13,463 results match your criteria type hpv


Effectiveness Of Human Papillomavirus (HPV) Vaccination Against Penile Hpv Infection In Men Who Have Sex With Men And Transgender Women.

J Infect Dis 2021 Jul 28. Epub 2021 Jul 28.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: In the United States, HPV vaccination has been recommended since 2011 for males aged 11-12 years, with catch-up vaccination recommended through age 26 years for previously unvaccinated men who have sex with men (MSM).

Methods: During 2016-2018, a cross-sectional study enrolled MSM and transgender women aged 18-26 years in Seattle, Washington. Participants submitted self-collected penile swab specimens for HPV genotyping. Read More

View Article and Full-Text PDF

Lineage analysis of human papillomavirus type 39 in cervical samples of Iranian women.

Virol J 2021 Jul 22;18(1):152. Epub 2021 Jul 22.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14155, Iran.

Background: The data with regards to the regional variants of distinct HPV types is of great value. Accordance with this, this study aimed to investigate the sequence variations of E6 gene and long control region of HPV 39 among normal, premalignant and malignant cervical samples in order to characterize the frequent HPV 39 variants circulating in Tehran, Iran.

Methods: In total, 70 cervical samples (45 normal, 16 premalignant, and 9 malignant samples) infected with HPV 39 were analyzed by nested-PCR and sequencing. Read More

View Article and Full-Text PDF

The impact of HPV vaccination on the prevention of oropharyngeal cancer: A scoping review.

Community Dent Health 2021 Jul 15. Epub 2021 Jul 15.

Centre for Dental Public Health and Primary Care, Queen Mary University London, United Kingdom.

Introduction: HPV-associated oropharyngeal cancer (OPC) has one of the most rapidly rising incidences of any cancer in high-income countries. HPV vaccination is being tested to prevent HPV-associated OPC.

Objective: To determine the effect of Human Papilloma Virus (HPV) vaccination on the prevention of OPC in adults worldwide. Read More

View Article and Full-Text PDF

Surgeon practice patterns in transoral robotic surgery for HPV-related oropharyngeal cancer.

Oral Oncol 2021 Jul 20;121:105460. Epub 2021 Jul 20.

Caruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States. Electronic address:

Objectives: Analyze how otolaryngologists approach HPV-related oropharyngeal cancer in terms of patient selection for transoral surgery, perceptions of treatment related risks and benefits, and adjuvant treatment decisions.

Materials And Methods: A survey on HPV-related cancer management was distributed to otolaryngologists in the US through RedCap. Differences in responses were analyzed using Pearson's chi-squared and Fisher's exact tests. Read More

View Article and Full-Text PDF

Seborrheic Keratosis-Like Lesion of the Cervix: First Report of the Cytological Features of a Low-Risk HPV 42-Associated Lesion.

Acta Cytol 2021 Jul 22:1-5. Epub 2021 Jul 22.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, United Kingdom.

Introduction: Seborrheic keratosis-like lesion of the cervix and vagina is a rare lesion and shows similar morphology to vulvar seborrheic keratosis; 3 of the 7 previously reported cases were associated with low-risk human papillomavirus (HPV) type 42. We report a case of seborrheic keratosis-like lesion of the cervix and provide the first description of the cytological features of this lesion.

Case Presentation: A woman in her late forties presented with postcoital bleeding. Read More

View Article and Full-Text PDF

Willingness to pay for and acceptance of cervical cancer prevention methods: A systematic review and meta-analysis.

Med J Islam Repub Iran 2021 23;35:81. Epub 2021 Jun 23.

Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.

The Willingness to pay (WTP) for and acceptance of cervical cancer prevention (CCP) methods have an important role in the control of this type of cancer. Therefore, the aim of this study was to estimate the WTP and acceptance of CCP methods with the contingent valuation method (CVM). In this systematic review and meta-analysis study, the required information was collected by searching relevant keywords in PubMed, Scopus, Embase, Web of Knowledge, and their Persian equivalent in the Scientific Information Database (SID) and Elmnet databases during January 1, 2000 to June 30, 2020. Read More

View Article and Full-Text PDF

Increased PD-1 Level in Severe Cervical Injury Is Associated With the Rare Programmed Cell Death 1 () rs36084323 A Allele in a Dominant Model.

Front Cell Infect Microbiol 2021 1;11:587932. Epub 2021 Jul 1.

Laboratory of Immunogenetics, Department of Immunology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.

