2,725 results match your criteria tyrosinase inhibition

Pecan ( (Wagenh.) K. Koch) Nut Shell as an Accessible Polyphenol Source for Active Packaging and Food Colorant Stabilization.

ACS Sustain Chem Eng 2020 May 13;8(17):6700-6712. Epub 2020 Apr 13.

Department of Chemical Sciences, University of Naples "Federico II", Via Cintia 4, I-80126 Naples, Italy.

Herein, the antioxidant and food stabilizing properties of a pecan nut shell (PNS) hydroalcoholic extract (PNSE) are reported. Chemical degradation of PNSE demonstrated the presence of condensed tannins as the main phenolic components. PNSE showed remarkable antioxidant properties in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay (EC = 0. Read More

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Formulation and evaluation of antioxidant and antityrosinase activity of Polygonum amplexicaule herbal gel.

Pak J Pharm Sci 2020 Sep;33(5):1961-1969

Department of Biochemistry, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan.

Medicinal plants are long been used for pharmaceutical and cosmetic industry. Among medicinal plants, Polygonum amplexicaule of family polygonaceae has traditional use in medicines and skin care. P. Read More

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September 2020

A basic domain-derived tripeptide inhibits MITF activity by reducing its binding to promoter of target genes.

J Invest Dermatol 2021 Apr 3. Epub 2021 Apr 3.

Department of Anatomy and Cell Biology, School of Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address:

The keratinocytes in ultraviolet (UV)-irradiated skin produce and secrete α-melanocyte-stimulating hormone (α-MSH). α-MSH upregulates the expression of microphthalmia-associated transcription factor (MITF) in melanocytes via the cyclic adenosine monophosphate/protein kinase A/cAMP response element-binding protein (cAMP/PKA/CREB) signaling pathway. Thereafter, MITF induces the expression of melanogenic genes, including the tyrosinase, tyrosinase related protein-1 (TYRP-1), and tyrosinase related protein-2 (TYRP-2) genes, which leads to the synthesis and accumulation of melanin. Read More

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Antityrosinase Mechanism and Antimelanogenic Effect of Arbutin Esters Synthesis Catalyzed by Whole-Cell Biocatalyst.

J Agric Food Chem 2021 Apr 6. Epub 2021 Apr 6.

Department of Spine Surgery, Center for Orthopaedic Surgery, The Third Affiliated Hospital of Southern Medical University, Academy of Orthopedics of Guangdong Province, Guangzhou 510630, China.

Tyrosinase is a key enzyme responsible for enzymatic browning of fruits and vegetables and skin disorders due to overproduction of melanin. Arbutin is an inhibitor of tyrosinase; however, its high polarity and weak transdermal absorption capacity limit its applications. In this paper, a green solvent system was developed to successfully synthesize arbutin esters with improved liposolubilities (Clog values = 0. Read More

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5-Substituted isatin thiosemicarbazones as inhibitors of tyrosinase: Insights of substituent effects.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 9;255:119669. Epub 2021 Mar 9.

College of Chemistry and Environmental Engineering, Institute of Environmental Toxicology and Environmental Ecology, Yancheng Teachers University, Xiwang Avenue South Rd. 2, Yancheng 224007, PR China. Electronic address:

Seven isatin-thiosemicarbazone analogues bearing different substituents (R) attached at C-5 of the indoline ring, TSC-ISA-R (R = -H, -CH, -OCH, -OCF, -F, -Cl and -NO), were synthesized and evaluated as inhibitors of mushroom tyrosinase (TYR). The inhibitory behaviour and performance of TSC-ISA-R were investigated spectroscopically in relation to the substituent modifications through examining their inhibition against the diphenolase activity of TYR using L-DOPA as a substrate. The IC values of TSC-ISA-R were determined to be in the range of 81-209 μM. Read More

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Multifunctional Tyrosinase Inhibitor Peptides with Copper Chelating, UV-Absorption and Antioxidant Activities: Kinetic and Docking Studies.

