21,384 results match your criteria ulcers tumors

Hydropenia may accelerates the progression of orthotopic bladder cancer induced by N-methyl-N-nitrosourea by increasing the expression levels of AQP1, AQP3, and AQP4.

Transl Androl Urol 2021 Jun;10(6):2447-2453

Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Urology, Shanghai, China.

Background: Increasing evidence has demonstrated aquaporins (AQPs) to be critical players in carcinogenesis. Here, we aimed to explore the role of hydropenia in the progression of bladder cancer (BCa), as well as to assess the expression of AQP1, AQP3, and AQP4 in bladder tissues from hydropenic and N-methyl-N-nitrosourea (MNU)-treated rats.

Methods: An orthotopic BCa model was induced by administering Sprague Dawley rats with MNU. Read More

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Giant Pilomatrical Tumor With Broad Epidermal Components: An Example of Histological Diversity and a Potential Diagnostic Pitfall of Tumors With Pilomatrical Differentiation.

Am J Dermatopathol 2021 Jul 20. Epub 2021 Jul 20.

Departments of Diagnostic Pathology, and Dermatology, Kyoto University Hospital, Kyoto, Japan; Department of Dermatology, Kagawa University Hospital, Kagawa, Japan; and National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Abstract: The diagnosis of pilomatricoma, the most common matrical tumor, is generally straightforward; however, it exhibits diverse histology associated with various morphological stages and several clinical variants, and matrical differentiation can occur in various neoplastic diseases. A 56-year-old man was admitted to our hospital to resect an 11.0-cm skin tumor on his right shoulder. Read More

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Disseminated mucocutaneous trichosporonosis in a patient with histiocytic sarcoma.

An Bras Dermatol 2021 Jul 17. Epub 2021 Jul 17.

Instituto Dermatológico de Jalisco "Dr. José Barba Rubio", Zapopan, Jalisco, Mexico. Electronic address:

Trichosporon asahii is the causal agent of trichosporonosis. Patients with immunosuppression or hematological malignancies are at higher risk of infection. Skin and mucosal involvement appear as fast-growing papulonodular lesions and necrotic ulcers. Read More

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Primary angiosarcoma of the oral cavity in a young adult.

Autops Case Rep 2021 8;11:e2020217. Epub 2020 Dec 8.

Homi Bhabha Cancer Hospital, Department of Head and Neck Oncology, Varanasi, Uttar Pradesh, India.

Angiosarcoma is a rare neoplasm, constituting only 2% of all the soft tissue tumors and most frequently involves the skin of the head and neck region in elderly males. They are extremely aggressive tumors with high rates of metastasis and poor outcomes. We report a unique case of angiosarcoma involving an unusual site - upper alveolus and maxilla in a young patient highlighting the diagnostic challenges in such a scenario. Read More

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December 2020

[Management of obstructive jaundice in patients with neoplasms of the major duodenal papilla].

Khirurgiia (Mosk) 2021 (7):49-56

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia.

Objective: To develop the indications and assess an effectiveness of treatment of patients with ampullary tumors followed by mechanical jaundice.

Material And Methods: There were 26 patients with major duodenal papilla neoplasms for the period 2015-2020 at the Sklifosovsky Research Institute for Emergency Care.

Results: Twenty patients underwent transpapillary interventions: papillosphincterotomy followed by lithoextraction and bilio-duodenal stenting in 4 (15. Read More

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Two Cases of Epstein-Barr Virus-Positive Mucocutaneous Ulcer Mimicking Head and Neck Cancers in 18F-FDG PET/CT.

Clin Nucl Med 2021 Jul 14. Epub 2021 Jul 14.

From the Departments of Diagnostic Imaging and Nuclear Medicine Diagnostic Pathology, Graduate School of Medicine, Kyoto University, Kyoto City, Japan.