The high-risk oncogenic human papillomavirus (HPV) has developed mechanisms for evasion of the immune system, favoring the persistence of the infection. The chronic inflammation further contributes to the progression of tissue injury to cervical cancer. The programmed cell death protein (PD-1) after contacting with its ligands (PD-L1 and PD-L2) exerts an inhibitory effect on the cellular immune response, maintaining the balance between activation, tolerance, and immune cell-dependent lesion. Read More

View Article and Full-Text PDF

Prevalence of human papillomavirus genotypes in high-grade cervical precancer and invasive cervical cancer from cancer registries before and after vaccine introduction in the United States.

Cancer 2021 Jul 21. Epub 2021 Jul 21.

Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: US population-based cancer registries can be used for surveillance of human papillomavirus (HPV) types found in HPV-associated cancers. Using this framework, HPV prevalence among high-grade cervical precancers and invasive cervical cancers were compared before and after HPV vaccine availability.

Methods: Archived tissue from 2 studies of cervical precancers and invasive cervical cancers diagnosed from 1993-2005 (prevaccine) were identified from 7 central cancer registries in Florida; Hawaii; Iowa; Kentucky; Louisiana; Los Angeles County, California; and Michigan; from 2014 through 2015 (postvaccine) cases were identified from 3 registries in Iowa, Kentucky, and Louisiana. Read More

View Article and Full-Text PDF

Evaluation of hydrogen peroxide virucidal efficacy against yellow fever virus 17DD vaccine strain for application in a vaccine manufacturing industry.

J Pharm Biomed Anal 2021 Jul 13;204:114264. Epub 2021 Jul 13.

Laboratory of Microbiology Control, Department of Quality Control, Bio-Manguinhos/Fiocruz, Brazil. Electronic address:

The aim of this study was to evaluate the inactivation performance of hydrogen peroxide to the yellow fever virus 17DD vaccine strain, used for the production of attenuated yellow fever vaccine, in two matrixes: formulated yellow fever vaccine (FYV) and yellow fever viral suspension - active pharmaceutical ingredient (API). The samples were dried on stainless steel and exposed to hydrogen peroxide liquid (HPL) at concentrations of 30, 10, 3 and 1% for 20 and 60 min; and to hydrogen peroxide vapour (HPV) in an isolator. The exposure to HPL 30 and 10 %, within 20 min, reduced the virus titre at least 3. Read More

View Article and Full-Text PDF

Distribution of human papillomavirus in precancerous and cancerous cervical neoplasia in Tunisian women.

Infect Agent Cancer 2021 Jul 16;16(1):52. Epub 2021 Jul 16.

Department of Human and Experimental Pathology, Pasteur Institute of Tunis, University Tunis El Manar, Tunis, Tunisia.

Background: High-risk human papillomavirus (HR-HPV) are responsible for cervical cancer (CC) which represents the second most prevalent gynecological cancer among Tunisian women. Preventive strategies against CC are based on prophylactic vaccines that have not yet been implemented into the national vaccination program of Tunisia. Therefore, the present study aimed to investigate the HPV genotypes distribution in cervical neoplasia in Tunisian women in order to predict the impact of using current HPV vaccines on cancer prevention in Tunisia. Read More

View Article and Full-Text PDF

Distribution of High-risk Human Papillomavirus Genotypes in Cervical Secretions in Punjab.

J Coll Physicians Surg Pak 2021 Jul;30(7):786-791

Institute of Molecular Biology & Biotechnology (IMBB), University of Lahore, Lahore, Pakistan.

Objective: To determine the high risk-human papillomavirus (HR-HPV) prevalence, genotype distribution, and associated risk factors in women with general gynaecological problems.

Study Design: Descriptive, cross-sectional study.

Place And Duration Of Study: Lady Wallingdon Hospital, Lahore from August 2018 to May 2019. Read More

View Article and Full-Text PDF

Anogenital HPV Infection, Seroprevalence, and Risk Factors for HPV Seropositivity Among Sexually Active Men Enrolled in a Global HPV Vaccine Trial.

Clin Infect Dis 2021 Jul 15. Epub 2021 Jul 15.

Department of Infectious Diseases, University of California San Francisco, San Francisco, CA, USA.

Background: In men, human papillomavirus (HPV)-related cancer incidence is rising, but data regarding male HPV infection and seroprevalence are available from only a few countries.

Methods: This analysis of a global HPV vaccine trial evaluated baseline data from 1399 HIV-negative heterosexual men (HM) and men who have sex with men (MSM). Key objectives included assessment of HPV prevalence and risk factors for seropositivity to 9-valent HPV (9vHPV) vaccine types (6/11/16/18/31/33/45/52/58), and concordance between seropositivity and prevalent HPV type. Read More

View Article and Full-Text PDF

Human papillomavirus genotyping predicts residual/recurrent disease after local treatment for cervical intraepithelial neoplasia better than viral DNA testing.

