103,179 results match your criteria turnover

Fast cycle H2O2 nebulisationagainst frequent healthcare-associated microorganisms: efficacy assessment.

J Hosp Infect 2021 May 11. Epub 2021 May 11.

Division of Microbiology, Department of Pathology, Faculty of Medicine, University of Porto, Portugal; CINTESIS, Center for Health Technology and Services Research, Portugal; Burn Unit and Department of Plastic and Reconstructive Surgery, University Hospital Center of São João, Porto, Portugal.

Background: Aiming to control microbial contamination in hospital settings, hydrogen peroxide based technology is currently in use. However, the required long cycles result in prolonged room turnover time, thus precluding a wider implementation of the technology.

Aim: This study aims to assess the efficacy of a shorter cycle of nebulised H2O2 against healthcare-associated microorganisms, further comparing among multidrug-resistant and multidrug-susceptible strains. Read More

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The role of GSK3 in metabolic pathway perturbations in cancer.

Biochim Biophys Acta Mol Cell Res 2021 May 11:119059. Epub 2021 May 11.

Lady Davis Institute for Medical Research, 3755, Chemin de la Côte-Sainte-Catherine, Montréal, QC, Canada, H3T 1E2; Gerald Bronfman Department of Oncology, McGill University, 5100 Maisonneuve Blvd West, Montréal, QC, Canada, H4A 3T2; Department of Medicine, Division of Experimental Medicine, McGill University, 1001 Décarie Blvd, Montréal, QC, Canada, H4A 3J1; Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montréal, QC, Canada, H3G 1Y6.

Malignant transformation and tumor progression are accompanied by significant perturbations in metabolic programs. As such, cancer cells support high ATP turnover to construct the building blocks needed to fuel neoplastic growth. The coordination of metabolic networks in malignant cells is dependent on the collaboration with cellular signaling pathways. Read More

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Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.

Curr Biol 2021 May 8. Epub 2021 May 8.

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA. Electronic address:

The primary cilium is an essential organizing center for signal transduction, and ciliary defects cause congenital disorders known collectively as ciliopathies. Primary cilia form by two pathways that are employed in a cell-type- and tissue-specific manner: an extracellular pathway in which the cilium grows out from the cell surface and an intracellular pathway in which the nascent cilium first forms inside the cell. After exposure to the external environment, cilia formed via the intracellular pathway may have distinct functional properties, as they often remain recessed within a ciliary pocket. Read More

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Determinants of healthcare worker turnover in intensive care units: A micro-macro multilevel analysis.

PLoS One 2021 14;16(5):e0251779. Epub 2021 May 14.

Modélisation Epidémiologie et Surveillance des Risques Sanitaires (MESuRS) Laboratory, Conservatoire National des Arts et Métiers (Cnam), Paris, France.

Background: High turnover among healthcare workers is an increasingly common phenomenon in hospitals worldwide, especially in intensive care units (ICUs). In addition to the serious financial consequences, this is a major concern for patient care (disrupted continuity of care, decreased quality and safety of care, increased rates of medication errors, …).

Objective: The goal of this article was to understand how the ICU-level nurse turnover rate may be explained from multiple covariates at individual and ICU-level, using data from 526 French registered and auxiliary nurses (RANs). Read More

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Are diabetes microvascular complications risk factors for fragility fracture?

Curr Opin Endocrinol Diabetes Obes 2021 May 14. Epub 2021 May 14.

Division of Pediatric Endocrinology and Diabetology Wells Center for Pediatric Research, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, Indiana, USA.

Purpose Of Review: We describe relationships between microvascular complications and bone fragility fracture in the context of diabetes. We highlight gaps in knowledge and suggest areas of further study.

Recent Findings: Evidence in type 1 diabetes (T1D) demonstrates that low bone mineral density (BMD) is associated with microvascular complications and linked to increased fracture risk. Read More

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Tuning Oxygen Reduction Catalysis of Dinuclear Cobalt Polypyridyl Complexes by the Bridging Structure.

