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Autoantibodies against apolipoprotein A-1 after COVID-19 predict symptoms persistence.

Eur J Clin Invest 2022 May 22:e13818. Epub 2022 May 22.

Division of Laboratory Medicine, Department of Diagnostics and of Medical Specialties, Geneva University Hospitals and Geneva University, Geneva, Switzerland.

Background: SARS-CoV-2 infection triggers different auto-antibodies, including anti-apolipoprotein A-1 IgGs (AAA1), which could be of concern as mediators of persistent symptoms. We determined the kinetics of AAA1 response over after COVID-19, and the impact of AAA1 on the inflammatory response and symptoms persistence.

Methods: All serologies were assessed at one, three, six, and twelve months in 193 hospital employees with COVID-19. Read More

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Clinically Elevated Parent Depressive Symptoms and Stress at Child Type 1 Diabetes Diagnosis: Associations with Parent Diabetes Self-Efficacy at 18-Months Post-Diagnosis.

Pediatr Diabetes 2022 May 22. Epub 2022 May 22.

Children's National Hospital, Center for Translational Research, Washington, District of Columbia.

Eighteen percent of new diagnoses of type 1 diabetes (T1D) occur in children ages 9 and younger, and the burden of diabetes management in young children predominantly falls on parents. Despite the significant amount of information parents must learn and implement quickly after diagnosis, little research has examined diabetes self-efficacy in parents of young children soon after diagnosis in a longitudinal manner. The current study examined changes in parent diabetes self-efficacy over time, and parent depressive symptoms and stress soon after child T1D diagnosis as predictors of parent diabetes self-efficacy at 12- and 18-months post-diagnosis. Read More

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Type 1 Diabetes in Laos, 2016 - 2021.

Pediatr Diabetes 2022 May 22. Epub 2022 May 22.

Southport and Ormskirk Hospital NHS Trust, Ormskirk, United Kingdom.

Introduction: Before 2016, no child was known to survive type 1 diabetes (T1D) in Laos, a lower-middle income country (LMIC) in South-east Asia. In partnership with the Laos government, a non-government organization (NGO) called Action4Diabetes (A4D) has since been providing insulin, blood glucose monitoring kits, HbA1c testing, and emergency hospital expenses for Laotian children and young people (CYP) with T1D, and education for healthcare professionals. Here, we report the demographics and clinical outcomes of the CYP with T1D enrolled in A4D's Clinic Support Programme. Read More

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Antigen targeting to dendritic cells: still a place in future immunotherapy?

Eur J Immunol 2022 May 22. Epub 2022 May 22.

Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.

The hallmark of dendritic cells (DCs) is their potent and outstanding capacity to activate naive resting T cells. As such, DCs are the sentinels of the immune system and instrumental for the induction of immune responses. This is one of the reasons, why DCs became the focus of immunotherapeutical strategies to fight infections, cancer and autoimmunity. Read More

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Analysis of prognostic factors in grade 3 endometrioid type endometrial carcinoma.

Int J Gynaecol Obstet 2022 May 22. Epub 2022 May 22.

Department of Gynecologic Oncology, Privata Clinic Istanbul, Turkey.

Objective: To investigate the prognostic factors of patients with Grade 3 endometrioid endometrial cancer (G3EEC).

Methods: This four-center, retrospective study included a total of 129 women with G3EEC. Demographic, clinicopathological, and survival data were collected. Read More

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A Case Control Study of Risk Assessment of Diabetes and Nephropathy with eNOS (T786C and 27bp VNTR) Gene Polymorphisms.

J Assoc Physicians India 2022 May;70(5):11-12

Assistant Professor, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana.

Objectives: To determine the association of eNOS (T786C and 27bp VNTR) gene polymorphism with the risk of type II diabetes mellitus and diabetic nephropathy in North India.

Methods: The prospective case control study was conducted over a period of 18 months. A total of 100 patients of Type 2 Diabetes Mellitus (A1: 50 cases without Diabetic nephropathy-DN and 50 cases with DN) aged 18-75 years and 50 healthy adults as control (Group B) were included. Read More

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Retino-Renal Dissociation in Type 2 Diabetes Mellitus: An Observational Cross Sectional Study at a Tertiary Care Center of Sub-Himalayan Region.

