2,597 results match your criteria type wilcoxon

Phenotyping coronavirus disease 2019 during a global health pandemic: lessons learned from the characterization of an early cohort.

J Biomed Inform 2021 Apr 7:103777. Epub 2021 Apr 7.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN2525 West End Ave, Suite 1475 Nashville, TN USA 37203.

From the start of the coronavirus disease 2019 (COVID-19) pandemic, researchers have looked to electronic health record (EHR) data as a way to study possible risk factors and outcomes. To ensure the validity and accuracy of research using these data, investigators need to be confident that the phenotypes they construct are reliable and accurate, reflecting the healthcare settings from which they are ascertained. We developed a COVID-19 registry at a single academic medical center and used data from March 1 to June 5, 2020 to assess differences in population-level characteristics in pandemic and non-pandemic years respectively. Read More

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An Immune Recovery-Based Revaccination Protocol for Pediatric Hematopoietic Stem Cell Transplant Recipients: Revaccination Outcomes Following Pediatric HSCT.

Transplant Cell Ther 2021 Apr 28;27(4):317-326. Epub 2021 Jan 28.

Division of Pediatric Infectious Diseases, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, Colorado.

Following hematopoietic stem cell transplant (HSCT), patients are at increased risk of vaccine-preventable diseases (VPDs) and experience worse outcomes of VPDs compared to immunocompetent patients. Therefore, patients are routinely vaccinated post-HSCT to restore VPD immunity. Published guidelines recommend revaccination based on time post-HSCT, although optimal revaccination timing and the value of using other clinical and laboratory variables to guide revaccination remain unclear. Read More

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Current practice and perspectives of healthcare providers regarding preconception care for women with type 1 diabetes in China.

Diabetes Metab Res Rev 2021 Apr 2. Epub 2021 Apr 2.

Department of Endocrinology and Metabolism, the Third Affiliated Hospital of Sun Yat-sen University, Guangdong Diabetes Prevention and Control Research Center, Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China.

Aims: We aimed to investigate the current practice and perspectives of healthcare providers (HCPs) regarding preconception care (PCC) for women with type 1 diabetes (T1D) in China.

Materials And Methods: A questionnaire based on in-depth interviews with HCPs involved in PCC was released online and advertised via doctor unions in China. The data were categorical variables and were analysed by multivariable logistic regression, Chi-square test or Wilcoxon rank-sum test. Read More

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Microcomputed Tomographic Assessment of the Single Cone Root Canal Fillings Performed by Undergraduate Student, Postgraduate Student and Specialist Endodontist.

J Clin Med 2021 Mar 5;10(5). Epub 2021 Mar 5.

Institute of Dentistry, Faculty of Medicine, Vilnius University, Zalgirio 115, LT-08217 Vilnius, Lithuania.

The present study evaluated the obturation quality of root canals filled with BioRoot RCS sealer and single gutta-percha point by undergraduate student (US), postgraduate student (PS) and endodontist (ED). Twenty-one plastic models of upper premolars were enlarged with HyFlex EDM instruments to a size 40/0.04 taper and randomly divided into three groups (7 teeth/14 canals per group): US, PS and ED. Read More

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Variation of Efficacy of Filtering Face Pieces Respirators over Time in a Dental Setting: A Pilot Study.

Dent J (Basel) 2021 Mar 24;9(4). Epub 2021 Mar 24.

Department of Biomedical and Neuromotor Sciences-Unit of Dentistry, University of Bologna, 40100 Bologna, Italy.

Since aerosol continuously persists in dental settings, where different procedures and patients come in succession, the use of oronasal masks is highly recommended. Among them, respirators known as Filtering Face Pieces (FFP) show a protective superiority compared to surgical masks. Even concerning respirators classified as non-reusable, it is not known how many hours of use are necessary to compromise their filtering capacity. Read More

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Lower Extremity Rehabilitation in Patients with Post-Stroke Sequelae through Virtual Reality Associated with Mirror Therapy.

Int J Environ Res Public Health 2021 Mar 6;18(5). Epub 2021 Mar 6.

Faculty of Medicine, Transilvania University of Brașov, 500036 Brașov, Romania.

More innovative technologies are used worldwide in patient's rehabilitation after stroke, as it represents a significant cause of disability. The majority of the studies use a single type of therapy in therapeutic protocols. We aimed to identify if the association of virtual reality (VR) therapy and mirror therapy (MT) exercises have better outcomes in lower extremity rehabilitation in post-stroke patients compared to standard physiotherapy. Read More

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Nursing diagnosis "Terminality Syndrome": a content analysis.