Inorg Chem 2021 May 14. Epub 2021 May 14.

Department of Chemistry, College of Science, Rikkyo University, 3-34-1, Nishi-Ikebukuro, Toshima, Tokyo 171-8501, Japan.

The four-electron oxygen reduction reaction (4e-ORR) is the mainstay in chemical energy conversion. Elucidation of factors influencing the catalyst's reaction rate and selectivity is important in the development of more active catalysts of 4e-ORR. In this study, we investigated chemical and electrochemical 4e-ORR catalyzed by Co(μ-O) complexes bridged by xanthene () and anthracene () and by a Co(OH) complex bridged by anthraquinone (). Read More

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An alginate-confined peroxygenase-CLEA for styrene epoxidation.

Chem Commun (Camb) 2021 May 14. Epub 2021 May 14.

Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ, Delft, The Netherlands.

Oxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM. Read More

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Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention.

Ann Transl Med 2021 Apr;9(8):729

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.

Liver fibrosis is the excessive expression and accumulation of extracellular matrix proteins in the liver. Fibrotic scarring occurs as the consequence of chronic injury and inflammation. While the successful treatment of hepatitis B and C reduced the burden of liver disease related to viral hepatitis, non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) are nowadays the leading causes of hepatic fibrosis worldwide. Read More

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Post-translational Control of RNA-Binding Proteins and Disease-Related Dysregulation.

Front Mol Biosci 2021 27;8:658852. Epub 2021 Apr 27.

Instituto de Investigaciones Químicas, Centro de Investigaciones Científicas Isla de la Cartuja, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas, Seville, Spain.

Cell signaling mechanisms modulate gene expression in response to internal and external stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription and translation processes. The post-transcriptional control of mRNA metabolism is mediated by the so-called RNA-binding proteins (RBPs), which assemble with specific transcripts forming messenger ribonucleoprotein particles of highly dynamic composition. Read More

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Profilin2 regulates actin rod assembly in neuronal cells.

Sci Rep 2021 May 13;11(1):10287. Epub 2021 May 13.

Institute of Neuroanatomy and Cell Biology, Hannover Medical School, Hannover, Germany.

Nuclear and cytoplasmic actin-cofilin rods are formed transiently under stress conditions to reduce actin filament turnover and ATP hydrolysis. The persistence of these structures has been implicated in disease pathology of several neurological disorders. Recently, the presence of actin rods has been discovered in Spinal Muscular Atrophy (SMA), a neurodegenerative disease affecting predominantly motoneurons leading to muscle weakness and atrophy. Read More

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A robust polyfunctional Pd(II)-based magnetic amphiphilic nanocatalyst for the Suzuki-Miyaura coupling reaction.

Sci Rep 2021 May 13;11(1):10239. Epub 2021 May 13.

Department of Chemistry, Zanjan Branch, Islamic Azad University, P. O. Box 49195-467, Zanjan, Iran.

Herein, a robust Pd(II)-based polyfunctional magnetic amphiphilic artificial metalloenzyme was prepared by anchoring a Pd(2,2'-dipyridylamine)Cl bearing hydrophilic monomethyl ether poly(ethylene glycol) (mPEG) chains on the surface of amino-functionalized silica-coated magnetic nanoparticles. The 2,2'-dipyridylamine (dpa) has shown excellent complexation properties for Pd(II) and it could be easily anchored onto functionalized magnetic support by the bridging nitrogen atom. Moreover, the bridging nitrogen atom at the proximity of Pd(II) catalytic center could play an important role in dynamic suppramolecular interactions with substrates. Read More

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Knowledge, barriers and facilitators regarding COVID-19 vaccine and vaccination programme among the general population: A cross-sectional survey from one thousand two hundred and forty-nine participants.

Diabetes Metab Syndr 2021 May 1;15(3):987-992. Epub 2021 May 1.

