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Sci Transl Med 2021 Apr 5. Epub 2021 Apr 5.

AbCellera Biologics Inc., Vancouver, BC, V5Y0A1, Canada.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a public health threat for which preventive and therapeutic agents are urgently needed. Neutralizing antibodies are a key class of therapeutics which may bridge widespread vaccination campaigns and offer a treatment solution in populations less responsive to vaccination. Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led to the identification of LY-CoV555 (also known as bamlanivimab), a potent anti-spike neutralizing antibody from a hospitalized, convalescent patient with coronavirus disease 2019 (COVID-19). Read More

Sci Rep 2020 Nov 9;10(1):19329. Epub 2020 Nov 9.

Plasma Physics Laboratory, Princeton University, Princeton, NJ, 08543, USA.

A method for machine learning and serving of discrete field theories in physics is developed. The learning algorithm trains a discrete field theory from a set of observational data on a spacetime lattice, and the serving algorithm uses the learned discrete field theory to predict new observations of the field for new boundary and initial conditions. The approach of learning discrete field theories overcomes the difficulties associated with learning continuous theories by artificial intelligence. Read More

AAPS J 2020 10 18;22(6):134. Epub 2020 Oct 18.

MRL, Merck & Co., Inc., Kenilworth, New Jersey, USA.

A physiologically based pharmacokinetic (PBPK) human model for alpelisib, an oral α-specific class I phosphatidylinositol-3-kinase (PI3K) inhibitor, was established to simulate oral absorption and plasma pharmacokinetics of healthy subjects to allow model-informed drug development. The GastroPlus™ model consisted of an advanced absorption gut model, which was linked to a 2-compartmental model. Systemic clearance and volume of distribution were estimated using population pharmacokinetics (popPK). Read More

bioRxiv 2020 Oct 1. Epub 2020 Oct 1.

SARS-CoV-2 poses a public health threat for which therapeutic agents are urgently needed. Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led to the identification of LY-CoV555, a potent anti-spike neutralizing antibody from a convalescent COVID-19 patient. Biochemical, structural, and functional characterization revealed high-affinity binding to the receptor-binding domain, ACE2 binding inhibition, and potent neutralizing activity. Read More

NTM 2020 09;28(3):451-479

Department of the History of Science and Scientific Archaeology, University of Science and Technology of China, Jinzhai Road 96, 230026, Hefei, Anhui, China.

A reanalysis of the eight astronomical images that Johann Adam Schall von Bell incorporated in the first Chinese treatise on the telescope to illustrate the telescopic discoveries made by Galileo Galilei shows that they were borrowed from the works on telescopic astronomy by Galileo Galilei and Johann Georg Locher, a student of Christopher Scheiner. Except minor changes to both Galileo's illustrations of the telescopic view of the moon and nebulae and Locher's illustration of sunspots, Locher's images about the phases of Venus and Jovian satellites were redrawn presumably to convey a clearer commitment to Tycho Brahe's system of the world and most of the contents in Locher's image of Saturn was replaced by Schall's own observation. These changes seem to be the result of two important factors that confined the transcultural transmission of astronomical knowledge from Europe to China through the Jesuits in the seventeenth century, namely the official standpoint of the Catholic Church on the ongoing cosmological issues and the cultural tradition of Chinese astronomy. Read More

Ann Sci 2020 Jan 11;77(1):96-107. Epub 2020 Mar 11.

Centro Interuniversitário de História das Ciências e da Tecnologia, Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal.

It is known that throughout the seventeenth century the world system proposed by Tycho Brahe (1546-1601) assumed a preponderant position in the Iberian cosmological debate, according to many opinions the one showing the best agreement to empirical evidence. Moreover, the Tychonian model (or variants thereof) did not present the difficulties of apparent contradiction with scriptures, as the heliocentric system of Nicolaus Copernicus (1473-1543) did, since it kept the earth fixed at the centre of the world. However, Tycho, as a Lutheran author, was targeted by the Inquisition. Read More

Sci Rep 2019 12 24;9(1):19801. Epub 2019 Dec 24.

Department of Applied Mathematics, University of Colorado Boulder, Boulder, Colorado, 80309, United States of America.

