827 results match your criteria type ivb

Morquio-like dysostosis multiplex presenting with neuronopathic features is a distinct -related phenotype.

JIMD Rep 2021 Jul 8;60(1):23-31. Epub 2021 Mar 8.

Serviço de Genética Médica, HCPA Porto Alegre Brazil.

Background: Morquio B disease (MBD) is a distinct -related dysostosis multiplex presenting a mild phenocopy of -related Morquio A disease. Previously reported cases from European countries carry the W273L variant on at least one allele and exhibit a pure skeletal phenotype (). Only a minority of MBD cases have been described with additional neuronopathic findings (). Read More

View Article and Full-Text PDF

In silico analysis of echinocandins binding to the main proteases of coronaviruses PEDV (3CL) and SARS-CoV-2 (M).

In Silico Pharmacol 2021 1;9(1):41. Epub 2021 Jul 1.

OncoWitan, 59290 Lille, Wasquehal France.

The porcine epidemic diarrhea virus (PEDV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are two highly pathogenic viruses causing tremendous damages to the swine and human populations, respectively. Vaccines are available to prevent contamination and to limit dissemination of these two coronaviruses, but efficient and widely affordable treatments are needed. Recently, four natural products targeting the 3C-like protease (3CL) of PEDV and inhibiting replication of the virus in vitro have been identified: tomatidine, epigallocatechin-3-gallate, buddlejasaponin IVb and pneumocandin B0. Read More

View Article and Full-Text PDF

Legionella pneumophila LegC7 effector protein drives aberrant endoplasmic reticulum:endosome contacts in yeast.

Traffic 2021 08 7;22(8):284-302. Epub 2021 Jul 7.

Department of Microbiology, University of Georgia, Athens, Georgia, USA.

Legionella pneumophila is a facultative intracellular bacterial pathogen, causing the severe form of pneumonia known as Legionnaires' disease. Legionella actively alters host organelle trafficking through the activities of "effector" proteins secreted via a type-IVB secretion system, in order to construct the bacteria-laden Legionella-containing vacuole (LCV) and prevent lysosomal degradation. The LCV is created with membrane derived from host endoplasmic reticulum (ER), secretory vesicles and phagosomes, although the precise molecular mechanisms that drive its synthesis remain poorly understood. Read More

View Article and Full-Text PDF

Complete disease remission in a and co-mutated brain oligometastatic lung cancer patient after immuno-chemotherapy and surgical resection: a case report.

Transl Lung Cancer Res 2021 May;10(5):2298-2305

Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China.

Lung cancer is the most common primary malignancy and tends to metastasize to the brain. A multimodal approach, including systematic therapy (targeted therapy, chemotherapy, immunotherapy) and local consolidative therapy (surgical intervention, radiation therapy, ablation therapy), is essential for treatment of oligometastatic lung cancer. The systemic immunotherapy has been shown to increase response rate and survival, which then has the potential benefit of making localized treatment more feasible for some cases of oligometastatic cancer. Read More

View Article and Full-Text PDF

Epidemiology of the Staphylococcus aureus CA-MRSA USA300 in Belgium.

Eur J Clin Microbiol Infect Dis 2021 Jun 23. Epub 2021 Jun 23.

Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles (LHUB-ULB), CNR Staphylocoques, Route de Lennik 808, 1070, Brussels, Belgium.

The methicillin-resistant Staphylococcus aureus (MRSA) sequence type (ST) 8 Panton-Valentine toxin (PVL)-positive USA300 clone has a worldwide distribution. The USA300 North American (NA) variant, harbouring the arginine catabolic mobile element (ACME), is predominant in the USA while the Latin American (LV) variant is predominant in Northern South America. Both variants have failed to become endemic in Europe. Read More

View Article and Full-Text PDF

Does surgical treatment for unstable fragility fracture of the pelvis promote early mobilization and improve survival rate and postoperative clinical function?

Eur J Trauma Emerg Surg 2021 Jun 22. Epub 2021 Jun 22.

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Purpose: This retrospective multicenter study aimed to compare rates of early mobilization and survival and functional outcome of surgical treatment (S) with that of conservative treatment (C) according to each unstable fragility fracture of the pelvis (FFP) classification type with displacement of the posterior component ≥ 5 mm.

