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Prognosis of lung cancer associated with cystic airspaces: A propensity score matching analysis.

Lung Cancer 2021 Jul 17;159:111-116. Epub 2021 Jul 17.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China. Electronic address:

Objective: The association between the morphological characteristics and survival outcome of lung cancer associated with cystic airspaces (LCCAs) is unclear due to rarity of this disease. The current study attempted to compare the survival outcome between LCCAs and non-LCCAs and investigate the correlation between imaging features and prognosis of LCCA.

Method: Of 10,835 patients diagnosed with non-small cell lung carcinoma (NSCLC) between January 2015 and December 2016, 123 patients with LCCA were included. Read More

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Neonatal streptozotocin treatment rapidly causes different subtype of hepatocellular carcinoma without persistent hyperglycemia in 4CS mice fed on a normal diet.

Pathol Res Pract 2021 Jul 21;225:153559. Epub 2021 Jul 21.

Department of Pathology and Laboratory Medicine and Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan; Molecular Pathology and Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. Electronic address:

Although diabetes mellitus (DM) is a well-known risk factor for hepatocellular carcinoma (HCC), the underlying mechanisms have not yet to be defined. We previously reported that DIAR mice fed with standard murine diet developed type 1 diabetes and HCC at age of 16 weeks old with a neonatal streptozotocin treatment (n-STZ). Because DIAR mice did not manifest obesity nor develop steatohepatitis, hyperglycemia with streptozotocin trigger or streptozotocin alone might turn on the hepato-carcinogenesis. Read More

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Reduction in healthcare services during the COVID-19 pandemic: Patient screening based on symptoms is an effective strategy for avoiding delayed laryngeal cancer diagnosis.

Am J Otolaryngol 2021 Jul 24;42(6):103162. Epub 2021 Jul 24.

Otolaryngology Unit, Azienda USL-IRCCS di Reggio Emilia, Italy.

Objective: Restriction in healthcare services during the COVID-19 pandemic caused delays in the diagnosis and treatment of several diseases. To overcome the risk of missed diagnosis of head and neck cancers, before deleting the scheduled appointments, we have introduced a selection of the patients by examining the clinical presenting issue and previous medical history. The aim of this study is to show the effects of the abovementioned strategy on the diagnosis and management of laryngeal cancer. Read More

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The safety and efficacy of cold vs. hot snare polypectomy including colorectal polyps ≥1 cm in size.

Dig Endosc 2021 Jul 29. Epub 2021 Jul 29.

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

Cold snare polypectomy (CSP; polypectomy without electrocautery) has rapidly spread worldwide during the past decade in what has been called a Cold Revolution. We performed a PubMed literature search for studies investigating CSP outcomes for colorectal polyps. Five randomized controlled trials (RCTs) assessed the complete resection rates (CRRs). Read More

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Diffuse bone marrow uptake related to granulocyte colony-stimulating factor-producing maxillary sinus carcinoma on 4-borono-2-F-fluoro-L-phenylalanine positron emission tomography/computed tomography.

World J Nucl Med 2021 Apr-Jun;20(2):188-191. Epub 2020 Oct 23.

Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Nangoku, Kochi, Japan.

Granulocyte colony-stimulating factor (G-CSF) can be produced by tumor cells and is known to promote tumor growth, thereby potentially accelerating disease progression. Squamous cell carcinoma (SCC) at maxillary sinus is aggressive growth with poor prognosis. Maxillary sinus carcinomas are rare and can be clinically silent in the early stages or manifest with the same signs and symptoms of more common illnesses, leading to their delayed diagnosis of disease. Read More

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October 2020

Influencing Factors and Prognostic Value of F-FDG PET/CT Metabolic and Volumetric Parameters in Non-Small Cell Lung Cancer.

Int J Gen Med 2021 21;14:3699-3706. Epub 2021 Jul 21.

Department of Nuclear Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310006, People's Republic of China.

