Search Our Scientific Publications & Authors

J Gastrointest Surg 2021 Apr 9. Epub 2021 Apr 9.

Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN, USA.

Inflamm Bowel Dis 2021 Apr 9. Epub 2021 Apr 9.

Gastroenterology and Nutrition Unit, Meyer Children's Hospital, Florence, Italy.

Background: The aim of the present study was to investigate outcomes of anti-TNF-alpha (ATA) withdrawal in selected pediatric patients with inflammatory bowel disease who achieved clinical remission and mucosal and histological healing (MH and HH).

Methods: A retrospective analysis was performed on children and adolescents affected by Crohn disease (CD) and ulcerative colitis (UC) who were followed up at 2 tertiary referral centers from 2008 through 2018. The main outcome measure was clinical relapse rates after ATA withdrawal. Read More

Saudi J Gastroenterol 2021 Apr 5. Epub 2021 Apr 5.

Department of Gastroenterology, Department of Gastroenterology, The 900th Hospital of Joint Logistic Support Force, PLA, Fujian Medical University Fuzong Clinical College, Fuzhou, China.

Background: We aimed to evaluate the therapeutic effect of additional ursodeoxycholic acid (UDCA) with mesalazine, compared to mesalazine alone in patients with ulcerative colitis (UC). The mechanism was evaluated by monitoring the changes of IL-23-IL-17 axis and the intestinal microflora.

Methods: In this prospective, single center study, patients with UC were randomly assigned to the Mesalazine group (n=20) or the UDCA + Mesalazine group (n=20). Read More

Brief Bioinform 2021 Apr 8. Epub 2021 Apr 8.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China.

How best to utilize the microbial taxonomic abundances in regard to the prediction and explanation of human diseases remains appealing and challenging, and the relative nature of microbiome data necessitates a proper feature selection method to resolve the compositional problem. In this study, we developed an all-in-one platform to address a series of issues in microbiome-based human disease prediction and taxonomic biomarkers discovery. We prioritize the interpretation, runtime and classification accuracy of the distal discriminative balances analysis (DBA-distal) method in selecting a set of distal discriminative balances, and develop DisBalance, a comprehensive platform, to integrate and streamline the workflows of disease model building, disease risk prediction and disease-related biomarker discovery for microbiome-based binary classifications. Read More

Med Microecol 2020 Dec 20;6. Epub 2020 Oct 20.

Division of Medical Ethics, Department of Population Health, NYU Grossman School of Medicine, 550 First Avenue, New York, NY, 10016, USA.

Fecal microbiota transplantation (FMT) has rapidly grown in notoriety and popularity worldwide as a treatment for both recurrent and refractory infection (CDI), as well as for a myriad of other indications, with varying levels of evidence to justify its use. At present, FMT use in the U.S. Read More

J Inflamm Res 2021 1;14:1243-1255. Epub 2021 Apr 1.

Gastroenterology Department, The Shanghai Tenth People's Hospital, Tongji University, Shanghai, People's Republic of China.

Purpose: To investigate the therapeutic effect of polyglycoside (TWP), a derivative from a Chinese traditional herb, on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis, in a model for inflammatory bowel disease (IBD) in rats.

Methods: TWP was administrated to Wistar rats during TNBS-induced colitis to determine its therapeutic effect on active inflammation using the Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR), flow cytometry, and Western blotting. Peripheral blood CD4 T-cells were isolated from patients with ulcerative colitis (UC) and incubated with TWP to verify its immune regulation mechanism by qRT-PCR and flow cytometry. Read More

Dis Colon Rectum 2021 Apr 5. Epub 2021 Apr 5.

Department of Colon & Rectal Surgery, Cleveland Clinic, Cleveland OH, USA Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland OH, USA.

Background: Inflammatory bowel disease patients are at increased risk of venous thromboembolism.

Objective: To define the economic burden associated with inpatient venous thromboembolism after surgery for IBD, which presently remains undefined.

Design: A retrospective, cross-sectional analysis using the National Inpatient Sample from 2004-2014. Read More

Expert Opin Pharmacother 2021 Apr 9:1-7. Epub 2021 Apr 9.

IBD Center, Sakura Medical Center, Toho University, Chiba, Japan.