The Morbidity and Mortality Weekly Reports of the U.S. Centers for Disease Control and Prevention document a raw proxy for counts of pertussis cases in the U. Read More

Talanta 2019 Nov 26;204:82-88. Epub 2019 May 26.

Department of Chemistry, Materials and Chemical Engineering ''Giulio Natta'', Politecnico di Milano, Via Mancinelli 7, Milano, 20131, Italy. Electronic address:

The application of analytical chemistry to the exploration of the World Cultural Heritage represents a major challenge in that most protocols and strategies are invasive and require micro-sampling. We report a novel methodology for harvesting material deposited on the surface of ancient documents while avoiding their damage or contamination. The technology here described relates to the capture of metals on these specimens. Read More

J Plast Reconstr Aesthet Surg 2019 Sep 17;72(9):1564-1569. Epub 2019 May 17.

3D Lab Radboudumc, Radboud University Medical Center, Nijmegen, the Netherlands.

Background: Three-dimensional (3D) surface images acquired from stereophotogrammetry are increasingly being used to plan or evaluate treatment by plastic surgeons. Stereophotogrammetry exists in active, passive, and hybrid forms. Active and hybrid stereophotogrammetry are believed to capture darker surfaces more accurately than passive stereophotogrammetry. Read More

J Pharm Sci 2019 06 2;108(6):2191-2198. Epub 2019 Feb 2.

Novartis Institutes for BioMedical Research, PK Sciences, East Hanover, New Jersey 07936.

In adult patients, nilotinib is indicated for chronic myeloid leukemia at an approved oral dose of 300 or 400 mg BID. Physiologically based pharmacokinetic (PBPK) model was developed to describe and supplement limited PK data in the pediatric population ranging from 2 to less than 6 years of age and ultimately inform dosing regimen. An adult Simcyp PBPK model was established and verified with clinical pharmacokinetic data after a single or multiple oral doses of 400 mg nilotinib (230 mg/m). Read More

Cytometry A 2018 10;93(10):977-979

Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany.

J Am Med Inform Assoc 2018 12;25(12):1608-1617

Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.

Objective: In 2013, we released Project Tycho, an open-access database comprising 3.6 million counts of infectious disease cases and deaths reported for over a century by public health surveillance in the United States. Our objective is to describe how Project Tycho version 1 (v1) data has been used to create new knowledge and technology and to present improvements made in the newly released version 2. Read More

Forensic Sci Int 2018 Nov 9;292:131-137. Epub 2018 Aug 9.

Department of Culture and Society-Section for Medieval and Renaissance Archaeology, Aarhus University, Moesgaard Alle 20, DK 8270 Højbjerg, Denmark.

The virtual approach in physical and forensic anthropology is increasingly used to further analyze human remains, but also to propose new didactic means for visualization and dissemination of scientific results. Computerized facial approximation (FA) offers an alternative to manual methods, but usually requires a complete facial skeleton to allow for the estimation of the facial appearance of an individual. This paper presents the case of Tycho Brahe, Danish astronomer born during the XVIth century, whose remains were reanalyzed at the occasion of a short exhumation in 2010. Read More

PLoS One 2018 19;13(4):e0195920. Epub 2018 Apr 19.

PACEA-UMR 5199, University of Bordeaux, Pessac, France.

The exhumation of Danish astronomer Tycho Brahe (1546-1601) was performed in 2010 to verify speculative views on the cause of his death. Previous analyses of skeletal and hair remains recovered from his grave refuted the presumption that he died from poisoning. These studies also outlined the possibility that he actually died from an acute illness, echoing the rather vague and inaccurate testimony of some historical records. Read More

Arch Plast Surg 2017 Jul 15;44(4):257-258. Epub 2017 Jul 15.

Department of Plastic Surgery, Inha University School of Medicine, Incheon, Korea.

J Pharm Sci 2016 10 6;105(10):3205-3213. Epub 2016 Aug 6.

Drug Metabolism & Pharmacokinetics, Novartis Institutes for Biomedical Research, East Hanover, New Jersey 07936.

Artemether is co-administered with lumefantrine as part of a fixed-dose combination therapy for malaria in both adult and pediatric patients. However, artemether exposure is higher in younger infants (1-3 months) with a lower body weight (<5 kg) as compared to older infants (3-6 months) with a higher body weight (≥5 to <10 kg), children, and adults. In contrast, lumefantrine exposure is similar in all age groups. Read More

Health Serv Res 2017 02 21;52(1):176-190. Epub 2016 Mar 21.