Foods 2021 Mar 22;10(3). Epub 2021 Mar 22.

Analytical Biochemistry Research Centre, University Innovation Incubator Building, Universiti Sains Malaysia, Lebuh Bukit Jambul, Bayan Lepas 11900, Penang, Malaysia.

Nature-derived tyrosinase inhibitors are of great industrial interest. Three monophenolase inhibitor peptides (MIPs) and three diphenolase inhibitor peptides (DIPs) from a previous study were investigated for their in vitro tyrosinase inhibitory effects, mode of inhibition, copper-chelating activity, sun protection factor (SPF) and antioxidant activities. DIP1 was found to be the most potent tyrosinase inhibitor (IC = 3. Read More

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Health Potential of Clery Strawberries: Enzymatic Inhibition and Anti- Activity Evaluation.

Molecules 2021 Mar 19;26(6). Epub 2021 Mar 19.

Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma "La Sapienza", Piazzale Aldo Moro 5, 00185 Roma, Italy.

Strawberries, belonging to cultivar Clery ( × Duchesne ex Weston) and to a graft obtained by crossing Clery and L., were chosen for a study on their health potential, with regard to the prevention of chronic and degenerative diseases. Selected samples, coming from fresh and defrosted berries, submitted to different homogenization techniques combined with thermal and microwave treatments, had been previously analyzed in their polyphenolic content and antioxidant capacity. Read More

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Antioxidant Compounds, Kirenol and Methyl ent-16α, 17-dihydroxy-kauran-19-oate Bioactivity-Guided Isolated from Attenuates MITF-Mediated Melanogenesis via Inhibition of Intracellular ROS Production.

Molecules 2021 Mar 30;26(7). Epub 2021 Mar 30.

College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, 255 Jungangno, Suncheon-si 57922, Korea.

(Compositae), an annual herb indigenous to Korean mountainous regions and has been eaten as a food in Korea. This study investigated ABTS, DPPH and nitric oxide (NO) radical-scavenging activities, and melanin production and TYR inhibitory effects-guided fractionation to identify therapeutic phytochemicals from that can attenuate oxidation and melanogenesis in murine melanoma B16F10 cells. Nine compounds with inhibitory effects on melanin production, and TYR activity, and ABTS, DPPH, and NO radical scavenging activity were isolated from the 100% ethanol fraction from . Read More

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Biochemical Properties of Tyrosinase from and ; Undecanoic Acid from an Endophyte of Is a Novel Potent Tyrosinase Inhibitor.

Molecules 2021 Mar 1;26(5). Epub 2021 Mar 1.

Enzymology and Fungal Biotechnology Lab., Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.

Tyrosinase is a copper-containing monooxygenase catalyzing the -hydroxylation of tyrosine to 3,4-dihydroxyphenylalanine then to dopaquinone that is profoundly involved in melanin synthesis in eukaryotes. Overactivation of tyrosinase is correlated with hyperpigmentation that is metabolically correlated with severe pathological disorders, so, inhibition of this enzyme is the most effective approach in controlling the overproduction of melanin and its hazardous effects. Thus, searching for a powerful, selective inhibitor of human tyrosinase to limit the hyper-synthesis of melanin is a challenge. Read More

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Phenolic Compounds and Biological Activity of Selected Species.

Plants (Basel) 2021 Mar 15;10(3). Epub 2021 Mar 15.

Centre of the Region Haná for Biotechnological and Agricultural Research, Department of Genetic Resources for Vegetables, Medicinal and Special Plants, Crop Research Institute, Šlechtitelů 29, 78371 Olomouc, Czech Republic.

species are widely used as food, medicine, spices, and flavoring agents. Thus, chemical composition is an important parameter for assessing the quality of mints. In general, the contents of menthol, menthone, eucalyptol, and limonene comprise one of the major parameters for assessing the quality of commercially important mints. Read More

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Evaluation of Antioxidant and Enzyme Inhibition Properties of L'Hér. Extracts Obtained with Different Solvents.

Molecules 2021 Mar 28;26(7). Epub 2021 Mar 28.