J Assoc Physicians India 2022 May;70(5):11-12

Professor Rtd., Indira Gandhi Medical College, Shimla, Himachal Pradesh.

Introduction: Diabetic retinopathy, the diabetes-specific long-term microvascular complication is an important predictor of diabetic nephropathy. Diabetes induced retinopathy mostly proceeds nephropathy in patients with Type1 diabetes; however, this sequence is not consistent in patients with Type 2 diabetes and has significant discordance.

Methods: It was a hospital-based prospective, observational study conducted at Indira Gandhi Medical College, Shimla Himachal Pradesh a tertiary care center in the sub-Himalayan region of India from July 2016 to June 2017. Read More

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Evaluation of Teneligliptin a DPP4 Inhibitor in Terms of Efficacy and Safety with Respect to QT/QTc Prolongation in Patients with Type II Diabetes Mellitus (T2DM).

J Assoc Physicians India 2022 May;70(5):11-12

Tutor, Department of Pharmacology, MGM Medical College, Aurangabad, Maharashtra.

Introduction: Low risk of hypoglycemia and weight neutrality have increased the administration of dipeptidyl peptidase 4 (DPP-4) inhibitors in patients with T2DM in clinical practice. Currently Teneligliptin is prescribed as a second or third add on to the standard treatment with other classes of oral hypoglycemic agents (OHAs) to achieve targeted glycemic control in type 2 DM patients.

Methods: An open label, interventional, single arm, 12 weeks study was conducted on160 patients with type 2 DM at MGM Medical College, Aurangabad with Teneligliptin 20 mg once a day as add on to the ongoing standard treatment with other classes of OHAs. Read More

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Prevalence and Profile of Obstructive Sleep Apnea in Patients with Interstitial Lung Diseases of North India.

J Assoc Physicians India 2022 May;70(5):11-12

Professor, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi.

Background: The OSA is commonly found in ILD with overall incidence varying from 17 to 88 %. The morbidity and mortality of OSA are high when it occurs with chronic respiratory diseases like ILD. There is lack of data on sleep breathing disorder in ILD patients from India. Read More

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AGEs-RAGE axis mediates myocardial fibrosis via activation of cardiac fibroblasts induced by autophagy in heart failure.

Exp Physiol 2022 May 22. Epub 2022 May 22.

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

New Findings: What is the central question of this study? Does the AGEs-RAGE axis mediate myocardial fibrosis in heart failure? What is the main finding and its importance? The AGEs-RAGE axis is involved in the pathogenesis of myocardial fibrosis through CFs activation induced by autophagy in heart failure. Inhibiting AGEs-RAGE axis attenuates dysfunction in the heart and attenuates myocardial fibrosis in mice with TAC via suppressing CFs activation.

Abstract: Background: Heart failure is the end stage of cardiovascular diseases, and is a critical medical condition that poses an important therapeutic challenge for physicians due to its high morbidity and mortality. Read More

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The complex role of telocytes in female prostate tumorigenesis in a rodent model.

Cell Biol Int 2022 May 21. Epub 2022 May 21.

Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), São Paulo, Brazil.

The prostate is not an organ exclusive to the male. It is also found in females of several species, including humans, in which part of the Skene gland is homologous to the male prostate. Evidence is accumulating that changes in the stroma are central to tumorigenesis. Read More

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Assessing the application of Spot Spray in Nanguo pear orchards: effect of nozzle type, spray volume rate and adjuvant.

Pest Manag Sci 2022 May 21. Epub 2022 May 21.

College of Electronic Engineering, South China Agricultural University, Guangzhou, 510642, China.

Background: Aerial spray is one of the most important applications of unmanned aerial vehicle (UAV) in agriculture. This work aimed to promote the use of UAVs as an alternative to knapsack electric sprayers in pesticide application in Nanguo pear orchards which planted in mountain terraced orchard scenarios. The spray deposition of four types of nozzles (SX110015, XR80015, IDK90015 and TR80015), two spray volume rates (45 L·ha , 90 L·ha ) and with or without a commercial surfactant adjuvant were evaluated based on the Spot Spray mode. Read More

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Progress in understanding the mechanisms of resistance to BCL-2 inhibitors.

