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Comparison of Bone Mineral Density and Markers of Bone Turnover in Osteoporotic Women after 6-Month Treatment with Alendronate or Bazedoxifene: A Randomized Controlled Trial.

J Bone Metab 2021 May 31;28(2):131-137. Epub 2021 May 31.

Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background: In a randomized controlled trial, we compared the bone mineral densities (BMDs) and blood markers of bone turnover during short-term treatment of osteoporotic women with bisphosphonate alendronate or bazedoxifene, a selective estrogen receptor modulator.

Methods: Ten and eleven patients were randomized to the alendronate and bazedoxifene groups, respectively. BMDs were measured before and after 6 months of treatment. Read More

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Caloric restriction enhances vascular tone of cerebral and mesenteric resistance arteries in aged rats.

Mech Ageing Dev 2021 Jun 12:111520. Epub 2021 Jun 12.

Department of Biology, Ecology and Earth Sciences, University of Calabria, 87036, Rende, Italy; Department of Obstetrics, Gynecology and Reproductive Science, University of Vermont, Burlington, VT, 05405, USA. Electronic address:

Vascular changes of tone and biomechanical properties induced by ageing increase the risk for cardiovascular diseases. Caloric restriction (CR) has been shown to protect against cardiovascular diseases and improve endothelial dysfunction in cerebral resistance arteries. We hypothesise that CR will enhance vascular tone and structural properties of cerebral resistance arteries and exert comparable beneficial effects on the systemic vasculature of aged rat model. Read More

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Implant failure following pedicle based dynamic stabilization of the lumbar spine.

Acta Orthop Belg 2021 Mar;87(1):191-196

Pedicle-based dynamic stabilization (PBDS) devices such as Dynesys are promoted as an alternative and less invasive option for rigid stabilization of one and even more levels of the lumbar spine. Promising features of the Dynesys system, as well as shortcomings, became obvious in several clinical studies. Since 2012, we started using a new PBDS device as an alternative for the Dynesys, to avoid the screw loosening and the kyphosing effect. Read More

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Potential Role of Natriuretic Response to Furosemide Stress Test During Acute Heart Failure.

Circ Heart Fail 2021 Jun 15;14(6):e008166. Epub 2021 Jun 15.

Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, Spain (P.C.P., J.N., L.M.F., Z.B.-B., J.C.L.-A., J.d.J.B., M.D.G.-C.C., P.E.S., R.S.-B., F.A.Y., J.F.D.).

Background: Poor natriuresis has been associated with a poorer response to diuretic treatment and worse prognosis in acute heart failure. Recommendations on how and when to measure urinary sodium (UNa) are lacking. We aim to evaluate UNa quantification after a furosemide stress test (FST) capacity to predict appropriate decongestion during acute heart failure hospitalization. Read More

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Cancer incidence in the middle region of Libya: Data from the cancer epidemiology study in Misurata.

Cancer Rep (Hoboken) 2021 Jun 15:e1448. Epub 2021 Jun 15.

Faculty of Medicine, University of Misurata, Misrata, Libya.

Background: Cancer incidence and cancer registries are essential for local epidemiological information. In Libya, scarce evidence exists with regard to incidence rates and distribution.

Aim: To estimate cancer incidence in Libya and draw trends of cancer type distribution compared to regional and worldwide data. Read More

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Treatment for grade 4 peripheral intravenous infiltration with type 3 skin tears: A case report and literature review.

Int Wound J 2021 Jun 15. Epub 2021 Jun 15.

Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Ontario, Canada.

Grade 4 peripheral intravenous infiltration with skin tears has seldom been reported. On 4 August 2020, a 35-year-old female patient was admitted to the emergency department of our hospital because of postprandial abdominal pain for 2 hours. She was diagnosed with a severe acute pancreatitis with type II diabetes mellitus. Read More

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Can Autologous Adipose-Derived Mesenchymal Stem Cell Transplantation Improve Sexual Function in People with Sexual Functional Deficiency?