J Obstet Gynaecol Res 2021 Jul 12. Epub 2021 Jul 12.

Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Japan.

Aim: Type-specific persistent infection (TSPI) of human papillomavirus (HPV) is reportedly associated with a high risk of residual/recurrent disease after local treatment for cervical intraepithelial neoplasia (CIN). This study aimed to evaluate whether HPV genotyping is more accurate in detecting residual/recurrent disease than HPV DNA testing and identify which HPV genotype can predict a high risk of residual/recurrent disease.

Methods: We retrospectively reviewed patient outcomes and results of HPV DNA testing and genotyping at 6-12 months after local treatment for CIN2/3 for 439 women. Read More

View Article and Full-Text PDF

Prevalence of oral human papillomavirus infection among Indian HIV-positive men who have sex with men: a cross-sectional study.

BMC Infect Dis 2021 Jul 12;21(1):675. Epub 2021 Jul 12.

Division of Infectious Diseases, Department of Medicine, University of California, Box 0654, 513 Parnassus Ave, Room S420, San Francisco, CA, 94143, USA.

Background: Oral human papillomavirus (HPV) infection has been causally linked to a subset of oropharyngeal cancers in Western populations, and both oropharyngeal cancer and oral HPV infection are increased among HIV-positive individuals. India has high incidences of oral and oropharyngeal cancers, and Indian HIV-positive men who have sex with men (MSM) may be at increased risk of developing oropharyngeal cancers. However, there is little information available on the prevalence of oral HPV in this population. Read More

View Article and Full-Text PDF

The estimated burden of 15 vaccine-preventable diseases from 2008 to 2020 in Japan: A transition by the COVID-19 pandemic.

Authors:
Taito Kitano

J Infect Chemother 2021 Jul 5. Epub 2021 Jul 5.

Division of infectious Diseases, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan. Electronic address:

Background: Evaluating the national burdens across multiple vaccine-preventable diseases (VPDs) can be informative to identify the areas for improvements in the national immunization program.

Methods: The annual burden of diseases from 2008 to 2020 in Japan were calculated with the incidence- and pathogen-based approach for the 15 VPDs (hepatitis B virus infection, human papillomavirus (HPV), influenza, invasive pneumococcal disease, invasive Haemophilus influenzae type b (Hib) disease, invasive meningococcal disease, Japanese encephalitis, measles, mumps, pertussis, rotavirus, rubella, tetanus, tuberculosis and varicella), using disability-adjusted life year (DALY).

Results: The average annual burden between 2008 and 2020 is the highest in influenza (114,129 DALY/year), followed by HPV infection, hepatitis B virus infection, tuberculosis and mumps (109,782, 69,883, 23,855 and 5693 DALY/year). Read More

View Article and Full-Text PDF

[Epidemiologic and histopathologic characteristics of 1280 uterine cervical cancers in Kinshasa].

Gynecol Obstet Fertil Senol 2021 Jul 6. Epub 2021 Jul 6.

Département d'Anatomie Pathologique, Faculté de Médecine, Université de Kinshasa, BP834, Kinshasa XI, République Démocratique du Congo.

Objective : Due to the lack of both cancer registry and large scale cervical screening in most african countries, only theoretical studies are available. The objective of our work was to provide epidemiological and histopathological characteristics of cervical cancer based on concrete observations. Methods : This study was carried out on all cancers (n = 5801) collected in the last 10 years from 5 pathology laboratories of Kinshasa ; the histologic slides of the cervical cancers (n = 1280) were reviewed by at least two pathologists and classified according to the 2014 OMS classification. Read More

View Article and Full-Text PDF

The Influence of Psychological Stress on HPV Infection Manifestations and Carcinogenesis.

Cell Physiol Biochem 2021 Jul;55(S2):71-88

Department of Gynaecology and Obstetrics, University Hospital Center Zagreb, Zagreb, Croatia.

Psychological stress is an important factor involved in disease manifestations of human papillomavirus (HPV) infection, and it can participate in HPV-associated carcinogenesis. The impact or effect which stress can have (exert) depends on a person's genetic pool, experiences and behaviors. Due to inconsistencies in some study results, this issue remains a subject of research. Read More

View Article and Full-Text PDF

Risks for cervical abnormalities in women with non-16/18 high-risk human papillomavirus infections in south Shanghai, China.

J Med Virol 2021 Jul 7. Epub 2021 Jul 7.

