22,327 results match your criteria uncertainty model


Impact of China's waste import policy on the scrap copper recovery pattern and environmental benefits.

Waste Manag 2021 Sep 22;135:287-297. Epub 2021 Sep 22.

Research Center for Central China Economic and Social Development, Nanchang University, Nanchang 330031, PR China; School of Economics and Management, Nanchang University, Nanchang 330031, PR China. Electronic address:

The international trade weight of scrap copper has exceeded 6 million tons annually over the past two decades. China introduced the "National Sword" policy in 2017, which brought uncertainty to the international recycling of scrap copper. We use the international scrap copper trade figures from 1998 to 2019 in UN Comtrade, and seek to analyze the impact of China's import ban by setting up a difference-in-differences (DID) model based on the gravity model. Read More

View Article and Full-Text PDF
September 2021

[Surgery or not on an atypical breast lesion? Taking anxiety into account in shared decision support from a prospective cohort of 300 patients].

Gynecol Obstet Fertil Senol 2021 Sep 22. Epub 2021 Sep 22.

Université de Bordeaux, Bordeaux Population Health (U1219), Equipe Méthodes pour la Recherche Interventionnelle en Santé des Populations (MéRISP), France.

Introduction: Organized and individual breast screening have been accompanied by an increase in the detection of "atypical breast lesions "(ABL). Recently, the NOMAT multicenter study proposed a predictive model of the risk of developing breast cancer after detection of an ABL in order to avoid surgical removal of "low-risk" lesions. It also aimed to provide information on psychological experience, in particularly anxiety, to assist in the shared medical decision process. Read More

View Article and Full-Text PDF
September 2021

Periodically aperiodic pattern of SARS-CoV-2 mutations underpins the uncertainty of its origin and evolution.

Environ Res 2021 Sep 22:112092. Epub 2021 Sep 22.

Department of Molecular Medicine and USF Health Byrd Alzheimer's Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA; Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy pereulok, 9, Dolgoprudny, 141700, Russia. Electronic address:

Various lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have contributed to prolongation of the coronavirus disease 2019 (COVID-19) pandemic. Several non-synonymous mutations in SARS-CoV-2 proteins have generated multiple SARS-CoV-2 variants. In our previous report, we have shown an evenly uneven distribution of unique protein variants of SARS-CoV-2 is geo-location or demography-specific. Read More

View Article and Full-Text PDF
September 2021

Mapping of static magnetic fields near the surface of mobile phones.

Sci Rep 2021 Sep 24;11(1):19002. Epub 2021 Sep 24.

Department of Radiobiology, Cancer Research Institute, Biomedical Research Center, University Science Park for Biomedicine, Slovak Academy of Sciences, Bratislava, Slovakia.

Whether the use of mobile phones (MP) represents a health hazard is still under debate. As part of the attempts to resolve this uncertainty, there has been an extensive characterization of the electromagnetic fields MP emit and receive. While the radiofrequencies (RF) have been studied exhaustively, the static magnetic fields (SMF) have received much less attention, regardless of the fact there is a wealth of evidence demonstrating their biological effects. Read More

View Article and Full-Text PDF
September 2021

Improved speciation profiles and estimation methodology for VOCs emissions: A case study in two chemical plants in eastern China.

Environ Pollut 2021 Sep 17;291:118192. Epub 2021 Sep 17.

School of the Environment and State Key Laboratory of Pollution Control and Resource Reuse, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu, 210023, China; Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (CICAEET), Nanjing University of Information Science and Technology, Jiangsu, 210044, China.

Volatile organic compounds (VOCs) poses a serious health risk through not only their own toxicity but also their role as precursors of ozone and secondary organic aerosols. The chemical industry, as one of the pillar industries in eastern China, is a key source of VOCs emissions. In this study, speciated VOCs emissions were measured in two chemical plants in eastern China. Read More

View Article and Full-Text PDF
September 2021

Tutorial for $DESIGN in NONMEM: Clinical Trial Evaluation and Optimization.

CPT Pharmacometrics Syst Pharmacol 2021 Sep 24. Epub 2021 Sep 24.

This NONMEM tutorial shows how to evaluate and optimize clinical trial designs, using algorithms developed in design software such as PopED and PFIM 4.0. Parameter precision and model parameter estimability is obtained by assessing the Fisher Information Matrix (FIM), providing expected model parameter uncertainty. Read More

View Article and Full-Text PDF
September 2021

Intolerance of Uncertainty: From Transdiagnostic Model to Clinical Management.