Stem Cell Rev Rep 2021 Jun 15. Epub 2021 Jun 15.

Vinmec Research Institute of Stem Cell and Gene Technology (VRISG), Vinmec Health Care System, Hanoi, Vietnam.

Background: Sexual functional deficiency occurs at some point in life and becomes a problematic issue in middle-aged adulthood. Regenerative medicine, especially mesenchymal stem cell (MSC) transplantation, has developed extensively, with preclinical and clinical trials emphasizing the benefits of stem cell therapy for restoration of sexual deficiency. This study was designed to develop a new therapeutic stem cell treatment for people with sexual functional deficiency. Read More

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Does a combination treatment of repetitive transcranial magnetic stimulation and occupational therapy improve upper limb muscle paralysis equally in patients with chronic stroke caused by cerebral hemorrhage and infarction?: A retrospective cohort study.

Medicine (Baltimore) 2021 Jun;100(24):e26339

Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo.

Abstract: The clinical presentation of stroke is usually more severe in patients with intracerebral hemorrhage (ICH) than in those with cerebral infarction (CI); recovery of stroke-related muscle paralysis is influenced and limited by the type of stroke. To date, many patients have been treated by neurorehabilitation; however, the changes in the recovery of motor paralysis depending on the type of stroke, ICH or CI, have not been established. This study aimed to determine this difference in improvement of upper extremity paralysis using 2-week in-hospital NovEl intervention Using Repetitive transcranial magnetic stimulation combined with Occupational therapy (NEURO). Read More

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Epilepsy surgery in infants up to 3 months of age: Safety, feasibility, and outcomes: A multicenter, multinational study.

Epilepsia 2021 Jun 14. Epub 2021 Jun 14.

Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Objective: Drug-resistant epilepsy (DRE) during the first few months of life is challenging and necessitates aggressive treatment, including surgery. Because the most common causes of DRE in infancy are related to extensive developmental anomalies, surgery often entails extensive tissue resections or disconnection. The literature on "ultra-early" epilepsy surgery is sparse, with limited data concerning efficacy controlling the seizures, and safety. Read More

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Botulinum toxin A (Botox) injection into muscles of pelvic floor as a treatment for persistent pelvic pain secondary to pelvic floor muscular spasm: A pilot study.

Aust N Z J Obstet Gynaecol 2021 Jun 15. Epub 2021 Jun 15.

Endosurgery Department, Mercy Hospital for Women, Melbourne, Victoria, Australia.

Background: Persistent pelvic pain (PPP) remains an important cause of morbidity. Pelvic floor muscle spasm is an important contributor to PPP.

Aims: The study's primary aim was to assess if botulinum toxin (BoNT) injection to pelvic floor muscles altered pain scores or quality of life (QoL) at six, 12 and 26 weeks. Read More

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Operative vs. Non-operative Treatment of Acute Displaced Distal Clavicle Fractures: A Multicentre Randomized Controlled Trial.

J Orthop Trauma 2021 Jun 14. Epub 2021 Jun 14.

St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada Department of Orthopaedic Surgery, University of Arizona College of Medicine - Phoenix, Phoenix, Arizona, U.S. Department of Surgery, Western University, London, Ontario, Canada.

Objectives: To evaluate the differences in patient outcomes following operative or non-operative treatment for displaced, Type II distal clavicle fractures.

Design: Multi-centre, prospective, randomized controlled trial.

Setting: Level I trauma centresPatients/Participants: Patients with completely displaced type II distal clavicle fractures. Read More

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Postpartum Stress and Neural Regulation of Emotion among First-Time Mothers.

Cogn Affect Behav Neurosci 2021 Jun 14. Epub 2021 Jun 14.

Department of Psychology, University of Denver, 2155 South Race Street, Denver, CO, 80208-3500, USA.