Rev Bras Enferm 2021 24;74(1):e20190808. Epub 2021 Mar 24.

Universidade Federal Fluminense. Rio de Janeiro, Rio de Janeiro, Brazil.

Objectives: to validate the nursing diagnosis "Terminality Syndrome" with experts.

Methods: a quantitative research of content validation type based on collective wisdom approach. An online semi-structured questionnaire was used as an instrument for data collection, and Content Validity Index and Wilcoxon test were used for comparing possible differences. Read More

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Molecular Characterization of Residual Bladder Cancer after Neoadjuvant Pembrolizumab.

Eur Urol 2021 Mar 27. Epub 2021 Mar 27.

Decipher Biosciences Inc., Vancouver, British Columbia, Canada. Electronic address:

Background: In patients with muscle-invasive urothelial bladder cancer (MIBC), molecular alterations in immunotherapy-resistant tumors found at radical cystectomy (RC) remain largely unstudied.

Objective: To investigate the biology of pembrolizumab-resistant tumors in comparison to an RC cohort treated without any systemic therapy and a cohort of neoadjuvant chemotherapy (NAC)-treated tumors.

Design, Setting, And Participants: Transcriptome-wide expression profiling was performed on 26 RC samples from patients with ypT2-4 disease after pembrolizumab treatment, of which 22 had matched pretherapy samples. Read More

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Radiomics Texture Features in Advanced Colorectal Cancer: Correlation with Mutation and 5-year Overall Survival.

Radiol Imaging Cancer 2020 Sep 18;2(5):e190084. Epub 2020 Sep 18.

Abdominal Imaging Division, Department of Radiology (A.A.N., A. Parakh, A. Pourvaziri, A.K., D.V.S.), and Cancer Center (R.B.C., D.P.R.), Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114; and Facultad de Medicina y Hospital Universitario "Dr. José E. González," Universidad Autónoma de Nuevo León, Monterrey, Mexico (A.A.N.).

Purpose: To explore the potential of radiomics texture features as potential biomarkers to enable detection of the presence of mutation and prediction of 5-year overall survival (OS) in stage IV colorectal cancer (CRC).

Materials And Methods: In this retrospective study, a total of 145 patients (mean age, 61 years ± 14 [standard deviation {SD}]; 68 female patients and 77 male patients) with stage IV CRC who underwent molecular profiling and pretreatment contrast material-enhanced CT scans between 2004 and 2018 were included. Tumor radiomics texture features, including the mean, the SD, the mean value of positive pixels (MPP), skewness, kurtosis, and entropy, were extracted from regions of interest on CT images after applying three Laplacian-of-Gaussian filters known as spatial scaling factors (SSFs) (SSF = 2, fine; SSF = 4, medium; SSF = 6, coarse) by using specialized software; values of these parameters were also obtained without filtration (SSF = 0). Read More

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September 2020

Type II Endoleak Nidus Volume on Arterial and Delayed Phases of Initial CT Angiography after Endovascular Abdominal Aortic Aneurysm Repair Predicts Persistent Endoleak and Aneurysm Sac Enlargement.

Radiol Cardiothorac Imaging 2021 Feb 4;3(1):e200527. Epub 2021 Feb 4.

Division of Vascular and Interventional Radiology, Department of Radiology, University of North Carolina at Chapel Hill, 2016 Old Clinic, CB 7510, Chapel Hill, NC 27599 (H.Y., A.J.I., C.T.B.); Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC (L.M.B.B.), Department of Surgery, Massachusetts General Hospital, Boston, Mass (J.S.E.).

Purpose: To evaluate type II endoleak nidus volume (ENV) in the arterial phase (ENV) and delayed phase (ENV) of the first postoperative CT angiography (CTA) as a predictor of persistent endoleak and aneurysm sac enlargement at follow-up CTA in patients with endovascular aneurysm repair (EVAR) of abdominal aortic aneurysm.

Materials And Methods: Ninety-three patients (mean age ± standard deviation, 72 years ± 8; range, 56-88 years) with EVAR and type II endoleak were included in a single-institution retrospective study conducted between March 1, 2005, and December 31, 2018. ENV, ENV, change of volume (ENV), and percentage of ENV and ENV in aneurysm sac volume (ASV) (ENV/ASV%, ENV/ASV%, respectively) were measured on first postoperative CTA images. Read More

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February 2021

Evaluation of the impact of a dental trauma care program on oral health-related quality of life of children and their families.