Department of Obstetrics and Gynecology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

The study was aimed to analyze the prevalence characteristics of non-16/18 high-risk human papillomaviruses (HR-HPV) and the related risks for cervical abnormalities in south Shanghai. A total of 2291 HPV women who had been referred for a colposcopy due to HPV infection from @@@@@2016.12 to 2019. Read More

View Article and Full-Text PDF

Mixed HPV-related Neuroendocrine Carcinoma and HPV-related Squamous Cell Carcinoma of the Base of Tongue in a Patient With Incidental Identification of Synchronous Metastatic Papillary Thyroid Carcinoma.

Anticancer Res 2021 Jul;41(7):3639-3642

Department of Pathology and Laboratory Medicine, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.

Background: While it is not uncommon in patients with head and neck cancer to present with multiple metachronous primary neoplasms, rarely do these present as a singular mass composed of intertwined, histologically distinct malignant tumors. Sometimes referred to as collision tumors, these entities are poorly understood and only appear in a handful of case studies in the literature.

Case Report: Here we present a 58-year-old male diagnosed with a human papillomavirus-related collision tumor consisting of oropharyngeal squamous cell carcinoma and small-cell neuroendocrine carcinoma, as well as an incidentally discovered metastatic thyroid papillary carcinoma, despite an unremarkable thyroid gland. Read More

View Article and Full-Text PDF

Sequential acquisition of human papillomavirus infection between genital and oral anatomic sites in males.

Int J Cancer 2021 Jul 5. Epub 2021 Jul 5.

Center for Immunization and Infection Research in Cancer, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

Oral human papillomavirus (HPV) is associated with increasing rates of HPV-associated oropharyngeal cancer (OPC) in men. Sequential infection from one site to another has been demonstrated at the cervix and anus. Thus, risk of an oral HPV infection after a genital infection of the same type in the HPV infection in men study was investigated. Read More

View Article and Full-Text PDF

Prevalence of oral human papillomavirus infection: Impact of sex, race/ethnicity and vaccination status.

Clin Infect Dis 2021 Jul 4. Epub 2021 Jul 4.

Center for Interdisciplinary Research in Women's Health, The University of Texas Medical Branch, Galveston, TX, USA.

Background: Prior studies have demonstrated differences by sex and race/ethnicity in oral HPV prevalence. This study examined the impact of vaccination on these disparities.

Methods: We examined participants 18-59 years old in the National Health and Nutrition Examination Survey from 2011-16 who reported their HPV vaccination status and submitted an adequate oral sample (N=9,437). Read More

View Article and Full-Text PDF

PD-L1 expression, tumor-infiltrating lymphocytes, mismatch repair deficiency, EGFR alteration and HPV infection in sinonasal squamous cell carcinoma.

Mod Pathol 2021 Jul 3. Epub 2021 Jul 3.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

The antitumor efficacies of immune checkpoint inhibitors (ICIs) and the usefulness of potential predictive markers such as programmed death-ligand 1 (PD-L1) expression, density of tumor-infiltrating lymphocytes (TILs) and microsatellite instability (MSI) in sinonasal squamous cell carcinoma (SNSCC) have not been fully elucidated. We retrospectively analyzed 131 SNSCCs with immunohistochemistry for PD-L1 expression, TIL subpopulations and loss of mismatch repair (MMR) proteins as a surrogate for MSI-high. We also comprehensively evaluated the mutual relationships among these immuno-markers, high-risk human papillomavirus (HPV) infection, epidermal growth factor receptor (EGFR) gene status, and KRAS mutation. Read More

View Article and Full-Text PDF

Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.

BMC Cancer 2021 Jul 3;21(1):769. Epub 2021 Jul 3.

Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, 317000, China.

Background: Human papillomavirus (HPV) type 16 accounts for a larger share of cervical cancer and has been a major health problem worldwide for decades. The progression of initial infection to cervical cancer has been linked to viral sequence properties; however, the role of HPV16 variants in the risk of cervical carcinogenesis, especially with longitudinal follow-up, is not fully understood in China.

Methods: We aimed to investigate the genetic variability of HPV16 E6 and E7 oncogenes in isolates from cervical exfoliated cells. Read More

View Article and Full-Text PDF

The confounding effect of multi-type human papillomavirus infections on type-specific natural history parameter identification.

Epidemics 2021 Jun 24;36:100468. Epub 2021 Jun 24.

Infectious Disease Control and Vaccinations Unit, Department of Health Security, Finnish Institute for Health and Welfare, Finland. Electronic address:

The natural history of human papillomavirus (HPV) from infection to cervical cancer differs between HPV types. Accordingly, type-specific natural history parameters are crucial for the mathematical models used to optimize the nearly life-long series of disease prevention measures. These parameters are estimated from genotyped data from trials and population level screening programs, typically one type at a time, which requires projecting the multiple-type data to the single type. Read More

View Article and Full-Text PDF

Interobserver reproducibility of differentiated exophytic vulvar intraepithelial lesion (DEVIL) and the distinction from its mimics.

