37,664 results match your criteria ultrasound derived


Longitudinal evaluation of five nasopharyngeal carcinoma animal models on the microPET/MR platform.

Eur J Nucl Med Mol Imaging 2021 Dec 4. Epub 2021 Dec 4.

Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Purpose: We longitudinally evaluated the tumour growth and metabolic activity of three nasopharyngeal carcinoma (NPC) cell line models (C666-1, C17 and NPC43) and two xenograft models (Xeno76 and Xeno23) using a micropositron emission tomography and magnetic resonance (microPET/MR). With a better understanding of the interplay between tumour growth and metabolic characteristics of these NPC models, we aim to provide insights for the selection of appropriate NPC cell line/xenograft models to assist novel drug discovery and evaluation.

Methods: Mice were imaged by F-deoxyglucose ([F]FDG) microPET/MR twice a week for consecutive 3-7 weeks. Read More

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December 2021

Nanoparticle theranostics in cardiovascular inflammation.

Semin Immunol 2021 Nov 30:101536. Epub 2021 Nov 30.

Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy. Electronic address:

Theranostics, literally derived from the combination of the words diagnostics and therapy, is an emerging field of clinical and preclinical research, where contrast agents, drugs and diagnostic techniques are combined to simultaneously diagnose and treat pathologies. Nanoparticles are extensively employed in theranostics due to their potential to target specific organs and their multifunctional capacity. In this review, we will discuss the current state of theranostic nanomedicine, providing key examples of its application in the imaging and treatment of cardiovascular inflammation. Read More

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November 2021

Estimated fetal weight at mid-gestation in prediction of pre-eclampsia in singleton pregnancies.

Ultrasound Obstet Gynecol 2021 Dec 3. Epub 2021 Dec 3.

Fetal Medicine Research Institute, King's College Hospital, London, UK.

Objective: To examine the distribution of birthweight with gestational age in pregnancies complicated by preeclampsia (PE) and examine the potential value of sonographic estimated fetal weight (EFW) at mid-gestation as a predictor of PE.

Methods: The data for this study were derived from prospective screening for adverse obstetric outcomes in 93,911 women with singleton pregnancies attending for routine pregnancy care at 19+0 to 24+6 weeks' gestation in two UK maternity hospitals. This visit included recording of maternal demographic characteristics and medical history, sonographic EFW and measurement of mean arterial pressure (MAP) and uterine artery pulsatility index (UtA-PI). Read More

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December 2021

Effect of Intranodally Administered Dendritic Cell-Based HIV Vaccine in Combination With Pegylated Interferon α-2a on Viral Control Following ART Discontinuation: A Phase 2A Randomized Clinical Trial.

Front Immunol 2021 11;12:767370. Epub 2021 Nov 11.

Infectious Diseases Department-HIV Unit, Hospital Clínic Barcelona, Barcelona, Spain.

Introduction: Functional cure has been proposed as an alternative to lifelong antiretroviral therapy and therapeutic vaccines represent one of the most promising approaches.

Materials And Methods: We conducted a double-blind randomized placebo-controlled clinical trial to evaluate the safety, immunogenicity, and effect on viral dynamics of a therapeutic vaccine produced with monocyte-derived dendritic cells (MD-DC) loaded with a high dose of heat-inactivated autologous (HIA) HIV-1 in combination with pegylated interferon alpha 2a (IFNα-2a) in people with chronic HIV-1.

Results: Twenty-nine male individuals on successful ART and with CD4+ ≥450 cells/mm were randomized 1:1:1:1 to receive three ultrasound-guided inguinal intranodal immunizations, one every 2 weeks: (1) vaccine ~10 MD-DC pulsed with HIA-HIV-1 (10 HIV RNA copies) ( = 8); (2) vaccine plus three doses of 180 mcg IFNα-2a at weeks 4-6 ( = 6); (3) placebo = saline ( = 7); and (4) placebo plus three doses of 180 mcg IFNα-2a ( = 8). Read More

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November 2021

Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function genes.