: Budesonide foam 2 mg twice daily induced complete mucosal healing in patients with mild-to-moderate ulcerative colitis (UC) in a phase 3 study. Post-marketing surveillance is underway to assess the real-world outcomes in UC patients.: The authors performed an interim analysis of post-marketing surveillance in 182 patients with mild-to-moderate UC who received 2 mg budesonide foam rectally. Read More

Medicine (Baltimore) 2021 Apr;100(14):e25355

School of Clinical Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.

Background: Ulcerative colitis (UC) is a kind of chronic non-specific ulcerative colitis, which is characterized by repeated abdominal pain, diarrhea, and mucus purulent stool. The disease is more recurrent, easy to delay, and canceration, seriously affect the quality of life, increase the economic burden of patients and society, treatment is more difficult, the World Health Organization as one of the modern refractory diseases. Shenling Atractylodes Powder in the treatment of ulcerative colitis showed a strong advantage, the effect is accurate. Read More

Medicine (Baltimore) 2021 Apr;100(14):e25200

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Abstract: Persistent disease activity is associated with a poor prognosis in patients with inflammatory bowel disease (IBD). This study aims to explore the accuracy of the highly sensitive C-reactive protein/albumin ratio (CAR) in determining IBD activity.The clinical data of 231 IBD patients treated at Peking Union Medical College Hospital from 2012 to 2018 were analyzed retrospectively. Read More

CEN Case Rep 2021 Apr 7. Epub 2021 Apr 7.

Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, 1370-1 Okamoto, Kamakura, Kanagawa, 247-0072, Japan.

Diarrhea is a common complication in kidney transplant recipients. Common causes of diarrhea include infection, side effect from medication, rejection, and malignancy. A less common but important cause of diarrhea is de novo inflammatory bowel disease (IBD). Read More

Pol J Radiol 2021 3;86:e143-e150. Epub 2021 Mar 3.

Department of Diagnostic Imaging, Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.

Purpose: The diagnosis of Crohn's disease (CD), one of the inflammatory bowel diseases (IBD), along with ulcerative colitis (UC), is often challenging due to the limitations of small intestine visualisation. Magnetic resonance enterography (MRE) enables imaging of intraluminal and extraintestinal complications without ionizing radiation. The objective of this study is to select CD-related MRE features and determine the feasibility of this technique to indicate a group of patients that should be subjected to more invasive diagnostic procedures. Read More

Front Immunol 2021 22;12:586930. Epub 2021 Mar 22.

Department of Experimental Pathology and Immunology, American University of Beirut, Faculty of Medicine, Beirut, Lebanon.

The Epstein-Barr virus (EBV) commonly infects humans and is highly associated with different types of cancers and autoimmune diseases. EBV has also been detected in inflamed gastrointestinal mucosa of patients suffering from prolonged inflammation of the digestive tract such as inflammatory bowel disease (IBD) with no clear role identified yet for EBV in the pathology of such diseases. Since we have previously reported immune-stimulating capabilities of EBV DNA in various models, in this study we investigated whether EBV DNA may play a role in exacerbating intestinal inflammation through innate immune and regeneration responses using the model. Read More

Front Neurosci 2021 22;15:650971. Epub 2021 Mar 22.

Laboratoire Inter-Universitaire de Psychologie Personnalité, Cognition, Changement Social, University Grenoble Alpes, University Savoie Mont Blanc, Grenoble, France.

The vagus nerve is a mixed nerve, comprising 80% afferent fibers and 20% efferent fibers. It allows a bidirectional communication between the central nervous system and the digestive tract. It has a dual anti-inflammatory properties via activation of the hypothalamic pituitary adrenal axis, by its afferents, but also through a vago-vagal inflammatory reflex involving an afferent (vagal) and an efferent (vagal) arm, called the cholinergic anti-inflammatory pathway. Read More

World J Gastroenterol 2021 Mar;27(12):1226-1239

Health Sciences Postgraduate Program, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80440-220, PR, Brazil.

Background: Coronavirus disease 2019 (COVID-19) pandemic is still evolving globally, and Brazil is currently one of the most affected countries. It is still debated whether patients with inflammatory bowel disease (IBD) are at a higher risk for developing COVID-19 or its complications.

