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Pigmented Villonodular Synovitis as an Atypical Cause of Deep Motor Branch Neuropathy.

J Orthop Case Rep 2021 Apr;11(4):80-84

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.

Objectives: Compression of the ulnar nerve in Guyon's canal results in ulnar tunnel syndrome (UTS). The patient may present with sensory and motor deficits (zone 1), motor deficit (zone 2), or sensory deficit (zone 3). The most common causes of UTS include ganglion cysts, idiopathic ulnar nerve compression, occupational pressure neuritis (repetitive compression), prolonged compression, hook of hamate fractures, and arterial thrombus or aneurysm. Read More

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Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis.

Oncotarget 2021 Jul 20;12(15):1470-1489. Epub 2021 Jul 20.

Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Objective: Aberrations in the PI3K/AKT/mTOR survival pathway in many cancers are the most common genomic abnormalities. The phytochemical and bioactive agent sulforaphane (SFN) has nutrigenomic potential in activating the expression of several cellular protective genes via the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2 is primarily related to mechanisms of endogenous cellular defense and survival. Read More

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Urban road greenbelt configuration: The perspective of PM removal and air quality regulation.

Environ Int 2021 Jul 24;157:106786. Epub 2021 Jul 24.

Key Laboratory for Urban Habitat Environmental Science and Technology, School of Urban Planning and Design, Peking University, Shenzhen 518055, PR China. Electronic address:

The establishment of the road green belt (RGB) is an effective means to reduce particle matter (PM) emissions from road traffic. This study tested the ability of 23 common tree species in Shenzhen to reduce PM concentrations using field investigations and wind tunnel tests. The association between leaf microstructure and individual reduction ability was also analyzed. Read More

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Arthroscopic anterior cruciate ligament reconstruction in a patient with multiple hereditary exostoses.

Acta Biomed 2021 Jul 26;92(S3):e2021004. Epub 2021 Jul 26.

San Pier Damiano Hospital - Faenza (RA).

Background Multiple hereditary exostoses (MHE) also known as Multiple Osteochondromas is a rare benign bone tumour disease, characterized by multiple osteocartilaginous masses. The knee is one of the most affected sites. Anterior cruciate ligament (ACL) surgery is the most common and generally most successful surgical knee procedure; however, the association between MHE and ACL reconstruction is very rare and may represent a challenging procedure because of the anatomical anomaly related to presence of multiple masses around the knee. Read More

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Unplanned Office Visits Following Outpatient Hand Surgery.

Hand (N Y) 2021 Jul 26:15589447211028932. Epub 2021 Jul 26.

Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA, USA.

Background: Returning to the office for an unplanned visit postoperatively can be burdensome to both the patient and provider. The purpose of this study was to quantify the rate of unplanned office visits after common soft tissue hand surgeries and assess the reasons for these unplanned visits.

Methods: Patients who underwent common soft tissue hand surgeries over a 6-month time period were queried from an electronic medical record database. Read More

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Ulnar Nerve Dislocation and Subluxation from the Cubital Tunnel Are Common in College Athletes.

J Clin Med 2021 Jul 15;10(14). Epub 2021 Jul 15.

Department of Orthopaedic Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.

Background: Hypermobility of the ulnar nerve from the cubital tunnel reportedly occurs in healthy people without symptoms of ulnar neuropathy. However, the occurrence rate in athletes is unknown. We examined the occurrence rate of ulnar nerve hypermobility using ultrasonography, symptoms, and physical findings in athletes and compared the results of four types of sports. Read More

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Ultrasound-Guided Near-Nerve Needle Sensory Technique for the Diagnosis of Tarsal Tunnel Syndrome.

J Clin Med 2021 Jul 11;10(14). Epub 2021 Jul 11.

Department of Nursery and Physiotherapy, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, Spain.

Background: Tarsal tunnel syndrome (TTS) is one of the most common entrapment syndromes. Although diagnosis is supported by imaging tests, it has so far been based on clinical findings. Neurophysiological tests are not effective for providing an accurate diagnosis. Read More

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Diffusion tensor imaging in cubital tunnel syndrome.

Sci Rep 2021 Jul 22;11(1):14982. Epub 2021 Jul 22.