Histopathology 2021 Jul 2. Epub 2021 Jul 2.

Division of Women's and Perinatal Pathology, Department of Pathology, Women's Hospital - Harvard Medical School, Boston, MA, United States.

Aim: Most vulvar squamous cell carcinomas are HPV-associated or TP53-mutant. A third category of HPV-independent, TP53-wild-type lesions is uncommon and not fully understood. Differentiated Exophytic Vulvar Intraepithelial Lesion (DEVIL) has been characterized as a precursor in this latter category. Read More

View Article and Full-Text PDF

HPV Genotyping by Molecular Mapping of Tissue Samples in Vaginal Squamous Intraepithelial Neoplasia (VaIN) and Vaginal Squamous Cell Carcinoma (VaSCC).

Cancers (Basel) 2021 Jun 29;13(13). Epub 2021 Jun 29.

Department of Obstetrics and Gynecology, Kanazawa Medical University, Kahoku-gun 920-0293, Japan.

HPV genotypes were determined in 63 vaginal squamous intraepithelial neoplasia (VaIN) and 7 vaginal squamous cell carcinomas (VaSCC). Of these, 37 cases had VaIN alone, and 26 cases had both VaIN and cervical intraepithelial neoplasia (CIN) or condyloma. HPV typing was performed in scraped cells by Genosearch-31 (GS-31) and in the archived tissues by uniplex E6/E7 PCR. Read More

View Article and Full-Text PDF

Mutation Profiles, Glycosylation Site Distribution and Codon Usage Bias of Human Papillomavirus Type 16.

Viruses 2021 Jun 30;13(7). Epub 2021 Jun 30.

BGI-Shenzhen, Shenzhen 518083, China.

Human papillomavirus type 16 (HPV16) is the most prevalent HPV type causing cervical cancers. Herein, using 1597 full genomes, we systemically investigated the mutation profiles, surface protein glycosylation sites and the codon usage bias (CUB) of HPV16 from different lineages and sublineages. Multiple lineage- or sublineage-conserved mutation sites were identified. Read More

View Article and Full-Text PDF

Genetic and Epigenetic Variations of HPV52 in Cervical Precancer.

Int J Mol Sci 2021 Jun 16;22(12). Epub 2021 Jun 16.

Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

The goal of this study was to identify human papillomavirus (HPV) type 52 genetic and epigenetic changes associated with high-grade cervical precancer and cancer. Patients were selected from the HPV Persistence and Progression (PaP) cohort, a cervical cancer screening program at Kaiser Permanente Northern California (KPNC). We performed a nested case-control study of 89 HPV52-positive women, including 50 cases with predominantly cervical intraepithelial neoplasia grade 3 (CIN3) and 39 controls without evidence of abnormalities. Read More

View Article and Full-Text PDF

Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview.

Int J Mol Sci 2021 Jun 3;22(11). Epub 2021 Jun 3.

Perha Pharmaceuticals, Perharidy Peninsula, 29680 Roscoff, France.

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein kinases are involved in multiple cellular functions, including intracellular signaling, mRNA splicing, chromatin transcription, DNA damage repair, cell survival, cell cycle control, differentiation, homocysteine/methionine/folate regulation, body temperature regulation, endocytosis, neuronal development, synaptic plasticity, etc. Abnormal expression and/or activity of some of these kinases, DYRK1A in particular, is seen in many human nervous system diseases, such as cognitive deficits associated with Down syndrome, Alzheimer's disease and related diseases, tauopathies, dementia, Pick's disease, Parkinson's disease and other neurodegenerative diseases, Phelan-McDermid syndrome, autism, and CDKL5 deficiency disorder. Read More

View Article and Full-Text PDF

Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells.

Genes (Basel) 2021 Jun 17;12(6). Epub 2021 Jun 17.

Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany.

(1) Kinase inhibitors (KI) targeting components of the DNA damage repair pathway are a promising new type of drug. Combining them with ionizing radiation therapy (IR), which is commonly used for treatment of head and neck tumors, could improve tumor control, but could also increase negative side effects on surrounding normal tissue. (2) The effect of KI of the DDR (ATMi: AZD0156; ATRi: VE-822, dual DNA-PKi/mTORi: CC-115) in combination with IR on HPV-positive and HPV-negative HNSCC and healthy skin cells was analyzed. Read More

View Article and Full-Text PDF