29,481 results match your criteria twelve years

Risk of Infection after Deep Brain Stimulation Surgery with Externalization and Local-Field Potential Recordings: Twelve-Year Experience from a Single Institution.

Stereotact Funct Neurosurg 2021 May 10:1-9. Epub 2021 May 10.

Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Introduction: Deep brain stimulation (DBS) has been an established surgical procedure in the field of functional neurosurgery for many years. The experimental electrophysiological method of local field potential (LFP) recordings in postsurgically externalized patients has made substantial contributions to the better understanding of pathophysiologies underlying movement disorders. As interest in LFP recordings for the development of improved stimulation strategies increases, this study's aim was to provide evidence concerning safety of this research method, in a major DBS center. Read More

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Survival Outcomes of Hemoperfusion and Hemodialysis versus Hemodialysis in Patients with End-Stage Renal Disease: A Systematic Review and Meta-Analysis.

Blood Purif 2021 May 10:1-13. Epub 2021 May 10.

Department of Nephrology, Dialysis and Transplantation, International Renal Research Institute (IRRIV), San Bortolo Hospital, Vicenza, Italy.

Background: The maintenance treatment of ESRD puts a great burden on individual patients, society, and the country of China as a whole. Hemoperfusion plus hemodialysis (HP + HD) in ESRD patients can yield modified outcomes such as prolonged life expectancy and improved dialysis quality and quality of life. This study aimed to systematically analyze the effect of HP + HD on the overall survival (OS) rates of ESRD patients and to provide support for clinical decision-making. Read More

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Management of childhood and adolescent latent tuberculous infection (LTBI) in Germany, Austria and Switzerland.

PLoS One 2021 10;16(5):e0250387. Epub 2021 May 10.

Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité -Universitätsmedizin, Berlin, Germany.

Background: Majority of active tuberculosis (TB) cases in children in low-incidence countries are due to rapid progression of infection (latent TB infection (LTBI)) to disease. We aimed to assess common practice for managing paediatric LTBI in Austria, Germany and Switzerland prior to the publication of the first joint national guideline for paediatric TB in 2017.

Methods: Online-based survey amongst pediatricians, practitioners and staff working in the public health sector between July and November 2017. Read More

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Real-world treatment patterns and outcomes of abemaciclib for the treatment of HR+, HER2- metastatic breast cancer.

Curr Med Res Opin 2021 May 10. Epub 2021 May 10.

Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

This retrospective observational study described baseline characteristics, real-world treatment patterns, and outcomes among patients with metastatic breast cancer treated with abemaciclib in the United States. De-identified electronic health record-derived data were used to describe patients who began abemaciclib treatment on or after 30 June 2016 and ≥4 months before data cutoff (31 December 2018). Real-world response (rwR) and real-world progression assessments were abstracted from clinical documentation. Read More

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First Report of Alfalfa Anthracnose Caused by in Xinjiang, China.

Plant Dis 2021 May 10. Epub 2021 May 10.

Bazhou Agricultural Technology Promotion Center, plant protection , korla, xinjiang, China;

Alfalfa ( L.) is widely planted in the world as one of the most important leguminous forage crops, and it is also the first choice of forage crops for animal feed in Xinjiang. In June 2018, alfalfa plants with typical anthracnose symptoms were observed in 75% of alfalfa fields in Hutubi County, Xinjiang, China. Read More

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Exploring the association of early life physical activity and risk of dementia: a systematic review.

Minerva Med 2021 May 10. Epub 2021 May 10.

NESMOS Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

Introduction: Physical activity has been included in the list of twelve modifiable risk factors for dementia, despite conflicting results from observational and controlled studies. In particular it is not clear whether physical inactivity near the time of dementia diagnosis is a consequence or cause of dementia. We review all available studies reporting the possible association between having engaged in PA before 60 years of age and the risk of dementia. Read More

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Systolic and Diastolic Functions After a Brief Acute Bout of Mild Exercise in Normobaric Hypoxia.

Front Physiol 2021 23;12:650696. Epub 2021 Apr 23.

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Acute hypoxia (AH) is a challenge to the homeostasis of the cardiovascular system, especially during exercise. Research in this area is scarce. We aimed to ascertain whether echocardiographic, Doppler, and tissue Doppler measures were able to detect changes in systolic and diastolic functions during the recovery after mild exercise in AH. Read More

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Occurrence of Latent Bacteria during Cryopreservation of Long-Term In Vitro Cultures of Coltsfoot, Tussilago farfara.

