323,860 results match your criteria tumors lungs

LKB1 down-modulation by miR-17 identifies NSCLC patients with worse prognosis eligible for energy-stress based treatments.

J Thorac Oncol 2021 Apr 19. Epub 2021 Apr 19.

Tumor Genomics Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

Introduction: Preclinical models recently unveiled vulnerability of LKB1/KRAS co-mutated non-small cell lung cancer (NSCLC) to metabolic stress-based treatments. Since miR-17 is a potential epigenetic regulator of LKB1, we hypothesized that wild type LKB1 NSCLC with high miR-17 expression may be sensitive to energetic stress condition, and eligible for metabolic frailties-based therapeutic intervention.

Methods: We took advantage of NSCLC cell lines with different combinations of KRAS mutation and LKB1 deletion, and of patient-derived xenografts (PDXs) with high (L/miR17H) or low (L/miR17L) miR-17 expression. Read More

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DNA methylation profiling discriminates between malignant pleural mesothelioma and neoplastic or reactive histological mimics.

J Mol Diagn 2021 Apr 19. Epub 2021 Apr 19.

Department of Neuropathology, Institute of Pathology, University Hospital of Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.

Diagnosis of malignant pleural mesothelioma (MPM) is a challenging task because of its potential overlap with other neoplasms or even with reactive conditions. Recently, DNA methylation analysis proved to be an effective tool for tumor diagnosis. In the present study, this approach was tested for MPM diagnosis. Read More

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Nano-realgar suppresses lung cancer stem cell growth by repressing metabolic reprogramming.

Gene 2021 Apr 19:145666. Epub 2021 Apr 19.

Department of Oncology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People's Republic of China. Electronic address:

Background: Recent studies in cancer biology suggest that metabolic glucose reprogramming is a potential target for cancer treatment. However, little is known about drug intervention in the glucose metabolism of cancer stem cells (CSCs) and its related underlying mechanisms.

Methods: The crude realgar powder was Nano-grinded to meets the requirements of Nano-pharmaceutical preparations, and Nano-realgar solution (NRS) was prepared for subsequent experiments. Read More

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Targeted RNA-sequencing for the evaluation of gene fusions in lung tumours: current status and future prospects.

Expert Rev Mol Diagn 2021 Apr 22. Epub 2021 Apr 22.

Institute for Pathology and Center for Integrated Oncology (CIO), University Hospital Cologne.

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Evaluation of the diagnostic accuracy of bronchial brushing cytology in lung cancer: A meta-analysis.

Cancer Cytopathol 2021 Apr 22. Epub 2021 Apr 22.

Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

Background: Flexible bronchoscopy is commonly used to examine patients suspected to have lung cancer. Bronchial brushing is one of the cytological technologies for lung specimens obtained through a bronchoscope. However, the accuracy of bronchial brushing cytology (BBC) for lung cancer diagnosis is still inconclusive. Read More

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Perillyl alcohol for pediatric TP53- and RAS-mutated SHH-medulloblastoma: an in vitro and in vivo translational pre-clinical study.

Childs Nerv Syst 2021 Apr 22. Epub 2021 Apr 22.

Laboratory of Cell Biology and Oncogenetics, Department of Biology, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, Bairro Monte Alegre, Ribeirão Preto, São Paulo, CEP 14040-900, Brazil.

Purpose: Inhalation of perillyl alcohol (POH) recently emerged as an investigational promising antiglioma strategy. However, little attention has been paid to its therapeutic potential for other brain tumors, especially in the pediatric setting.

Methods: The effects of POH were explored in medulloblastoma cell models belonging to the SHH variant with activation of RAS (ONS-76) or with TP53 mutations (DAOY and UW402), by means of proliferation and invasion assays. Read More

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Cisplatin resistance reversal in lung cancer by tumor acidity-activable vesicular nanoreactors via tumor oxidative stress amplification.

J Mater Chem B 2021 Apr 22;9(13):3055-3067. Epub 2021 Mar 22.

CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui, China.