Methods: We analyzed 64 patients with unstable type III and IV FFP who could move and transfer themselves before injury and had ≥ 5 mm displacement of the posterior component. We compared survival rate, early mobilization, walking ability at final follow-up, and complications at admission for each type of surgical and conservative treatment. Read More

View Article and Full-Text PDF

[Surgical strategy for suppurative complications of pancreatic necrosis].

Khirurgiia (Mosk) 2021 (6):10-18

Samara City Hospital No. 10, Samara, Russia.

Severe acute pancreatitis is one of the most difficult problems in emergency abdominal surgery. Mortality among patients with this disease ranges from 20 to 80 percent. The use of staged surgical intervention in the treatment of purulent complications of acute severe pancreatitis may affect not only the risk of open surgery, but also the number of post-operative complications. Read More

View Article and Full-Text PDF

Total Hip Arthroplasty in a Patient with Mucopolysaccharidosis Type IVB.

Case Rep Orthop 2021 28;2021:5584408. Epub 2021 Apr 28.

Department of Orthopedic Surgery, ENDO-Klinik Hamburg, Holstenstr. 2, 22767 Hamburg, Germany.

. Morquio syndrome or mucopolysaccharidosis (MPS) type IV is a rare autosomal recessive lysosomal storage disease, characterized by abnormal metabolism of glycosaminoglycans associated with specific skeletal deformities, also known as dysostosis multiplex. . Read More

View Article and Full-Text PDF

Longitudinal Development of Refractive Error in Children Treated With Intravitreal Bevacizumab or Laser for Retinopathy of Prematurity.

Transl Vis Sci Technol 2021 04;10(4):14

Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Purpose: To compare the patterns of longitudinal refractive error development during the first 3.5 years in children with severe retinopathy of prematurity (ROP) treated with intravitreal bevacizumab (IVB) or laser photocoagulation.

Methods: This prospective cohort study enrolled extremely preterm infants (birth weight < 1000 g, gestational age 23-27 weeks) with type 1 ROP from multiple hospitals in Dallas between 1999 and 2017; IVB group (N = 22); laser group (N = 26). Read More

View Article and Full-Text PDF

Expression, purification and characterization of the IcmG and IcmK proteins of the type IVB secretion system from Coxiella burnetii.

Protein Expr Purif 2021 Oct 11;186:105905. Epub 2021 May 11.

Division of Biochemistry, Department of Chemistry, University of Crete, GR-71003, Voutes, Greece. Electronic address:

Coxiella burnetii, the causative agent of Q fever, is an intracellular bacterial pathogen. Studies on Coxiella have shown that a type IVB secretion system (T4BSS) contributes to the establishment of the infection by transferring protein molecules. In this report, we focus on two core proteins of the Coxiella T4BSS, namely the IcmG/DotF protein (CBU_1626) and the IcmK/DotH protein (CBU_1628). Read More

View Article and Full-Text PDF
October 2021

A rare case of bilateral occipital condyle fractures associated with inferior clivus separation fracture resulting in craniocervical dislocation: a case report and modification of the Anderson and Montesano classification is proposed.

Acta Neurochir (Wien) 2021 Aug 14;163(8):2307-2311. Epub 2021 May 14.

London Bridge Hospital, London, UK.

The authors report a very rare case of bilateral occipital condyle fractures (OCF) that was associated with complete separation fracture of the inferior clivus resulting in craniocervical dislocation alongside dissociation of C1-C2 joint complex. Also, a new type of the Anderson and Montesano classification system is presented with two subtypes of injuries. Type IVA occurs when the OCF is associated a clivus avulsion fracture, while Type IVB occurs when the OCF is associated with complete "en piece" separation fracture of the inferior clivus. Read More

View Article and Full-Text PDF

Transition-Metal Borides (MBenes) as New High-Efficiency Catalysts for Nitric Oxide Electroreduction to Ammonia by a High-Throughput Approach.

Yi Xiao Chen Shen

Small 2021 Jun 13;17(24):e2100776. Epub 2021 May 13.

Institute of Materials Science, TU Darmstadt, 64287, Darmstadt, Germany.