Eur Respir J 2021 Dec 2. Epub 2021 Dec 2.

Department of Physiology, and Department of Cardiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

Mutations in have been found in patients with congenital heart disease-associated pulmonary arterial hypertension (CHD-PAH). Our study aimed to clarify whether deficient BMPR2 signalling acts through downstream effectors, inhibitors of DNA-binding proteins (IDs), during heart development to contribute to the progress of PAH in CHD patients. To confirm that IDs are downstream effectors of BMPR2 signalling in cardiac mesoderm progenitors (CMPs) and contribute to PAH, we generated Cardiomyocytes (CMs)-specific knockout mice (Ids cDKO), and 12/25 developed mild PAH with altered haemodynamic indices and pulmonary vascular remodelling. Read More

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December 2021

High prevalence of hepatic steatosis and hepatic fibrosis in patients with type 2 diabetes mellitus.

Clin Nutr ESPEN 2021 Dec 6;46:519-526. Epub 2021 Sep 6.

Fortis C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, Chirag Enclave, Nehru Place, New Delhi, India; Centre of Nutrition & Metabolic Research (C-NET), National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Diabetes Foundation (India), SDA, New Delhi, India; Fortis Flt. Lt. Rajan Dhall Hospital, Vasant Kunj, New Delhi, India. Electronic address:

Aim: To determine the prevalence of hepatic steatosis and fibrosis in patients with T2DM from North India.

Research Design And Methods: In this cross-sectional study, Asian Indian patients with T2DM (n,250) underwent liver ultrasonography (USG), Fibroscan for assessment of hepatic steatosis (Controlled Attenuation Parameter, CAP) and hepatic fibrosis (Kilopascals, kPa) respectively. Pearson's correlation analysis & logistic regression analysis for significant predictors of hepatic steatosis and fibrosis were done. Read More

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December 2021

The validity of ultrasound-derived equation models to predict whole-body muscle mass: A systematic review.

Clin Nutr ESPEN 2021 Dec 11;46:133-141. Epub 2021 Sep 11.

Vrije Universiteit Brussel, Faculty of Physical Education and Physiotherapy, Department Physiotherapy and Human Anatomy, Research Unit Experimental Anatomy, Laarbeeklaan 103, 1090, Brussels, Belgium.

Background & Aims: Sarcopenia is defined as the age-related loss in muscle quantity and quality which is associated with physical disability. The assessment of muscle quantity plays a role in the diagnosis of sarcopenia. However, the methods used for this assessment have many disadvantages in daily practice and research, like high costs, exposure to radiation, not being portable, or doubtful reliability. Read More

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December 2021

[Differential diagnosis of pure ground glass nodules in lung with spectral CT imaging].

Zhonghua Yi Xue Za Zhi 2021 Dec;101(45):3742-3747

Department of Imaging, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.

To evaluate the differential diagnostic performance of quantitative parameters derived from the spectral CT imagingin pure ground-glass nodules. A total of 44 patients with pure ground glass nodules underwent chest energy spectrum CT and with known subsequently pathological findings in the Imaging Department of the Second Affiliated Hospital of Soochow University from August 2017 to September 2019 were retrospectively analyzed. Among them, there are 18 males and 26 females, aged from 26 to 79 (51±12) years. Read More

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December 2021

Effects of obesity on left atrial phasic functions in patients with chronic ischemic heart disease and preserved left ventricular ejection fraction without recent myocardial infarction: a two-dimensional speckle-tracking echocardiography study.

J Ultrasound 2021 Dec 2. Epub 2021 Dec 2.

Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Karegar Shomali Street, Tehran, I.R. of Iran.

