13,552 results match your criteria umbilical artery

High-Dose Compared With Standard-Dose Oxytocin Regimens to Augment Labor in Nulliparous Women: A Randomized Controlled Trial.

Obstet Gynecol 2021 May 6. Epub 2021 May 6.

Yale School of Medicine, New Haven, Connecticut; Northwestern University Feinberg School of Medicine, Northwestern University, and Northwestern Memorial Hospital, Chicago, Illinois; and the University of California, San Francisco, San Francisco, California.

Objective: To evaluate whether a high-dose oxytocin regimen reduces the risk for primary cesarean birth and other obstetric morbidities when compared with standard dosing.

Methods: In a double-blind randomized clinical trial of nulliparous women at or beyond 36 weeks of gestation who were undergoing augmentation of labor, participants were assigned to high-dose (initial and incremental rates of 6 milliunits/min) or standard-dose (initial and incremental rates of 2 milliunits/min) oxytocin regimens. The primary outcome was cesarean birth. Read More

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Nationwide survey (Japan) on spontaneous hemoperitoneum in pregnancy.

J Obstet Gynaecol Res 2021 May 4. Epub 2021 May 4.

Department of Obstetrics and Gynecology, Mie University School of Medicine, Mie, Japan.

Aim: The purpose of this study was to evaluate the current state and clinical characteristics of spontaneous hemoperitoneum in pregnancy (SHiP) in Japan by performing a comprehensive survey.

Methods: We reviewed data on pregnant women who developed SHiP during 2013-2017 (for 5 years), and were admitted to any of the perinatal centers in Japan. The survey assessed maternal background and maternal and neonatal prognosis. Read More

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Influence of the second stage of labor on maternal and neonatal outcomes in vaginal births after caesarean section: a multicenter study in Germany.

BMC Pregnancy Childbirth 2021 May 4;21(1):356. Epub 2021 May 4.

Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany.

Background: The American College of Obstetricians and Gynecologists (ACOG) introduced a new standard of care in 2014, extending the duration of the second stage of labor in order to reduce caesarean delivery (CD) rates and its severe complications. The aim of the present study is to evaluate success rates of trial of labor after caesarean section (TOLAC), as well as maternal and neonatal outcomes after the establishment of the recent guidelines.

Methods: A retrospective study was performed at two large departments in Germany from January 2008 to January 2018. Read More

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Effect of lncRNA-ATB/miR-651-3p/Yin Yang 1 pathway on trophoblast-endothelial cell interaction networks.

J Cell Mol Med 2021 May 4. Epub 2021 May 4.

Department of Obstetrics and Gynecology, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.

Our previous studies have confirmed that lncRNA-ATB may be involved in the pathogenesis of preeclampsia, however, it is uncertain whether lncRNA-ATB influence the interaction between trophoblast and endothelial cells, which is crucial to the uterine spiral artery remodelling. Scratch wound healing and transwell invasion assay were conducted to test the migration and invasion of trophoblast cells. Co-culture model was used to simulate the physiological environment in vivo. Read More

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Obstetric Outcomes in Singleton Pregnancies with Abnormal Placental Cord Insertions.

Am J Perinatol 2021 May 2. Epub 2021 May 2.

Division of Maternal-Fetal Medicine, Washington University in St. Louis, Missouri.

Objective:  There is wide variation in the management of pregnancies complicated by abnormal placental cord insertion (PCI), which includes velamentous cord insertion (VCI) and marginal cord insertion (MCI). We tested the hypothesis that abnormal PCI is associated with small for gestational age (SGA) infants.

Study Design:  This is a retrospective cohort study of all pregnant patients undergoing anatomic ultrasound at a single institution from 2010 to 2017. Read More

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Mermaid syndrome associated with VACTERL-H syndrome.

Folia Med (Plovdiv) 2021 Apr;63(2):272-276

Medical University of Plovdiv, Plovdiv, Bulgaria.