Authors:
Patrizia Amici

Psychiatr Danub 2021 Sep;33(Suppl 9):22-25

via Garibaldi, 3, 24030 Mapello (BG), Italy,

The Covid-19 pandemic has brought out in some individuals an intolerance of uncertainty in their current circumstances. Intolerance of uncertainty is a transdiagnostic process that envisages future events as threatening and undesirable, with which the individual has little or no ability to cope. This makes such individuals more vulnerable to worry and negative emotions, as well as to developing various disorders. Read More

View Article and Full-Text PDF
September 2021

DynaNet: Neural Kalman Dynamical Model for Motion Estimation and Prediction.

IEEE Trans Neural Netw Learn Syst 2021 Sep 24;PP. Epub 2021 Sep 24.

Dynamical models estimate and predict the temporal evolution of physical systems. State-space models (SSMs) in particular represent the system dynamics with many desirable properties, such as being able to model uncertainty in both the model and measurements, and optimal (in the Bayesian sense) recursive formulations, e.g. Read More

View Article and Full-Text PDF
September 2021

The deep hip muscles are unlikely to contribute to hip stability in the sagittal plane during walking: a stiffness approach.

IEEE Trans Biomed Eng 2021 Sep 24;PP. Epub 2021 Sep 24.

- Objective: This study determined whether the deep hip muscles could contribute to hip stability.

Methods: Hip stability was defined as rotational hip stiffness in the sagittal plane, which was calculated for walking trials for 12 participants via electromyography (EMG)informed neuromusculoskeletal modelling that included all 22 hip spanning muscles. Three model configurations were compared that differed in the excitations of the deep hip muscles, but were identical in the excitations of all other muscles: (1) deep hip muscles informed by intramuscular EMG measurements (assisted activation); (2) deep hip muscles with simulated zero activation (no activation); (3) deep hip muscles with simulated maximal activation (maximal activation). Read More

View Article and Full-Text PDF
September 2021

Predictors of acute deep venous thrombosis in patients hospitalized for COVID-19.

Medicine (Baltimore) 2021 Sep;100(38):e27216

Department of Radiology, Weill Cornell Medicine, New York, NY.

Abstract: Deep venous thrombosis (DVT) is associated with high mortality in coronavirus disease 2019 (COVID-19) but there remains uncertainty about the benefit of anti-coagulation prophylaxis and how to decide when ultrasound screening is indicated. We aimed to determine parameters predicting which COVID-19 patients are at risk of DVT and to assess the benefit of prophylactic anti-coagulation.Adult hospitalized patients with positive severe acute respiratory syndrome coronavirus-2 reverse transcription-polymerase chain reaction (RT-PCR) undergoing venous duplex ultrasound for DVT assessment (n = 451) were retrospectively reviewed. Read More

View Article and Full-Text PDF
September 2021

Extending density surface models to include multiple and double-observer survey data.

PeerJ 2021 2;9:e12113. Epub 2021 Sep 2.

Integrated Statistics, Woods Hole, MA, United States of America.

Spatial models of density and abundance are widely used in both ecological research (., to study habitat use) and wildlife management (, for population monitoring and environmental impact assessment). Increasingly, modellers are tasked with integrating data from multiple sources, collected different observation processes. Read More

View Article and Full-Text PDF
September 2021

Non-invasive positive airway pressure therapy for improving erectile dysfunction in men with obstructive sleep apnoea.

Cochrane Database Syst Rev 2021 Sep 23;9:CD013169. Epub 2021 Sep 23.

Cochrane Afilliate Rio de Janeiro, Cochrane, Petrópolis, Brazil.

Background: Obstructive sleep apnoea syndrome (OSAS) is associated with several chronic diseases, including erectile dysfunction (ED). The association of OSAS and ED is far more common than might be found by chance; the treatment of OSAS with non-invasive positive airway pressure therapy is associated with improvement of respiratory symptoms, and may contribute to the improvement of associated conditions, such as ED.

Objectives: To assess the effectiveness and acceptability of non-invasive positive airway pressure therapy for improving erectile dysfunction in OSAS. Read More

View Article and Full-Text PDF
September 2021

A Mixed-Methods Study of Teaching Health Center Residents' Experiences of Mentorship, Career Planning, and Post-Residency Practice Environments.

Acad Med 2021 Sep 21. Epub 2021 Sep 21.