Early parenting relies on emotion regulation capabilities, as mothers are responsible for regulating both their own emotional state and that of their infant during a time of new parenting-related neural plasticity and potentially increased stress. Previous research highlights the importance of frontal cortical regions in facilitating effective emotion regulation, but few studies have investigated the neural regulation of emotion among postpartum women. The current study employed a functional neuroimaging (fMRI) approach to explore the association between perceived stress, depressive symptoms, and the neural regulation of emotion in first-time mothers. Read More

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Extent to which COVID-19 will affect future use of the train in Israel.

Transp Policy (Oxf) 2021 Jun 9. Epub 2021 Jun 9.

Transportation Research Institute, Technion City, Haifa, 32000, Israel.

Many countries have taken a variety of measures to stop the spread of SARS-CoV-2, the coronavirus responsible for COVID-19 infections. Among the most important of these involve using social distancing to prevent contact. Restricted social contacts have important effects on activity participation and on travel demand. Read More

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Persistently lower bone mass and bone turnover among south african children living with well-controlled HIV.

AIDS 2021 Jun 14. Epub 2021 Jun 14.

Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Rutgers University, Piscataway, NJ, USA Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Office of Scholarship & Research, School of Nursing, Columbia University, New York, NY, USA New York Nutrition Obesity Research Center, Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA Department of Medicine, Division of Infectious Disease, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA Department of Pediatrics, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA.

Objective: We evaluated longitudinal trends and associations between bone mass, bone turnover and inflammatory markers among South African children living with HIV (CLHIV) and controls.

Design: We previously reported decreased bone mass among CLHIV independent of marked inflammation and increased bone turnover. The goal of this study was to evaluate longitudinal changes in bone mass, bone turnover and inflammation over two years. Read More

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Effect of the type of specialized nutrition support on the course of the patient with amyotrophic lateral sclerosis (ALS). Interhospital registry SCLEDyN.

Endocrinol Diabetes Nutr 2021 Jun 11. Epub 2021 Jun 11.

Hospital Clínico Universitario de Valladolid, Valladolid, España; Instituto de Investigación en Endocrinología y Nutrición (IENVA), Universidad de Valladolid, Valladolid, España.

Introduction: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease in which specialized nutritional support is essential. The objectives of our study were to describe nutritional support at the beginning of follow-up and its impact on anthropometry and survival.

Methods: An interhospital registry was created for the hospitals of Castilla-León through a web platform designed for this purpose. Read More

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Changes in the ambulatory care of prostate cancer patients during the SARS-CoV-2 pandemic. Literature review and contribution of our group in telematic care.

Actas Urol Esp 2021 Apr 30. Epub 2021 Apr 30.

Servicio de Urología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.

Introduction And Objective: The COVID-19 pandemic has brought about changes in the management of urology patients, especially those with prostate cancer. The aim of this work is to show the changes in the ambulatory care practices by individualized telematic care for each patient profile.

Materials And Methods: Articles published from March 2020 to January 2021 were reviewed. Read More

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Xylological Variant of Reverse Fregoli Syndrome, Delusions of Being a Tree.

CNS Spectr 2021 Apr;26(2):145

Smell and Taste Treatment and Research Foundation, Chicago, IL, USA.

Introduction: The delusion of being a living animate non-animal object has not heretofore been reported.

Methods: A 21-year-old right-handed cisgender female, two months prior to presentation, noted stiffness and difficulty with ambulation. One-month prior to admission, she experienced recurrent depression with myriad vegetative and nonvegetative symptoms of depression. Read More

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Baseline Characteristics and Current Standard of Care (SOC) Among US Veterans with Major Depressive Disorder (MDD).

CNS Spectr 2021 Apr;26(2):174-175

Janssen Scientific Affairs, LLC, Titusville, NJ, USA.

Study Objectives: To describe characteristics of veterans with MDD and the different treatment regimens received during the first observed and treated major depressive episode (MDE).

