic Applications.

ACS Appl Mater Interfaces 2020 May 14;12(21):23655-23666. Epub 2020 May 14.

Research Unit Plasma Technology (RUPT), Department of Applied Physics, Faculty of Engineering & Architecture, Ghent University, Ghent 9000, Belgium.

One of the leading causes of failure for any bone implant is implant-associated infections. The implant-bone interface is in fact the crucial site of infection where both the microorganisms and cells compete to populate the newly introduced implant surface. Most of the work dealing with this issue has focused on the design of implant coatings capable of preventing infection while ignoring cell proliferation or vice versa. Read More

View Article and Full-Text PDF

Copper-enriched diamond-like carbon coatings promote regeneration at the bone-implant interface.

Heliyon 2020 Apr 25;6(4):e03798. Epub 2020 Apr 25.

Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.

There have been several attempts to design innovative biomaterials as surface coatings to enhance the biological performance of biomedical implants. The objective of this study was to design multifunctional Cu/a-C:H thin coating depositing on the Ti-6Al-4V alloy (TC4) magnetron sputtering in the presence of Ar and CH for applications in bone implants. Moreover, the impact of Cu amount and sp/sp ratio on the interior stress, corrosion behavior, mechanical properties, and tribological performance and biocompatibility of the resulting biomaterial was discussed. Read More

View Article and Full-Text PDF

Fixed dose combinations for cardiovascular treatment via coaxial electrospraying: Coated amorphous solid dispersion particles.

Int J Pharm 2020 Mar 16;577:118949. Epub 2019 Dec 16.

KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, 3000 Leuven, Belgium. Electronic address:

As a result of an aging population, the need for fixed dose combinations in the treatment of cardiovascular diseases, that are easy to swallow and administer, has been growing remarkably. In this work, the feasibility of coaxial electrospraying (CES) was investigated to manufacture in one single step, a powder of individually coated particles containing atenolol (ATE), lovastatin (LOV) and acetylsalicylic acid (ASA). To improve the dissolution rate of the poorly water soluble LOV, an amorphous solid dispersion (ASD) of LOV with Soluplus® (SOL) was formulated and Eudragit S100®, an enteric copolymer that only dissolves above pH 7, was applied as coating to avoid LOV hydrolysis in acidic medium. Read More

View Article and Full-Text PDF

Further studies on the signal enhancement effect in laser diode thermal desorption-triple quadrupole mass spectrometry using microwell surface coatings.

J Mass Spectrom 2019 Dec 11;54(12):948-956. Epub 2019 Dec 11.

Department of Chemistry, Université de Sherbrooke, Sherbrooke, Canada.

The laser diode thermal desorption (LDTD) ionization source allows ultrafast and sensitive analysis of small molecules by mass spectrometry. Signal enhancement in LDTD has been observed when coating the surface of sample microwells with a solution of ethylenediaminetetraacetic acid (EDTA) or nitrilotriacetic acid. Here we present a quantitative analysis of signal enhancement using solutions of diverse commercial proteins (lysozyme, immunoglobulin G, albumin, and fibrinogen) as coatings. Read More

View Article and Full-Text PDF
December 2019

The Preparation and Properties of Multilayer Cu-MTaO Composite Coatings on Ti6Al4V for Biomedical Applications.

Nanomaterials (Basel) 2019 Oct 21;9(10). Epub 2019 Oct 21.

School of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China.

For the enhancement of the anticorrosion and antibacterial performance of the biomedical alloy Ti6Al4V, a novel Cu incorporated multilayer TaOceramic composite coating Cu-TaO/TaO/TaO-TiO/TiO/Ti (coating codeCu-MTaO) was developed by radio frequency (RF) and direct current (DC) reactive magnetron sputtering. Meanwhile, to better display the multilayer TaO coating mentioned above, a monolayer TaO ceramic coating was deposited onto the surface of Ti6Al4V alloy as a reference. The surface morphology, microstructure, phase constituents, and elemental states of the coating were evaluated by atomic force microscopy, scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy, respectively. Read More

View Article and Full-Text PDF
October 2019

Textured Manganite Films Anywhere.

ACS Appl Mater Interfaces 2019 Oct 25;11(40):37302-37312. Epub 2019 Sep 25.

Normandie Univ, ENSICAEN, UNICAEN, CNRS, CRISMAT , 14000 Caen , France.

New paradigms are required in microelectronics when the transistor is in its downscaling limit and integration of materials presenting functional properties not available in classical silicon is one of the promising alternatives. Here, we demonstrate the possibility to grow LaSrMnO (LSMO) functional materials on amorphous substrates with properties close to films grown on single-crystalline substrates using a two-dimensional seed layer. X-ray diffraction and electron backscatter diffraction mapping demonstrate that the CaNbO nanosheet (NS) layer induces epitaxial stabilization of LSMO films with a strong out-of-plane (001) texture, whereas the growth of LSMO films on uncoated glass substrates exhibits a nontextured polycrystalline phase. Read More

View Article and Full-Text PDF
October 2019

Novel PEG-Modified Hybrid PLGA-Vegetable Oils Nanostructured Carriers for Improving Performances of Indomethacin Delivery.