Leeds Institute for Medical Research, University of Leeds, Leeds, UK.

Cubital tunnel syndrome (CuTS) is the 2nd most common compressive neuropathy. To improve both diagnosis and the selection of patients for surgery, there is a pressing need to develop a reliable and objective test of ulnar nerve 'health'. Diffusion tensor imaging (DTI) characterises tissue microstructure and may identify differences in the normal ulnar from those affected by CuTS. Read More

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Adolescents and adults with Fontan circulation: insights from the PREpArE-Fontan registry.

Cardiol Young 2021 Jul 23:1-9. Epub 2021 Jul 23.

Adult Congenital Heart Disease Unit, Queen Elizabeth Hospital Birmingham, Birmingham, UK.

The Patient Registry for Adolescents and Adults with Stable Fontan Circulation aims to describe a contemporary cohort of Fontan patients who could be eligible for a clinical trial investigating macitentan, an endothelin receptor antagonist. This international, non-interventional, multicentre, cross-sectional, observational registry enrolled patients with "stable" Fontan circulation ≥10 years following extra-cardiac conduit or lateral tunnel procedure. Main exclusion criteria were NYHA functional class IV, reoperation of Fontan circulation, or signs of disease worsening. Read More

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Median-to-Ulnar Nerve Communication in Carpal Tunnel Syndrome: An Electrophysiological Study.

Neurol Int 2021 Jul 12;13(3):304-314. Epub 2021 Jul 12.

Department of Biomedicine, Neuroscience and Advanced Diagnostic (BIND), University of Palermo, 90127 Palermo, Italy.

The median-to-ulnar communicating branch (MUC) is an asymptomatic variant of the upper limb innervation that can lead to interpretation errors in routine nerve conduction studies. The diagnosis of carpal tunnel syndrome (CTS) or ulnar nerve lesions can be complicated by the presence of MUC. In this study, we describe electrophysiological features of MUC in CTS patients presenting to our clinic. Read More

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Clinical and Radiological Outcomes of Anteromedial Portal Versus Transtibial Technique in ACL Reconstruction: A Systematic Review.

Orthop J Sports Med 2021 Jul 2;9(7):23259671211024591. Epub 2021 Jul 2.

Department of Orthopedic Surgery, Faculty of Medicine, University of Thessaly, Larissa, Greece.

Background: The drilling technique used to make a femoral tunnel is critically important for determining outcomes after anterior cruciate ligament (ACL) reconstruction. The 2 most common methods are the transtibial (TT) and anteromedial (AM) techniques.

Purpose: To determine whether graft orientation and placement affect clinical outcomes by comparing clinical and radiological outcomes after single-bundle ACL reconstruction with the AM versus TT technique. Read More

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Exploring Area-Dependent PrCaMnO-Based Memristive Devices as Synapses in Spiking and Artificial Neural Networks.

Front Neurosci 2021 2;15:661261. Epub 2021 Jul 2.

Peter Grünberg Institut (PGI-7/10), Forschungszentrum Jülich GmbH & JARA-FIT, Jülich, Germany.

Memristive devices are novel electronic devices, which resistance can be tuned by an external voltage in a non-volatile way. Due to their analog resistive switching behavior, they are considered to emulate the behavior of synapses in neuronal networks. In this work, we investigate memristive devices based on the field-driven redox process between the p-conducting PrCaMnO (PCMO) and different tunnel barriers, namely, AlO, TaO, and WO. Read More

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Kinesio taping as an alternative treatment for manual laborers with carpal tunnel syndrome: A double-blind randomized clinical trial.

J Back Musculoskelet Rehabil 2021 Jul 9. Epub 2021 Jul 9.

Department of Physical Therapy, School of Rehabilitation, Semnan University of Medical Sciences, Semnan, Iran.

Background: Carpal tunnel syndrome (CTS) is one of the most common forms of peripheral neuropathies due to median nerve compression. Occupational factors, such as repetitive hand motions are believed to be associated with this condition.

Objective: This clinical trial assessed the effect of Kinesio taping (KT) of hand flexor muscles on the management of mild to moderate CTS in Iranian manual laborers. Read More

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ACL Study Group presents the global trends in ACL reconstruction: biennial survey of the ACL Study Group.