Objective: This study aims to explore factors influencing metabolic and volumetric parameters of [F]fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) imaging in non-small cell lung cancer (NSCLC) and the predictive value for prognosis of NSCLC.

Methods: Retrospective analysis was performed on 133 NSCLC patients who received F-FDG PET/CT imaging. After F-FDG injection at 3. Read More

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Computed Tomography Morphological Classification of Lung Adenocarcinoma and Its Correlation with Epidermal Growth Factor Receptor Mutation Status: A Report of 1075 Cases.

Int J Gen Med 2021 21;14:3687-3698. Epub 2021 Jul 21.

Department of Radiology, University of Chinese Academy of Sciences Chongqing Renji Hospital (Fifth People's Hospital of Chongqing), Chongqing, 400062, People's Republic of China.

Background: Many delayed diagnoses of lung adenocarcinoma (LADC) are identified due to poor understanding of protean imaging findings. Moreover, clarifying the relationship between computed tomography (CT) morphological classification and epidermal growth factor receptor (EGFR) mutations of LADC might inform therapeutic decision-making while obtaining pathological specimens is difficult. Here, we retrospectively analyzed CT manifestations of LADC and investigated the morphological classification of tumors in relation to EGFR mutation status. Read More

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Superior Mesenteric Artery Injury during Radical Nephrectomy in an Infant: Delayed Diagnosis and Successful Management.

J Indian Assoc Pediatr Surg 2021 May-Jun;26(3):188-191. Epub 2021 May 17.

Consultant Pediatric Surgeon, Ankura Hospital, Hyderabad, Telangana, India.

Superior mesenteric artery (SMA) injury during a left radical nephrectomy is an uncommon complication in children with a potentially devastating outcome. Successful management depends on early diagnosis and re-establishing SMA perfusion. We report the successful management of an iatrogenic SMA injury during radical nephrectomy in a 10-month-old boy with left upper polar Wilms' tumor. Read More

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Delayed adjuvant imatinib in patients with high risk of recurrence of gastrointestinal stromal tumor after radical surgery: a retrospective cohort study.

J Cancer Res Clin Oncol 2021 Jul 28. Epub 2021 Jul 28.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37 Guo Xue Rd., Chengdu, 610041, Sichuan Province, China.

Purpose: To investigate the impact of delayed adjuvant imatinib on GIST patients with high risk of recurrence.

Method: Adult GIST patients were retrospectively collected from our hospital between 2011 and 2018, and patients having high risk of recurrence were included for subsequent analyses. The primary endpoint was recurrence-free survival (RFS). Read More

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Association of human breast cancer CD44/CD24 cells with delayed distant metastasis.

Elife 2021 Jul 28;10. Epub 2021 Jul 28.

Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.

Tumor metastasis remains the main cause of breast cancer-related deaths, especially delayed breast cancer distant metastasis. The current study assessed the frequency of CD44/CD24 breast cancer cells in 576 tissue specimens for associations with clinicopathological features and metastasis and investigated the underlying molecular mechanisms. The results indicated that higher frequency (≥19. Read More

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Clinically decisive (dis)agreement in multidisciplinary team assessment of esophageal squamous cell carcinoma; a prospective, national, multicenter study.

Acta Oncol 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Surgical Gastroenterology, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.

Background: Decisions regarding tumor staging, operability, resectability, and treatment strategy in patients with esophageal cancer are made at multidisciplinary team (MDT) conferences. We aimed to assess interobserver agreement from four national MDT conferences and whether this would have a clinical impact.

Methods: A total of 20 patients with esophageal cancer were included across all four upper gastrointestinal (GI) cancer centers. Read More

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Oligometastatic prostate cancer treatment.

Future Oncol 2021 Jul 23. Epub 2021 Jul 23.

Department of Urology & Gynecology, Istituto Nazionale Tumori IRCCS Fondazione G Pascale Napoli, 80131, Italy.