Dent Traumatol 2021 Mar 27. Epub 2021 Mar 27.

Postgraduate Program in Dentistry of the Health Institute of Nova Friburgo (PPGO-ISNF), Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil.

Background/aim: A traumatic dental injury (TDI) may have physical and psychosocial consequences for children and their families, and it may impact their oral health-related quality of life (OHRQoL). The aim of this study was to assess the OHRQoL of children affected by TDI and their families after enrollment in the Dental Trauma Care Program (DTCP).

Methods: This longitudinal clinical study involved a consecutive sample of 2- to 6-year-old children registered in the DTCP over a period of six years. Read More

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Effects of charcoal-based whitening toothpastes on human enamel in terms of color, surface roughness, and microhardness: an in vitro study.

Clin Oral Investig 2021 Mar 27. Epub 2021 Mar 27.

Department of Restorative Dentistry, School of Dentistry, Hacettepe University, 06100 Sıhhıye, Ankara, Turkey.

Objective: Charcoal based oral care products have gained popularity in the last few years. The aim of this in vitro study was to compare the effects of different charcoal based whitening toothpastes on color, surface roughness and microhardness of human enamel.

Materials And Methods: Forty-eight specimens obtained from human permanent upper incisor teeth were randomly divided into 4 groups(n=12):Group-1:Colgate Total 12(CT); Group-2:Body Kingdom(BK); Group-3:Black is White(BW), Group-4:Colgate optic white(COW). Read More

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Use of Three-Dimensional Arterial Spin Labeling to Evaluate Renal Perfusion in Patients With Chronic Kidney Disease.

J Magn Reson Imaging 2021 Mar 26. Epub 2021 Mar 26.

Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: A noninvasive method for evaluating renal blood flow (RBF) in patients with chronic kidney disease (CKD) may have clinical value in disease staging, management, and prognostication.

Purpose: To evaluate effectiveness of three-dimensional pseudocontinuous arterial spin labeling (pCASL) and pulsed arterial spin labeling (PASL) in assessment of cortex and outer medulla (cortex/OM) RBF in CKD patients and healthy volunteers (HVs).

Study Type: Prospective, in a single institution. Read More

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Influence of stereotactic imaging on operative time in deep brain stimulation.

Surg Neurol Int 2021 2;12:82. Epub 2021 Mar 2.

Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.

Background: Various techniques are used across institutions for implantation of deep brain stimulation (DBS) leads. The most used techniques for each step include preoperative MRI fused to in-frame CT, intraoperative fluoroscopy, and postoperative CT, but postimplantation MRI also is used, as it was at our center. We present the quality assurance study performed at our institution after a change from postimplantation MRI performed across the hospital to postimplantation in room CT. Read More

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A Prospective, Longitudinal Magnetic Resonance Imaging Evaluation of Cerebrovascular Reactivity and Infarct Development in Patients With Intracranial Stenosis.

J Magn Reson Imaging 2021 Mar 24. Epub 2021 Mar 24.

Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Background: Patients with symptomatic atherosclerotic and non-atherosclerotic (i.e., moyamoya) intracranial steno-occlusive disease experience high 2-year infarct rates. Read More

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Treatment effects of palliative care consultation and patient contentment: A monocentric observational study.

Medicine (Baltimore) 2021 Mar;100(12):e24320

Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinik und Poliklinik für Strahlentherapie.

Abstract: Palliative care is a central component of the therapy in terminally ill patients. During treatment in non-palliative departments this can be realized by consultation.To analyze the change in symptom burden during palliative care consultation. Read More

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Patient feedback surveys among pregnant women in Eswatini to improve antenatal care retention.

PLoS One 2021 24;16(3):e0248685. Epub 2021 Mar 24.

Mailman School of Public Health, ICAP-Columbia University, New York, NY, United States of America.

Background: Uptake and retention in antenatal care (ANC) is critical for preventing adverse pregnancy outcomes for both mothers and infants.

Methods: We implemented a rapid quality improvement project to improve ANC retention at seven health facilities in Eswatini (October-December 2017). All pregnant women attending ANC visits were eligible to participate in anonymous tablet-based audio assisted computer self-interview (ACASI) surveys. Read More

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Remnant cholesterol is prospectively associated with CVD events and all-cause mortality in kidney transplant recipients: the FAVORIT study.

Nephrol Dial Transplant 2021 Mar 24. Epub 2021 Mar 24.

Center for Primary Care, Prevention, Brown University, Providence, RI, USA.