Department of Biology, Science Faculty, Selcuk University, Campus, 42130 Konya, Turkey.

L'Hér methanol extract was studied by NMR and two different LC-DAD-MS using electrospray (ESI) and atmospheric pressure chemical ionization (APCI) sources to obtain a quali-quantitative fingerprint. Forty different phytochemicals were identified, and twenty of them were quantified, whereas the main constituents were dihydro α ionol--[arabinosil(1-6) glucoside] (133 mg/g), dihydro β ionol--[arabinosil(1-6) glucoside] (80 mg/g), β-sitosterol (49 mg/g), and isorhamnetin-3--rutinoside (26 mg/g). was extracted with different solvents-namely, water, methanol, dichloromethane, and ethyl acetate-and the extracts were assayed using different in vitro tests. Read More

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Effect-Directed Profiling of 17 Different Fortified Plant Extracts by High-Performance Thin-Layer Chromatography Combined with Six Planar Assays and High-Resolution Mass Spectrometry.

Molecules 2021 Mar 8;26(5). Epub 2021 Mar 8.

PiLeJe Industrie, Naturopôle Nutrition Santé, Les Tiolans, 03800 Saint-Bonnet-de-Rochefort, France.

An effect-directed profiling method was developed to investigate 17 different fortified plant extracts for potential benefits. Six planar effect-directed assays were piezoelectrically sprayed on the samples separated side-by-side by high-performance thin-layer chromatography. Multipotent compounds with antibacterial, α-glucosidase, β-glucosidase, AChE, tyrosinase and/or β-glucuronidase-inhibiting effects were detected in most fortified plant extracts. Read More

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Isolation, Characterization, and Medicinal Potential of Polysaccharides of .

Molecules 2021 Mar 8;26(5). Epub 2021 Mar 8.

Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.

Mushroom polysaccharides are active medicinal compounds that possess immune-modulatory and anticancer properties. Currently, the mushroom polysaccharides krestin, lentinan, and polysaccharopeptides are used as anticancer drugs. They are an unexplored source of natural products with huge potential in both the medicinal and nutraceutical industries. Read More

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Fiaud's Acid, a novel organocatalyst for diastereoselective bis α-aminophosphonates synthesis with in-vitro biological evaluation of antifungal, antioxidant and enzymes inhibition potential.

Bioorg Med Chem Lett 2021 Mar 30:128000. Epub 2021 Mar 30.

Ecocompatible Asymmetric Catalysis Laboratory (LCAE) Badji Mokhtar Annaba-University, B.P 12, 23000 Annaba, Algeria.

(S, S)-1-hydroxy-1-oxo-2-c,5-t-diphenylphospholane or Fiaud's acid is used as a novel and effective chiral organocatalyst for bis α-aminophosphonates synthesis with excellent diastereoselectivity and yields within short reaction time. All synthesized bis α-aminophosphonates revealed a good to excellent antifungal capacity, where the six compounds 4a, 4b, 4e, 4h, 4k and 4l are the best fungicide inhibiting the growth of Fusarium oxysporumandBotrytis cinereaby 65% to 84% with IC values less than 0.02 mg/mL. Read More

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PEPPSI complexes as potential prodrugs: enzyme inhibition, antioxidant activity, electrochemical characterization, molecular docking analysis.

Z Naturforsch C J Biosci 2021 Apr 1. Epub 2021 Apr 1.

Department of Basic Education, Faculty of Education, Cumhuriyet University, Sivas, Turkey.