Oligometastatic prostate cancer is an intermediate state between localized disease and widespread metastasis. Its biological and clinical peculiarities are still to be elucidated. New imaging techniques contribute to the detection of patients with oligometastatic disease. Read More

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Fabrication of a multi-level drug release platform with liposomes, chitooligosaccharides, phospholipids and injectable chitosan hydrogel to enhance anti-tumor effectiveness.

Carbohydr Polym 2021 Oct 10;269:118322. Epub 2021 Jun 10.

Department of Materials Science and Engineering, Institute of Biomedical Engineering, The First Affiliated Hospital, Jinan University, Guangzhou 510632, PR China.

Some anti-cancer drugs have poor solubility and availability, and are easily eliminated by rapid metabolism in vivo. To fix the drugs at the administration site and delay their release, a release platform with multi-level and multi-function was designed. The results showed that the curcumin (Cur) loaded liposomes ([email protected]) were coated sequentially with positive Chitooligosaccharides ([email protected]) and negative phospholipids ([email protected]), to enhance water solubility, encapsulation efficiency, and delayed the release of the Cur, stability and cell intake of the liposomes, and the bioactivity of the system. Read More

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October 2021

Retroperitoneum ganglioneuroma: imaging features and surgical outcomes of 35 cases at a Chinese Institution.

BMC Med Imaging 2021 Jul 22;21(1):114. Epub 2021 Jul 22.

Department of Radiology, Changhai Hospital, The Navy Medical University (Second Military Medical University), 168 Changhai Road, Shanghai, China.

Background: The preoperative evaluation is crucial for diagnosis and surgical plan of retroperitoneum ganglioneuroma (GN). In this study, we reviewed a relatively large series of histopathological proved retroperitoneum GN cases, summarized the imaging features and further depicted risk factors of increased surgical blood loss.

Methods: A total of 35 (18 male, 17 female) patients were retrospectively enrolled from January 2012 to June 2019 at our institution. Read More

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Clinical utility of next-generation sequencing-based ctDNA testing for common and novel ALK fusions.

Lung Cancer 2021 Jul 17;159:66-73. Epub 2021 Jul 17.

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA; Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York NY, USA.

Objectives: Liquid biopsy for plasma circulating tumor DNA (ctDNA) next-generation sequencing (NGS) can detect ALK fusions, though data on clinical utility of this technology in the real world is limited.

Materials And Methods: Patients with lung cancer without known oncogenic drivers or who had acquired resistance to therapy (n = 736) underwent prospective plasma ctDNA NGS. A subset of this cohort (n = 497) also had tissue NGS. Read More

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Application of bacterial directed enzyme prodrug therapy as a targeted chemotherapy approach in a mouse model of breast cancer.

Int J Pharm 2021 Jul 23:120931. Epub 2021 Jul 23.

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran; Novel Diagnostics and Therapeutics Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address:

Cancer is the second leading cause of death in the world. Some of the usual cancer treatments include surgery, chemotherapy, and radiotherapy. However, due to low efficacy and side effects of these treatments, novel targeted therapeutic methods are needed. Read More

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Merkel cell carcinoma is still an unexpected diagnosis.

J Eur Acad Dermatol Venereol 2021 Jul 26. Epub 2021 Jul 26.

Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

To the editor: Merkel cell carcinoma (MCC) is a rare, but highly aggressive cutaneous neuroendocrine skin cancer that generally occurs in elderly Caucasian people, on sun-exposed areas (1). In Sweden, the incidence of MCC, adjusted to the European standard population, increased from 0.11 to 0. Read More

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Does nutrition support during chemotherapy increase long-term survival of cancer patients? Lessons from the past and future perspectives.

Support Care Cancer 2021 Jul 26. Epub 2021 Jul 26.

Faculty of Medicine, University of Milan, Via Festa del Perdono 11, 20100, Milan, Italy.

Purpose: The aim of this review was to analyze the potential effect of the nutritional support (oral supplementation/counseling, tube feeding, parenteral nutrition) combined with chemotherapy on long-term survival of cancer patients.