Drug resistance of cisplatin significantly limits its therapeutic efficacy in clinical applications against different cancers. Herein, we develop a novel strategy to overcome cisplatin drug resistance through sensitizing cisplatin-resistant human lung cancer cells (A549R) under amplified oxidative stress using a vesicular nanoreactor for simultaneous cisplatin delivery and HO generation. We engineer the nanoreactor by the self-assembly of the amphiphilic diblock copolymers to co-deliver glucose oxidase (GOD) and cisplatin (Cis) (Cis/GOD@Bz-V). Read More

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Icebreaker-inspired Janus nanomotors to combat barriers in the delivery of chemotherapeutic agents.

Nanoscale 2021 Apr 25;13(13):6545-6557. Epub 2021 Mar 25.

School of Life Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, P.R. China.

Cancer chemotherapy remains challenging to pass through various biological and pathological barriers such as blood circulation, tumor infiltration and cellular uptake before the intracellular release of antineoplastic agents. Herein, icebreaker-inspired Janus nanomotors (JMs) are developed to address these transportation barriers. Janus nanorods (JRs) are constructed via seed-defined growth of mesoporous silica nanoparticles on doxorubicin (DOX)-loaded hydroxyapatite (HAp) nanorods. Read More

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Artificial intelligence in musculoskeletal oncological radiology.

Radiol Oncol 2020 Nov 10;55(1):1-6. Epub 2020 Nov 10.

Department of Orthopaedic Surgery, University Medical CenterMaribor, Slovenia.

Background: Due to the rarity of primary bone tumors, precise radiologic diagnosis often requires an experienced musculoskeletal radiologist. In order to make the diagnosis more precise and to prevent the overlooking of potentially dangerous conditions, artificial intelligence has been continuously incorporated into medical practice in recent decades. This paper reviews some of the most promising systems developed, including those for diagnosis of primary and secondary bone tumors, breast, lung and colon neoplasms. Read More

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November 2020

Effectiveness of radiologist training in improving reader agreement for Lung-RADS 4X categorization.

Eur Radiol 2021 Apr 21. Epub 2021 Apr 21.

National Cancer Center, Goyang, South Korea.

Objectives: To identify the agreement on Lung CT Screening Reporting and Data System 4X categorization between radiologists and an expert-adjudicated reference standard and to investigate whether training led to improvement of the agreement measures and diagnostic potential for lung cancer.

Methods: Category 4 nodules in the Korean Lung Cancer Screening Project were identified retrospectively, and each 4X nodule was matched with one 4A or 4B nodule. An expert panel re-evaluated the categories and determined the reference standard. Read More

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Organ-restricted vascular delivery of nanoparticles for lung cancer therapy.

Adv Ther (Weinh) 2020 Jul 13;3(7). Epub 2020 May 13.

Comprehensive Pneumology Center (CPC), University Hospital Ludwig-Maximilians University, and Helmholtz Zentrum München, Munich, Germany. Member of the German Center for Lung Research (DZL), 81377 Munich, Germany.

Nanoparticle-based targeted drug delivery holds promise for treatment of cancers. However, most approaches fail to be translated into clinical success due to ineffective tumor targeting in vivo. Here, the delivery potential of mesoporous silica nanoparticles (MSN) functionalized with targeting ligands for EGFR and CCR2 is explored in lung tumors. Read More

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Interlobar Pulmonary Hamartoma With an Unusual Neighboring Lesion: A Case Report.

Cureus 2021 Mar 20;13(3):e14008. Epub 2021 Mar 20.

Internal Medicine, Salmaniya Medical Complex, Manama, BHR.

Pulmonary hamartomas are benign lung tumors. They are uncommon and represent a small percentage of all solitary lung lesions. Hamartomas are composed of an abnormal mixture of epithelial and mesenchymal elements. Read More

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Prostate-Specific Membrane Antigen Expression in Patients With Differentiated Thyroid Cancer With Thyroglobulin Elevation and Negative Iodine Scintigraphy Using 68Ga-PSMA-HBED-CC PET/CT.