Department of Population, Family, and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Objective: To understand the relationship between state-level spending by public health departments and the incidence of three vaccine preventable diseases (VPDs): mumps, pertussis, and rubella in the United States from 1980 to 2009.

Data Sources: This study uses state-level public health spending data from The Census Bureau and annual mumps, pertussis, and rubella incidence counts from the University of Pittsburgh's project Tycho.

Study Design: Ordinary least squares (OLS), fixed effects, and random effects regression models were tested, with results indicating that a fixed effects model would be most appropriate model for this analysis. Read More

Urology 2016 Feb 5;88:33-5. Epub 2015 Nov 5.

Department of Surgery (Urology), Joan C. Edwards School of Medicine, Marshall University, Huntington, WV. Electronic address:

Nuncius 2015 ;30(1):37-74

At the center of this article is an iconographic analysis of the eight silver reliefs on the sides of a table clock made in 1591 by Jost Burgi, the court clockmaker of Landgrave Wilhelm iv of Hessen-Kassel. The reliefs present an astronomical ancestral picture gallery, running from the Patriarchs of the Old Testament to Copernicus. The author argues that the "storyboard" for this sequence of images must have been conceived down to its smallest details by the Kassel court astronomer Christoph Rothmann; indeed, many of the scenes shown, along with many particular details depicted within them, are literally described in Rothmann's never-published manuscript Observationes stellarum fixarum of 1589. Read More

Nuncius 2015 ;30(1):9-36

When Tycho Brahe published a description of his astronomical instruments in 1598 as part of a strategy to procure royal patronage, it was not with one of his grander, precision measurement tools that he opened his account, but rather a small brass quadrant with limited observational utility. The defining feature of this instrument was seemingly a small emblematic image inscribed within the arc of the quadrant. Through this symbolic motif Tycho conveyed a moralising message about the relative worth of astronomy. Read More

Eur J Pharm Sci 2014 Oct 4;63:103-12. Epub 2014 Jul 4.

Novartis Institutes for Biomedical Research, 1 Health Plaza, East Hanover, NJ 07470, USA.

Alisporivir is a novel cyclophilin-binding molecule with potent anti-hepatitis C virus (HCV) activity. In vitro data from human liver microsomes suggest that alisporivir is a substrate and a time-dependent inhibitor (TDI) of CYP3A4. The aim of the current work was to develop a novel physiologically based pharmacokinetic (PBPK) model to quantitatively assess the magnitude of CYP3A4 mediated drug-drug interactions with alisporivir as the substrate or victim drug. Read More

ISME J 2015 Jan 8;9(1):32-45. Epub 2014 Jul 8.

UMR7266 LIENSs 'Littoral, Environnement et Sociétés', CNRS/Université de La Rochelle, Institut du Littoral et de l'Environnement, La Rochelle, France.

In intertidal marine sediments, characterized by rapidly fluctuating and often extreme light conditions, primary production is frequently dominated by diatoms. We performed a comparative analysis of photophysiological traits in 15 marine benthic diatom species belonging to the four major morphological growth forms (epipelon (EPL), motile epipsammon (EPM-M) and non-motile epipsammon (EPM-NM) and tychoplankton (TYCHO)) found in these sediments. Our analyses revealed a clear relationship between growth form and photoprotective capacity, and identified fast regulatory physiological photoprotective traits (that is, non-photochemical quenching (NPQ) and the xanthophyll cycle (XC)) as key traits defining the functional light response of these diatoms. Read More

Sudhoffs Arch 2014 ;98(2):234-8

We report on a newly discovered letter by Christoph Rothmann, dated July 1st 1584, and addressed to Johann Ernst of Anhalt. The letter supports the earlier assumption that Johann Ernst recommended Rothmann to Landgrave Wilhelm of Hesse, as Rothmann asks for Johann Ernst's help on the matter in this new source. More importantly Rothmann refers to his attempts to make Copernicus' calculations compatible with the Ptolomean model, which demonstrates that already at this stage of his career he was working on such a compromise, and not only after being influenced by Raimarus Ursus or Tycho Brahe, as has been argued by some authors. Read More

Complement Ther Med 2013 Apr 10;21 Suppl 1:S34-47. Epub 2012 Feb 10.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Hufelandstr. 55, D-45147 Essen, Germany.