Mermaid syndrome or sirenomelia is an extremely rare congenital malformation with an incidence between 1.5 and 4.2 per 1,000,000 pregnancies. Read More

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Case Report: Congenital Arthrogryposis and Unilateral Absences of Distal Arm in Congenital Zika Syndrome.

Front Med (Lausanne) 2021 13;8:499016. Epub 2021 Apr 13.

Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Yucatan, Mexico.

Zika virus was recognized as a teratogen in 2015, when prenatal Zika infection was associated with neonatal microcephaly. The transmission, virulence, tropism, and consequences of Zika virus infection during pregnancy are currently studied. Decreased neural progenitor cells, arrest in neuronal migration and/or disruption of the maturation process of the fetus central nervous system have been associated. Read More

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Oxytocin Administration in Low-Risk Women, a Retrospective Analysis of Birth and Neonatal Outcomes.

Int J Environ Res Public Health 2021 Apr 20;18(8). Epub 2021 Apr 20.

Research Group in Global Health, Gender and Society (GHenderS), Universitat Ramon Llull, Carrer Padilla 326, 08025 Barcelona, Spain.

Background: In recent years, higher than the recommended rate of oxytocin use has been observed among low-risk women. This study examines the relationship between oxytocin administration and birth outcomes in women and neonates.

Methods: A retrospective analysis of birth and neonatal outcomes for women who received oxytocin versus those who did not. Read More

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Use of the Renal Artery Doppler to Identify Small for Gestational Age Fetuses at Risk for Adverse Neonatal Outcomes.

J Clin Med 2021 Apr 23;10(9). Epub 2021 Apr 23.

Department of Women and Child Heath, University of Padua School of Medicine, 35122 Padova, Italy.

Objective: To measure the sensitivity and positive predictive value (PPV) for an adverse neonatal outcome among growth-restricted fetuses (FGR) comparing the cerebral-placental ratio (CPR) with the cerebral-renal ratio (CRR).

Methods: Retrospective analysis of 92 women who underwent prenatal ultrasound at the University of Maryland and the University of Padua. Renal, middle cerebral and umbilical artery Doppler waveforms were recorded for all scans during the third trimester. Read More

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Sustained Maternal Smoking Triggers Endothelial-Mediated Oxidative Stress in the Umbilical Cord Vessels, Resulting in Vascular Dysfunction.

Antioxidants (Basel) 2021 Apr 9;10(4). Epub 2021 Apr 9.

Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, H-6701 Szeged, Hungary.

Nitric oxide (NO) bioavailability is fundamental in the regulation of redox balance and functionality of the endothelium, especially in the case of the umbilical cord (UC), which has no innervation. The analysis of UC vessel-related complications could serve as a useful tool in the understanding of the pathophysiological mechanisms leading to neonatal cardiovascular disorders. Therefore, the aim of this study was to characterize the mechanisms that rule the severity of prenatal endothelial dysfunction, induced by the long-term effect of maternal smoking. Read More

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Analgesic efficacy of remifentanil patient-controlled analgesia versus combined spinal-epidural technique in multiparous women during labour.

Ginekol Pol 2021 Apr 29. Epub 2021 Apr 29.

Institute of Anatomy, Faculty of Medicine, University of Ljubljana, Slovenia.

Objectives: To compare the analgesic profile of remifentanil patient-controlled analgesia (RPCA) and combined spinal-epidural analgesia technique (CSEA) in multiparous women during the entire labour. We hypothesized that CSEA would provide a better and more sustained pain reduction than RPCA.

Material And Methods: A prospective observational trial under ID NCT02963337 at a university hospital in Slovenia 2017-2018. Read More

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Galectin-3 Derived from HucMSC Exosomes Promoted Myocardial Fibroblast-to-Myofibroblast Differentiation Associated with -catenin Upregulation.

Int J Stem Cells 2021 Apr 30. Epub 2021 Apr 30.

School of Medicine, Jiangsu University, Zhenjiang, China.