Clin Nucl Med 2021 Apr 21. Epub 2021 Apr 21.

From the Radiation Medicine Centre, Bhabha Atomic Research Centre Department of Endocrinology, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Purpose Of The Report: Prostate-specific membrane antigen (PSMA) is a member of superfamily of zinc-dependent exopeptidases that is robustly expressed in prostate cancer cells and nonprostatic solid tumor neovasculature including microvessels of thyroid tumors. Its expression in differentiated thyroid cancer (DTC) has been confirmed in many recent studies, but systematic studies exploring PSMA expression in patients with DTC with thyroglobulin elevation and negative iodine scintigraphy (TENIS) are lacking. The aim of the present study was to evaluate the role of PSMA scan in TENIS patients with DTC. Read More

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Phase I/Ib clinical trial of Sabatolimab, an Anti-TIM-3 Antibody, Alone and in Combination With Spartalizumab, an Anti-PD-1 Antibody, in Advanced Solid Tumors.

Clin Cancer Res 2021 Apr 21. Epub 2021 Apr 21.

Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center.

Purpose: Sabatolimab (MBG453) and spartalizumab are monoclonal antibodies that bind T-cell immunoglobulin domain and mucin domain-3 (TIM-3) and programed death-1 (PD-1), respectively. This phase I/II study evaluated the safety and efficacy of sabatolimab, with or without spartalizumab, in patients with advanced solid tumors.

Experimental Design: Primary objectives of the phase I/Ib part were to characterize the safety and estimate recommended doses for future studies (RP2Ds). Read More

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DNA methylation of tumor associated calcium signal transducer 2 (TACSTD2) loci shows association with clinically aggressive renal cell cancers.

BMC Cancer 2021 Apr 21;21(1):444. Epub 2021 Apr 21.

Department of Urology and Urologic Oncology, Hannover Medical School, 30625, Hannover, Germany.

Background: DNA methylation is frequently observed in the development and progression of many human tumors as well as renal cell cancer (RCC). Tumor Associated Calcium Signal Transducer 2 (TACSTD2) participates in cell cycle progression through MAPK signalling pathway activation. Moreover, tumor-specific hypermethylation and association with aggressive cancer characteristics has been found for lung adenocarcinoma, hepatocellular carcinoma and cholangiocarcinoma. Read More

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Survival prediction for non-small cell lung cancer patients treated with CT-guided microwave ablation: development of a prognostic nomogram.

Int J Hyperthermia 2021 ;38(1):640-649

Department of Minimally Invasive Tumor Therapies Center, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Objectives: To explore the outcomes of CT-guided percutaneous microwave ablation (MWA) in non-small cell lung cancer (NSCLC) patients, and then develop an effective nomogram to predict the survival.

Methods: NSCLC patients treated with MWA were randomly allocated to either the training cohort or the validation cohort (3:1). The primary outcome measurement was overall survival (OS), whose predictors were identified by univariate and multivariate analyses in the training cohort. Read More

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January 2021

Secretory carcinoma of the skin with lymph node metastases and recurrence in the both lungs: a case report.

J Cutan Pathol 2021 Apr 21. Epub 2021 Apr 21.

Department of Pathology, Okayama University Hospital, Okayama, Japan.

Secretory carcinoma of the skin is an extremely rare adnexal tumor, histopathologically identical to homologous lesions in the salivary glands and breast tissue. Although this tumor was previously reported as indolent, we report a case of secretory carcinoma of the skin with metastases and recurrence. The patient, 31-year-old women, had a subcutaneous mass in the right axilla. Read More

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Rare pulmonary tumors and carcinoma mimickers; experience from an interventional radiology unit with radiologic-pathologic correlation-A pictoral essay.

Curr Med Imaging 2021 Apr 19. Epub 2021 Apr 19.

Hacettepe University, School of Medicine, Department of Radiology Ankara, Turkey.

Background: Although imaging findings along with patients' clinical history may give clue for the etiology of a pulmonary lesion, the differentiation of benign pulmonary lesions from lung cancer could be challenging.