Here, the authors performed density functional theory calculations to study the catalytic performance of the nitric oxide reduction reaction (NORR) via a series of transition metal borides (MBenes). This work screened the M B type MBenes from the IVB to V transition metals from the periodic table and systematically probed the catalytic activity and selectivity for the NORR process. It has been reported that Fe B , Mn B , and Rh B can be high-performance catalysts for converting NO to NH with smaller limiting potentials than other MBenes, and Nb B and Hf B have low limiting potentials of -0. Read More

View Article and Full-Text PDF

Design, synthesis and anti-HIV evaluation of novel 5-substituted diarylpyrimidine derivatives as potent HIV-1 NNRTIs.

Bioorg Med Chem 2021 Jun 5;40:116195. Epub 2021 May 5.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji'nan 250012, China; China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, 44 West Culture Road, 250012 Jinan, Shandong, PR China. Electronic address:

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are widely used in combination therapies against HIV-1. As a continuation of our efforts to discover and develop "me-better" drugs of DAPYs, novel diarylpyrimidine derivatives were designed, synthesized and evaluated for their anti-HIV activities in MT-4 cells. All the compounds demonstrated strong inhibition activity against wide-type HIV-1 strain (III) with EC values in the range of 2. Read More

View Article and Full-Text PDF

Type A thymoma with simultaneous solitary intrapulmonary metastasis: A case report.

Thorac Cancer 2021 06 7;12(12):1923-1926. Epub 2021 May 7.

Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

A 79-year-old woman was referred to our facility because of an abnormal chest shadow. Chest computed tomography (CT) showed a solitary right middle lung nodule with a maximum diameter of 3 mm and anterior mediastinal nodule with a maximum diameter of 21 mm. The lung nodule was suspected of being a primary lung cancer rather than a metastatic tumor because there were no primary malignant tumors, apart from an anterior mediastinal tumor visible on diagnostic imaging, including F fluorodeoxyglucose-positron emission tomography, and a solitary lung nodule. Read More

View Article and Full-Text PDF

Factors associated with reactivation after intravitreal bevacizumab or ranibizumab therapy in infants with retinopathy of prematurity.

Retina 2021 May 3. Epub 2021 May 3.

Department of Ophthalmology, Kindai University Faculty of Medicine, 377-2, Ohonohigashi, Osakasayama, Osaka, 589-8511, Japan Department of Pediatrics, Kindai University Faculty of Medicine, 377-2, Ohonohigashi, Osakasayama, Osaka, 589-8511, Japan.

Purpose: To investigate the efficacy and risk factors of intravitreal anti-vascular endothelial growth factor injection (anti-VEGF therapy) for retinopathy of prematurity (ROP).

Methods: We retrospectively reviewed 80 consecutive eyes of 43 patients with type 1 ROP or worse who received anti-VEGF therapy during January 2012-February 2018. Patients were divided into those who were injected with 0. Read More

View Article and Full-Text PDF

Pedicle screw system reconstruction in shoulder resection type IV-total scapulectomy: A case report and short term follow up.

Int J Surg Case Rep 2021 May 27;82:105899. Epub 2021 Apr 27.

Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia. Electronic address:

Introduction: Shoulder resection remains a challenging procedure after scapulectomy for tumour resection. The results have various functional outcome, wound coverage, and cosmetic aspect. In this case report, we reported the outcome of pedicle screw application after scapulectomy procedure within 1 month follow up after surgical tumour excision. Read More

View Article and Full-Text PDF

Characteristics and classification of medial malleolar fractures.

Bone Joint J 2021 May;103-B(5):931-938

Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing, China.

Aims: The morphology of medial malleolar fracture is highly variable and difficult to characterize without 3D reconstruction. There is also no universally accepeted classification system. Thus, we aimed to characterize fracture patterns of the medial malleolus and propose a classification scheme based on 3D CT reconstruction. Read More

View Article and Full-Text PDF

Skeletal Abnormalities and VDR1 Gene Polymorphisms in Mucopolysaccharidosis Patients.

Pharmgenomics Pers Med 2021 17;14:349-358. Epub 2021 Mar 17.

Department of Medical Genetics, Clinical Emergency Hospital for Children, Cluj-Napoca, Romania.

Introduction: Articular and bone damage, which is so disabling in Mucopolysaccharidosis (MPS), requires attention as to the explanatory bias of the pathogenetic mechanisms identified to date. The vitamin D receptor (VDR) has been investigated in many studies in correlation with bone metabolism, osteoporosis, and the impaired bone mineral density associated with certain polymorphisms of the VDR gene.