Authors:
Yilan Xu Haige Ye

Exp Hematol Oncol 2022 May 21;11(1):31. Epub 2022 May 21.

Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University-Zhejiang, Wenzhou, China.

Venetoclax is a new type of BH3 mimetic compound that can target the binding site in the BCL-2 protein and induce apoptosis in cancer cells by stimulating the mitochondrial apoptotic pathway. Venetoclax is especially used to treat haematological malignancies. However, with the recent expansion in the applications of venetoclax, some cases of venetoclax resistance have appeared, posing a major problem in clinical treatment. Read More

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The new era of add-on asthma treatments: where do we stand?

Allergy Asthma Clin Immunol 2022 May 21;18(1):42. Epub 2022 May 21.

Division of Pulmonary, Critical Care, and Sleep Medicine, Yale Center for Asthma and Airway Disease, Yale University School of Medicine, New Haven, CT, USA.

Globally, a small proportion (5-12%) of asthma patients are estimated to have severe disease. However, severe asthma accounts for disproportionately high healthcare resource utilization. The Global Initiative for Asthma (GINA) management committee recommends treating patients with asthma with inhaled corticosteroids plus long-acting β-agonists and, when needed, adding a long-acting muscarinic receptor antagonist or biologic agent. Read More

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Quality of care in patients with type 1 diabetes during the COVID-19 pandemic: a cohort study from Southern Brazil.

Diabetol Metab Syndr 2022 May 21;14(1):75. Epub 2022 May 21.

Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos 2350, Porto Alegre, RS, 90035-003, Brazil.

Background: Optimal glycemic control is the main goal for patients with diabetes. The results of type 1 diabetes patients' neglected demands during the pandemic can determine a long-term negative clinical, social, and economic impact, and result in worse diabetes control and a higher incidence of chronic complications. Therefore, this study aims to evaluate the impact of the COVID-19 outbreak in the quality of care of patients with type 1 diabetes in Southern Brazil. Read More

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Can metformin relieve tibiofemoral cartilage volume loss and knee symptoms in overweight knee osteoarthritis patients? Study protocol for a randomized, double-blind, and placebo-controlled trial.

BMC Musculoskelet Disord 2022 May 21;23(1):486. Epub 2022 May 21.

Clinical Research Centre, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.

Background: Osteoarthritis (OA) is the most common joint disease, and is most frequently seen in the knees. However, there is no effective therapy to relieve the progression of knee OA. Metformin is a safe, well-tolerated oral medication that is extensively used as first-line therapy for type 2 diabetes. Read More

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P-selectin glycoprotein ligand-1 (PSGL-1/CD162) is incorporated into clinical HIV-1 isolates and can mediate virus capture and subsequent transfer to permissive cells.

Retrovirology 2022 May 21;19(1). Epub 2022 May 21.

Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, Canada.

Background: P-selectin glycoprotein ligand-1 (PSGL-1/CD162) has been studied extensively for its role in mediating leukocyte rolling through interactions with its cognate receptor, P-selectin. Recently, PSGL-1 was identified as a novel HIV-1 host restriction factor, particularly when expressed at high levels in the HIV envelope. Importantly, while the potent antiviral activity of PSGL-1 has been clearly demonstrated in various complementary model systems, the breadth of PSGL-1 incorporation across genetically diverse viral isolates and clinical isolates has yet to be described. Read More

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A mixed-methods approach to understanding the perspectives, experiences, and attitudes of a culturally tailored cognitive behavioral therapy/motivational interviewing intervention for African American patients with type 2 diabetes: a randomized parallel design pilot study.