Cryo Letters 2019 Nov-Dec;40(6):333-340

Department of Pharmacognosy; Core Facility Botanical Garden, University of Vienna, Vienna, Austria.

Background: Long-term in vitro cultures of Tussilago farfara (L.), a traditional medicinal plant in Austria, had been stored at 14°C for over 20 years. The cultures were vigorous and showed no visual signs of bacterial presence. Read More

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Effects of Anodal Transcranial Direct Current Stimulation on Training Volume and Pleasure Responses in the Back Squat Exercise Following a Bench Press.

J Strength Cond Res 2021 May 5. Epub 2021 May 5.

Laboratory of Physical Activity Neuroscience (LABNAF), Physical Activity Sciences Postgraduate Program, Salgado de Oliveira University (UNIVERSO), Niterói, Brazil; Laboratory of Physical Activity Neuroscience (LABNAF), Neurodiversity Institute, Queimados, RJ, Brazil; Physical Activity Sciences Laboratory (LACAF), Physical Activity Sciences Postgraduate Program, Salgado de Oliveira University (UNIVERSO), Niterói, Brazil; Federal Rural University of Rio de Janeiro, Physical Education and Sports Department, Seropédica, (Rio de Janeiro), Brazil; and University of A Coruña, Department of Physical Education and Sport, Faculty of Sport Sciences and Physical Education, A Coruña, Spain.

Abstract: Rodrigues, GM, Machado, S, Faria Vieira, LA, Ramalho de Oliveira, BR, Jesus Abreu, MA, Marquez, G, Maranhão Neto, GA, and Lattari, E. Effects of anodal transcranial direct current stimulation on training volume and pleasure responses in the back squat exercise following a bench press. J Strength Cond Res XX(X): 000-000, 2021-This study aimed to investigate the effects of anodal transcranial direct current stimulation (a-tDCS) on volume-load and pleasure responses in a back squat following a bench press. Read More

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How people with lumbar spinal stenosis make decisions about treatment: A qualitative study using the Health Belief Model.

Musculoskelet Sci Pract 2021 May 3;54:102383. Epub 2021 May 3.

Arizona School of Health Sciences, A.T. Still University, Mesa, AZ, USA.

Objective: Surgery rates for lumbar spinal stenosis (LSS) have increased despite inherent risks, high reoperation rates, and a lack of evidence for benefit over conservative treatment. Scant research has investigated how people make decisions about treatment, which may help clinicians better support patients during the course of care. The purpose of the present study was to explore the beliefs of people with LSS and how they make decisions about treatment. Read More

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Ketamine Use in Hysterosalpingography (the Jimah Procedure): A Follow-Up of Bilateral Tubal Evaluation of 27 Infertile  Women  at a Teaching Hospital, Ghana.

Radiol Res Pract 2021 17;2021:6657137. Epub 2021 Apr 17.

Department of Radiology, Korle Bu Teaching Hospital, Accra, Ghana.

Background: Pain, anxiety, and distress are common in radiological investigations including hysterosalpingogram (HSG). Studies suggest that sedation allows patients to better tolerate diagnostic imaging and image-guided procedures by relieving anxiety, discomfort, and pain. This study aimed at assessing the safety and effectiveness of ketamine use in HSG and the proportion of true positive bilateral tubal blockage during HSG using the Jimah Procedure. Read More

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Comparative Effects of Repetitive Odor Identification and Odor Memory Tasks on Olfactory Engagement in Older Populations - A Pilot fMRI Study.

Neuropsychiatr Dis Treat 2021 30;17:1279-1288. Epub 2021 Apr 30.

Department of Psychiatry and Behavioral Sciences, Howard University, Washington DC, USA.

Objective: This study evaluated human Blood Oxygen Level-Dependent (BOLD) responses in primary and higher-order olfactory regions of older adults, using odor memory and odor identification tasks. The goal was to determine which olfactory and memory regions of interest are more strongly engaged in older populations comparing these two odor training tasks.

Methods: Twelve adults 55-75 years old (75% females) without intranasal or major neurological disorders performed repetitive odor memory and identification tasks using a 3-tesla magnetic resonance scanner. Read More

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Sex differences in the association between maternal depression and child and adolescent cognitive development: a systematic review and meta-analysis.