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Background And Aims: The success of the COVID-19 vaccination program is dependent on people's knowledge and attitude regarding the vaccination program. Higher vaccine acceptance can be ensured by strengthening the facilitators and limiting the barriers being observed among the general population.

Material And Methods: Indexed study is a cross-sectional web-based survey using a pre-validated questionnaire to assess knowledge, barriers and facilitators of COVID-19 vaccine and vaccination programme administered on adults across India using a Google online survey platform. Read More

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Silencing Hoxa2 reverses dexamethasone-induced dysfunction of MC3T3-E1 osteoblasts and osteoporosis in rats.

Adv Clin Exp Med 2021 May 13. Epub 2021 May 13.

Department of Orthopedics, Liuzhou People's Hospital, Guangxi Medical University, China.

Background: Osteoporosis is damaging the health of women worldwide. Osteoporosis results from the imbalance between bone resorption and formation, which may be regulated by homeobox A2 (Hoxa2). However, the specific role and mechanism of Hoxa2 in osteogenesis and dexamethasone (Dex)-induced osteoporosis remain unknown. Read More

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Ten steps to investigate a cellular system with mathematical modeling.

PLoS Comput Biol 2021 May 13;17(5):e1008921. Epub 2021 May 13.

MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, the Netherlands.

Cellular and intracellular processes are inherently complex due to the large number of components and interactions, which are often nonlinear and occur at different spatiotemporal scales. Because of this complexity, mathematical modeling is increasingly used to simulate such systems and perform experiments in silico, many orders of magnitude faster than real experiments and often at a higher spatiotemporal resolution. In this article, we will focus on the generic modeling process and illustrate it with an example model of membrane lipid turnover. Read More

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Rookies connected: Interpersonal relationships among newcomers, newcomer adjustment processes, and socialization outcomes.

J Appl Psychol 2021 May 13. Epub 2021 May 13.

Department of Work and Organizations, Carlson School of Management, University of Minnesota.

How do relationships among newcomers in the same cohort impact how quickly they develop clear understandings of their new roles and, ultimately, key socialization outcomes? We study newcomers' relationships with cohort members in the same unit (i.e., intra-unit relationships) and those in different units (i. Read More

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A Worksite Self-management Program for Workers with Chronic Health Conditions Improves Worker Engagement and Retention, but not Workplace Function.

J Occup Rehabil 2021 May 13. Epub 2021 May 13.

University of South-Eastern Norway, Raveien 215, 3184, Borre, Norway.

Purpose An increasing number of workers in the US have chronic health conditions that limit their ability to work, and few worksite interventions have been tested to improve worker coping and problem solving at work. The purpose of this study was to evaluate a worksite-based health self-management program designed to improve workplace function among workers with chronic health conditions. Methods We conducted a randomized, controlled trial of a worksite self-management program ("Manage at Work") (clinicaltrials. Read More

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Assembly processes lead to divergent soil fungal communities within and among twelve forest ecosystems along a latitudinal gradient.

New Phytol 2021 May 13. Epub 2021 May 13.

Hawkesbury Institute for the Environment, Western Sydney University, Locked Bag 1797, Penrith, NSW, 2751, Australia.

Latitudinal gradients provide opportunities to better understand soil fungal community assembly and its relationship with vegetation, climate, soil and ecosystem function. Understanding the mechanisms underlying community assembly is essential for predicting compositional responses to changing environments. We quantified the relative importance of stochastic and deterministic processes in structuring soil fungal communities using patterns of community dissimilarity observed within and between twelve natural forests and related these to environmental variation within and among sites. Read More

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Fine root dynamics across pantropical rainforest ecosystems.

Glob Chang Biol 2021 May 12. Epub 2021 May 12.

Forestry Research Institute of Ghana, Council for Scientific and Industrial Research, University, P.O. Box 63, Kumasi, Ghana.