Introduction: Few data document the use of complementary and alternative medicine (CAM) in Europe, with even fewer investigating use by children.

Methods: A narrative, non-systematic review of CAM use in Europe was performed by combining data from published surveys with expert perspectives. Limitations created by a lack of representative studies, varying definitions of CAM use, and what qualifies as CAM in different countries was partially overcome by integrating local experts to summarise information available only in the national language and provide their perspectives about CAM availability, quality, use and popularity in their countries using a semi-structured questionnaire. Read More

AAPS J 2013 Jan 10;15(1):143-58. Epub 2012 Nov 10.

Novartis Institutes for BioMedical Research, DMPK, One Health Plaza 436/3253, East Hanover, NJ 07936 USA.

Practical food effect predictions and assessments were described using in silico, in vitro, and/or in vivo preclinical data to anticipate food effects and Biopharmaceutics Classification System (BCS)/Biopharmaceutics Drug Disposition Classification System (BDDCS) class across drug development stages depending on available data: (1) limited in silico and in vitro data in early discovery; (2) preclinical in vivo pharmacokinetic, absorption, and metabolism data at candidate selection; and (3) physiologically based absorption modeling using biorelevant solubility and precipitation data to quantitatively predict human food effects, oral absorption, and pharmacokinetic profiles for early clinical studies. Early food effect predictions used calculated or measured physicochemical properties to establish a preliminary BCS/BDDCS class. A rat-based preclinical BCS/BDDCS classification used rat in vivo fraction absorbed and metabolism data. Read More

Ultrastruct Pathol 2012 Oct;36(5):312-9

Electron Microscopic Center, Department of Pathology, University of Rostock, Rostock, Germany.

Hairs more than 400 years old of the famous astronomer Tycho Brahe were studied by electron microscopy to evaluate the hypothesis that Johannes Kepler murdered his teacher Brahe by mercury intoxication. The beard hairs showed a well-preserved ultrastructure with typical hair scales and melanosomes. The authors detected an accumulation of electron-dense granules of about 10 nm inside the outer hair scales, but not in the hair shaft and roots. Read More

Philos Trans A Math Phys Eng Sci 2012 Aug;370(1973):3852-86

UK Astronomy Technology Centre, Royal Observatory, Blackford Hill, Edinburgh EH9 3HJ, UK.

Since the dawn of civilization, the human race has pushed technology to the limit to study the heavens in ever-increasing detail. As astronomical instruments have evolved from those built by Tycho Brahe in the sixteenth century, through Galileo and Newton in the seventeenth, to the present day, astronomers have made ever more precise measurements. To do this, they have pushed the art and science of precision engineering to extremes. Read More

Nature 2012 Jan 11;481(7380):164-6. Epub 2012 Jan 11.

Department of Physics and Astronomy, Louisiana State University, Baton Rouge, Louisiana 70803, USA.

A type Ia supernova is thought to begin with the explosion of a white dwarf star. The explosion could be triggered by the merger of two white dwarfs (a 'double-degenerate' origin), or by mass transfer from a companion star (the 'single-degenerate' path). The identity of the progenitor is still controversial; for example, a recent argument against the single-degenerate origin has been widely rejected. Read More

Proc Natl Acad Sci U S A 2010 Apr 19;107(16):7141-6. Epub 2010 Apr 19.

Benoziyo Center for Astrophysics, Weizmann Institute of Science, Israel.

The unprecedented spatial and spectral resolutions of Chandra have revolutionized our view of the X-ray emission from supernova remnants. The excellent datasets accumulated on young, ejecta-dominated objects like Cas A or Tycho present a unique opportunity to study at the same time the chemical and physical structure of the explosion debris and the characteristics of the circumstellar medium sculpted by the progenitor before the explosion. Supernova remnants can thus put strong constraints on fundamental aspects of both supernova explosion physics and stellar evolution scenarios for supernova progenitors. Read More

Lakartidningen 2009 Nov 11-17;106(46):3095-8

Ogonkliniken, Akademiska sjukhuset, Uppsala.