Polymers (Basel) 2018 May 24;10(6). Epub 2018 May 24.

Advanced Polymer Materials Group, University Politehnica of Bucharest, 1-7 Gh Polizu Street, 011061 Bucharest, Romania.

The purpose of this work was to more exhaustively study the influence of nanocarrier matrix composition and also the polyethylene glycol (PEG)-modified surface on the performances of formulations as lipophilic drug delivery systems. Poly (d,l-lactide--glycolide), two vegetable oils (Nigella sativa oil and Echium oil) and indomethacin were employed to prepare novel PEG-coated nanocarriers through emulsion solvent evaporation method. The surface modification was achieved by physical PEG adsorption (in the post-production step). Read More

View Article and Full-Text PDF

In vitro and in vivo investigations of a-C/a-C:Ti nanomultilayer coated Ti6Al4V alloy as artificial femoral head.

Mater Sci Eng C Mater Biol Appl 2019 Jun 10;99:816-826. Epub 2019 Feb 10.

Department of Orthopedics, General Hospital of PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.

Hydrogen-free a-C/a-C:Ti nanomultilayer (a-C NM) films were deposited on medical Ti6Al4V by the magnetron sputtering technique under bias-graded voltage. Cell tests and implantations were performed for the a-C NM films coated Ti6Al4V with the uncoated Ti6Al4V as the control. The canine total hip arthroplasty (THA) surgeries were conducted for 12 dogs using the coated femoral heads, with the CoCr heads as the control. Read More

View Article and Full-Text PDF

Improving Stability and Dissolution of Amorphous Clofazimine by Polymer Nano-Coating.

Pharm Res 2019 Mar 15;36(5):67. Epub 2019 Mar 15.

School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.

Purpose: To inhibit the surface crystallization and enhance the dissolution of the basic amorphous drug clofazimine by polymer nano-coating.

Methods: The free surface of amorphous clofazimine was coated by dip coating in an alginate solution at pH 7. The stability of the coated amorphous drug against crystallization was evaluated by X-ray diffraction and light microscopy. Read More

View Article and Full-Text PDF

Effects of Silicone Oil on Electrowetting to Actuate a Digital Microfluidic Drop on Paper.

J Nanosci Nanotechnol 2018 10;18(10):7147-7150

The effects of an immiscible, lubricating polydimethylsiloxane fluid, referred to as silicone oil, on the static deformation and on the dynamic motion of a water drop on paper induced by electrowetting were investigated. The deformation of a drop on a hydrophobic film of amorphous fluoropolymers top-coated with less hydrophobic silicone oil was much more predictable, reversible and reproducible than on the uncoated surface. In the dynamic tribological experiment for a sliding drop along an inclined surface, a significant decrease in the friction coefficient, with an unexpected dependency of the contact area, was observed. Read More

View Article and Full-Text PDF
October 2018

Hexagonal MoTe with Amorphous BN Passivation Layer for Improved Oxidation Resistance and Endurance of 2D Field Effect Transistors.

Sci Rep 2018 Jun 6;8(1):8668. Epub 2018 Jun 6.

Department of Materials Science and Engineering, Advanced Materials and Manufacturing Processing Institute, University of North Texas, Denton, TX, 76203, USA.

Environmental and thermal stability of two-dimensional (2D) transition metal dichalcogenides (TMDs) remains a fundamental challenge towards enabling robust electronic devices. Few-layer 2H-MoTe with an amorphous boron nitride (a-BN) covering layer was synthesized as a channel for back-gated field effect transistors (FET) and compared to uncovered MoTe. A systematic approach was taken to understand the effects of heat treatment in air on the performance of FET devices. Read More

View Article and Full-Text PDF

Improved Battery Performance of Nanocrystalline Si Anodes Utilized by Radio Frequency (RF) Sputtered Multifunctional Amorphous Si Coating Layers.

ACS Appl Mater Interfaces 2018 Jan 10;10(3):2242-2248. Epub 2018 Jan 10.

Advanced Functional Thin Films Department, Surface Technology Division, Korea Institute of Materials Science (KIMS) , Changwon, Gyeongnam 51508, Republic of Korea.

Despite the high theoretical specific capacity of Si, commercial Li-ion batteries (LIBs) based on Si are still not feasible because of unsatisfactory cycling stability. Herein, amorphous Si (a-Si)-coated nanocrystalline Si (nc-Si) formed by versatile radio frequency (RF) sputtering systems is proposed as a promising anode material for LIBs. Compared to uncoated nc-Si (retention of 0. Read More

View Article and Full-Text PDF
January 2018

Characterization of the Adsorption Mechanism of Manganese Phosphate Conversion Coating Derived Tribofilms.

Tribol Lett 2018 12;66(4):131. Epub 2018 Sep 12.