Aim: This study aims to observe whether there is an association between clinical features, phospho-calcium metabolism parameters and the VDR gene polymorphisms in patients with MPS. Read More

View Article and Full-Text PDF

The role of maternal effects on offspring performance in familiar and novel environments.

Heredity (Edinb) 2021 Jul 6;127(1):52-65. Epub 2021 Apr 6.

Division of Ecology & Evolution, Research School of Biology, The Australian National University, Canberra, ACT, Australia.

Maternal effects are an important evolutionary force that may either facilitate adaptation to a new environment or buffer against unfavourable conditions. The degree of variation in traits expressed by siblings from different mothers is often sensitive to environmental conditions. This could generate a Maternal-by-Environment interaction (M × E) that inflates estimates of Genotype-by-Environment effects (G × E). Read More

View Article and Full-Text PDF

Orbital Design of Two-Dimensional Transition-Metal Peroxide Kagome Crystals with Anionogenic Dirac Half-Metallicity.

J Phys Chem Lett 2021 Apr 2;12(14):3528-3534. Epub 2021 Apr 2.

Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Materials for Energy Conversion, CAS Center for Excellence in Nanoscience, and School of Chemistry and Materials Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.

Assembling p orbital ferromagnetic half-metallicity and a topological element, such as a Dirac point at the Fermi level, in a single nanomaterial is of particular interest for long-distance, high-speed, and spin-coherent transportation in nanoscale spintronic devices. On the basis of the tight-binding model, we present an orbital design of a two-dimensional (2D) anionogenic Dirac half-metal (ADHM) by patterning cations with empty d orbitals and anions with partially filled p-type orbitals into a kagome lattice. Our first-principles calculations show that 2D transition-metal peroxides TM(O) (TMO, TM = Ti, Zr, Hf), containing group IVB transition-metal cations [TM] bridged with dioxygen anions [O] in a kagome structure, are stable ADHMs with a Curie temperature over 103 K. Read More

View Article and Full-Text PDF

Prognostic impact of the subclassification of Müllerian cancer stage IV in the FIGO 2014 staging system with a focus of extra-abdominal lymph node metastases.

Int J Clin Oncol 2021 Jul 30;26(7):1330-1335. Epub 2021 Mar 30.

Department of Gynecology and Obstetrics, Graduate School of Medical Science, Kyushu University Hospital, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: The International Federation of Gynecology and Obstetrics (FIGO) staging system for Müllerian cancer was changed in 2014. Our objective was to evaluate the prognostic impact of stage IV subclassification in this new staging system, especially focusing on extra-abdominal lymph node metastasis.

Methods: Eighty-two patients with stage IV Müllerian cancer treated between 2005 and 2016 at our hospital were retrospectively analyzed. Read More

View Article and Full-Text PDF

Coxiella burnetii encodes an LvgA-related protein important for intracellular replication.

Cell Microbiol 2021 Jun 22;23(6):e13331. Epub 2021 Apr 22.

Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.

Coxiella burnetii is a bacterial pathogen that replicates in a specialised lysosome-derived organelle called the Coxiella-containing vacuole (CCV). Establishment of the CCV requires the Dot/Icm type IVB secretion system. A previous transposon mutagenesis screen identified the gene cbu1754 as being important for the intracellular replication of C. Read More

View Article and Full-Text PDF

Contributions of lipopolysaccharide and the type IVB secretion system to Coxiella burnetii vaccine efficacy and reactogenicity.

NPJ Vaccines 2021 Mar 19;6(1):38. Epub 2021 Mar 19.

Coxiella Pathogenesis Section, Laboratory of Bacteriology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.

Coxiella burnetii is the bacterial causative agent of the zoonosis Q fever. The current human Q fever vaccine, Q-VAX, is a fixed, whole cell vaccine (WCV) licensed solely for use in Australia. C. Read More

View Article and Full-Text PDF

Disentangling molecular and clinical stratification patterns in beta-galactosidase deficiency.

J Med Genet 2021 Mar 18. Epub 2021 Mar 18.

Department of Pediatric Metabolism, Reference Center of Inherited Metabolic Disorders, Femme Mère Enfant Hospital, Lyon, France.

