3,891 results match your criteria tumor-bearing nude

Using Liposomes to Alleviate the Toxicity of Chelerythrine, a Natural PKC Inhibitor, in Treating Non-Small Cell Lung Cancer.

Front Oncol 2021 27;11:658543. Epub 2021 May 27.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Aim Of The Study: CHE can inhibit the proliferation of lung cancer cells and induce apoptosis. However, despite having toxicity, CHE has not been thoroughly investigated in term of its antitumor effect. The present study evaluated the antitumor effect of CHE on non-small cell lung cancer cell line HCC827. Read More

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Liposome-Coated Arsenic-Manganese Complex for Magnetic Resonance Imaging-Guided Synergistic Therapy Against Carcinoma.

Int J Nanomedicine 2021 1;16:3775-3788. Epub 2021 Jun 1.

Department of Radiology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian Province, 361023, People's Republic of China.

Purpose: A liposome-coated arsenic-manganese complex, denoted as [email protected] was constructed for the targeted delivery of arsenic trioxide (ATO) against carcinoma.

Methods: Arsenite, the prodrug of ATO, was encapsulated within a liposome via electrostatic interaction with the manganese ions. The as-prepared material was characterized with dynamic light scattering and transmission electron microscopy. Read More

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Silencing of cystatin SN (CST1) abrogates cancer progression and stem cell properties in papillary thyroid carcinoma (PTC).

FEBS Open Bio 2021 Jun 8. Epub 2021 Jun 8.

Department of Ultrasound, First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Liyushan South Road No.137, Urumqi, 830054, People's Republic of China.

Papillary thyroid carcinoma (PTC) accounts for approximately 80% of total thyroid cancer worldwide. Although the prognosis for early-stage PTC is favorable, the 5-year survival rate of patients with late-stage PTC is still very poor. Cystatin SN (cystatin 1, CST1) facilitates the progression of multiple cancers, but its role in regulating papillary thyroid carcinoma (PTC) pathogenesis is still largely unknown. Read More

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TRPM2 promotes pancreatic cancer by PKC/MAPK pathway.

Cell Death Dis 2021 Jun 7;12(6):585. Epub 2021 Jun 7.

General Surgery Department, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.

The mechanism of pancreatic cancer (PA) is not fully understanded. In our last report, TRPM2 plays a promising role in pancreatic cancer. However, the mechanism of TRPM2 is still unknown in this dismal disease. Read More

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P-selectin glycoprotein ligand 1 promotes T cell lymphoma development and dissemination.

Transl Oncol 2021 Jun 2;14(8):101125. Epub 2021 Jun 2.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal; Centre for Biomedical Research (CBMR), University of Algarve, Faro, Portugal. Electronic address:

P-selectin glycoprotein ligand-1 (PSGL-1) is a membrane-bound glycoprotein expressed in lymphoid and myeloid cells. It is a ligand of P-, E- and L-selectin and is involved in T cell trafficking and homing to lymphoid tissues, among other functions. PSGL-1 expression has been implicated in different lymphoid malignancies, so here we aimed to evaluate the involvement of PSGL-1 in T cell lymphomagenesis and dissemination. Read More

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Design and Evaluation of Ra-Labeled and Anti-PSMA Targeted NaA Nanozeolites for Prostate Cancer Therapy-Part II. Toxicity, Pharmacokinetics and Biodistribution.

Int J Mol Sci 2021 May 27;22(11). Epub 2021 May 27.

Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.

Metastatic castration-resistant prostate cancer (mCRPC) is a progressive and incurable disease with poor prognosis for patients. Despite introduction of novel therapies, the mortality rate remains high. An attractive alternative for extension of the life of mCRPC patients is PSMA-based targeted radioimmunotherapy. Read More

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Restricting Glutamine Uptake Enhances NSCLC Sensitivity to Third-Generation EGFR-TKI Almonertinib.

Front Pharmacol 2021 14;12:671328. Epub 2021 May 14.

Faculty of Pharmacy, Bengbu Medical College, Bengbu, China.

The emergence of secondary resistance is the main failure cause of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) as a targeted therapy for non-small cell lung cancer (NSCLC). EGFR mutations of NSCLC cells can markedly increase glutamine transporter (SLC1A5) expression, thereby increasing glutamine metabolism. Glutamine metabolites can activate EGFR downstream signals, including mTOR, ERK1/2, STAT3, etc. Read More

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Build an implanted "arsenal": detachable microneedles for NIR-triggered cancer photothermo-chemotherapy.

Biomater Sci 2021 May 25. Epub 2021 May 25.

MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, 310027, P. R. China.

The current trend in tumor research is shifting from monotherapy to multimodal therapy. However, how to achieve on-demand drug delivery and minimize the invasiveness of treatment are still big challenges. Herein, we present a detachable microneedles (MNs) system, which consists of polycaprolactone (PCL) needles and polyvinylpyrrolidone/poly (vinyl alcohol) substrate, to build an implanted drug depot for on-demand photothermo-chemotherapy. Read More

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Cancer blues? A promising judgment bias task indicates pessimism in nude mice with tumors.