Aim: To assess geographical distribution of IBD patients at the highest risk and correlate these data with COVID-19 mortality rates in Brazil. Read More

World J Gastroenterol 2021 Mar;27(12):1194-1212

Akita Health Care Center, Akita Red Cross Hospital, Akita 010-0001, Japan.

Background: It is a crucial issue for patients with refractory ulcerative colitis (UC), including steroid-dependent and steroid-refractory patients, to achieve and maintain steroid-free remission. However, clinical studies focused on the achievement of steroid-free remission in refractory UC patients are insufficient. Cytapheresis (CAP) is a non-pharmacological extracorporeal therapy that is effective for active UC with fewer adverse effects. Read More

BMC Gastroenterol 2021 Apr 7;21(1):152. Epub 2021 Apr 7.

Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.

Background: Although the association between eating habits which can be modified and digestive diseases has been reported, to date, no research has evaluated the association between eating habits and ulcerative colitis (UC). Thus, we investigate the association between eating behavior and clinical outcome in Japanese patients with UC.

Methods: Eating quickly, eating until full, and skipping breakfast data was obtained from a self-administered questionnaire. Read More

Expert Rev Gastroenterol Hepatol 2021 Apr 7. Epub 2021 Apr 7.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

: To ascertain the role of antibiotics in induction and maintenance of remission in ulcerative colitis (UC): We searched electronic databases for keywords ulcerative colitis or inflammatory bowel disease and antibiotics or antimicrobials. We did a meta-analysis of randomized trials comparing antibiotics with control/placebo for clinical response, need for second line therapy, colectomy, and adverse effects. Subgroup analysis to clarify the mode of administration, number of antibiotics or the setting of use (acute severe UC or active non-severe UC) were also performed. Read More

Scand J Gastroenterol 2021 Apr 7:1-6. Epub 2021 Apr 7.

Department of Internal Medicine, Turku University Hospital, University of Turku, Turku, Finland.

Background: Inflammatory bowel disease (IBD), consisting of Crohn's disease and ulcerative colitis, can be a lifelong burden generating high costs to an economic system. Data regarding the cost of workplace presenteeism and absenteeism in workers with IBD are limited. Our objective was to assess these costs in employed adults. Read More

Tech Coloproctol 2021 Apr 7. Epub 2021 Apr 7.

Department of Colorectal and Anal Surgery of Zhongnan Hospital of Wuhan University, Clinical Center of Intestinal and Colorectal Diseases of Hubei Province, Hubei Key Laboratory of Intestinal and Colorectal Diseases (Zhongnan Hospital of Wuhan University), Colorectal and Anal Disease Research Center of Medical School (Zhongnan Hospital of Wuhan University), Quality Control Center of Colorectal and Anal Surgery of Health Commission of Hubei Province, No. 169, DongHu Road, Wuhan, China.

Background: Ileal J-pouch anal anastomosis (J-IPAA) is the standard approach for patients requiring restorative proctocolectomy due to familial adenomatous polyposis (FAP) or ulcerative colitis (UC). To obviate the risk of a J-tip leak, we modified the J-pouch with a D-pouch anal anastomosis (D-IPAA) designed to eliminate the ileal stump. The aim of our study was to evaluate the feasibility, safety and medium-term functional outcomes of D-IPAA. Read More

Clin Transl Gastroenterol 2021 Apr 6;12(4):e00331. Epub 2021 Apr 6.

Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Introduction: DEFA1A3 encodes human neutrophil peptides (HNPs) 1-3 and has multiple copy number variations (CNVs). HNPs are associated with innate immunity. Ulcerative colitis (UC), a chronic inflammatory gastrointestinal disorder, is a life-threatening condition, and predictive markers of UC severity are needed. Read More

Neuroimage Clin 2021 Mar 9;30:102613. Epub 2021 Mar 9.

G. Oppenheimer Center for Neurobiology of Stress and Resilience at UCLA, United States; Vatche and Tamar Manoukian Division of Digestive Diseases at UCLA, United States; UCLA Microbiome Center, United States. Electronic address:

Objective: We aimed to identify differences in network properties of white matter microstructure between asymptomatic ulcerative colitis (UC) participants who had a history of chronic gut inflammation, healthy controls (HCs) and a disease control group without gut inflammation (irritable bowel syndrome; IBS).