Psychol Med 2021 May 7:1-10. Epub 2021 May 7.

Department of Social and Preventive Medicine, Université de Montréal, 7101 Avenue Parc, Montréal, Canada.

Background: Maternal depression is negatively associated with cognitive development across childhood and adolescence, with mixed evidence on whether this association differs in boys and girls. Herein, we performed a systematic review and meta-analysis of sex-specific estimates of the association between maternal depression and offspring cognitive outcomes.

Method: Seven databases (PubMed, EMBASE, PsycINFO, ERIC, CINAHL, Scopus, ProQuest) were searched for studies examining the longitudinal association between maternal depression and offspring (up to 18 years) cognitive outcomes. Read More

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Clinical outcome of a conservative approach to giant cell tumor of ankle and foot bones.

Foot (Edinb) 2021 Jan 11;47:101766. Epub 2021 Jan 11.

Musculoskeletal Oncology, Max Institute of Cancer Care, Saket, New Delhi, India.

Giant cell tumor of the bone (GCTB) affecting foot and ankle is rare, and the literature available on their clinical behavior and reconstructive options is scarce. Many authors consider these sites a special subset with high rates of local recurrence. Eighteen patients with GCTB of foot and ankle were treated from (March 2014 to February 2020). Read More

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January 2021

Virtual triage and outcomes of diabetic foot complications during Covid-19 pandemic: A retro-prospective, observational cohort study.

PLoS One 2021 6;16(5):e0251143. Epub 2021 May 6.

Tameside and Glossop Integrated Care NHS Foundation Trust, Tameside on Lyne, United Kingdom and Manchester Metropolitan University, Manchester, United Kingdom.

Aims: Limb and patient outcomes in people with diabetic foot complications including diabetic foot ulcer (DFU) provided virtual triage and personalized video consultations during COVID-19 pandemic are not known.

Methods: Patients with foot complications attending the diabetic foot clinic prior to lockdown who sought teleconsultations during COVID-19 lockdown underwent virtual triage to include clinical history, visual inspection of feet, domiciliary wound care (community nurse assisted dressings) and offloading instructions. The subsequent ulcer, limb and mortality outcomes during the following 24 weeks of COVID-19 lockdown (April-September 2020, group 1) were assessed and compared with those who attended foot clinic during the same period in 2019 (April-September, group 2). Read More

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The Healthy Taiwanese Eating Approach is inversely associated with all-cause and cause-specific mortality: A prospective study on the Nutrition and Health Survey in Taiwan, 1993-1996.

PLoS One 2021 6;16(5):e0251189. Epub 2021 May 6.

Institute of Population Health Science, National Health Research Institutes, Miaoli, Taiwan, R.O.C.

Background: Few longitudinal studies have investigated the association between foods/dietary pattern and mortality risk in the Asian population. We investigated the prospective association between foods/dietary pattern and risk of death among ethnic Chinese adults in Taiwan.

Methods: The study population included 2475 young and middle-aged adults (aged 18-65 years at baseline) who completed the questionnaires and physical examinations in the Nutrition and Health Survey in Taiwan from 1993 to 1996. Read More

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Genome-wide association analysis for yield-related traits at the R6 stage in a Chinese soybean mini core collection.

Genes Genomics 2021 May 6. Epub 2021 May 6.

National Center for Soybean Improvement, Key Laboratory of Biology and Genetics and Breeding for Soybean, Ministry of Agriculture, State Key Laboratory for Crop Genetics and Germplasm Enhancement, College of Agriculture, Nanjing Agricultural University, Weigang No. 1, Nanjing, 210095, Jiangsu, China.

Background: Soybean (Glycine max (L.) Merr.) is an economically important crop for vegetable oil and protein production, and yield is a critical trait for grain/vegetable uses of soybean. Read More

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Gender Differences and Mortality Trends After Transcatheter Aortic Valve Implantation: A 10-Year Analysis From a Single Tertiary Center.

J Invasive Cardiol 2021 May 6. Epub 2021 May 6.

Division of Interventional Cardiology of MedStar, Cardiovascular Research Network at MedStar Washington Hospital Center, 110 Irving Street, Suite 4B-1, Washington, D.C., 20010.

Aim: To evaluate gender differences and mortality trends in a population undergoing transcatheter aortic valve implantation (TAVI) and to analyze the correlates to all-cause mortality at follow-up.