In this study, enzyme inhibition and antioxidant activity analyzes of previously characterized pyridine-enhanced precatalyst preparation stabilization and initiation (PEPPSI)-type Palladium(II) complexes with benzimidazole-type ligands {dichloro[L]pyridine palladium(II), L1: 1-(2-methyl-2-propenyl)-3-[benzylbenzimidazole]-2-ylidene, L2: 1-(2-methyl-2-propenyl)-3-[4-chloro benzylbenzimidazole]-2-ylidene, L3: 1-(2-methyl-2-propenyl)-3-[3-methylbenzylbenzimidazole]-2-ylidene, L4: 1-(2-methyl-2-propenyl)-3-[3,4,5-thrimethoxybenzylbenzimidazole]-2-ylidene, L5: 1-(2-methyl-2-propenyl)-3-[3-naphthylbenzylbenzimidazole]-2-ylidene, L6: 1-(2-methyl-2-propenyl)-3-[anthracen-9-ylmethylbenzimidazole]-2-ylidene} were performed and evaluated as potential drugs for neurodegenerative disorders such as Alzheimer disease and Parkinson disease. Inhibition of tyrosinase enzyme of N-heterocyclic carbenes (NHC) complexes was determined for the first time in literature. Chelating activities of the complexes were determined and compared with EDTA. Read More

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The effect of Aspalathus linearis (Burm.f.) R.Dahlgren and its compounds on tyrosinase and melanogenesis.

Sci Rep 2021 Mar 29;11(1):7020. Epub 2021 Mar 29.

Department of Plant and Soil Sciences, University of Pretoria, Pretoria, South Africa.

Pigmentation, a process controlled by melanogenesis, plays a vital role in protecting the skin against harmful ultraviolet rays. The level of protection is compromised in case of hypopigmentation. This study aimed to evaluate an Aspalathus linearis extract, fractions and phytoconstituents, for their efficacy on melanogenesis stimulation. Read More

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A novel method for explaining the product inhibition mechanisms via molecular docking: inhibition studies for tyrosinase from .

J Biomol Struct Dyn 2021 Mar 29:1-14. Epub 2021 Mar 29.

Department of Biochemistry, Faculty of Sciences and Arts, Iğdır University, Iğdır, Turkey.

The present study aims to investigate the substrate (4-methyl catechol and catechol) specificity and inhibition mechanisms (l-ascorbic acid, citric acid, and l-cysteine) of the tyrosinase enzyme (TYR), which is held responsible for browning in foods and hyperpigmentation in the human skin, through kinetic and molecular docking studies. During the experimental studies, the diphenolase activities of TYR were determined, following which the inhibitory effects of the inhibitors upon the diphenolase activities of TYR. The inhibition types were determined as competitively for l-ascorbic acid and citric acid and noncompetitive for l-cysteine. Read More

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A Strategy Based on the Enzyme-Catalyzed Polymerization Reaction of Asp-Phe-Tyr Tripeptide for Cancer Immunotherapy.

J Am Chem Soc 2021 Apr 25;143(13):5127-5140. Epub 2021 Mar 25.

Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P.R. China.

Immunotherapy has provided a promising strategy for the treatment of cancers. However, even in tumors with high antigen burdens, the systemic inhibition of the antigen presentation still greatly restricts the application of immunotherapy. Here, we construct a tumor protein-engineering system based on the functional tripeptide, Asp-Phe-Tyr (DFY), which can automatically collect and deliver immunogenetic tumor proteins from targeted cells to immune cells. Read More

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A novel tyrosinase from with comparable monophenolase and diphenolase activity suffers substrate inhibition.

Appl Environ Microbiol 2021 Mar 19. Epub 2021 Mar 19.

Dalian Engineering Research Center for Carbohydrate Agricultural Preparations, Liaoning Provincial Key Laboratory of Carbohydrates, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

Tyrosinase is a bifunctional enzyme mediating the -hydroxylation and two-electron oxidation of monophenols to -quinones. The monophenolase activity of tyrosinase is much desired for the industrial synthesis of catechols. However, the generally low ratio of monophenolase/diphenolase activity of tyrosinase limited its utilization in the industry. Read More

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Separation, identification, and molecular docking of tyrosinase inhibitory peptides from the hydrolysates of defatted walnut (Juglans regia L.) meal.

Food Chem 2021 Mar 9;353:129471. Epub 2021 Mar 9.