Purpose: Left atrial (LA) phasic functions in various subgroups of subjects with obesity are differently impaired, suggesting that obesity may have diverse effects in dissimilar subgroups of subjects with obesity. We aimed to compare the effects of obesity on LA phasic functions in patients suffering from chronic ischemic heart disease with a preserved left ventricular ejection fraction and without a recent myocardial infarction.

Methods: In our cross-sectional study, 145 consecutive candidates for isolated coronary artery bypass graft (CABG) surgery were divided according to the presence of obesity into 2 groups: obese (36 patients) and nonobese (103 patients), and LA phasic functions were evaluated by two-dimensional speckle-tracking echocardiography (2D STE). Read More

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December 2021

Noninvasive assessment of hepatic steatosis using a pathologic reference standard: comparison of CT, MRI, and US-based techniques.

Ultrasonography 2021 Oct 25. Epub 2021 Oct 25.

Department of Radiology, Seoul National University Hospital, Seoul, Korea.

Purpose: The present study compared the performance of computed tomography (CT), magnetic resonance imaging-derived proton density fat fraction (MRI-PDFF), controlled attenuation parameter (CAP), grayscale ultrasonography (US), and attenuation imaging (ATI) for the diagnosis of hepatic steatosis (HS).

Methods: In total, 120 prospectively recruited patients who underwent hepatic resection between June 2018 and June 2020 were retrospectively analyzed. CT, MRI-PDFF, CAP, grayscale US, and ATI were performed within 3 months before surgery. Read More

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October 2021

Improved performance and consistency of deep learning 3D liver segmentation with heterogeneous cancer stages in magnetic resonance imaging.

PLoS One 2021 1;16(12):e0260630. Epub 2021 Dec 1.

Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut, United States of America.

Purpose: Accurate liver segmentation is key for volumetry assessment to guide treatment decisions. Moreover, it is an important pre-processing step for cancer detection algorithms. Liver segmentation can be especially challenging in patients with cancer-related tissue changes and shape deformation. Read More

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December 2021

Spectral fundus autofluorescence peak emission wavelength in ageing and AMD.

Acta Ophthalmol 2021 Dec 1. Epub 2021 Dec 1.

Department of Ophthalmology, University Hospital Jena, Jena, Germany.

Purpose: To investigate the spectral characteristics of fundus autofluorescence (FAF) in AMD patients and controls.

Methods: Fundus autofluorescence spectral characteristics was described by the peak emission wavelength (PEW) of the spectra. Peak emission wavelength (PEW) was derived from the ratio of FAF recordings in two spectral channels at 500-560 nm and 560-720 nm by fluorescence lifetime imaging ophthalmoscopy. Read More

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December 2021

Reference values for fetal Doppler-based cardiocirculatory indices in monochorionic-diamniotic twin pregnancy.

BMC Pregnancy Childbirth 2021 Nov 30;21(1):797. Epub 2021 Nov 30.

Siriraj Fetal Therapy Center (SiFTC), Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Siriraj, Bangkoknoi, Bangkok, 10700, Thailand.

Background: Placental anastomoses in monochorionic diamniotic (MCDA) twin pregnancy have a major impact on fetal circulation. This study was designed to define reference ranges of cardiac and vascular Doppler indices in MCDA twin pregnancies.

Methods: This cross-sectional study included 442 uncomplicated MCDA twin fetuses undergoing Doppler ultrasonography at 18-35 weeks of gestation. Read More

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November 2021

Trends in the application of deep learning networks in medical image analysis: Evolution between 2012 and 2020.

Eur J Radiol 2021 Nov 24;146:110069. Epub 2021 Nov 24.

School of Health Management, China Medical University, Shenyang, Liaoning 110122, PR China.

Purpose: To evaluate the general rules and future trajectories of deep learning (DL) networks in medical image analysis through bibliometric and hot spot analysis of original articles published between 2012 and 2020.