Background And Objectives: Galectin-3 promotes fibroblast-to-myofibroblast differentiation and facilitates injury repair. Previous studies have shown that exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-ex) promote the differentiation of myocardial fibroblasts into myofibroblasts under inflammatory environment. Whether hucMSC-ex derived Galectin-3 (hucMSC-ex-Galectin-3) plays an important role in fibroblast-to-myofibroblast differentiation is the focus of this study. Read More

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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Regulate Macrophage Polarization to Attenuate Systemic Lupus Erythematosus-Associated Diffuse Alveolar Hemorrhage in Mice.

Int J Stem Cells 2021 Apr 30. Epub 2021 Apr 30.

Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China.

Background And Objectives: To investigate the effect and the underlying mechanism of exosomes secreted by human umbilical cord mesenchymal stem cells (hUCMSCs) on diffuse alveolar hemorrhage (DAH) in murine lupus.

Methods And Results: Exosomes were extracted from cultured hUCMSCs by ultracentrifugation. The expressions of exosome markers (Alix, CD63 and TSG101) were measured for identification of hUCMSC-derived exosomes (hUCMSC-exosomes). Read More

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Doppler ultrasound in pregnancy - quality requirements of DEGUM and clinical application (part 2).

Ultraschall Med 2021 Apr 27. Epub 2021 Apr 27.

Obstetrics and Prenatal Medicine, University Hospital, Bonn, Germany.

This second part on Doppler sonography in prenatal medicine and obstetrics reviews its clinical applications. While this has not become the initially anticipated screening tool, it is used for the diagnosis and surveillance of a variety of fetal pathologies. For example, the sonography-based determination of uterine artery blood flow indices is an important parameter for the first trimester multimodal preeclampsia risk assessment, increasing accuracy and providing indication for the prophylactic treatment with aspirin. Read More

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How to define late Fetal growth Restriction.

Minerva Obstet Gynecol 2021 Apr 27. Epub 2021 Apr 27.

Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic), IDIBAPS, University of Barcelona, Barcelona, Spain -

A fraction of third-trimester small fetuses does not achieve their endowed growth potential mainly due to placental insufficiency, usually not evident in terms of impaired umbilical artery Doppler, but severe enough to increase the risk of perinatal adverse outcomes and long-term complications. The identification of those fetuses at higher-risk helps to optimize their follow-up and to decrease the risk of intrauterine demise. Several parameters can help in the identification of those fetuses at higher risk, defined as Fetal Growth Restricted (FGR) fetuses. Read More

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Sirenomelia: two case reports.

J Med Case Rep 2021 Apr 26;15(1):217. Epub 2021 Apr 26.

Medical Genetics Center of Genome, No 54319, Genome Building, Mohtasham St., Isfahan, Iran.

Background: Sirenomelia, also called mermaid syndrome, is a rare lethal multi-system congenital deformity with an incidence of one in 60,000-70,000 pregnancies. Sirenomelia is mainly characterized by the fusion of lower limbs and is widely associated with severe urogenital and gastrointestinal malformations. The presence of a single umbilical artery derived from the vitelline artery is the main anatomical feature distinguishing sirenomelia from caudal regression syndrome. Read More

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Prevalence of umbilical artery Doppler waveform abnormality during the early second trimester and the subsequent variation of waveforms in monochorionic diamniotic twin pregnancies: A prospective cohort study.

J Obstet Gynaecol Res 2021 Apr 25. Epub 2021 Apr 25.

Department of Maternal Fetal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan.

Aim: To investigate the prevalence of qualitative abnormal umbilical artery Doppler waveforms (Abnormal UA) during the early second trimester and the subsequent variation of waveforms in monochorionic diamniotic (MCDA) twin pregnancies.

Methods: This prospective cohort study included 153 MCDA twin pregnancies. Pulsed Doppler examinations for UA were performed at four points, including the free-loop (FL) and near the placental cord insertion site (CI) of each UA, between 16 and 17 weeks' gestation. Read More

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Temporary pacemaker implantation through umbilical vein in a low birth weight neonate with congenital complete heart block.