J.H. Strasser is senior research scientist, Fitzhugh Mullan Institute for Health Workforce Equity, Department of Health Policy and Management, George Washington University Milken Institute School of Public Health, Washington, DC. M.M. Jewers is co-founder and vice president, Open Avenues Foundation, and chief operating officer, Project Alianza, Boston, Massachusetts. H. Kepley is deputy director, National Center for Health Workforce Analysis, Bureau of Health Workforce, Health Resources and Services Administration, Rockville, Maryland. C. Chen is an associate professor of health policy and management, Fitzhugh Mullan Institute for Health Workforce Equity, Department of Health Policy and Management, George Washington University Milken Institute School of Public Health, Washington, DC. C. Erikson is deputy director, Health Workforce Research Center on Health Professions Education and Training, Fitzhugh Mullan Institute for Health Workforce Equity, Department of Health Policy and Management, George Washington University Milken Institute School of Public Health, Washington, DC. M. Regenstein is professor, Department of Health Policy and Management, George Washington University Milken Institute School of Public Health, Washington, DC.

Purpose: The Teaching Health Center (THC) Graduate Medical Education program enables primary care physicians to train in community-based, underserved settings by shifting the payment structure and training environment for graduate medical education. To understand how THCs have successfully trained primary care physicians who practice in community-based settings, the authors conducted a mixed methods exploratory study to examine THC residency graduates' experiences of mentorship and career planning during their residencies, perceptions of preparation for post-residency practice, and how these experiences were related to post-residency practice environments.

Method: Surveys were conducted for all 804 graduating THC residents nationally, 2014-2017 (533, 66% response rate). Read More

View Article and Full-Text PDF
September 2021

Evaluating the long-term impact of projected climate on rice-lentil-groundnut cropping system in Lower Gangetic Plain of India using crop simulation modelling.

Int J Biometeorol 2021 Sep 23. Epub 2021 Sep 23.

ICAR-Central Research Institute for Dryland Agriculture, Santoshnagar, Hyderabad, 500 059, Telangana, India.

Most simulations of food production in response to various climates to date have used simulations of the same crop over multiple years. This study evaluated the impact of projected climate on performance of rice-lentil-groundnut cropping sequence in New Alluvial Zone of West Bengal, India, using DSSAT model. The study period consisted of baseline (1980-2010), mid-century (2040-2069) and end-century (2070-2099). Read More

View Article and Full-Text PDF
September 2021

Treatment for Severe Lupus Nephritis: A Cost-Effectiveness Analysis in China.

Front Pharmacol 2021 6;12:678301. Epub 2021 Sep 6.

Division of Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Lupus nephritis (LN) is the most common secondary glomerular diseases that will cause end-stage renal disease (ESRD) and renal-related death. The cost-effectiveness of various treatments for LN recommended by official guidelines has not been investigated in China. Our study is to evaluate clinical prognosis and cost-effectiveness of the current treatments for severe LN. Read More

View Article and Full-Text PDF
September 2021

Stochastic modeling of geometrical uncertainties on complex domains, with application to additive manufacturing and brain interface geometries.

Comput Methods Appl Mech Eng 2021 Nov 30;385. Epub 2021 Jun 30.

Department of Electrical and Computer Engineering, Purdue University, IN, 47907, USA.

We present a stochastic modeling framework to represent and simulate spatially-dependent geometrical uncertainties on complex geometries. While the consideration of random geometrical perturbations has long been a subject of interest in computational engineering, most studies proposed so far have addressed the case of regular geometries such as cylinders and plates. Here, standard random field representations, such as Kahrunen-Loève expansions, can readily be used owing, in particular, to the relative simplicity to construct covariance operators on regular shapes. Read More

View Article and Full-Text PDF
November 2021

The opportunity of patient-journey studies for academic clinical research in oncology.

BMJ Open 2021 Sep 22;11(9):e052871. Epub 2021 Sep 22.

Clinical Trial Unit, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy.

A wave of new treatments and treatment combinations are becoming available for solid tumours. Trials performed to obtain registration establish a positive benefit-risk but unavoidably leave many questions unanswered on place-in-therapy and the relative efficacy of different treatment sequences. Such limitations create problems in terms of strength of treatment guidelines and reimbursement (in countries where a public payer exists). Read More

View Article and Full-Text PDF
September 2021

Achieving broad absorption band and high incident angles by stochastically-distributed oblique-flat-sheet metamaterial perfect absorbers.

Sci Rep 2021 Sep 21;11(1):18713. Epub 2021 Sep 21.

Department of Materials Engineering, Ming Chi University of Technology, New Taipei, 24301, Taiwan, ROC.