Methods: Original articles related to DL and medical imaging were retrieved from the PubMed database. For the analysis, data regarding radiological subspecialties; imaging techniques; DL networks; sample size; study purposes, setting, origins and design; statistical analysis; funding sources; authors; and first authors' affiliation was manually extracted from each article. Read More

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November 2021

A biomimetic nanocomposite made of a ginger-derived exosome and an inorganic framework for high-performance delivery of oral antibodies.

Nanoscale 2021 Nov 30. Epub 2021 Nov 30.

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province 110016, PR China.

For inflammatory bowel disease (IBD) therapy, systemic exposure of anti-TNF-α antibodies brought by current clinical injection always causes serious adverse effects. Colon-targeted delivery of anti-TNF-α antibodies through the oral route is of great importance but remains a formidable challenge. Here, we reported a biomimetic nanocomposite made of a ginger-derived exosome and an inorganic framework for this purpose. Read More

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November 2021

Risk of fetal loss after chorionic villus sampling in twin pregnancies derived from propensity score matching analysis.

Ultrasound Obstet Gynecol 2021 Nov 29. Epub 2021 Nov 29.

Fetal Medicine Research Institute, King's College Hospital, London, UK.

Objective: To estimate the risk of fetal loss associated to chorionic villus sampling (CVS) in twin pregnancies using propensity score analysis.

Methods: This was a multicenter cohort study performed in eight fetal-medicine units in which the leadership were trained at the Harris Birthright Research Centre for fetal medicine in London and the protocols for screening, invasive testing and pregnancy management are similar. The study population of 8581 twin pregnancies undergoing ultrasound examination at 11-13 weeks' gestation, included 445 twin pregnancies that had CVS. Read More

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November 2021

Machine learning-based prediction of invisible intraprostatic prostate cancer lesions on  Ga-PSMA-11 PET/CT in patients with primary prostate cancer.

Eur J Nucl Med Mol Imaging 2021 Nov 30. Epub 2021 Nov 30.

Department of Nuclear Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.

Purpose:  Ga-PSMA PET/CT has high specificity and sensitivity for the detection of both intraprostatic tumor focal lesions and metastasis. However, approximately 10% of primary prostate cancer are invisible on PSMA-PET (exhibit no or minimal uptake). In this work, we investigated whether machine learning-based radiomics models derived from PSMA-PET images could predict invisible intraprostatic lesions on  Ga-PSMA-11 PET in patients with primary prostate cancer. Read More

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November 2021

Vaginal cysts: An important differential diagnosis in the anterior compartment.

Eur J Obstet Gynecol Reprod Biol 2021 Nov 22;267:280-284. Epub 2021 Nov 22.

Department of Gynaecology, St. Georg Hospital of Eisenach, Academic Teaching Hospital of Jena University, Germany; Women's University Hospital of Jena, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.

Introduction: Benign anterior-vaginal-wall cysts (0.5-1% prevalence) often mimic other structures (e.g. Read More

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November 2021

Whole-body diffusion-weighted MRI of normal lymph nodes: prospective apparent diffusion coefficient histogram and nodal distribution analysis in a healthy cohort.

Cancer Imaging 2021 Nov 27;21(1):64. Epub 2021 Nov 27.

Department of Diagnostic Radiology, Institute of Cancer Research and The Royal Marsden NHS, Foundation Trust, Downs Road, Sutton, London, Surrey, SM2 5PT, UK.

Background: Whole body DWI (WB-DWI) enables the identification of lymph nodes for disease evaluation. However, quantitative data of benign lymph nodes across the body are lacking to allow meaningful comparison of diseased states. We evaluated apparent diffusion coefficient (ADC) histogram parameters of all visible lymph nodes in healthy volunteers on WB-DWI and compared differences in nodal ADC values between anatomical regions. Read More

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November 2021

Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases.

Diagn Pathol 2021 Nov 27;16(1):112. Epub 2021 Nov 27.

Department of Pathology, Xijing Hospital, 4th Military Medical University, No. 169 Chang Le Xi Road,, Xi'an, 710032, Shaanxi, China.