Cardiol Young 2021 Apr 23:1-3. Epub 2021 Apr 23.

Department of Pediatric Cardiology, Max Superspeciality Hospital, Saket, Delhi, India.

Congenital heart block is a rare and lethal condition in paediatric population associated with maternal connective tissue disorders and rarely with structural cardiac disease like atrioventricular canal defects with or without left isomerism and congenitally corrected transposition of great arteries. Pacing in neonate if indicated is generally accomplished by epicardial pacing systems. However, in cases of significant bradycardia and haemodynamic instability, temporary pacemaker implantation via transvenous approach remains as a suitable option. Read More

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Effects of colloid preload on the incidence of hypotension in spinal anesthesia for cesarean section: a systematic review and meta-analysis.

Chin Med J (Engl) 2021 Apr 20;134(9):1043-1051. Epub 2021 Apr 20.

Department of Anesthesia, China-Japan Friendship Hospital, Beijing, China.

Background: Hypotension is a common complication caused by spinal anesthesia (SA), which may have adverse impacts on the condition of the parturient and fetus. Liquid infusion was found to be relatively effective for reducing the incidence of hypotension. However, the question of whether colloid preload can optimize hemodynamic variables in the cesarean section remains controversial. Read More

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Perinatal outcomes and factors affecting the survival rate of fetuses with twin-to-twin transfusion syndrome treated with fetoscopic laser coagulation: a single-center seven-year experience.

J Matern Fetal Neonatal Med 2021 Apr 20:1-12. Epub 2021 Apr 20.

Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, Seoul, Republic of Korea.

Objectives: This single-center study aimed to assess the perinatal outcomes and its associated factors in fetuses with twin-to-twin transfusion syndrome (TTTS) treated by fetoscopic laser coagulation (FLC).

Methods: In this retrospective study, we included fetuses prenatally diagnosed with TTTS at Asan Medical Center, Seoul, Korea, between October 2011 and December 2018. All patients with TTTS stage II or higher and those with stage I TTTS coupled with symptomatic polyhydramnios or cardiac dysfunction were eligible for FLC. Read More

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Velamentous cord insertion ruptured during labour leading to acute fetal blood loss.

BMJ Case Rep 2021 Apr 19;14(4). Epub 2021 Apr 19.

Integrated Women's Health, St Luke's International Hospital, Tokyo, Japan.

Umbilical cord rupture (UCR) in utero is a very rare and critical emergency that can cause fetal death within minutes. A 38-year-old nulliparous woman was admitted at 39 weeks in labour. Sudden watery vaginal discharge and bleeding with a rapid drop in the fetal heart rate to 60 beats/min necessitated an emergency caesarean section. Read More

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Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3.

Theranostics 2021 12;11(11):5404-5417. Epub 2021 Mar 12.

The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, 250012 Jinan, China.

Abnormal autophagic death of endothelial cells is detrimental to plaque structure as endothelial loss promotes lesional thrombosis. As emerging functional biomarkers, circular RNAs (circRNAs) are involved in various diseases, including cardiovascular. This study is aimed to determine the role of hsa_circ_0030042 in abnormal endothelial cell autophagy and plaque stability. Read More

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Doppler studies of placental function.

Placenta 2021 Apr 2;108:91-96. Epub 2021 Apr 2.

Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, And Center for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.

Placental-associated diseases account for most cases of adverse perinatal outcome in developing countries. Doppler evaluation has been incorporated as a predictive parameter at early pregnancy for high-risk placental disease, in the diagnosis and management of those fetuses with impaired intrauterine growth and for the evaluation of fetal wellbeing in those high-risk pregnancies. Uterine Doppler at second trimester predicts most instances of early-onset preeclampsia and intrauterine growth restriction. Read More

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Umbilical Cord Ulcerations with Naked Umbilical Artery.

J Pediatr 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan.

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Wiad Lek 2021 ;74(1):28-34


Objective: The aim: Improving perinatal outcomes in pregnant women at high risk of intrauterine infection by developing diagnostic criteria and algorithms for managing pregnancy and childbirth.