In this work, we integrated a periodic seed layer and oblique deposition method to fabricate a stochastically-distributed oblique-flat-sheet metamaterial perfect absorber (MPA). Such design could increase its absorption bandwidth and tolerance to high angle-incidence due to the fact that various oblique flat sheets offer different resonance conditions while even a single oblique flat sheet could provide different optical paths for resonance. On the other hand, a seed layer could reduce uncertainty regarding to direct oblique deposition and provide abilities to manipulate the bandwidth of the MPA. Read More

View Article and Full-Text PDF
September 2021

Do regionally targeted lockdowns alter movement to non-lockdown regions? Evidence from Ontario, Canada.

Health Place 2021 Sep 18:102668. Epub 2021 Sep 18.

Faculty of Health Disciplines, Athabasca University, Athabasca, Alberta, Canada.

Regionally targeted interventions are being used by governments to slow the spread of COVID-19. In areas where free movement is not being actively restricted, there is uncertainty about how effective such regionally targeted interventions are due to the free movement of people between regions. We use mobile-phone network mobility data to test two hypotheses: 1) do regions targeted by exhibit increased outflows into other regions and 2) do regions targeted by interventions increase outflows specifically into areas with lesser restrictions. Read More

View Article and Full-Text PDF
September 2021

Transport and lymphatic uptake of monoclonal antibodies after subcutaneous injection.

Microvasc Res 2021 Sep 18:104228. Epub 2021 Sep 18.

School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA. Electronic address:

Subcutaneous injection has emerged to become a feasible self-administration practice for biotherapeutics due to the patient comfort and cost effectiveness. However, the available knowledge about transport and absorption of these agents after subcutaneous injection, is limited. Here, a mathematical framework to study the subcutaneous drug delivery of mAbs from injection to lymphatic uptake is presented. Read More

View Article and Full-Text PDF
September 2021

Naomi: a new modelling tool for estimating HIV epidemic indicators at the district level in sub-Saharan Africa.

J Int AIDS Soc 2021 Sep;24 Suppl 5:e25788

Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention, Lilongwe, Malawi.

Introduction: HIV planning requires granular estimates for the number of people living with HIV (PLHIV), antiretroviral treatment (ART) coverage and unmet need, and new HIV infections by district, or equivalent subnational administrative level. We developed a Bayesian small-area estimation model, called Naomi, to estimate these quantities stratified by subnational administrative units, sex, and five-year age groups.

Methods: Small-area regressions for HIV prevalence, ART coverage and HIV incidence were jointly calibrated using subnational household survey data on all three indicators, routine antenatal service delivery data on HIV prevalence and ART coverage among pregnant women, and service delivery data on the number of PLHIV receiving ART. Read More

View Article and Full-Text PDF
September 2021

Achieving consistency in measures of HIV-1 viral suppression across countries: derivation of an adjustment based on international antiretroviral treatment cohort data.

J Int AIDS Soc 2021 Sep;24 Suppl 5:e25776

UNAIDS, Geneva, Switzerland.

Introduction: The third of the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 targets is to achieve a 90% rate of viral suppression (HIV viral load <1000 HIV-1 RNA copies/ml) in patients on antiretroviral treatment (ART) by 2020. However, some countries use different thresholds when reporting viral suppression, and there is thus a need for an adjustment to standardize estimates to the <1000 threshold. We aim to propose such an adjustment, to support consistent monitoring of progress towards the "third 90" target. Read More

View Article and Full-Text PDF
September 2021

A Model-Based Framework to Inform the Dose Selection and Study Design of Emicizumab for Pediatric Patients with Hemophilia A.

J Clin Pharmacol 2021 Sep 21. Epub 2021 Sep 21.

Genentech Inc., South San Francisco, CA, USA.

Emicizumab is a bispecific antibody mimicking the cofactor function of activated coagulation factor VIII to prevent bleeds in patients with hemophilia A. The dose selection for the first-in-child phase III study of emicizumab was addressed by pediatric pharmacokinetic prediction using an adult/adolescent population pharmacokinetic model developed in phase I-I/II studies. The model was modified to incorporate functions describing the age-dependent increase in body weight (BW) with or without clearance maturation to account for the differences in emicizumab pharmacokinetics between adults/adolescents and children. Read More

View Article and Full-Text PDF
September 2021

Design of an Interactive Web Application for Teaching Uncertainty Interpretations of Clinical Tests.

Stud Health Technol Inform 2021 Sep;283:156-162

Chair of Medical Informatics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background: Assessing the uncertainty of diagnostic findings is essential for advising patients. Previous research has demonstrated the difficulty of computing the expected correctness of positive or negative results, although clinical decision support (CDS) tools promise to facilitate adequate interpretations.