Abstract: Epstein-Barr virus-positive mucocutaneous ulcer is a newly recognized clinicopathological entity among mature B-cell neoplasms according to the 2016 revision of the World Health Organization diagnostic criteria. Here, we present FDG PET/CT images of 2 Epstein-Barr virus-positive mucocutaneous ulcer cases. Both cases shown in the images mimicked head and neck cancers, which are similar to carcinomas of the tonsil and gingiva, respectively, and both lesions showed intense FDG uptake on PET scan. Read More

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Is intra-operative enteroscopy still relevant in small bowel disorders in the era of capsule endoscopy and device assisted enteroscopy? real-world experience from a tertiary care hospital.

J Gastroenterol Hepatol 2021 Jul 16. Epub 2021 Jul 16.

Asian Institute of Gastroenterology, Hyderabad, Telangana, India.

Background And Aims: With the advent of video capsule endoscopy (VCE) and device assisted enteroscopy (DAE),the indication of intra-operative enteroscopy (IOE) has become limited due to reported high morbidity/mortality. Most of the earlier studies on IOE were small/from pre VCE/DAE era. We aimed to evaluate the impact of IOE in management of small bowel disorders (SBD)in post VCE/DAE era. Read More

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When acral malignant melanoma facades as diabetic foot!

BMJ Case Rep 2021 Jul 15;14(7). Epub 2021 Jul 15.

Department of Diabetes and Endocrinology, The Dudley Group NHS Foundation Trust, Dudley, West Midlands, UK.

An 85-year-old Indian man presented with non-healing foot ulcer over the left heel. There was initial response to wound size with standard treatment including offloading, debridement and antibiotic therapy. However, subsequently, there was no progress noted. Read More

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Case Report: Low-Dose Apatinib in the Treatment of Intrahepatic Biliary Cystadenoma With Recurrence and Malignant Transformation.

Front Oncol 2021 28;11:676092. Epub 2021 Jun 28.

Department of Ultrasound Diagnostics, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Apatinib is a new oral tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor-2. It has been proven effective in treating multiple solid tumors. Herein, we report the case of a 67-year-old Chinese patient who was diagnosed with recurrent and malignant transformation of intrahepatic biliary cystadenoma. Read More

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Usefulness of artificial intelligence in gastric neoplasms.

World J Gastroenterol 2021 Jun;27(24):3543-3555

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon 24289, Kangwon Do, South Korea.

Recently, studies in many medical fields have reported that image analysis based on artificial intelligence (AI) can be used to analyze structures or features that are difficult to identify with human eyes. To diagnose early gastric cancer, related efforts such as narrow-band imaging technology are on-going. However, diagnosis is often difficult. Read More

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Nonclinical genotoxicity and carcinogenicity profile of apremilast, an oral selective inhibitor of PDE4.

Regul Toxicol Pharmacol 2021 Jul 5;125:104985. Epub 2021 Jul 5.

Amgen Inc., Thousand Oaks, CA, 91320, USA.

Apremilast is an oral, selective small molecule inhibitor of phosphodiesterase-4 (PDE4) that has been approved for the treatment of active psoriatic arthritis, moderate to severe plaque psoriasis, and for patients with oral ulcers associated with Behçet's disease. Apremilast modulates the inflammatory cascade in cells by inhibiting PDE4, thus preventing the degradation of cyclic adenosine monophosphate, resulting in the upregulation of interleukin (IL)-10 and the downregulation of proinflammatory cytokines, including IL-23, interferon gamma (IFNγ), and tumor necrosis factor alpha (TNFα). Here, we evaluated the genotoxic and carcinogenic potential of apremilast using Good Laboratory Practice (GLP)-compliant in vitro and in vivo studies. Read More

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Vonoprazan versus proton pump inhibitors for postendoscopic submucosal dissection bleeding in the stomach: a multicenter population-based comparative study.

Gastrointest Endosc 2021 Jul 5. Epub 2021 Jul 5.

Department of Gastroenterology, St. Luke's International Hospital, Tokyo, Japan.