Background: Medullary thyroid carcinoma (MTC) is a malignant tumor derived from C cells. It accounts for about 10% of all thyroid malignancies. More than 14 histological variants have been described. Read More

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November 2021

Correction to: Multilineage differentiation of muscle-derived stem cells from GFP transgenic mice.

Biotechnol Lett 2021 Nov 27. Epub 2021 Nov 27.

Department of Orthopaedics, The Affiliated Hospital of Guiyang Medical College, Guiyang, 550004, China.

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November 2021

L. Pruning Waste for Bud-Preparations as Source of Phenolic Compounds-Traditional and Innovative Extraction Techniques to Produce New Natural Products.

Plants (Basel) 2021 Oct 20;10(11). Epub 2021 Oct 20.

Department of Agriculture, Forestry and Food Science, University of Torino, Largo Braccini 2, 10095 Grugliasco, Italy.

Herbal products are now considered among the most important sources of phenolic compounds: the FINNOVER project aimed at the creation and development of sustainable supply chains to extract and use natural biologically active agents. is one of the most utilised herbal products derived from buds and sprouts as polyphenolic food supplements for its homeostatic and astringent properties. This research was aimed to describe the antioxidant capacity and the phytochemical composition of herbal products by the application of spectroscopic and chromatographic fingerprints considering phenolics as potential markers to significantly differentiate traditional preparations (macerates) from innovative extracts obtained by an ultrasound extraction from buds. Read More

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October 2021

Evaluation of the Predictive Role of Blood-Based Biomarkers in the Context of Suspicious Prostate MRI in Patients Undergoing Prostate Biopsy.

J Pers Med 2021 Nov 19;11(11). Epub 2021 Nov 19.

Department of Urology, Medical University of Vienna, 1090 Vienna, Austria.

The aim of this study was to assess the predictive value of pre-biopsy blood-based markers in patients undergoing a fusion biopsy for suspicious prostate magnetic resonance imaging (MRI). We identified 365 consecutive patients who underwent MRI-targeted and systematic prostate biopsy for an MRI scored Prostate Imaging-Reporting and Data System Version (PI-RADS) ≥ 3. We evaluated the neutrophil/lymphocyte ratio (NLR), derived neutrophil/lymphocyte ratio (dNLR), platelet/lymphocyte ratio (PLR), systemic immune inflammation index (SII), lymphocyte/monocyte ratio (LMR,) de Ritis ratio, modified Glasgow Prognostic Score (mGPS), and prognostic nutrition index (PNI). Read More

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November 2021

Can Deep Learning-Based Volumetric Analysis Predict Oxygen Demand Increase in Patients with COVID-19 Pneumonia?

Medicina (Kaunas) 2021 Oct 22;57(11). Epub 2021 Oct 22.

Department of Diagnostic Radiology, Tokyo Medical and Dental University Hospital of Medicine, Tokyo 113-8510, Japan.

: This study aimed to investigate whether predictive indicators for the deterioration of respiratory status can be derived from the deep learning data analysis of initial chest computed tomography (CT) scans of patients with coronavirus disease 2019 (COVID-19). : Out of 117 CT scans of 75 patients with COVID-19 admitted to our hospital between April and June 2020, we retrospectively analyzed 79 CT scans that had a definite time of onset and were performed prior to any medication intervention. Patients were grouped according to the presence or absence of increased oxygen demand after CT scan. Read More

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October 2021

A Fast Bubble Detection Method in Microtubes Based on Pulsed Ultrasound.

Micromachines (Basel) 2021 Nov 15;12(11). Epub 2021 Nov 15.

School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710049, China.

In the process of biological microfluidic manipulation, the bubbles generated in the tube will seriously reduce the gauging accuracy. This paper introduces an improving method that can estimate the size of microbubbles in real time. Hence, the measurement data of the liquid volume can be modified according to this method. Read More

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November 2021

FTIR Spectroscopic Imaging Supports Urine Cytology for Classification of Low- and High-Grade Bladder Carcinoma.