Objective: The aim of this review article was to increase the awareness of the carcinoma mimicking lung lesions.

Methods: This paper was designed to illustrate rare pulmonary tumors and carcinoma mimickers with emphasis on radiologic-pathologic correlation. Read More

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Ultrasound-guided transthoracic needle biopsy of the lung: sensitivity and safety variables.

Eur Radiol 2021 Apr 21. Epub 2021 Apr 21.

Québec Heart and Lung Institute Research Center, Université Laval, Québec City, Québec, Canada.

Objectives: Variables affecting the performance of ultrasound-guided transthoracic needle biopsy (US-TTNB) are not well established. We examined clinical and imaging variables affecting the sensitivity and the complication rates of US-TTNB.

Methods: We retrospectively reviewed a consecutive series of 528 US-TTNBs performed from 2008 to 2017. Read More

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High-risk-pattern lung adenocarcinoma with epidermal growth factor receptor mutation is associated with distant metastasis risk and may benefit from adjuvant targeted therapy.

Interact Cardiovasc Thorac Surg 2021 Apr 21. Epub 2021 Apr 21.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery II, Peking University Cancer Hospital & Institute, Beijing, China.

Objectives: This study aimed to evaluate the value of the high-risk-pattern histology (micropapillary and solid components) for predicting distant metastasis in lung adenocarcinoma and to determine the survival benefit with adjuvant targeted therapy for resected non-small cell lung cancer with high-risk-pattern histology.

Methods: Patients receiving surgery for non-small cell lung cancer were included in this retrospective study. Histological classification was performed according to 2015 World Health Organization classification. Read More

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Stereotactic Ablative Radiotherapy for Central and Ultra-Central Lung Tumors.

Ther Radiol Oncol 2019 May 24;3. Epub 2019 May 24.

Department of Radiation Oncology and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Stereotactic ablative radiotherapy (SABR) has emerged as a standard-of-care treatment for patients with early stage non-small cell lung cancer (NSCLC) who are poor surgical candidates. Current evidence supports the consensus that lung SABR with BED ≥100 Gy leads to high local tumor control, and that the treatment is generally well-tolerated when applied to peripheral lung tumors. However, several studies present conflicting evidence for the treatment of central and ultra-central lung tumors, with some showing superb outcomes and others showing concerning rates of morbidity and mortality. Read More

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[One-stage surgery in patients with both cardiac and non-cardiac diseases].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Mar;53(2):327-331

Department of Gynecology, Peking University First Hospital, Beijing 100034, China.

Objective: To investigate the possibility and feasibility of one-stage cardiac and non-cardiac surgery.

Methods: From July 1999 to August 2018, one hundred and eleven patients suffering from cardiac and non-cardiac diseases were treated by one-stage cardiac and non-cardiac operation in Department of Cardiac Surgery and Thoracic Surgery, General Surgery, Urinary Surgery, and Gynecology, Peking University First Hospital. There were 83 males (74. Read More

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[Semiquantitative parameters of F-FDG PET/CT, gene mutation states of epidermal growth factor receptor and anaplastic lymphoma kinase in prognosis evaluation of patients with lung adenocarcinoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Oct;53(2):246-254

Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China.

Objective: To explore the valuable predictors for evaluating progression-free survival (PFS) in patients with lung adenocarcinoma, we analyzed the potential roles of standardized uptake value (SUV)-derived parameters from F-FDG PET/CT, combining with the gene mutation states of epidermal growth factor receptor () and anaplastic lymphoma kinase (), and other clinical characteristics.

Methods: Data of 84 lung adenocarcinoma patients pre-treated, who underwent F-FDG PET/CT scans, gene mutations test, rearrangement assay and other relative tests, were retrospectively collected. Then a series of clinical parameters including / mutation status and SUV-derived features [maximum standardized uptake value (SUVmax), average of standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)] were evaluated. Read More

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October 2020

Anemia may increase the overall risk of cancer: Findings from a cohort study with a 12-year follow-up period in South Korea.