Background And Aims: The effectiveness of vonoprazan relative to that of proton pump inhibitors (PPIs) after gastric endoscopic submucosal dissection (ESD) is unclear. Although previous studies used post-ESD ulcer healing as the outcome measure, post-ESD bleeding rate is the most objective and appropriate outcome measure as it has less ascertainment bias. We aimed to compare the post-ESD bleeding rates between vonoprazan and PPIs. Read More

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PKCδ/MAPKs and NF-κB Pathways are Involved in the Regulation of Ingenane-Type Diterpenoids from on Macrophage Function.

J Inflamm Res 2021 25;14:2681-2696. Epub 2021 Jun 25.

Center for Pharmaceutical Sciences and Engineering, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, People's Republic of China.

Purpose: Linn. has important medicinal value in the treatment of ulcers, tumors, inflammation, chronic respiratory troubles, and so on. Although many ingredients with anti-inflammatory activity have been discovered and isolated from the , the current research still cannot explain its multivariate effects on the immune response. Read More

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Gastric lymphoma at high risk of perforation successfully managed with chemotherapy alone.

BMJ Case Rep 2021 Jul 6;14(7). Epub 2021 Jul 6.

Haematology, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK.

We report the case of a previously healthy 49-year-old woman who presented with upper gastrointestinal bleeding, which was found at laparotomy to be due to high-grade B cell gastric lymphoma. CT scans showed that this was partially adherent to the spleen, with erosion of the gastric wall and suggested impending perforation. Given the risk of perforation, further surgical intervention (gastrectomy and splenectomy) was considered; however, after multidisciplinary team discussion, we chose to offer chemotherapy and careful inpatient observation instead. Read More

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Malignant fibrous histiocytoma of the floor of mouth: a case report and review of the literature.

J Stomatol Oral Maxillofac Surg 2021 Jul 2. Epub 2021 Jul 2.

Department of Oral and Maxillofacial Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma in late adulthood and usually occurs in the limbs, trunk, and peritoneum. Less than 10% of MFH cases occur in the head and neck region. The clinical manifestations and pathological features of MFH are atypical, and it is difficult to make a clinical diagnosis. Read More

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Effect of a Cytoprotective Dose of Dehydroleucodine, Xanthatin, and 3-Benzyloxymethyl-5-furan-2-one on Gastric Mucosal Lesions Induced by Mast Cell Activation.

Int J Mol Sci 2021 Jun 1;22(11). Epub 2021 Jun 1.

Instituto de Histología y Embriología "Dr. Mario H. Burgos" (IHEM-CCT Mendoza-CONICET), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, 5500 Mendoza, Argentina.

The aim of this study was to determine whether the lactones dehydroleucodine, xanthatin and 3-benzyloxymethyl-5H-furan-2-one, would be effective in an animal model of gastric ulcer induced by mast cell activation. Rats were divided into ten groups. Treatments were repeated for four days. Read More

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Surgical solution of the extensive post-radiation defect developped 33 years after radiotherapy for breast carcinoma case report.

Rozhl Chir 2021 ;100(4):186-191

Introduction: Damage of the skin and its underlying structures is a common side effect of radiotherapy. These conditions limit further treatment and dealing with these complications is a routine practice of clinical oncologist. The majority of the complications are immediate, with a perspective of healing ad integrum within a few weeks. Read More

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A review of hydroxyurea-related cutaneous adverse events.

Expert Opin Drug Saf 2021 Jun 28:1-7. Epub 2021 Jun 28.

Department of Internal Medicine III, University Hospital of Ulm, Germany.

: Hydroxyurea (HU) is an S-phase specific oral chemotherapeutic agent that inhibits ribonucleotide diphosphate reductase. It is the most common used cytoreductive drug in patients (pts) with negative myeloproliferative neoplasms (MPN) and sickle cell disease (SCD). The World Health Organization lists HU as an "essential drug". Read More

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Gastric cancer - histopathological correlations between tumor and non-tumor gastric mucosa changes.