J ISAKOS 2021 Jul 16. Epub 2021 Jul 16.

Orthopaedics, Practice LEONARDO, Hirslanden Clinic Birshot, Münchenstein, Switzerland.

Objectives: The primary objective of this survey was to gauge the current global trends in anterior cruciate ligament reconstruction (ACLR) as reported by the members of the Anterior Cruciate Ligament (ACL) Study Group (SG).

Methods: A survey was created and distributed among the members of the ACL SG consisting of 87 questions and 16 categories related to ACLR, including member demographics, preoperative management, primary ACLR techniques and graft choice, use of concomitant procedures and biological augmentation, postoperative rehabilitation, and more.

Results: The survey was completed by the 140 members of the ACL SG. Read More

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Risk Factors of Carpal Tunnel Syndrome in Taiwan: A Population-Based Cohort Study.

Ann Plast Surg 2021 Jul 13. Epub 2021 Jul 13.

From the Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Keelung & Chang Gung University College of Medicine, Taoyuan, Taiwan Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou & Chang Gung University College of Medicine, Taoyuan, Taiwan Graduate Institute of Clinical Medical Sciences and Research Services Center for Health Information, Chang Gung University, Taoyuan, Taiwan.

Background: Carpal tunnel syndrome (CTS), 1 of the most common peripheral neuropathies of the upper extremity, has been studied for decades regarding its epidemiology and associated medical conditions. We conducted a large-scale, age- and gender-matched study from an Asian population database to investigate the relationship between the incidence and the demographic characteristics.

Methods: A retrospective cohort study using data of National Health Insurance Research Database was conducted. Read More

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Investigating the effects of volar wrist cock-up splint and dorsal lock wrist hand orthosis in reducing signs of carpal tunnel syndrome.

Med J Islam Repub Iran 2021 24;35:53. Epub 2021 Apr 24.

Department of Orthotics & Prosthetics, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.

Carpal tunnel syndrome (CTS) is the most common compressive neuropathy presenting with sharp pain, parenthesis, dysfunction of the hand in coordination and gripping. Splinting is the most common conservative intervention to improve pain and enological symptom of this Syndrome (CTS). With regard to the importance of these interventions and controversies about different designs of splints, the aim of this study was to compare the therapeutic effects of volar wrist cock-up orthosis and dorsal lock wrist hand orthosis on pain, sensory and motor latency in carpal tunnel syndrome. Read More

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Influential factors of surgical decompression for ulnar nerve neuropathy in Guyon's canal.

J Chin Med Assoc 2021 Jul 13. Epub 2021 Jul 13.

Department of Surgery, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan, ROC Department of Orthopaedics & Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Institute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan, ROC Department of Orthopaedics, Chiayi Christian Hospital, Chiayi, Taiwan, ROC Chung Hwa University of Medical Technology, Tainan, Taiwan, ROC Taipei City Hospital-ZhongXiao Branch, Taipei, Taiwan, ROC Department of Orthopaedics, Huang Tien General Hospital, Taichung, Taiwan, ROC.

Background: Guyon's canal syndrome is nerve compressive pathology which can lead to sensory and/or motor function deficits. This problem is usually difficult to distinguish from cubital tunnel syndrome and relatively less common than cubital tunnel syndrome. This study evaluated the functional results and patient-reported outcomes following decompression of the ulnar nerve in Guyon's canal. Read More

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Treatment of Peripheral Nerve Compression Syndromes of the Upper Extremities: a Systematic Review.

Z Orthop Unfall 2021 Jul 14. Epub 2021 Jul 14.

Department of Plastic, Hand and Burns Surgery, RWTH Aachen University Hospital, Aachen, Germany.

Background: Nerve compression syndromes are referred to as chronic irritation or pressure palsies of peripheral nerves in areas of preformed anatomical constriction. Carpal tunnel syndrome is the most common nerve compression syndrome, followed by cubital tunnel syndrome. In addition, less frequent nerve compression syndromes of the upper extremities that affect the median, ulnar or radial nerves have been described. Read More

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Ultrasound-guided musculoskeletal interventional procedures around the elbow, hand and wrist excluding carpal tunnel procedures.