Pilot Feasibility Stud 2022 May 21;8(1):107. Epub 2022 May 21.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Background: African American (AA) adults are 60% more likely to be diagnosed with diabetes mellitus (DM) and experience more complications than non-Hispanic White adults. Cognitive behavioral therapy (CBT) has shown to be an effective modality for helping patients improve health behaviors and regulate emotional states. Motivational interviewing (MI) addresses participant engagement and motivation. Read More

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A rare phenomenon of pregorexia in Pakistani women: need to understand the related behaviors.

J Eat Disord 2022 May 21;10(1):74. Epub 2022 May 21.

Department of Psychology, International Islamic University, Islamabad, 44000, Pakistan.

Background: In Pakistan, for a decade or so, there has been a huge increase in body ideals, and thinness and eating disorders reported during pregnancy. The purpose of the present research was to study the lived experiences and behaviors characterized by pregorexia in Pakistani young women.

Method: A phenomenological approach was used to study eating disorder-related behaviors among pregnant women. Read More

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A clinical and biomechanical comparison of INFIX plus single versus double sacroiliac screw fixation for unstable pelvic ring injury.

J Orthop Surg Res 2022 May 21;17(1):285. Epub 2022 May 21.

Department of Orthopaedics, The Fifth Affiliated Hospital, Southern Medical University, No. 566 Congcheng Avenue, Conghua District, Guangzhou, 510900, People's Republic of China.

Background: The aim of this study is to compare the clinical and biomechanical outcome of INFIX plus single with two sacroiliac screw fixation for unstable pelvic fractures of Type C.

Methods: Sixteen cadavers were randomly subjected to INFIX plus single or double sacroiliac screw fixations and then mounted onto the ElectroForce loading machine under different vertical loads. To investigate the clinical outcomes of the two techniques, nineteen patients were retrospectively analyzed. Read More

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Transition to adult care of young patients with neurofibromatosis type 1 and cognitive deficits: a single-centre study.

Orphanet J Rare Dis 2022 May 21;17(1):208. Epub 2022 May 21.

Department of Paediatrics and Adolescent Medicine, Centre for Rare Diseases, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.

Background: The transition of adolescents to adult care is known to be challenging. Studies indicate that patients with a chronic disease and cognitive deficits are at risk of inadequate transition to adult care, which eventually may result in disease deterioration. This study investigated the transition process for patients with neurofibromatosis type 1 (NF1) and discussed whether patients with NF1 and cognitive deficits should receive additional attention in their transitional period. Read More

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Association of bone-related biomarkers with femoral neck bone strength.

BMC Musculoskelet Disord 2022 May 21;23(1):482. Epub 2022 May 21.

Department of Orthopedics, The General Hospital of Western Theater Command, Rongdu Avenue No. 270, Chengdu, 610083, China.

Background: Femoral neck fractures are the worst consequence of osteoporosis (OP), and its early prevention and treatment have become a public health problem. This study aims to investigate the relationship of bone-related biomarkers, femoral neck bone mineral density (BMD) and maximum load (L), selecting the indicator which can reflect femoral neck bone loss and reduced bone strength.

Methods: A total of 108 patients were recruited from January 2017 to December 2019. Read More

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Recurrent heart failure hospitalizations increase the risk of mortality in heart failure patients with atrial fibrillation and type 2 diabetes mellitus in the United Kingdom: a retrospective analysis of Clinical Practice Research Datalink database.

BMC Cardiovasc Disord 2022 May 21;22(1):234. Epub 2022 May 21.

Novartis Pharma AG, 4056, Basel, Switzerland.

Background: Heart failure (HF) is a global illness and is a leading cause of hospitalizations. Recurrent HF hospitalization (HFH) is associated with increased risk of cardiovascular (CV) and all-cause mortality, thereby burdening the health system. Type 2 diabetes mellitus (T2DM) and atrial fibrillation (AF) are two important comorbidities in patients living with HF. Read More

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Longitudinal study on the progression of muscle status among community-dwelling ambulatory older multiethnic Asians with type 2 diabetes mellitus.

BMC Geriatr 2022 May 21;22(1):446. Epub 2022 May 21.

SingHealth Polyclinics, 167 Jalan Bukit Merah Connection One Tower 5 #15-10, Singapore, 150167, Singapore.