Methods: Using various electronic databases, we retrieved all English language papers on the combination nutritional support and chemotherapy and including data on long-term survival.

Results: 29 trials (4 non-RCT) were retrieved. Read More

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Current research progress in targeted anti-angiogenesis therapy for osteosarcoma.

Cell Prolif 2021 Jul 26:e13102. Epub 2021 Jul 26.

Division of Regenerative Biology, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.

Osteosarcoma (OS) is the most common primary malignant bone tumour with a peak in incidence during adolescence. Delayed patient presentation and diagnosis is common with approximately 15% of OS patients presenting with metastatic disease at initial diagnosis. With the introduction of neoadjuvant chemotherapy in the 1970s, disease prognosis improved from 17% to 60%-70% 5-year survival, but outcomes have not significantly improved since then. Read More

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De novo double-hit B-cell precursor leukemia/lymphoma - an unusual presentation as peritoneal lymphomatosis.

Autops Case Rep 2021 6;11:e2021278. Epub 2021 May 6.

Post Graduate Institute of Medical Education & Research, Departments of Histopathology, Chandigarh, India.

Peritoneal lymphomatosis (PL) is a rare presentation of extranodal precursor leukemia/lymphoma. The presentation is often non-specific, leading to delayed diagnosis and treatment. In this case, though the preliminary diagnosis was established on ascitic fluid cytology, the disease progressed rapidly, leading to demise before initiating chemotherapy. Read More

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Delaying Postoperative Radiotherapy in Low-Grade Esthesioneuroblastoma: Is It Worth the Wait?

J Neurol Surg B Skull Base 2021 Jul 25;82(Suppl 3):e166-e171. Epub 2020 Mar 25.

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States.

 Consensus in timing of radiotherapy is yet to be established in esthesioneuroblastoma (ENB).  This study was aimed to investigate if planned adjuvant radiotherapy improves tumor control after complete margin negative resection of low Hyams' grade (1 or 2) ENB.  A retrospective review of patients with pathologically confirmed negative margin resection of Kadish's stage B or C and Hyams' grade 1 and 2 ENBs was conducted. Read More

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Efficacy and prognosis of continuous renal replacement therapy at different times in the treatment of patients with sepsis-induced acute kidney injury.

Am J Transl Res 2021 15;13(6):7124-7131. Epub 2021 Jun 15.

Blood Purification Center, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University) Haikou, Hainan Province, China.

Objective: To investigate the efficacy and prognosis of CRRT at different times in the treatment of sepsis-induced acute kidney injury (SAKI).

Methods: A total of 156 patients with SAKI were grouped into two groups in accordance with a random number table, with 78 patients in each group. Patients in the observation group (OG) were treated with early CRRT, and in the control group (CG), patients were treated with delayed CRRT. Read More

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Non-invasive Biomarkers of Liver Inflammation and Cell Death in Response to Alcohol Detoxification.

Front Physiol 2021 7;12:678118. Epub 2021 Jul 7.

Center for Alcohol Research, University of Heidelberg, Heidelberg, Germany.

Introduction: Alcohol-related liver disease (ALD) represents the most common liver disease worldwide, however, the underlying molecular mechanisms are still poorly understood. Namely centrilobular inflammation and programmed cell death are characteristic to ALD and it remains to be elucidated why they persist despite the absence of alcohol.

Aims: To study the effects of alcohol withdrawal in a cohort of heavy drinkers and the role of cirrhosis by using non-invasive biomarkers such as cytokines, apoptotic and angiogenic markers. Read More

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American Brachytherapy Society (ABS) consensus statement for soft-tissue sarcoma brachytherapy.

Brachytherapy 2021 Jul 21. Epub 2021 Jul 21.

Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Purpose: Growing data supports the role of radiation therapy in the treatment of soft tissue sarcoma (STS). Brachytherapy has been used for decades in the management of STS and can be utilized as monotherapy or as a boost to external beam radiation. We present updated guidelines from the American Brachytherapy Society regarding the utilization of brachytherapy in the management of STS. Read More

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Undiagnosed Endoscopy Capsule Retention Causing Delayed Intestinal Obstruction in a Patient with a Small Bowel Neuroendocrine Tumor.