Beijing Engineering Research Center of Protein & Functional Peptides, China National Research Institute of Food & Fermentation Industries, Beijing 100015, People's Republic of China. Electronic address:

Defatted walnut meal protein was hydrolyzed using alcalase to yield tyrosinase inhibitory peptides. After separation by ultrafiltration and Sephadex G-25, the fraction with the highest tyrosinase inhibitory activity was identified using liquid chromatography-tandem mass spectrometry and 606 peptides were obtained. Then, molecular docking was used to screen for tyrosinase inhibitory peptides and to clarify the theoretical interaction mechanism between the peptides and tyrosinase. Read More

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Preparation and Evaluation of Nanostructured Lipid Carrier for Topical Delivery of Velutin: Synthetic Tyrosinase Inhibitor.

J Nanosci Nanotechnol 2021 Jul;21(7):4093-4097

Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea.

The purpose of this study is to produce nanostructured lipid carrier (NLC) that can solubilize poorly water-soluble velutin and verify an improved tyrosinase synthesis inhibition. A solubility test for velutin was conducted. Cetyl palmitate and caprylic/capric triglyceride were selected as solubilizer. Read More

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Lysophosphatidylcholine exerts an anti-skin photoaging effect via heat shock protein 70 induction.

J Cosmet Dermatol 2021 Mar 13. Epub 2021 Mar 13.

LG Science Park, LG Household & Health Care Ltd., Seoul, Korea.

Objective: Skin-brightening agents prevent melanogenesis and reduce melanin production. However, a lower melanin content leads to weaker protection against sunlight. In this study, we evaluated the effect of lysophosphatidylcholine (LPC) and its commercial-grade product, Lysofix Dry™ (LD), on heat shock protein 70 (HSP70) expression in epidermal cells and their anti-skin photoaging effect against ultraviolet B (UVB) and blue light. Read More

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Design and characterization of Nanostructured lipid carriers (NLC) and Nanostructured lipid carrier-based hydrogels containing Passiflora edulis seeds oil.

Int J Pharm 2021 Mar 10;600:120444. Epub 2021 Mar 10.

MedTech, UCIBIO-REQUIMTE, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

This study aims to design and characterize Nanostructured lipid carriers (NLC) and Nanostructured lipid carrier-based hydrogels with Passiflora edulis seeds oil, a by-product from Madeira Island food industry. NLC were prepared by the ultrasonication technique, using passion fruit seeds oil as a liquid lipid and glyceryl distearate as a solid lipid. These NLC were then gelled with Poly (acrylic acid). Read More

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Understanding the combined effect and inhibition mechanism of 4-hydroxycinnamic acid and ferulic acid as tyrosinase inhibitors.

Qun Yu Liuping Fan

Food Chem 2021 Aug 24;352:129369. Epub 2021 Feb 24.

State Key Laboratory of Food Science & Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China; Collaborat Innovat Ctr Food Safety & Qual Control, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China. Electronic address:

The development of tyrosinase inhibitors to prevent the enzymatic browning have become a research hotspot in food industry. 4-Hydroxycinnamic acid (CA) and ferulic acid (FA) are both the derivates of cinnamic acids, which are widely coexisted in plants seeds and leaves. CA combined with FA (inhibition rate of 90. Read More

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Microcapsule-based biosensor containing catechol for the reagent-free inhibitive detection of benzoic acid by tyrosinase.

Biosens Bioelectron 2021 May 3;180:113137. Epub 2021 Mar 3.

Université Grenoble Alpes, DCM UMR 5250, F-38000, Grenoble, France; CNRS, DCM UMR 5250, F-38000, Grenoble, France. Electronic address:

A biosensor based on the release of the enzyme substrate from its structure was developed for the inhibitive detection of benzoic acid. A polyurethane support comprising two perforated microcapsules (800 μm in diameter) filled with methylene blue as a model compound and covered with a conductive deposit of multiwalled carbon nanotubes, continuously released this stored dye for 24 h. An increase in methylene blue concentration of 0. Read More

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Phytochemical Investigations and In Vitro Bioactivity Screening on Melia azedarach L. Leaves Extract from Nepal.

