J Pharm Sci 2021 Apr 15. Epub 2021 Apr 15.
College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China; Guangdong Key Lab of Traditional Chinese Medicine Information Technology, College of Pharmacy, Jinan University, Guangzhou 510632, China; Cancer Research Institute of Jinan University, Guangzhou 510632, China. Electronic address:
This study aimed to evaluate the therapeutic efficacy of Emodin-loaded polymer lipid hybrid nanoparticles (E-PLNs) for breast cancer. The size, Zeta potential, surface morphology, encapsulation efficiency, stability, in vitro drug release of E-PLNs prepared by the nanoprecipitation method were characterized. The uptake, in-vitro cytotoxicities and apoptosis of free drug, E-PLNs were investigated against MCF-7 cells. Read More