Objectives: To teach the potential utility of CDS tools to medical students, we designed an interactive software module that computes and visualizes relevant probabilities from typical inputs. Read More

View Article and Full-Text PDF
September 2021

Capturing the dynamics of small populations: a retrospective assessment using long-term data for an island reintroduction.

J Anim Ecol 2021 Sep 21. Epub 2021 Sep 21.

Institute of Zoology, Zoological Society of London, Regent's Park, London, UK.

The art of population modelling is to incorporate factors essential for capturing a population's dynamics while otherwise keeping the model as simple as possible. However, it is unclear how optimal model complexity should be assessed, and whether this optimal complexity has been affected by recent advances in modelling methodology. This issue is particularly relevant to small populations because they are subject to complex dynamics but inferences about those dynamics are often constrained by small sample sizes. Read More

View Article and Full-Text PDF
September 2021

A hybrid framework for improving uncertainty quantification in deep learning-based QSAR regression modeling.

J Cheminform 2021 Sep 20;13(1):69. Epub 2021 Sep 20.

Shanghai Key Laboratory of Forensic Medicine, Academy of Forensic Science, Shanghai, 200063, China.

Reliable uncertainty quantification for statistical models is crucial in various downstream applications, especially for drug design and discovery where mistakes may incur a large amount of cost. This topic has therefore absorbed much attention and a plethora of methods have been proposed over the past years. The approaches that have been reported so far can be mainly categorized into two classes: distance-based approaches and Bayesian approaches. Read More

View Article and Full-Text PDF
September 2021

Efficient uncertainty quantification for Monte Carlo dose calculations using importance (re-)weighting.

Phys Med Biol 2021 Sep 20. Epub 2021 Sep 20.

Department of Medical Physics in Radiation Oncology, Deutsches Krebsforschungszentrum, Heidelberg, GERMANY.

To present an efficient uncertainty quantification method for range and set-up errors in Monte Carlo (MC) dose calculations. Further, we show that uncertainty induced by interplay and other dynamic influences may be approximated using suitable error correlation models.We introduce an importance (re-)weighting method in MC history scoring to concurrently construct estimates for error scenarios, the expected dose and its variance from a single set of MC simulated particle histories. Read More

View Article and Full-Text PDF
September 2021

Measuring the COVID-19 Mortality Burden in the United States : A Microsimulation Study.

Ann Intern Med 2021 Sep 21. Epub 2021 Sep 21.

University of Southern California, Los Angeles, California, and National Bureau of Economic Research, Cambridge, Massachusetts (D.L.).

Background: Fully assessing the mortality burden of the COVID-19 pandemic requires measuring years of life lost (YLLs) and accounting for quality-of-life differences.

Objective: To measure YLLs and quality-adjusted life-years (QALYs) lost from the COVID-19 pandemic, by age, sex, race/ethnicity, and comorbidity.

Design: State-transition microsimulation model. Read More

View Article and Full-Text PDF
September 2021

Increasing the spatial and temporal impact of ecological research: A roadmap for integrating a novel terrestrial process into an Earth system model.

Glob Chang Biol 2021 Sep 20. Epub 2021 Sep 20.

Department of Natural Resources and the Environment, University of New Hampshire, Durham, 03824.

Terrestrial ecosystems regulate Earth's climate through water, energy, and biogeochemical transformations. Despite a key role in regulating the Earth system, terrestrial ecology has historically been underrepresented in the Earth system models (ESMs) that are used to understand and project global environmental change. Ecology and Earth system modeling must be integrated for scientists to fully comprehend the role of ecological systems in driving and responding to global change. Read More

View Article and Full-Text PDF
September 2021

Cost-effectiveness analysis of domiciliary topical sevoflurane for painful leg ulcers.

PLoS One 2021 20;16(9):e0257494. Epub 2021 Sep 20.

Department of Anesthesiology, Complejo Hospitalario Universitario, Albacete, Spain.

Objectives: The general anesthetic sevoflurane is being repurposed as a topical analgesic for painful chronic wounds. We conducted a Bayesian cost-effectiveness analysis (CEA) comparing the addition of domiciliary topical sevoflurane to conventional analgesics (SEVOFLURANE, n = 38) versus conventional analgesics alone (CONVENTIONAL, n = 26) for the treatment of nonrevascularizable painful leg ulcers in an outpatient Pain Clinic of a Spanish tertiary hospital.

Methods: We used real-world data collected from charts to conduct this CEA from a public healthcare perspective and with a one-year time horizon. Read More

View Article and Full-Text PDF
September 2021