Introduction: This study aims to define the phenotypic and molecular spectrum of the two clinical forms of β-galactosidase (β-GAL) deficiency, GM1-gangliosidosis and mucopolysaccharidosis IVB (Morquio disease type B, MPSIVB).

Methods: Clinical and genetic data of 52 probands, 47 patients with GM1-gangliosidosis and 5 patients with MPSIVB were analysed.

Results: The clinical presentations in patients with GM1-gangliosidosis are consistent with a phenotypic continuum ranging from a severe antenatal form with hydrops fetalis to an adult form with an extrapyramidal syndrome. Read More

View Article and Full-Text PDF

Transcriptional profiling of biofilms formed on chilled beef by psychrotrophic meat spoilage bacterium, 1793.

Biofilm 2021 Dec 17;3:100045. Epub 2021 Feb 17.

CSIRO, Agriculture and Food, Werribee, 3030, Victoria, Australia.

is the predominant bacterial species associated with spoiled aerobically stored chilled meat worldwide. It readily forms biofilms on meat under refrigerated temperature conditions used in the meat industry. Biofilm growth leads to slime development on meat which in turn becomes a major quality defect. Read More

View Article and Full-Text PDF
December 2021

Hilar portal vein wedge resection and patch venoplasty in patients undergoing bile duct resection for hepatobiliary malignancy: A report of two cases.

Ann Hepatobiliary Pancreat Surg 2021 Feb;25(1):132-138

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Margin-free resection is one of the most important factors for favorable prognosis in patients undergoing resection for hepatobiliary malignancies. Herein, we present two cases of hepatobiliary malignancies in patients who underwent bile duct resection combined with hilar portal vein (PV) resection and vein allograft patch plasty. The first case was a 51-year-old female patient with gallbladder cancer, in whom we performed extended cholecystectomy, bile duct resection and extensive lymph node dissection. Read More

View Article and Full-Text PDF
February 2021

The Variation of the Pelvis in Unilateral Crowe Type IV Developmental Dysplasia of the Hip.

Orthop Surg 2021 Apr 22;13(2):546-552. Epub 2021 Feb 22.

Department of Orthopaedics, General Hospital of Chinese People's Liberation Army, Beijing, China.

Objective: To investigate variation of the pelvis in unilateral Crowe type IV developmental dysplasia of the hip (DDH) and analyze the reliability of pelvic landmarks.

Methods: We retrospectively received preoperative anteroposterior pelvic radiographs for 89 adult patients with unilateral Crowe type IV DDH at our institution between September 2008 and May 2019. Forty-eight patients without a false acetabulum was type IVA and 41 with a false acetabulum was type IVB. Read More

View Article and Full-Text PDF

Bevacizumab and neurodevelopmental outcomes of preterm infants with retinopathy of prematurity: should we still worry?

J Matern Fetal Neonatal Med 2021 Feb 22:1-8. Epub 2021 Feb 22.

Department of Neonatology, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, University of Health Sciences Turkey, Ankara, Turkey.

Aim: Bevacizumab may affect preterm infants' ongoing organogenesis with its antiangiogenic effects. We aimed to compare neurodevelopmental outcomes (NDO) of preterm infants treated for retinopathy of prematurity (ROP) with laser photocoagulation (LP), intravitreal bevacizumab (IVB) or both treatments, and to find out the effects of IVB on NDO.

Methods: Medical records of preterm infants with ROP treatment and evaluation for NDO were retrospectively collected between 1 January 2017 and 31 June 2019. Read More

View Article and Full-Text PDF
February 2021

Classification of brain arteriovenous malformations located in motor-related areas based on location and anterior choroidal artery feeding.

Stroke Vasc Neurol 2021 Feb 16. Epub 2021 Feb 16.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Objective: Surgical management of arteriovenous malformations (AVMs) involving motor cortex or fibre tracts (M-AVMs) is challenging. This study aimed to construct a classification system based on nidus locations and anterior choroidal artery (AChA) feeding to pre-surgically evaluate motor-related and seizure-related outcomes in patients undergoing resection of M-AVMs.

Methods And Materials: A total of 125 patients who underwent microsurgical resection of M-AVMs were retrospectively reviewed. Read More

View Article and Full-Text PDF
February 2021