Biochim Biophys Acta Mol Cell Res 2021 May 11:119059. Epub 2021 May 11.
Lady Davis Institute for Medical Research, 3755, Chemin de la Côte-Sainte-Catherine, Montréal, QC, Canada, H3T 1E2; Gerald Bronfman Department of Oncology, McGill University, 5100 Maisonneuve Blvd West, Montréal, QC, Canada, H4A 3T2; Department of Medicine, Division of Experimental Medicine, McGill University, 1001 Décarie Blvd, Montréal, QC, Canada, H4A 3J1; Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montréal, QC, Canada, H3G 1Y6.
Malignant transformation and tumor progression are accompanied by significant perturbations in metabolic programs. As such, cancer cells support high ATP turnover to construct the building blocks needed to fuel neoplastic growth. The coordination of metabolic networks in malignant cells is dependent on the collaboration with cellular signaling pathways. Read More