Fine roots constitute a significant component of the net primary productivity (NPP) of forest ecosystems but are much less studied than above-ground NPP. Comparisons across sites and regions are also hampered by inconsistent methodologies, especially in tropical areas. Here, we present a novel dataset of fine root biomass, productivity, residence time, and allocation in tropical old-growth rainforest sites worldwide, measured using consistent methods, and examine how these variables are related to consistently determined soil and climatic characteristics. Read More

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Selenium Status Affects Hypertrophic Growth of Skeletal Muscle in Growing Zebrafish by Mediating Protein Turnover.

J Nutr 2021 May 12. Epub 2021 May 12.

College of Fisheries, Huazhong Agricultural University, Wuhan, China.

Background: Selenium (Se) status is closely related to skeletal muscle physiological status. However, its influence on skeletal muscle growth has not been well studied.

Objectives: This study aimed to analyze the impacts of overall Se status (deficient, adequate, and high) on skeletal muscle growth using a growing zebrafish model. Read More

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Real-world effects and adverse events of romosozumab in Japanese osteoporotic patients: A prospective cohort study.

Bone Rep 2021 Jun 16;14:101068. Epub 2021 Apr 16.

Department of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.

Real-world data on the new anti-sclerostin antibody drug, romosozumab, remain scarce. There is a strong need to accumulate and analyze data on romosozumab treatment for such conditions as osteoporosis. The purpose of this study was to investigate the therapeutic and adverse effects of romosozumab for osteoporosis treatment in clinical practice. Read More

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Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.

Nat Commun 2021 May 12;12(1):2748. Epub 2021 May 12.

Institute of Biophysics and Physical Biochemistry, Regensburg Center for Biochemistry, University of Regensburg, Regensburg, Germany.

Imidazole glycerol phosphate synthase (HisFH) is a heterodimeric bienzyme complex operating at a central branch point of metabolism. HisFH is responsible for the HisH-catalyzed hydrolysis of glutamine to glutamate and ammonia, which is then used for a cyclase reaction by HisF. The HisFH complex is allosterically regulated but the underlying mechanism is not well understood. Read More

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Transcriptome responses of the dinoflagellate Karenia mikimotoi driven by nitrogen deficiency.

Harmful Algae 2021 Mar 27;103:101977. Epub 2021 Jan 27.

Fujian Engineering Research Center for Comprehensive Utilization of Marine Products Waste, Fuzhou University, Fujian 350116, China; Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou University, Fujian 350116, China. Electronic address:

The availability of ambient N nutrient is often correlated with the occurrences of harmful algal bloom formed by certain dinoflagellates, making it important to understand how these species might be responding to such conditions. Here, transcriptome sequencing of Karenia mikimotoi was conducted to understand the underlying molecular mechanisms by which this dinoflagellate copes with nitrogen (N) deficiency. Transcriptomic analysis revealed 8802 unigenes (3. Read More

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Organisational support and turnover intentions: A moderated mediation approach.

Nurs Open 2021 May 12. Epub 2021 May 12.

School of Nursing and Midwifery Amol, Mazandaran University of Medical Sciences, Sari, Iran.

Aim: The current study aims to examine the moderating role of psychological ownership in the process that translates organisational support into nurses' turnover intentions through job satisfaction.

Design: A cross-sectional research design was used to test the hypotheses.

Method: Using a purposive sampling 341 self-completed survey data were collected from nurses working in two public hospitals in Iran. Read More

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Genetic and epigenetic features of promoters with ubiquitous chromatin accessibility support ubiquitous transcription of cell-essential genes.

Nucleic Acids Res 2021 May 12. Epub 2021 May 12.

Program in Bioinformatics and Integrative Biology, UMass Medical School, Worcester, MA, USA.