Chem Biodivers 2021 Mar 8. Epub 2021 Mar 8.

Central Department of Botany, Tribhuvan University, 44613, Kirtipur, Kathmandu, Nepal.

Melia azedarach is a common tree used in the traditional medicine of Nepal. In this work, leaves were considered as source of bioactive constituents and composition of methanol extract was evaluated and compared with starting plant material. Flavonoid glycosides and limonoids were identified and quantified by HPLC-DAD-MS approaches in dried leaves and methanolic extract, while HPLC-APCI-MS and GC/MS analysis were used to study phytosterol and lipid compositions. Read More

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Depigmenting effect of Xanthohumol from hop extract in MNT-1 human melanoma cells and normal human melanocytes.

Biochem Biophys Rep 2021 Jul 24;26:100955. Epub 2021 Feb 24.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.

Xanthohumol (XH) is the most abundant prenylated flavonoid found in the hop plant (.) and has previously been shown to have depigmenting effects in B16F10 mouse melanoma cells; however, studies of its depigmenting efficacy in human melanocytes are still lacking. In this work, we explored the effects of XH on melanogenesis in MNT-1 human melanoma cells and normal human melanocytes from darkly-pigmented skin (HEM-DP). Read More

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Effect of 7-Methylsulfinylheptyl Isothiocyanate on the Inhibition of Melanogenesis in B16-F1 Cells.

Life (Basel) 2021 Feb 20;11(2). Epub 2021 Feb 20.

Department of Biomedical Science, College of Natural Sciences, Chosun University, Gwangju 61452, Korea.

Skin aging, characterized by hyperpigmentation, inflammation, wrinkles, and skin cancer, is influenced by intrinsic and extrinsic factors with synergistic effects. Autophagy maintains the homeostatic balance between the degradation, synthesis, and recycling of cellular proteins and organelles, and plays important roles in several cellular and biological processes, including aging. The compound 7-methylsulfinylheptyl isothiocyanate (7-MSI) is a sulfur-containing phytochemical produced by various plants, particularly cruciferous vegetables, with reported anti-inflammatory properties and a role in pathogen defense; however, its effects on skin whitening have not been studied in detail. Read More

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February 2021

Pharmacological Potential and Chemical Characterization of Benth.-A Native Tropical African Medicinal Plant.

Antibiotics (Basel) 2021 Feb 23;10(2). Epub 2021 Feb 23.

Department of Life Sciences and Biotechnology (SVeB), UR7 Terra&Acqua Tech, University of Ferrara, 44121 Ferrara, Italy.

To avail the possible pharmacological actions of Benth., the present investigation was designed to quantitatively analyze the total flavonoid and phenolic contents and assess the various antioxidant and enzyme inhibition properties of leaf and stem bark extracts (ethyl acetate, water and methanolic) of Anti-proliferative effect was also investigated against human colon cancer cells (HCT116) as well as the antimicrobial potential against multiple bacterial and fungal (yeasts and dermatophytes) strains. The methanolic and water extracts of the stem bark demonstrated the highest phenolic content (193. Read More

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February 2021

Phytochemical Characterization and Evaluation of Bioactive Properties of Tisanes Prepared from Promising Medicinal and Aromatic Plants.

Foods 2021 Feb 22;10(2). Epub 2021 Feb 22.

Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.

The chemical composition and biological properties correlation in several medicinal and aromatic plants is still underexplored, especially in its most common form of consumption as tisane. The present study aims to characterize the organic acids and vitamin E composition of five tisanes and their extracts by High-Performance Liquid Chromatography coupled to a diode-array detector (HPLC-DAD) and HPLC coupled to a fluorescence detector techniques, respectively, and the phenolic composition by HPLC-DAD-ESI/MS (mass spectrometry by electrospray ionization). It also focuses on their bioactive properties, namely antioxidant, antimicrobial, anti-inflammatory, cytotoxic, anti-tyrosinase, and anti-diabetic activities. Read More

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February 2021