Am J Case Rep 2021 Jul 24;22:e932419. Epub 2021 Jul 24.

2nd Propaedeutic Department of Surgery, Aristotle University School of Medicine, Hippokration General Hospital, Thessaloniki, Greece.

BACKGROUND Capsule endoscopy has played a significant role in small bowel investigation, providing the opportunity of detecting neoplastic lesions to a greater degree and at an earlier stage than other diagnostic procedures. Failure to excrete the capsule with the feces within 48 h can lead to capsule retention with increased risk of further complications such as bowel obstruction and perforation. Capsule retention can remain undetected in case of incomplete follow-up and poor patient compliance. Read More

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Surveillance for low-risk kidney cancer: a narrative review of contemporary worldwide practices.

Transl Androl Urol 2021 Jun;10(6):2762-2786

Urology Department, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

The management trend of low-risk kidney cancer over the last decade has been from treatment with radical nephrectomy, to use of nephron sparing procedures of partial nephrectomy and ablation, as well as the option of active surveillance (AS). This narrative review aims to summarise the available guidelines related to AS and review the published descriptions of regional practices on the management of low-risk kidney cancer worldwide. A search of PubMed, Google Scholar and Cochrane Library databases for studies published 2010 to June 2020 identified 15 studies, performed between 2000 and 2019, which investigated 13 different cohorts of low-risk kidney cancer patients on AS. Read More

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Risk factors of postoperative ileus following laparoscopic radical cystectomy and developing a points-based risk assessment scale.

Transl Androl Urol 2021 Jun;10(6):2397-2409

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, Beijing, China.

Background: Postoperative ileus (POI) is one of the most common complications after laparoscopic radical cystectomy (LRC). Albeit its high incidence, its risk factors are obscure, and few studies have attempted to explore them. Meanwhile, risk-assessing tools for predicting its happening are lacking. Read More

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Collagen XVII inhibits breast cancer cell proliferation and growth through deactivation of the AKT/mTOR signaling pathway.

PLoS One 2021 22;16(7):e0255179. Epub 2021 Jul 22.

Faculty of Pharmaceutical Sciences, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand.

Collagen XVII (COL17), a cell-matrix adhesion protein, has been found to be suppressed in breast cancer. Our previous data demonstrated a preventive role of COL17 in breast cancer invasiveness. The present study used the stable COL17-overexpressing MCF7 and MDA-MB-231 cells to reveal an anti-proliferative effect of COL17 on breast cancer cell through mTOR deactivation. Read More

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Fertility-sparing approach for endometrial cancer: the role of office hysteroscopy.

Minim Invasive Ther Allied Technol 2021 Jul 22:1-8. Epub 2021 Jul 22.

Department of Obstetrics and Gynecology, University of California Davis Medical Center, Sacramento, CA, USA.

Endometrial cancer is the most common gynecologic malignancy in developed countries, with increasing incidence among younger, nulliparous patients. These epidemiological shifts are attributed to increasing rates of obesity, in combination with delayed childbearing. This highlights a need for fertility-sparing options for individuals who wish to delay standard surgical management with hysterectomy, bilateral salpingoophorectomy, and assessment of pelvic/para-aortic lymph nodes. Read More

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Pseudopapillary Tumor of the Pancreas: A Rare Cause of Extrahepatic Portal Hypertension.

Cureus 2021 Jun 17;13(6):e15707. Epub 2021 Jun 17.

Department of Gastroenterology, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, IND.

A solid pseudopapillary tumor (SPT) of the pancreas is an uncommon neoplasm, characterized by a well-encapsulated mass, with low malignant potential. It occurs predominantly in young females. We present a case of SPT of the pancreas which presented with sinistral portal hypertension. Read More

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