J Ultrason 2021 Jun 18;21(85):e169-e176. Epub 2021 Jun 18.

Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Italy.

Ultrasound is a fast, reliable and radiation-free method for the assessment of a wide range of pathological conditions, as well as for the guidance of percutaneous interventional procedures around the elbow, hand and wrist. Intraarticular and periarticular interventional procedures can be easily performed under continuous ultrasound monitoring to ensure correct needle positioning and medication delivery to a specific target. The most common ultrasound-guided procedures performed around the elbow, wrist, and hand are described in this review, excluding carpal tunnel procedures. Read More

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Efficacy of kinesio taping on hand functioning in patients with mild carpal tunnel syndrome. A double-blind randomized controlled trial.

J Hand Ther 2021 Apr 14. Epub 2021 Apr 14.

Rehabilitation Unit, "Mons. L. Novarese" Hospital, Moncrivello, Vercelli, Italy.

Study Design: Double-blind randomized controlled trial.

Introduction: Carpal tunnel syndrome (CTS) is a common mononeuropathy that causes pain and disability in the affected hand. Kinesio taping (KT) has been recently proposed as a promising conservative approach in CTS patients. Read More

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Pharmacopuncture Combined with Electroacupuncture on Carpal Tunnel Syndrome: A Retrospective Case Series Study.

J Pharmacopuncture 2021 Jun;24(2):76-83

Chuk-u Acupuncture & Moxibustion Korean Medicine Clinic, Jeonju, Republic of Korea.

While carpal tunnel syndrome (CTS) is the most common entrapment neuropathy affecting the wrist, resulting in substantial physical, psychological, and economic effects, there is no gold standard therapy for CTS. In this case series study, we aimed to report CTS patients treated with Pharmacopuncture (CSP) and electroacupuncture (EA) showing improvements in their symptoms, and the combinatorial effects of CSP and EA. We collected medical records of CTS outpatients who received CSP and EA at Chuk-u Acupuncture & Moxibustion Korean Medicine Clinic from August 2017 to September 2018. Read More

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Outcomes and Material Cost Comparison of Transosseous Versus Suture Anchor Fixation of the Achilles Tendon: A Retrospective Study.

J Foot Ankle Surg 2021 Jun 10. Epub 2021 Jun 10.

Senior Biostatistician, Beaumont Research Institute, Royal Oak, MI.

Insertional Achilles tendinopathy is a common pathology that may be resistant to conservative treatment requiring surgical intervention. Treatment often involves partial to complete detachment of the Achilles tendon, debridement, and reattachment. Although 50% of the tendon may be safely resected without significantly compromising strength, the addition of a lengthening procedure requires further reinforcement. Read More

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Pregnancy-related Hand and Wrist Problems.

Arch Bone Jt Surg 2021 May;9(3):345-349

Department of Orthopedics, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran.

Hand and wrist disorders are common during pregnancy. Most of these problems develop during the third trimester when hormonal changes, fluid retention, and weight gain are maximum. This review study aimed to discuss pregnancy-related hand and wrist problems, and provide an overview of their pathology, clinical presentations, clinical examinations, and treatment options. Read More

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Common elective orthopaedic procedures and their clinical effectiveness: umbrella review of level 1 evidence.

BMJ 2021 07 7;374:n1511. Epub 2021 Jul 7.

National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK.

Objective: To determine the clinical effectiveness of common elective orthopaedic procedures compared with no treatment, placebo, or non-operative care and assess the impact on clinical guidelines.

Design: Umbrella review of meta-analyses of randomised controlled trials or other study designs in the absence of meta-analyses of randomised controlled trials.

Data Sources: Ten of the most common elective orthopaedic procedures-arthroscopic anterior cruciate ligament reconstruction, arthroscopic meniscal repair of the knee, arthroscopic partial meniscectomy of the knee, arthroscopic rotator cuff repair, arthroscopic subacromial decompression, carpal tunnel decompression, lumbar spine decompression, lumbar spine fusion, total hip replacement, and total knee replacement-were studied. Read More

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Dysregulation of epigenetic related genes in Diabetic Trigger finger Patients; preliminary analysis of Patient-Derived Samples.

