11 results match your criteria typhi-specific mucosal

  • Page 1 of 1

Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans.

Immun Ageing 2021 Apr 19;18(1):19. Epub 2021 Apr 19.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Background: The impact of aging on the immune system is unequivocal and results in an altered immune status termed immunosenescence. In humans, the mechanisms of immunosenescence have been examined almost exclusively in blood. However, most immune cells are present in tissue compartments and exhibit differential cell (e. Read More

View Article and Full-Text PDF

Oral typhoid vaccine Ty21a elicits antigen-specific resident memory CD4 T cells in the human terminal ileum lamina propria and epithelial compartments.

J Transl Med 2020 02 25;18(1):102. Epub 2020 Feb 25.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Background: Salmonella enterica serovar Typhi (S. Typhi) is a highly invasive bacterium that infects the human intestinal mucosa and causes ~ 11.9-20. Read More

View Article and Full-Text PDF
February 2020

Attenuated Oral Typhoid Vaccine Ty21a Elicits Lamina Propria and Intra-Epithelial Lymphocyte Tissue-Resident Effector Memory CD8 T Responses in the Human Terminal Ileum.

Front Immunol 2019 14;10:424. Epub 2019 Mar 14.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.

Tissue-resident memory T cells (T) are newly defined memory T cells (T) distinct from circulating T subsets which have the potential to mount rapid protective immune responses at the site of infection. However, very limited information is available regarding the role and contribution of T in vaccine-mediated immune responses in humans at the site of infection. Here, we studied the role and contribution of tissue resident memory T cells (T) located in the terminal ileum (TI) (favored site of infection for . Read More

View Article and Full-Text PDF

Association between . Typhi-specific memory CD4+ and CD8+ T responses in the terminal ileum mucosa and in peripheral blood elicited by the live oral typhoid vaccine Ty21a in humans.

Hum Vaccin Immunother 2019 2;15(6):1409-1420. Epub 2019 Apr 2.

a Center for Vaccine Development and Global Health , University of Maryland School of Medicine , Baltimore , MD , USA.

CD4+ and CD8+ T subsets are essential components of the adaptive immune system which act in concert at the site of infections to effectively protect against pathogens. Very limited data is available in humans regarding the relationship between CD4+ and CD8+ . Typhi responsive cells in the terminal ileum mucosa (TI) and peripheral blood following Ty21a oral typhoid immunization. Read More

View Article and Full-Text PDF

Effect of the live oral attenuated typhoid vaccine, Ty21a, on systemic and terminal ileum mucosal CD4+ T memory responses in humans.

Int Immunol 2019 02;31(2):101-116

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Our current understanding of CD4+ T-cell-mediated immunity (CMI) elicited by the oral live attenuated typhoid vaccine Ty21a is primarily derived from studies using peripheral blood. Very limited data are available in humans regarding mucosal immunity (especially CD4+ T) at the site of infection (e.g. Read More

View Article and Full-Text PDF
February 2019

Systemic and Terminal Ileum Mucosal Immunity Elicited by Oral Immunization With the Ty21a Typhoid Vaccine in Humans.

Cell Mol Gastroenterol Hepatol 2017 Nov 16;4(3):419-437. Epub 2017 Aug 16.

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland.

Background & Aims: Systemic cellular immunity elicited by the Ty21a oral typhoid vaccine has been extensively characterized. However, very limited data are available in humans regarding mucosal immunity at the site of infection (terminal ileum [TI]). Here we investigated the host immunity elicited by Ty21a immunization on terminal ileum-lamina propria mononuclear cells (LPMC) and peripheral blood in volunteers undergoing routine colonoscopy. Read More

View Article and Full-Text PDF
November 2017

PLGA-microencapsulation protects Salmonella typhi outer membrane proteins from acidic degradation and increases their mucosal immunogenicity.

Vaccine 2016 07 29;34(35):4263-4269. Epub 2016 Jun 29.

Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen, Switzerland. Electronic address:

Salmonella (S.) enterica infections are an important global health problem with more than 20 million individuals suffering from enteric fever annually and more than 200,000 lethal cases per year. Although enteric fever can be treated appropriately with antibiotics, an increasing number of antibiotic resistant Salmonella strains is detected. Read More

View Article and Full-Text PDF

Immunization with Ty21a live oral typhoid vaccine elicits crossreactive multifunctional CD8+ T-cell responses against Salmonella enterica serovar Typhi, S. Paratyphi A, and S. Paratyphi B in humans.

Mucosal Immunol 2015 Nov 15;8(6):1349-59. Epub 2015 Apr 15.

Department of Pediatrics, Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Previously we have extensively characterized Salmonella enterica serovar Typhi (S. Typhi)-specific cell-mediated immune (CMI) responses in volunteers orally immunized with the licensed Ty21a typhoid vaccine. In this study we measured Salmonella-specific multifunctional (MF) CD8+ T-cell responses to further investigate whether Ty21a elicits crossreactive CMI against S. Read More

View Article and Full-Text PDF
November 2015

Cross-reactive gut-directed immune response against Salmonella enterica serovar Paratyphi A and B in typhoid fever and after oral Ty21a typhoid vaccination.

Vaccine 2012 Sep 2;30(42):6047-53. Epub 2012 Aug 2.

Department of Bacteriology and Immunology, Haartman Institute, POB 21, 00014 University of Helsinki, Helsinki, Finland.

Background: There are no vaccines against paratyphoid fever in clinical use. The disease has become more wide-spread and there is a growing problem of antibiotic resistance among the strains. Previous reports suggest that the oral live Salmonella Typhi Ty21a-vaccine confers protection against paratyphoid B fever. Read More

View Article and Full-Text PDF
September 2012

Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization.

PLoS One 2012 5;7(6):e38408. Epub 2012 Jun 5.

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, continues to cause significant morbidity and mortality world-wide. CD8+ T cells are an important component of the cell mediated immune (CMI) response against S. Read More

View Article and Full-Text PDF
October 2012

Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans.

Infect Immun 1997 Feb;65(2):452-6

Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA.

A single-dose, oral Salmonella typhi vaccine strain has been sought as a carrier or vector of cloned genes encoding protective antigens of other pathogens. Such a hybrid vaccine, administered orally, would stimulate immune responses both at the mucosal surface and in the systemic compartment and would potentially provide protection against multiple pathogens. S. Read More

View Article and Full-Text PDF
February 1997
  • Page 1 of 1