Rom J Morphol Embryol 2020 Oct-Dec;61(4):1129-1141

Department of Dermatology, Department of Histology, University of Medicine and Pharmacy of Craiova, Romania;

Gastric cancer is a widely geographically distributed malignancy with high prevalence, therefore being a serious health problem that needs standardized methods for early diagnosis and treatment. The aim of the study was to evaluate the correlation of some epidemiological and clinical data with the histological features. The study group was made up of 66 patients that underwent surgical removal of the gastric neoplasm, and the pathological exam showed the morphological features of the tumor, as well as the ones of the unaffected mucosal tissue. Read More

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A germline c.1546dupC MEN1 mutation in an MEN1 family: A case report.

Medicine (Baltimore) 2021 Jun;100(25):e26382

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chung-Ang University, College of Medicine, Seoul, Korea.

Rationale: Multiple endocrine neoplasia type 1 (MEN1) is a rare tumor syndrome with an autosomal dominant inheritance, and genetic testing for MEN1 gene is important for both affected individuals and their relatives. We present a 2-person family affected by a germline c.1546dupC MEN1 mutation, and one of them had a full-spectrum of MEN-related endocrine tumors. Read More

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Multiple Gastric Carcinomas Associated with Epstein-Barr Virus and Helicobacter pylori: A Thought-Provoking Case.

Am J Case Rep 2021 Jun 23;22:e931668. Epub 2021 Jun 23.

Department of Surgery, Shiga General Hospital, Moriyama, Shiga, Japan.

BACKGROUND Epstein-Barr virus (EBV) and Helicobacter pylori (HP) infections are associated with gastric carcinoma (GC). We present a thought-provoking case of multiple GCs associated with EBV and HP infections. CASE REPORT HP infection was incidentally detected in an asymptomatic 60-year-old man. Read More

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Colorectal neoplasms in melanosis coli: a survey in Japan and a worldwide meta-analysis.

Int J Colorectal Dis 2021 Jun 22. Epub 2021 Jun 22.

Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, Okayama, Japan.

Purpose: The association between melanosis coli (MC) and colorectal neoplasms remains unclear. Thus, we primarily aimed to clarify the epidemiology of MC in the Japanese population, identify the relationship between the use of anthranoids and MC, and determine the prevalence of detected intestinal lesions in patients with MC. We subsequently conducted a meta-analysis of published data, including our results, to summarize the influence of MC on the prevalence of colonic neoplasms. Read More

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Artificial Intelligence in Endoscopy.

Dig Dis Sci 2021 Jun 21. Epub 2021 Jun 21.

Endoscopy Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Artificial intelligence (AI) is rapidly developing in various medical fields, and there is an increase in research performed in the field of gastrointestinal (GI) endoscopy. In particular, the advent of convolutional neural network, which is a class of deep learning method, has the potential to revolutionize the field of GI endoscopy, including esophagogastroduodenoscopy (EGD), capsule endoscopy (CE), and colonoscopy. A total of 149 original articles pertaining to AI (27 articles in esophagus, 30 articles in stomach, 29 articles in CE, and 63 articles in colon) were identified in this review. Read More

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Clinical diagnosis of oral erosive and ulcerative diseases in children.

Zhejiang Da Xue Xue Bao Yi Xue Ban 2021 Apr;50(2):155-161

Stomatology Hospital.

Mucosal disease is one of the most common oral cavity diseases in children, among which mucosal erosion and ulceration account for about 50%. Oral mucosal erosion and ulcer diseases in children are mostly acute with obvious pain, affecting speech, eating and swallowing. Some oral mucosal diseases are caused by infection and would result in epidemic among children. Read More

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Impact of the COVID-19 Pandemic on Consultations and Diagnoses in Gastroenterology Practices in Germany.

Front Med (Lausanne) 2021 31;8:684032. Epub 2021 May 31.

Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

The COVID-19 pandemic has been a major burden for healthcare systems worldwide and has caused multiple changes and problems in outpatient care. The aim of this study was to investigate the impact of the COVID-19 pandemic on consultations and diagnoses in gastroenterology practices in Germany. To this end, we retrospectively analyzed data from the Disease Analyzer database (IQVIA) using the International Classification of Diseases, 10th revision (ICD-10). Read More

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Clinicopathological characteristics and prognosis of 232 patients with poorly differentiated gastric neuroendocrine neoplasms.

World J Gastroenterol 2021 Jun;27(21):2895-2909

Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing 100029, China.

Background: Poorly differentiated gastric neuroendocrine neoplasms (PDGNENs) include gastric neuroendocrine carcinoma (NEC) and mixed adenoneuroendocrine carcinoma, which are highly malignant and rare tumors, and their incidence has increased over the past few decades. However, the clinicopathological features and outcomes of patients with PDGNENs have not been completely elucidated.

Aim: To investigate the clinicopathological characteristics and prognostic factors of patients with PDGNENs

Methods: The data from seven centers in China from March 2007 to November 2019 were analyzed retrospectively. Read More

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Chondrodermatitis Nodularis Nasi: A Case Report of a Rare Variant of Chondrodermatitis Nodularis Helicis.

Am J Dermatopathol 2021 Jun 15. Epub 2021 Jun 15.

Arizona College of Osteopathic Medicine - Midwestern University, Glendale, AZ; La Peau Dermatology Mesa, AZ; and American Dermatopathology Laboratory Centerville, OH.

Abstract: Chondrodermatitis nodularis helicis is an inflammatory condition affecting the helix or antihelix of the ear. It is commonly described as a solitary, painful, ulcerated nodule affecting the cartilage or skin because of continuous pressure, trauma, sun exposure, or ischemic changes. In this case report, we present a rare variant of chondrodermatitis, named chondrodermatitis nodularis nasi, which affects the skin and cartilage of the nose. Read More

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A Case Report of Subclinical Myasthenia Gravis Associated with Castleman's Disease.

Am J Case Rep 2021 Jun 11;22:e930948. Epub 2021 Jun 11.

Department of Thoracic Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

BACKGROUND Castleman's disease is defined as a benign lymphoproliferative disorder of uncertain origin. It is most commonly found in the area of mediastinum. Castleman's disease is classified based on pathological features into hyaline-vascular, plasma cell, and mixed variants, which the hyaline-vascular variant is the commonest in association with Myasthenia Gravis. Read More

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Second-look endoscopy findings after endoscopic submucosal dissection for colorectal epithelial neoplasms.

Korean J Intern Med 2021 Jun 9. Epub 2021 Jun 9.

Digestive Disease Center and Research Institute and Department of Internal Medicine, Soonchunhyang University School of Medicine, Bucheon, Korea.

Background/aims: Although second-look endoscopy (SLE) is frequently performed after gastric endoscopic submucosal dissection (ESD) to prevent bleeding, no studies have reported SLE findings after colorectal ESD. This study aimed to investigate SLE findings and their role in preventing delayed bleeding after colorectal ESD.

Methods: Post-ESD ulcer appearances were divided into coagulation (with or without remnant minor vessels) and clip closure groups. Read More

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Mature T/NK-Cell lymphomas of the oral and maxillofacial region: A multi-institutional collaborative study.

J Oral Pathol Med 2021 Jul 29;50(6):548-557. Epub 2021 Jun 29.

Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: The diagnosis of oral and maxillofacial mature T/NK-cell neoplasms is challenging because of their rarity, morphological heterogeneity and complex immunophenotype with scarce available data describing their clinical and microscopic aspects. Therefore, in this study, we investigated a series of mature T/NK-cell neoplasms affecting this anatomical region and provided an updated literature review.

Methods: Cases diagnosed as mature T/NK-cell lymphomas affecting the oral and maxillofacial region were retrospectively retrieved from six pathology files and their diagnoses were confirmed using haematoxylin and eosin-stained slides, immunohistochemical reactions and in situ hybridization for Epstein-Barr virus (EBV) detection. Read More

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