Cancer Epidemiol Biomarkers Prev 2021 Apr 20. Epub 2021 Apr 20.

Anesthesiology and Pain medicine, Seoul National University Bundang Hospital

Background: No previous study has assessed cancer risk in individuals with anemia diagnosed based on hemoglobin levels. Thus, we aimed to investigate whether anemia increases the risk of cancer.

Methods: Adult individuals who underwent a standardized medical examination during 2002-2003 in South Korea were included, and their cancer status was evaluated between January 2004 and December 2015 (12 years) as a primary endpoint. Read More

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The Value of F-FDG PET/CT in Predicting the Response to PD-1 Blocking Immunotherapy in Advanced NSCLC Patients with High-Level PD-L1 Expression.

Clin Lung Cancer 2021 Mar 20. Epub 2021 Mar 20.

Department of Medical Oncology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

Background: The objective of this study was to evaluate if F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT)-derived parameters are useful in predicting response and survival after programmed cell death protein 1 (PD-1) blocking immunotherapy in patients with advanced NSCLC characterized by a high programmed death-ligand 1 (PD-L1) expression (≥50%) on immunohistochemistry.

Patients And Methods: In 30 patients with advanced stage IV non-small-cell lung cancer (NSCLC) and high PD-L1 expression, F-FDG PET/CT parameters before start of treatment with PD-1 blocking immunotherapy were evaluated retrospectively. In 24 out of the 30 patients, F-FDG PET/CT was available 8 to 9 weeks after start of the treatment. Read More

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Analysis of risk factors for immune-related adverse events in various solid tumors using real-world data.

Future Oncol 2021 Apr 21. Epub 2021 Apr 21.

Department of Internal Medicine, Division of Gastroenterology & Hepatology, Keio University School of Medicine, Tokyo, 1608582, Japan.

The aim of this study was to determine the risk factors for immune-related adverse events (irAEs) induced by immune checkpoint inhibitors. The authors conducted a retrospective study in which patients with malignant melanoma, non-small-cell lung cancer, gastric cancer or renal cell carcinoma who received anti-PD-1/PD-L1 antibodies were included. Of 247 patients, 118 developed a total of 182 irAEs. Read More

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[Prognosis and complications of local excision for rectal cancer after neoadjuvant chemoradiotherapy].

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Apr;24(4):344-351

Department of General Surgery, Peking Union Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

To investigate the prognosis and postoperative complications of local excision for rectal cancer after neoadjuvant chemoradiotherapy (nCRT). A descriptive case series study was carried out. Patient inclusion criteria: (1) patients who underwent local excision by transanal endoscopic microsurgery (TEM) after nCRT; (2) magnetic resonance evaluated tumor regression grade (mrTRG) as 1, 2 after nCRT;(3) American Society of Anesthesiologists class I to III. Read More

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Shape switching of CaCO-templated nanorods into stiffness-adjustable nanocapsules to promote efficient drug delivery.

Acta Biomater 2021 Apr 17. Epub 2021 Apr 17.

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P.R. China. Electronic address:

Geometry and mechanical property have emerged as important parameters in designing nanocarriers, in addition to their size, surface charge, and hydrophilicity. However, inconsistent and even contradictory demands regarding the shape and stiffness of nanoparticles have been noted in blood circulation, tumor accumulation, and tumor cell internalization. Herein, CaCO nanorods (NRs) with an aspect ratio of around 2. Read More

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Improving feature selection performance for classification of gene expression data using Harris Hawks optimizer with variable neighborhood learning.

Brief Bioinform 2021 Apr 20. Epub 2021 Apr 20.

Department of Pathology and Pathophysiology, Hunan Normal University School of Medicine, Hunan Normal University, China.

Gene expression profiling has played a significant role in the identification and classification of tumor molecules. In gene expression data, only a few feature genes are closely related to tumors. It is a challenging task to select highly discriminative feature genes, and existing methods fail to deal with this problem efficiently. Read More

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