Methods: The study comprises a prospective cohort of 592 TAVI patients (53.4% female) treated between 2008 and 2018. Read More

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Braided nitinol stent for chronic iliofemoral venous disease - the real-world BLUEFLOW registry.

Vasa 2021 May 6:1-6. Epub 2021 May 6.

Radiology Department, Klinikum Friedrichshafen, Friedrichshafen, Germany.

In patients with iliofemoral chronic venous disease (CVD) secondary to post-thrombotic or non-thrombotic obstruction, venous outflow obstruction after adequate anticoagulation alone is still frequent and post-thrombotic syndrome is a common complication. Thus, we aimed to evaluate mid-term effectiveness and safety of a novel braided venous stent for venous outflow obstruction treatment. Consecutive patients who underwent venous recanalization with a new braided, closed cell,venous stent for non- or post-thrombotic CVD were eligible for inclusion in our retrospective, observational study. Read More

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Adolescent and Young Adult Urogenital Outcome following Childhood Hypospadias Repair: Perfection Revisited.

J Urol 2021 May 6:101097JU0000000000001869. Epub 2021 May 6.

Department of Urology, Division of Paediatric Urology, Ghent University Hospital, Ghent University, Ghent, Belgium.

Purpose: We assessed the long-term surgical, functional urinary and sexual outcome of adolescent and young adult men who underwent childhood hypospadias repair.

Materials And Methods: Men born with non-syndromic hypospadias and healthy male controls, aged 16-21 years old, were recruited and their surgical, urinary, sexual functional and aesthetic outcomes assessed. Good outcome was defined as a patent and orthotopic meatus without fistulae and straight erections (<30° curvature) without erectile or ejaculatory problems. Read More

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Does the Timing of 1-Stage Palatoplasty With Radical Muscle Dissection Effect Long-Term Midface Growth? A Single-Center Retrospective Analysis.

Cleft Palate Craniofac J 2021 May 6:10556656211013174. Epub 2021 May 6.

Chairman, Klinik Professor Sailer, Zurich, Switzerland.

Objective: To evaluate the long-term effect of timing of 1-stage palatoplasty on midfacial growth in patients with cleft lip and palate (CLP).

Design: Retrospective observational cohort study.

Study Setting: Institutional hospital. Read More

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Proprioceptive Neuromuscular Facilitation Protocol for Thumb Osteoarthritis: A Pilot Study.

Hand (N Y) 2021 May 6:1558944721990785. Epub 2021 May 6.

Gannon University, Ruskin, FL, USA.

Background: Osteoarthritis (OA) of the thumb carpometacarpal (CMC) joint often presents with joint instability and proprioceptive deficits. Proprioception has been found to play an important role in the rehabilitative process. The purpose of this study was to evaluate the effectiveness of a proprioceptive training program on pain and function in individuals with early-stage thumb Carpometacarpal joint OA. Read More

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Donor defects after lymph vessel transplantation and free vascularized lymph node transfer: A comparison and evaluation of complications.

World J Transplant 2021 Apr;11(4):129-137

Division of Plastic Surgery, Department for Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Goettingen, Goettingen 37075, Lower Saxony, Germany.

Background: Secondary lymphedema after surgical interventions is a progressive, chronic disease that is still not completely curable. Over the past years, a multitude of surgical therapy options have been described.

Aim: To summarize the single-center complications in lymph vessel (LVTx) and free vascularized lymph node transfer (VLNT). Read More

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Helpful post-diagnostic services for young onset dementia: Findings and recommendations from the Angela project.

Health Soc Care Community 2021 May 5. Epub 2021 May 5.

Faculty of Health Studies, Centre for Applied Dementia Studies, University of Bradford, Bradford, UK.

There is a significant lack of evidence regarding optimum models for service provision in young onset dementia (YOD). Our study aim was to gather detailed information about services experienced as helpful by those with YOD and family carers. The objective was to identify the core features of these services to inform service design, delivery and improvements. Read More

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Mortality and Neurologic Sequelae in Influenza-Associated Encephalopathy: Retrospective Multicenter PICU Cohort in France.

Pediatr Crit Care Med 2021 05 4. Epub 2021 May 4.