Background: The cholesterol content of circulating triglyceride-rich lipoproteins is characterized as remnant cholesterol, although little is known about its role in the development of CVD outcomes, all-cause mortality, or transplant failure in kidney transplant recipients. Our primary aim was to investigate the prospective association of remnant cholesterol and the risk of CVD events in renal transplant recipients with secondary aims evaluating remnant cholesterol and renal graft failure and all-cause mortality among participants in the Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) trial.

Methods: Among 4,110 enrolled participants, 98 were excluded for missing baseline remnant cholesterol levels and covariates. Read More

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Early Postoperative Pain After Total Knee Arthroplasty Is Associated With Subsequent Poorer Functional Outcomes and Lower Satisfaction.

J Arthroplasty 2021 Feb 25. Epub 2021 Feb 25.

Department of Orthopaedic Surgery, Singapore General Hospital, Singapore.

Background: There are few studies investigating the effects of acute postoperative pain on functional outcomes after total knee arthroplasty (TKA). The aims of this study are to identify perioperative factors associated with increased early postoperative pain and investigate the effects of acute postoperative day 1 and 2 pain on outcomes at 6 months and 2 years post-TKA.

Methods: 1041 unilateral TKA patients were included in this retrospective cohort study. Read More

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February 2021

Retinal oxygen saturation is associated with HbA1c but not with short-term diabetes control, internal environment, smoking and mild retinopathy - ROXINEGLYD study.

Acta Ophthalmol 2021 Mar 19. Epub 2021 Mar 19.

Department of Ophthalmology, University Hospital Olomouc, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic.

Purpose: Purpose of this prospective uncontrolled single-centre pilot study was to find an association of retinal oxygen saturation (SatO ) with acid-base balance (ABB), carboxyhaemoglobin concentration, current plasma glucose concentration (PG), mean PG and PG variability over the last 72 hr, haemoglobin A1c (HbA1c), and other conditions.

Methods: Forty-one adults (17 men) with type 1 (N = 14) or type 2 (N = 27) diabetes mellitus, age 48.6 ± 13. Read More

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ProgPerm: Progressive permutation for a dynamic representation of the robustness of microbiome discoveries.

BMC Bioinformatics 2021 Mar 17;22(1):126. Epub 2021 Mar 17.

Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Identification of features is a critical task in microbiome studies that is complicated by the fact that microbial data are high dimensional and heterogeneous. Masked by the complexity of the data, the problem of separating signals (differential features between groups) from noise (features that are not differential between groups) becomes challenging and troublesome. For instance, when performing differential abundance tests, multiple testing adjustments tend to be overconservative, as the probability of a type I error (false positive) increases dramatically with the large numbers of hypotheses. Read More

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Effectiveness of Standard Local Anesthetic Bupivacaine and Liposomal Bupivacaine for Postoperative Pain Control in Patients Undergoing Truncal Incisions: A Randomized Clinical Trial.

JAMA Netw Open 2021 Mar 1;4(3):e210753. Epub 2021 Mar 1.

McGovern Medical School at the University of Texas Health Science Center at Houston.

Importance: Liposomal bupivacaine for pain relief is purported to last 3 days compared with 8 hours with standard bupivacaine. However, its effectiveness is unknown in truncal incisions for cardiothoracic or vascular operations.

Objective: To compare the effectiveness of single-administration standard bupivacaine vs liposomal bupivacaine in patients undergoing truncal incisions. Read More

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Early Implant Placement In Ridge Preserved Extraction Sockets: A pre-clinical in vivo study.

Clin Oral Implants Res 2021 Mar 14. Epub 2021 Mar 14.

Melbourne Dental School, University of Melbourne, Parkville, Victoria, Australia.

Objectives: The aim was to analyze the outcomes of early implant placement after 6 and 12 weeks of healing in ridge reserved sites in a canine model.

Materials And Methods: Implants were placed in second maxillary incisors sites in 9 dogs 6 weeks after grafting of the sockets with 90% deproteinized bovine bone mineral in 10% collagen matrix (DBBMC) and closure with resorbable type I/III porcine collagen matrix (PCM). The implants were randomly assigned to 6 (T6) and 12 (T12) weeks of healing. Read More

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Application of artificial intelligence-based computer-assisted diagnosis on synthetic mammograms from breast tomosynthesis: comparison with digital mammograms.

Eur Radiol 2021 Mar 12. Epub 2021 Mar 12.

Department of Radiology, Yongin Severance Hospital, Research Institute of Radiological Science, Center for Clinical Imaging Data Science, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do, Republic of Korea.