Cancers (Basel) 2021 Nov 16;13(22). Epub 2021 Nov 16.

Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, 30-387 Krakow, Poland.

Bladder urothelial carcinoma (BC) is a common, recurrent, life-threatening, and unpredictable disease which is difficult to diagnose. These features make it one of the costliest malignancies. Although many possible diagnostic methods are available, molecular heterogeneity and difficulties in cytological or histological examination induce an urgent need to improve diagnostic techniques. Read More

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November 2021

Raman Imaging and Fluorescence Lifetime Imaging Microscopy for Diagnosis of Cancer State and Metabolic Monitoring.

Cancers (Basel) 2021 Nov 13;13(22). Epub 2021 Nov 13.

Department for Medical Technologies and Regenerative Medicine, Institute of Biomedical Engineering, University of Tübingen, 72076 Tübingen, Germany.

Hurdles for effective tumor therapy are delayed detection and limited effectiveness of systemic drug therapies by patient-specific multidrug resistance. Non-invasive bioimaging tools such as fluorescence lifetime imaging microscopy (FLIM) and Raman-microspectroscopy have evolved over the last decade, providing the potential to be translated into clinics for early-stage disease detection, in vitro drug screening, and drug efficacy studies in personalized medicine. Accessing tissue- and cell-specific spectral signatures, Raman microspectroscopy has emerged as a diagnostic tool to identify precancerous lesions, cancer stages, or cell malignancy. Read More

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November 2021

U SO CARE-The Impact of Cardiac Ultrasound during Cardiopulmonary Resuscitation: A Prospective Randomized Simulator-Based Trial.

J Clin Med 2021 Nov 9;10(22). Epub 2021 Nov 9.

Department of Intensive Care, University Hospital, 4031 Basel, Switzerland.

Background: Actual cardiopulmonary resuscitation (CPR) guidelines recommend point-of-care ultrasound (POCUS); however, data on POCUS during CPR are sparse and conflicting. This randomized trial investigated the effects of POCUS during CPR on team performance and diagnostic accuracy.

Methods: Intensive Care and Emergency Medicine residents performed CPR with or without available POCUS in simulated cardiac arrests. Read More

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November 2021

Sequential Extraction of Hydroxytyrosol, Mannitol and Triterpenic Acids Using a Green Optimized Procedure Based on Ultrasound.

Antioxidants (Basel) 2021 Nov 7;10(11). Epub 2021 Nov 7.

Department of Chemical, Environmental and Materials Engineering, Universidad de Jaén, Campus Las Lagunillas, S/N, 23071 Jaén, Spain.

Olive-derived biomasses contain bioactive compounds with health promoting effects as well as antioxidant and sweet-tasting properties. However, their sequential extraction has not been attained. In the present study, firstly antioxidants and mannitol were extracted from exhausted olive pomace (EOP) by an eco-friendly method, ultrasound-assisted water extraction (UAWE). Read More

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November 2021

Ten Fast Transfer Learning Models for Carotid Ultrasound Plaque Tissue Characterization in Augmentation Framework Embedded with Heatmaps for Stroke Risk Stratification.

Diagnostics (Basel) 2021 Nov 15;11(11). Epub 2021 Nov 15.

Stroke Diagnostic and Monitoring Division, AtheroPoint™ LLC, Roseville, CA 95661, USA.

Only 1-2% of the internal carotid artery asymptomatic plaques are unstable as a result of >80% stenosis. Thus, unnecessary efforts can be saved if these plaques can be characterized and classified into symptomatic and asymptomatic using non-invasive B-mode ultrasound. Earlier plaque tissue characterization (PTC) methods were machine learning (ML)-based, which used hand-crafted features that yielded lower accuracy and unreliability. Read More

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November 2021