Biomol Concepts 2020 Dec 31;11(1):221-229. Epub 2020 Dec 31.

Division of Endocrinology, Diabetes, and Metabolism, Augusta University, Augusta, GA 30904Georgia.

Background: Trigger finger (TF), a painful condition involving a finger flexor tendon, is a common problem with a prevalence of ~2-3% in the general population. However, the TF prevalence is higher among diabetic patients-ranges from 6.7% to 10%. Read More

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December 2020

Health-Related Exposures and Conditions among US Fishermen.

J Agromedicine 2021 Jul 6:1-8. Epub 2021 Jul 6.

Program in Environmental and Occupational Health, Oregon State University College of Public Health and Human Sciences, Corvallis, Oregon, USA.

Commercial fishing is a high-risk occupation, yet there is a lack of surveillance documenting health conditions, health behaviors, and health care coverage among US fishermen. We used publicly available data sources to identify exposures and health outcomes common among fishermen. We utilized the National Institute for Occupational Safety and Health-Worker Health Charts to estimate the prevalence of general exposures, psychosocial exposures, health behaviors, and health conditions from the national surveys National Health Interview Survey - Occupational Health Supplement (NHIS-OHS, 2015) and Behavioral Risk Factor Surveillance System (BRFSS) (2013-2015). Read More

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A safe and easy-to-use ultrasound-guided hydrodissection technique for the carpal tunnel syndrome: a minimally invasive approach.

J Ultrasound 2021 Jul 2. Epub 2021 Jul 2.

Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

Carpal tunnel syndrome (CTS), compression of the median nerve lying deep under the flexor retinaculum, is the most common entrapment neuropathy of the upper limb. After a failure of conservative treatments, such as non-steroidal anti-inflammatory drugs (NSAIDs) and splinting, interventional techniques are required. Hydrodissection is an injection technique that separates the nerve from the surrounding tissue. Read More

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The effects of pistol grip power tools on median nerve pressure and tendon strains.

Int J Occup Saf Ergon 2021 Jul 30:1-7. Epub 2021 Jul 30.

Mechanical and Mechatronics Engineering, University of Waterloo, Canada.

Tendonitis and carpal tunnel syndrome are common cumulative trauma disorders that can occur with repetitive usage of pistol grip power tools. The role of reaction torque resulting in a forceful rotary displacement of the tool handle, as well as the role of applied grip force, is not clear in the development of these disorders. This study aimed to quantify the flexor tendon strains and median nerve pressure during a typical power tool operation securing a threaded fastener. Read More

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Boosting the lithium storage performance of tin dioxide by carbon nanotubes supporting and surface engineering.

J Colloid Interface Sci 2021 Jun 16;602:789-798. Epub 2021 Jun 16.

School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University,Shanghai 200240, PR China. Electronic address:

In order to reduce the negative impact of the extra carbon coating on the electrochemical properties of the commonly sandwiched carbon [email protected] [email protected] ([email protected]@C) composites, the external C coating has been designed as a porous carbon in this work. The well-designed porous carbon coating offers an attractive advantage compared to the common carbon coatings, namely, it can not only better mitigate the volumetric variation of SnO by means of its spongy structure with better flexibility and rich free space, but also accelerate the lithium-ions diffusion by virtue of its open tunnel-like architecture. For this reason, this composite prepared here shows outstanding electrochemical performance stemming from the cooperative effect of inner CNT supporting and externally porous carbon coating, displaying 819. Read More

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Development of A 3D-Printed Navigational Template for Establishing Rabbit VX2 Lung Cancer Model.

J Surg Res 2021 Jun 28;267:358-365. Epub 2021 Jun 28.

Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, Shanghai, P.R. China.

Background: The CT-guided percutaneous puncture-inoculation for establishing the rabbit VX2 lung cancer model (LCM) is time-consuming, requires repeated CT scans, and has a high complication rate. Therefore, this study aimed to develop a navigational template using 3D technology to provide an alternative method for establishing the model with improved success and complication rates.

Materials And Methods: Ideal pressure was determined using chest CT data from 15 anesthetized rabbits fitted with sphygmomanometer cuff around their chests. Read More

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