Methods: A retrospective study was performed using the Veterans Health Administration (VHA) database from 4/1/2015 to 2/28/2019 (study period), supplemented with Medicare Part A/B/D data from 4/1/2015 to 12/31/2017. Adult veterans with ≥1 MDD diagnosis in the VHA database between 10/1/2015 and 2/28/2017 (index date) were included if they received ≥1 line of therapy (LOT) within a complete MDE. Read More

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Reversible GABAergic dysfunction involved in hippocampal hyperactivity predicts early-stage Alzheimer disease in a mouse model.

Alzheimers Res Ther 2021 Jun 14;13(1):114. Epub 2021 Jun 14.

Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing, 100069, China.

Background: Neuronal hyperactivity related to β-amyloid (Aβ) is considered an early warning sign of Alzheimer disease (AD). Although increasing evidence supports this opinion, the underlying mechanisms are still unknown.

Methods: Here, we recorded whole-cell synaptic currents and membrane potentials using patch clamping of acute hippocampal slices from human amyloid precursor protein (APP)/presenilin-1 transgenic (5XFAD) mice and their wild-type littermates. Read More

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Biportal endoscopic posterior lumbar decompression and vertebroplasty for extremely elderly patients affected by lower lumbar delayed vertebral collapse with lumbosacral radiculopathy.

J Orthop Surg Res 2021 Jun 14;16(1):380. Epub 2021 Jun 14.

Department of Orthopedic Surgery, Spine Center, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 1, Singil-ro, Yeongdeungpo-gu, Seoul, Republic of Korea, 07441.

Background: Lower lumbar osteoporotic vertebral compression fracture in extremely elderly patients can often lead to lumbosacral radiculopathy (LSR) due to delayed vertebral collapse (DVC). Surgical intervention requires posterior instrumented lumbar fusion as well as vertebral augmentation or anterior column reconstruction depending on the cleft formation and intravertebral instability. However, it is necessary to decide on surgery in consideration of the patient's frail status, surgical invasiveness, and rehabilitation. Read More

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[Short- and mid-term outcomes of percutaneous balloon mitral valvuloplasty under the guidance of ultrasound].

Zhonghua Yi Xue Za Zhi 2021 Jun;101(22):1690-1694

Structural Heart Disease Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.

To evaluate the safety, short- and mid-term outcomes of percutaneous balloon mitral valvuloplasty (PBMV) guided by the ultrasound. In this retrospective study, medical data of 15 patients [9 males and 6 females, with an age of (53±13) years] with PBMV under the guidance of ultrasound in Heart Center of Henan Provincial People's Hospital between December 2016 and January 2019 were collected and reviewed. The short-and mid-term outcomes were analyzed. Read More

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[A Case of Lymphoepithelioma-Like Carcinoma of the Ureter].

Hinyokika Kiyo 2021 May;67(5):205-209

The Department of Urology, Yokohama City University.

Lymphoepithelioma-like carcinoma (LELC) of the ureter is very rare and only 14 previous cases have been reported. Here, we report a case of LELC of the ureter. A 76-year-old woman was admitted to our hospital complaining of gross hematuria. Read More

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Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2/3 trial.

Lancet Oncol 2021 Jun 11. Epub 2021 Jun 11.

Canadian Clinical Trials Group, Queens's University, Kingston, ON, Canada.

Background: Conventional external beam radiotherapy is the standard palliative treatment for spinal metastases; however, complete response rates for pain are as low as 10-20%. Stereotactic body radiotherapy delivers high-dose, ablative radiotherapy. We aimed to compare complete response rates for pain after stereotactic body radiotherapy or conventional external beam radiotherapy in patients with painful spinal metastasis. Read More

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Pathways of emotional autonomy, problem-solving ability, self-efficacy, and self-management on the glycemic control of adolescents with type 1 diabetes: A prospective study.

Res Nurs Health 2021 Jun 14. Epub 2021 Jun 14.