Gene expression is controlled by regulatory elements within accessible chromatin. Although most regulatory elements are cell type-specific, a subset is accessible in nearly all the 517 human and 94 mouse cell and tissue types assayed by the ENCODE consortium. We systematically analyzed 9000 human and 8000 mouse ubiquitously-accessible candidate cis-regulatory elements (cCREs) with promoter-like signatures (PLSs) from ENCODE, which we denote ubi-PLSs. Read More

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The duration of denosumab treatment and the efficacy of zoledronate to preserve bone mineral density after its discontinuation.

J Clin Endocrinol Metab 2021 May 12. Epub 2021 May 12.

Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece.

Context: Zoledronate is used to prevent bone loss following denosumab discontinuation but its efficacy differs among studies.

Objective: To test if the duration of denosumab treatment affects the efficacy of subsequent zoledronate infusion.

Design: Multicenter, prospective cohort study. Read More

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Dynamics of the enterohepatic circulation of bile acids in healthy humans.

Am J Physiol Gastrointest Liver Physiol 2021 May 12. Epub 2021 May 12.

Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Germanygrid.15090.3d.

Regulation of bile acid metabolism is normally discussed as the regulation of bile acid synthesis, which serves to compensate for intestinal loss in order to maintain a constant pool size. After a meal, bile acids start cycling in the enterohepatic circulation. Farnesoid X receptor-dependent ileal and hepatic processes lead to negative feedback inhibition of bile acid synthesis. Read More

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Sustainability Assessment of a District-Wide Quality Improvement on Newborn Care Program in Rural Rwanda: A Mixed-Method Study.

Ann Glob Health 2021 Apr 19;87(1):40. Epub 2021 Apr 19.

Northwestern University Feinberg School of Medicine, USA.

Background: Neonatal mortality continues to be a global challenge, particularly in low- and middle-income countries. There is growing work to reduce mortality through improving quality of systems and care, but less is known about sustainability of improvements in the setting post initial implementation. We conducted a 12-month sustainability assessment of All Babies Count (ABC), a district-wide quality improvement project including mentoring and improvement collaborative designed to improve quality and reduce neonatal mortality in two districts in rural Rwanda. Read More

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Deep reefs are not refugium for shallow-water fish communities in the southwestern Atlantic.

Ecol Evol 2021 May 18;11(9):4413-4427. Epub 2021 Mar 18.

Departamento de Sistemática e Ecologia Centro de Ciências Exatas e da Natureza Universidade Federal da Paraíba João Pessoa PB Brazil.

The deep reef refugia hypothesis (DRRH) predicts that deep reef ecosystems may act as refugium for the biota of disturbed shallow waters. Because deep reefs are among the most understudied habitats on Earth, formal tests of the DRRH remain scarce. If the DRRH is valid at the community level, the diversity of species, functions, and lineages of fish communities of shallow reefs should be encapsulated in deep reefs. Read More

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Identification of an apoptosis-related prognostic gene signature and molecular subtypes of clear cell renal cell carcinoma (ccRCC).

J Cancer 2021 2;12(11):3265-3276. Epub 2021 Apr 2.

The Fifth Hospital of Xiamen, Xiamen 361101, Fujian Province, China.

Previously studies have shown that apoptosis-related genes play an essential role in normal cell turnover, maintaining the immune system function, and inducing cell death. However, their prognostic roles in clear cell renal cell carcinoma (ccRCC) have not been thoroughly investigated. In the present study, apoptosis-related genes expression profiles from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) database were used as training dataset and external validation dataset, respectively. Read More

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GRK3 deficiency elicits brain immune activation and psychosis.

Mol Psychiatry 2021 May 12. Epub 2021 May 12.

Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.

The G protein-coupled receptor kinase (GRK) family member protein GRK3 has been linked to the pathophysiology of schizophrenia and bipolar disorder. Expression, as well as protein levels, of GRK3 are reduced in post-mortem prefrontal cortex of schizophrenia subjects. Here, we investigate functional behavior and neurotransmission related to immune activation and psychosis using mice lacking functional Grk3 and utilizing a variety of methods, including behavioral, biochemical, electrophysiological, molecular, and imaging methods. Read More

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