1Laboratory for Surface Technology and Tribology, Department of Engineering Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

Casing connections in the oil and gas industry are typically coated with zinc and/or manganese phosphate for corrosion protection during storage. The presence of phosphate coatings is also known to give beneficial tribological performance. The coating allows the system to run without problems long after it is worn off. Read More

View Article and Full-Text PDF
September 2018

Influence of Substrate Heating and Nitrogen Flow on the Composition, Morphological and Mechanical Properties of SiN Coatings Aimed for Joint Replacements.

Materials (Basel) 2017 Feb 13;10(2). Epub 2017 Feb 13.

Materials in Medicine group, Division of Applied Materials Science, Department of Engineering Sciences, Uppsala University, Uppsala 752 37, Sweden.

Silicon nitride (SiN) coatings are promising for joint replacement applications due to their high wear resistance and biocompatibility. For such coatings, a higher nitrogen content, obtained through an increased nitrogen gas supply, has been found to be beneficial in terms of a decreased dissolution rate of the coatings. The substrate temperature has also been found to affect the composition as well as the microstructure of similar coatings. Read More

View Article and Full-Text PDF
February 2017

Solid state properties and drug release behavior of co-amorphous indomethacin-arginine tablets coated with Kollicoat® Protect.

Eur J Pharm Biopharm 2017 Oct 8;119:150-160. Epub 2017 Jun 8.

Div. of Pharmaceutical Technology, Dept. of Chemistry, University of Hamburg, Bundesstraße 45, 20146 Hamburg, Germany. Electronic address:

A promising approach to improve the solubility of poorly water-soluble drugs and to overcome the stability issues related to the plain amorphous form of the drugs, is the formulation of drugs as co-amorphous systems. Although polymer coatings have been proven very useful with regard to tablet stability and modifying drug release, there is little known on coating co-amorphous formulations. Hence, the aim of the present study was to investigate whether polymer coating of co-amorphous formulations is possible without inducing recrystallization. Read More

View Article and Full-Text PDF
October 2017

Mucoadhesive amorphous solid dispersions for sustained release of poorly water soluble drugs.

Eur J Pharm Biopharm 2017 Apr 11;113:157-167. Epub 2017 Jan 11.

College of Pharmacy, The University of Texas at Austin, 2409 University Avenue, A1920, Austin, TX 78712, USA.

The oral delivery of mucoadhesive patches has been shown to enhance the absorption of large molecules such as peptides. We hypothesized that this mechanism could have utility for poorly soluble small molecules by utilizing a mucoadhesive polymer as the matrix for an amorphous solid dispersion. Binary dispersions of itraconazole and carbomer (Carbopol 71G) were prepared utilizing a thermokinetic mixing process (KinetiSol Dispersing) and the physicochemical properties were investigated by powder X-ray diffraction, calorimetry, and liquid chromatography. Read More

View Article and Full-Text PDF

Enhancing the osteoblastic differentiation through nanoscale surface modifications.

J Biomed Mater Res A 2017 02 31;105(2):498-509. Epub 2016 Oct 31.

Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito exterior s/n, Ciudad Universitaria, México D.F., 04510, México.

Human mesenchymal stem cells (MSCs) showed larger differentiation into osteoblasts on nanoscale amorphous titanium oxide (TiO ) coatings in comparison to polycrystalline TiO coatings or native oxide layers. In this article, we showed that the subtle alterations in the surface properties due to a different atomic ordering of titanium oxide layers could substantially modify the osteoblastic differentiation of MSCs. Amorphous (a) and polycrystalline (c) TiO coatings were deposited on smooth (PT) and microstructured sandblasted/acid-etched (SLA) Ti substrates using a magnetron sputtering system. Read More

View Article and Full-Text PDF
February 2017

Hydroxyapatite coating on PEEK implants: Biomechanical and histological study in a rabbit model.

Mater Sci Eng C Mater Biol Appl 2016 Nov 15;68:723-731. Epub 2016 Jun 15.

Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, United States. Electronic address:

A bioactive two-layer coating consisting of hydroxyapatite (HA) and yttria-stabilized zirconia (YSZ) was investigated on cylindrical polyetheretherketone (PEEK) implants using ion beam assisted deposition (IBAD). Post-deposition heat treatments via variable frequency microwave annealing with and without subsequent autoclaving were used to crystallize the as-deposited amorphous HA layer. Microstructural analysis, performed by TEM and EDS, showed that these methods were capable of crystallizing HA coating on PEEK. Read More

View Article and Full-Text PDF
November 2016

Quercetin-Loaded Solid Lipid Nanoparticle Dispersion with Improved Physicochemical Properties and Cellular Uptake.

AAPS PharmSciTech 2017 Apr 1;18(3):875-883. Epub 2016 Jul 1.

College of Pharmacy, Gachon University, 191 Hambakmoero, Incheon, 406-799, South Korea.

The objective of this study was to formulate and characterize properties of solid lipid nanoparticle (SLN) dispersion containing quercetin. SLN was prepared by ultrasonication method using tripalmitin and lecithin as lipid core and then the surface was coated with chitosan. Entrapment efficiency was greater than 99%, and mean particle size of SLN was 110. Read More

View Article and Full-Text PDF