Pediatric Intensive Care Unit, Robert-Debré University Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), and Université de Paris, Paris, France. Pediatric Neurology Unit, Robert-Debré University Hospital, AP-HP, and Université de Paris, Paris, France. Pediatric Intensive Care Unit, Necker-Enfants-Malades University Hospital, AP-HP, and Université de Paris, Paris, France. Pediatric Intensive Care Unit, Lyon University Hospital, and Université de Lyon, Lyon, France. Pediatric Intensive Care Unit, Le Kremlin-Bicêtre University Hospital, AP-HP, and Université de Paris-Saclay, Saclay, France. Pediatric Intensive Care Unit, Trousseau University Hospital, AP-HP, and Sorbonne University, Paris, France. Pediatric Intensive Care Unit, Raymond Poincaré University Hospital, AP-HP, Garches, and Université de Versailles Saint-Quentin, Paris, France. Pediatric Neurology Unit, Necker-Enfants-Malades University Hospital, AP-HP, and Université de Paris, Paris, France.

Objectives: To describe and estimate the mortality rate of severe influenza-associated encephalopathy/encephalitis among children admitted to PICUs.

Design: Multicenter retrospective study.

Setting: Twelve French PICUs. Read More

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Cancer Therapeutics-related Cardiac Dysfunction in Patients Treated With Immune Checkpoint Inhibitors: An Understudied Manifestation.

J Immunother 2021 Jun;44(5):179-184


The widespread use of immune checkpoint inhibitors (ICI) has become a mainstay of care for a variety of malignancies. However, these therapies portend a range of adverse effects, including a potentially fatal form of cardiotoxicity which to date has not been elucidated. We aimed to evaluate the baseline characteristics of ICI-mediated cardiotoxicity. Read More

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Natural history study of adults with Wolf-Hirschhorn syndrome 2: Patient-reported outcomes study.

Am J Med Genet A 2021 May 5. Epub 2021 May 5.

Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy.

Wolf-Hirschhorn syndrome (WHS) is a contiguous gene disorder consisting of prenatal and postnatal growth deficiency, distinctive craniofacial features, intellectual disability, and seizures. The condition is caused by a partial loss of material from the distal portion of the short arm of chromosome 4 (4p16.3). Read More

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Young and early-onset dilated cardiomyopathy with malignant ventricular arrhythmia and sudden cardiac death induced by the heterozygous LDB3, MYH6, and SYNE1 missense mutations.

Ann Noninvasive Electrocardiol 2021 May 5:e12840. Epub 2021 May 5.

Department of Cardiology, The Cardiovascular Center, Interventional Medical Center, Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China.

Background: The whole exome sequencing (WES) with targeted gene analysis is an effective diagnostic tool for cardiomyopathy. The early-onset sudden cardiac death (SCD) was commonly associated with dilated cardiomyopathy (DCM) induced by pathogenic genetic mutations.

Methods: In a Chinese Han family, the patient of 24 years old occurred with early-onset and DCM and died of SCD associated with ICD storms induced by repetitive ventricular tachycardia/fibrillation (VT/F). Read More

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Inhaled antibiotics for treatment of adults with non-cystic fibrosis bronchiectasis: A systematic review and meta-analysis.

Eur J Intern Med 2021 May 1. Epub 2021 May 1.

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Clinical Research/Epidemiology in Pneumonia & Sepsis (CRIPS), Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain; Clinical Research in the ICU, Anesthesia Department, CHU Nimes, Universite de Nimes-Montpellier, France.

Background: Inhaled antibiotics (IA) in non-cystic fibrosis bronchiectasis (NCFB) are recommended by some clinical practice guidelines for prevention or treatment of NCFB exacerbations.

Methods: We performed a systematic review and meta-analysis to evaluate the efficacy and safety of IA use for treatment of adults with NCFB and Pseudomonas aeruginosa chronic bronchial infection. The search was performed in the Cochrane Library, PubMed, and Web of Science databases from 2000 to 2019. Read More

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Perioperative outcome and complications following single-staged Posterior Spinal Fusion (PSF) using pedicle screw instrumentation in Adolescent Idiopathic Scoliosis (AIS): a review of 1057 cases from a single centre.

BMC Musculoskelet Disord 2021 May 4;22(1):413. Epub 2021 May 4.

Department of Orthopaedic Surgery (NOCERAL), Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Background: There has been a growing interest in using all pedicle screw construct in posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS) surgery in recent years. However, studies focusing on perioperative outcome and complications utilizing only pedicle screw system in AIS population are lacking. This study aims to evaluate perioperative outcomes and to determine the prevalence of major and minor complications following single-staged PSF for AIS. Read More

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