College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan.

This prospective study tested a model to depict associations between a number of individual characteristics and 6-month glycated hemoglobin (HbA1c) levels in adolescents with type 1 diabetes (T1D). Adolescents (N = 232) aged 10-19 years with T1D were recruited from a medical center in Taiwan. Demographic characteristics, emotional autonomy, problem-solving ability, self-efficacy at baseline, and self-management information three months after baseline were collected using a self-reported questionnaire. Read More

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Clinical effects of direct anterior internal fixation with Herbert screws on hip joint function and quality of life in patients with Pipkin II femoral head fractures.

Arch Orthop Trauma Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Traumatic Orthopedics, Renmin Hospital, Hubei University of Medicine, No.39 Chaoyang Road, Maojian, Shiyan, 442000, Hubei, China.

Objective: The study aimed to explore the therapeutic effects of direct anterior internal fixation with Herbert screws on hip joint function and quality of life in patients with Pipkin type II femoral head fractures (FHF).

Methods: From Dec 2017 to Jul 2020, 68 patients with Pipkin type II FHF were received in our hospital and divided into two groups. The direct anterior internal fixation (DAIF) group including 34 cases were treated by direct anterior internal fixation with Herbert screws. Read More

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Evaluation of the histological and biomechanical properties of poly-4-hydroxybutyrate scaffold for pelvic organ prolapse, compared with polypropylene mesh in a rabbit model.

Int Urogynecol J 2021 Jun 14. Epub 2021 Jun 14.

Division of Female Pelvic Medicine and Reconstructive Surgery, Donald and Barbara Zucker School of Medicine at Northwell Health, Long Island, NY, USA.

Introduction And Hypothesis: Poly-4-hydroxybutyrate (P4HB) is a biopolymer produced by Escherichia coli K12 bacteria. P4HB is fully resorbed in vivo by 18-24 months post-implantation. The aim of this study is to evaluate P4HB in the rabbit abdomen and vagina to determine that the biomechanical and histological properties are similar to the standard polypropylene mesh. Read More

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Effectiveness of Perioperative Opioid Educational Initiatives: A Systematic Review and Meta-Analysis.

Anesth Analg 2021 Jun 11. Epub 2021 Jun 11.

Department of Anesthesiology, Hospital for Special Surgery, New York, New York.

Background: Opioids are the most commonly prescribed analgesics in the United States. Current guidelines have proposed education initiatives to reduce the risk of chronic opioid consumption, yet there is lack of efficacy data on such interventions. Our study evaluates the impact of perioperative opioid education on postoperative opioid consumption patterns including opioid cessation, number of pills consumed, and opioid prescription refills. Read More

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Effect of tailored information of vaccination schedule on vaccine uptake in northern Nigeria.

Hum Vaccin Immunother 2021 Jun 14:1-5. Epub 2021 Jun 14.

Independent, Adamawa State, Nigeria.

: A vaccination schedule is complex and dynamic that requires repetitive and timely clinic visits by children and their caretakers. This study investigates whether providing caregivers with one-time tailored information on the vaccination schedule improves the vaccine uptake among children.: The study participants were 534 women each with a child age 8 months or less; they were from 11 settlements in Jada, a local government area in Adamawa state, Nigeria. Read More

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Dapagliflozin: an effective adjunctive treatment in type 1 diabetes.

Cardiovasc Endocrinol Metab 2021 Jun 25;10(2):132-136. Epub 2021 Mar 25.

The School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, UK.

Introduction: Many people with type 1 diabetes (T1DM) continue to run high HbA1c levels with an associated elevated risk of cardiovascular events and increased mortality. We describe here how adjunctive prescription of an SGLT2 inhibitor has improved the glycaemic control of several people with T1DM, where the new technology has been intensively deployed.

Methods: We report outcomes of six adults with T1DM who have been given dapagliflozin in East Cheshire, UK. Read More

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