Int J Biol Macromol 2021 Jul 30. Epub 2021 Jul 30.
Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, China; School of Life Sciences, Zhengzhou University, Zhengzhou, China; College of Veterinary Medicine, Northwest A&F University, Yangling, China; Henan Zhongze Biological Engineering Co., Ltd, Zhengzhou, China; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China; Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonose, Yangzhou University, Yangzhou, China. Electronic address:
Pseudorabies virus (PRV) was isolated from some human cases recently and the infected patients manifested respiratory dysfunction and acute neurological symptoms. However, no effective drug or vaccine, preventing the progression of PRV infection, is available. Nectin-1 was the only reported receptor for PRV cell entry both swine and human origin, representing an excellent target to block PRV infection, and especially its transmission from pigs to humans. Read More