Patients And Methods: Materials and methods: The study of pregnancy and childbirth was conducted in 72 patients at high risk of IUI, which formed the main group. The control group consisted of 64 patients with a low infectious risk of IUI. Read More

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Predicting fetal and neonatal demise after fetoscopy for twin-twin transfusion syndrome using recursive partitioning.

Prenat Diagn 2021 Apr 13. Epub 2021 Apr 13.

Department of Obstetrics, Gynecology and Reproductive Sciences, The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical School, Fetal Center at Children's Memorial Hermann Hospital, Houston, Texas, USA.

Objective: Donor demise after laser surgery for twin-twin transfusion syndrome (TTTS) is well-characterized, but recipient demise is not, nor is neonatal death. This study aims to characterize factors associated with recipient death, donor death, and dual twin death after laser, both before and after birth.

Methods: This is a prospective cohort study of monochorionic twin pairs who underwent laser ablation for TTTS. Read More

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Five-vessel umbilical cord and fetal outcome: an obstetric overview.

J Matern Fetal Neonatal Med 2021 Apr 13:1-4. Epub 2021 Apr 13.

Department of Obstetrics and Gynaecology, ASTT LECCO, Ospedale Leopoldo Mandic, Lecco, Italy.

Purpose: The birth of a child with an increased number of blood vessels in the umbilical cord (UC) is a rare event and has been previously reported to be associated with a higher incidence of congenital anomalies.

Methods: A case of a healthy female infant with an intra-uterine growth restriction (IUGR), born from a bicornuate uterus at 37 weeks of gestation and weighing 2500 g with a diagnosis of five-vessel UC made post-natally, on gross examination of the UC and confirmed by histopathological examination is documented. In particular, sections from the UC showed four umbilical arteries (UA) and one umbilical vein (UV). Read More

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The expression of ATP-sensitive potassium channels in human umbilical arteries with severe pre-eclampsia.

Sci Rep 2021 Apr 12;11(1):7955. Epub 2021 Apr 12.

Department of Obstetrics, The Affiliated Hospital of Southwest Medical University, No.8 Kangcheng Road, Luzhou, 646000, Sichuan Province, China.

The aim of this study is to establish the expression of ATP-sensitive potassium channels(KATP) in human umbilical arteries with severe pre-eclampsia. Real-time quantitative PCR and western blotting were used to detect the mRNA and protein expression levels of KATP channel subunits Kir6.1 and SUR2B in human umbilical arteries from normal pregnant and those with severe pre-eclampsia, early onset severe pre-eclampsia and late onset severe pre-eclampsia. Read More

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Different modes of delivery and hormonal stress response.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Chair and Department of Biopharmacy, Faculty of Pharmacy, Medical Univeristy of Lodz, Poland.

Objectives: The aim of the study was to determine how the type of delivery affects the stress response cycle and the level of cortisol, progesterone and corticoliberin.

Material And Methods: The study was conducted among 26 pregnant women admitted to the Gynecology and Obstetrics Ward due to an approaching delivery date or the onset of labor. The participants were aged between 20 and 41 years, with a mean age of approximately 30 years. Read More

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Cardiotocograph (CTG) changes and maternal and neonatal outcomes in chorioamnionitis and/or funisitis confirmed on histopathology.

Eur J Obstet Gynecol Reprod Biol 2021 May 30;260:183-188. Epub 2021 Mar 30.

Global Academy of Medical Education & Training, London & Consultant Intrapartum Care Advisor, Basildon University Hospital, Mid and South Essex NHS Foundation Trust, Essex, UK. Electronic address:

Objective: To assess the cardiotocographic changes and maternal and neonatal outcomes in cases of chorioamnionitis and or funisitis confirmed on histopathology.

Study Design: A retrospective analysis of histopathology reports confirming chorioamnionitis and/or funisitis was carried out from 2014 to 2020 in a single centre. The preterm births (<37 weeks) were excluded. Read More

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