Design: Diffusion weighted imaging was conducted in age and sex-matched participants with UC, IBS, and HCs (N = 74 each), together with measures of gastrointestinal and psychological symptom severity. Using streamline connectivity matrices and graph theory, we aimed to quantify group differences in brain network connectivity. Read More

J Crohns Colitis 2021 Apr 5. Epub 2021 Apr 5.

Department of Gastroenterology and Inserm NGERE U1256, University Hospital of Nancy, University of Lorraine,Vandoeuvre-lès-Nancy, France.

Background And Aims: Histological healing might be the ultimate therapeutic goal in ulcerative colitis (UC). Our aim was to investigate the association between histological disease activity as measured by a validated index and long-term outcomes in patients with UC.

Methods: An observational retrospective cohort study was conducted at the Nancy University Hospital between January 2014 and March 2020. Read More

J Crohns Colitis 2021 Apr 5. Epub 2021 Apr 5.

University College London, London, United Kingdom.

JGH Open 2021 Jan 29. Epub 2021 Jan 29.

School of Telemedicine and Biomedical Informatics Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow India.

Background And Aim: Although telemedicine is an option for the care of inflammatory bowel disease (IBD) patients during the Coronavirus Disease (COVID)-19 pandemic, its feasibility and acceptability data are scant. Data on the frequency of COVID-19 among patients with IBD, quality of life (QOL), access to health care, psychological stress, and anxiety during the COVID-19 pandemic are scant.

Methods: Video/audio consultation for IBD patients was undertaken after a web-based appointment, and data on acceptability, IBD control, Hospital Anxiety Depression Scale (HADS), and World Health Organization Quality of Life questionnaire (WHOQOL-Bref) were obtained electronically. Read More

Microbiome 2021 04 5;9(1):83. Epub 2021 Apr 5.

College of Food Science and Nutritional Engineering, National Engineering Research Center for Fruit and Vegetable Processing, Key Laboratory of Fruits and Vegetables Processing, Ministry of Agriculture; Engineering Research Centre for Fruits and Vegetables Processing, Ministry of Education, China Agricultural University, No.17, Qinghua East Road, Haidian District, Beijing, 100083, China.

Background: Ulcerative colitis is a type of chronic inflammatory bowel disease closely associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation. Barley leaf (BL) has a long history of use in Traditional Chinese Medicine with potential health-promoting effects on intestinal functions. However, its mechanism of action is not yet clear. Read More

Biomed Pharmacother 2021 Apr 2;139:111127. Epub 2021 Apr 2.

State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry Centre, China Agricultural University, Beijing 100193, PR China; Beijing Bio-Feed Additives Key Laboratory, Beijing 100193, PR China. Electronic address:

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is rising constantly all over the world. However, current medical treatments are not universally practical. Microcin J25 (MccJ25), a member of the lasso peptides class, has excellent antimicrobial activity both in vitro and in vivo. Read More

ACS Nano 2021 Apr 5. Epub 2021 Apr 5.

School of Life Sciences, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China.

Ulcerative colitis (UC) is a relapsing disorder characterized by chronic inflammation of the intestinal tract. However, the home care of UC based on remote monitoring, due to the operational complexity and time-consuming procedure, restrain its widespread applications. Here we constructed an optotheranostic nanosystem for self-diagnosis and long-acting mitigations of UC at home. Read More

J Pak Med Assoc 2021 02;71(2(A)):479-483

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Cukurova University, Turkey.

Objective: To determine the cumulative effects of Mediterranean fever gene polymorphisms and mutations in patients with ınflammatory bowel diseases.

Methods: The case-control study was conducted from January, 2012, to January, 2016,at Cukurova University, Turkey, and comprised patients diagnosed with inflammatory bowel diseases and followed up at the Children Gastroenterology Department. By using molecular methods, 12 Mediterranean fevergene variants most frequently observed in the country were examined in all the diagnosed cases. Read More

Med Gas Res 2021 Apr-Jun;11(2):66-71

Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

Inflammatory bowel disease is a group of chronic recurrent diseases in the digestive tract, including ulcerative colitis and Crohn's disease. Over the past few decades, the treatment of IBD has made great progress but there is still a lot of room for improvement. Hyperbaric oxygen therapy (HBOT) was defined as the therapeutic effect of inhaling 100% oxygen higher than one atmosphere and reported to be used in stroke, decompression sickness and wound healing. Read More