Background: Muscle health decline with age, but its deterioration in older persons with type-2 diabetes mellitus (T2DM) over time is not well-established. This study aimed to determine the change in muscle mass, handgrip strength and gait speed over time among community-dwelling ambulatory older multi-ethnic Asian patients with T2DM and their associated factors.

Methods: Among 387 eligible patients aged 60-89 years who were recruited at baseline, 348 (89. Read More

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Functional characterization and comparison of lycopene epsilon-cyclase genes in Nicotiana tabacum.

BMC Plant Biol 2022 May 21;22(1):252. Epub 2022 May 21.

College of Life Sciences, Henan Agricultural University, Zhengzhou, 450002, Henan, China.

Background: Lycopene epsilon-cyclase (ε-LCY) is a key enzyme in the carotenoid biosynthetic pathway (CBP) of higher plants. In previous work, we cloned two Ntε-LCY genes from allotetraploid tobacco (Nicotiana tabacum), Ntε-LCY2 and Ntε-LCY1, and demonstrated the overall effect of Ntε-LCY genes on carotenoid biosynthesis and stress resistance. However, their genetic and functional characteristics require further research in polyploid plants. Read More

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Inference following multiple imputation for generalized additive models: an investigation of the median p-value rule with applications to the Pulmonary Hypertension Association Registry and Colorado COVID-19 hospitalization data.

BMC Med Res Methodol 2022 May 21;22(1):148. Epub 2022 May 21.

Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Denver Anschutz Medical Campus, 13001 E. 17th Pl, Aurora, CO, USA.

Background: Missing data prove troublesome in data analysis; at best they reduce a study's statistical power and at worst they induce bias in parameter estimates. Multiple imputation via chained equations is a popular technique for dealing with missing data. However, techniques for combining and pooling results from fitted generalized additive models (GAMs) after multiple imputation have not been well explored. Read More

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Reevaluation of a classification system: stable and unstable odontoid fractures in geriatric patients-a radiological outcome measurement.

Eur J Trauma Emerg Surg 2022 May 21. Epub 2022 May 21.

Department of Trauma Surgery, KABEG-Klinikum Klagenfurt a.W, Klagenfurt, Austria.

Objectives: We carried out a retrospective cohort study to differentiate geriatric odontoid fractures into stable and unstable and correlated it with fracture fusion rates. Results are based on the literature and on our own experience. The authors propose that the simple Anderson and D'Alonzo classification may not be sufficient for geriatric patients. Read More

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Effects of Treadmill Exercise on Social Behavior in Rats Exposed to Thimerosal with Respect to the Hippocampal Level of GluN1, GluN2A, and GluN2B.

J Mol Neurosci 2022 May 21. Epub 2022 May 21.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P.O. Box, Tehran, 13145-784, Iran.

Thimerosal (THIM) kills brain neurons via induction of apoptosis and necrosis and induces the pathological features of autism spectrum disorder (ASD) in rats. THIM also affects the function of glutamatergic receptors. On the other hand, exercise induces both improvement and impairment effects on memory, depending on intensity, type, and duration. Read More

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Streptomyces spinosus sp. nov. and Streptomyces shenzhenensis subsp. oryzicola subsp. nov. endophytic actinobacteria isolated from Jasmine rice and their genome mining for potential as antibiotic producers and plant growth promoters.

Antonie Van Leeuwenhoek 2022 May 21. Epub 2022 May 21.

Department of Medical Biotechnology, College of Medicine and Public Health, Flinders University, Adelaide 5042, Australia.

Two endophytic actinobacteria, strains SBTS01 and W18L9, were isolated from leaf sheath and leaf tissue, respectively, of Jasmine rice (Oryza sativa KDML 105) grown in a rice paddy field in Roi Et Province, Thailand. A polyphasic taxonomic study showed that both strains belong to the genus Streptomyces; they are aerobic, forming well-developed substrate mycelia and aerial mycelia with long chains of spores. Strain SBTS01 shares high 16S rRNA gene sequence similarity with Streptomyces rochei NRRL B-2410 (99. Read More

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