Objective: To compare the diagnostic agreement and performances of synthetic and conventional mammograms when artificial intelligence-based computer-assisted diagnosis (AI-CAD) is applied.

Material And Method: From January 2017 to April 2017, 192 patients (mean age 53.7 ± 11. Read More

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Reduced Field-of-View Diffusion-Weighted Magnetic Resonance Imaging of the Pancreas With Tilted Excitation Plane: A Preliminary Study.

J Magn Reson Imaging 2021 Mar 11. Epub 2021 Mar 11.

Department of Radiology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.

Background: Reduced field-of-view diffusion-weighted imaging (rDWI) with tilted two-dimensional radiofrequency (RF) excitation planes has not yet been applied to the imaging of the pancreas although the utility of this technique which allows the acquisition of high-quality images without aliasing artifacts in the phase-encoding direction has been evaluated for brain and spinal cord imaging.

Purpose: To evaluate the visual image quality of the pancreas by tilting the excitation plane (tilted rDWI) in comparison to conventional DWI (cDWI) and rDWI without using the tilted excitation plane.

Study Type: Retrospective. Read More

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Factors determining nurses' knowledge of evidence-based pressure ulcer prevention practices in Finland: a correlational cross-sectional study.

Scand J Caring Sci 2021 Mar 11. Epub 2021 Mar 11.

Department of Nursing Science, University of Turku, Turku, Finland.

Background: Pressure ulcers cause economic burden, human suffering, pain and decreased health-related quality of life in patients. Pressure ulcers are preventable in most cases, and nursing staff knowledge is a key factor in successful pressure ulcer prevention. Further evidence is needed to better tailor pressure ulcer prevention training programmes to the nursing staff. Read More

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CDCA8 as an independent predictor for a poor prognosis in liver cancer.

Cancer Cell Int 2021 Mar 8;21(1):159. Epub 2021 Mar 8.

Department of Oncology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, 519000, Guangdong, People's Republic of China.

Background: Human cell division cycle associated 8 (CDCA8) a key regulator of mitosis, has been described as a potential prognostic biomarker for a variety of cancers, such as breast, colon and lung cancers. We aimed to evaluate the potential role of CDCA8 expression in the prognosis of liver cancer by analysing data from The Cancer Genome Atlas (TCGA).

Methods: The Wilcoxon rank-sum test was used to compare the difference in CDCA8 expression between liver cancer tissues and matched normal tissues. Read More

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Characteristics and treatment effectiveness of the nummular headache: a systematic review and analysis of 110 cases.

BMJ Neurol Open 2020 12;2(1):e000049. Epub 2020 Mar 12.

Department of Neurology, Rowan University Cooper Medical School, Camden, New Jersey, USA.

Background/objective: Nummular headache (NH) is a primary headache disorder characterised by intermittent or continuous scalp pain, affecting a small circumscribed area of the scalp. As there are limited data in the literature on NH, we conducted this review to evaluate demographic characteristics and factors associated with complete resolution of the headache, and effectiveness of treatment options.

Methods: We performed a systematic review of cases reported through PubMed database, using Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol and 'nummular headache', 'coin-shaped headache' and 'coin-shaped cephalalgia' keywords. Read More

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Pb-Contaminated Soil from Quintero-Ventanas, Chile: Remediation Using .

ScientificWorldJournal 2021 23;2021:2974786. Epub 2021 Feb 23.

Facultad de Ingeniería, Universidad de Playa Ancha, Av. Carvallo 270, Valparaíso 2490000, Chile.

A phytoremediation process for lead (Pb) under laboratory conditions on contaminated soil from the Puchuncaví commune, Valparaíso Province, Chile, was carried out. It analyzed the phytoremediation potential of (Lag.) M. Read More

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February 2021

Does the Walch Type B Shoulder have a Transverse Force Couple Imbalance? - A Volumetric Analysis of Segmented Rotator Cuff Muscles in Osteoarthritic Shoulders.

J Shoulder Elbow Surg 2021 Mar 3. Epub 2021 Mar 3.

MQ Health Translational Shoulder Research Program, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, NSW, Australia. Electronic address:

Background: The etiology of the Walch type B shoulder remains unclear. We hypothesize that a scapulohumeral muscle imbalance, secondary to a disturbed transverse force couple (TFC) between the anterior and posterior rotator cuff muscles, may have a role in the pathogenesis of the type B morphology. The purpose of this study was to determine whether there is a transverse force couple imbalance in the Walch type B shoulder using an imaging-based 3D volumetric and fatty infiltration assessment of segmented rotator cuff muscles. Read More

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