Physiol Behav 2021 May 21;238:113465. Epub 2021 May 21.

Department of Integrative Biology, University of Guelph, Guelph, Canada. Electronic address:

In humans, affective states can bias responses to ambiguous information: a phenomenon termed judgment bias (JB). Judgment biases have great potential for assessing affective states in animals, in both animal welfare and biomedical research. New animal JB tasks require construct validation, but for laboratory mice (Mus musculus), the most common research vertebrate, a valid JB task has proved elusive. Read More

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Dihydroartemisinin prompts amplification of photodynamic therapy-induced reactive oxygen species to exhaust Na/H exchanger 1-mediated glioma cells invasion and migration.

J Photochem Photobiol B 2021 Jun 17;219:112192. Epub 2021 Apr 17.

Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Electronic address:

Photodynamic therapy (PDT) is a promising glioma therapy; however, its efficacy is compromised due to the PDT-induced reactive oxygen species (ROS) production being limited by the local hypoxic tumor microenvironment. Furthermore, Hypoxia activates sodium/hydrogen exchanger 1 (NHE1), an essential component for tumor progression and metastasis, enables glioma cells (GC) to escape PDT-mediated phototoxicity via increased H extrusion. However, interactions between NHE1 expression with ROS level involving response of GC remain unclear. Read More

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Exotoxin A-Based Immunotherapy Targeting CCK2R-Expressing Colorectal Malignancies: An In Vitro and In Vivo Evaluation.

Mol Pharm 2021 Jun 17;18(6):2285-2297. Epub 2021 May 17.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis/College of Veterinary Medicine/Double-First Class Discipline of Human-Animal Medicine, China-Japan Union Hospital, Jilin University, Changchun 130062, China.

Cholecystokinin-2 receptor (CCK2R) has been proven to be a specific biomarker for colorectal malignancies. Immunotoxins are a valuable class of immunotherapy agents consisting of a targeting element and a bacterial or plant toxin. Previous work demonstrated that targeting CCK2R is a good therapeutic strategy for the treatment of colorectal cancer (CRC). Read More

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Monitoring Treatment Efficacy of Antiangiogenic Therapy Combined With Hypoxia-Activated Prodrugs Online Using Functional MRI.

Front Oncol 2021 30;11:672047. Epub 2021 Apr 30.

Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Objective: This study aimed to investigate the effectiveness of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) and blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) in monitoring tumor responses to antiangiogenic therapy combined with hypoxia-activated prodrugs (HAPs).

Materials And Methods: Establishing colon cancer xenograft model by subcutaneously injecting the HCT116 cell line into BALB/C nude mice. Twenty-four tumor-bearing mice were randomly divided into four groups and injected with bevacizumab combined with TH-302 (A), bevacizumab (B), TH-302 (C), or saline (D) on days 1, 4, 7, 10 and 13. Read More

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Relationship between long non-coding RNA PCAT-1 expression and gefitinib resistance in non-small-cell lung cancer cells.

Respir Res 2021 May 12;22(1):146. Epub 2021 May 12.

Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, No. 519 Kunzhou Road, Kunming, 650118, Yunnan, China.

Background: Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has been used as first-line treatment for advanced non-small-cell lung cancer (NSCLC). However, during treatment, cancer cells often develop resistance to gefitinib, the mechanisms of which are not fully understood. This study was designed to elucidate the expression and role of long non-coding RNA (lncRNA)-PCAT-1, a potential biomarker for drug resistance and a therapeutic target for NSCLC, in gefitinib resistance in NSCLC cells. Read More

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Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer.

Drug Deliv 2021 Dec;28(1):920-929

Department of General Surgery, The Second Hospital of Lanzhou University, Lanzhou, PR China.

Oxaliplatin resistance is one of the main causes of failed colorectal cancer treatment, followed by recurrence and metastasis. In this study, we found that colorectal cancer cells secrete a high level of hyaluronic acid (HA), which interacts with its receptor CD44v6 to mediate colorectal cancer resistance to chemotherapy. HA oligosaccharide (oHA) is a degradation product of HA. Read More

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December 2021

A plant-based medicinal food inhibits the growth of human gastric carcinoma by reversing epithelial-mesenchymal transition via the canonical Wnt/β-catenin signaling pathway.

BMC Complement Med Ther 2021 May 8;21(1):137. Epub 2021 May 8.

West China School of Public Health and West China fourth Hospital, Sichuan University, Chengdu, China.

Background: Natural products, especially those with high contents of phytochemicals, are promising alternative medicines owing to their antitumor properties and few side effects. In this study, the effects of a plant-based medicinal food (PBMF) composed of six medicinal and edible plants, namely, Coix seed, Lentinula edodes, Asparagus officinalis L., Houttuynia cordata, Dandelion, and Grifola frondosa, on gastric cancer and the underlying molecular mechanisms were investigated in vivo. Read More

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Ultrasound-Targeted Microbubble Destruction Enhances Inhibitory Effect of Apatinib on Angiogenesis in Triple Negative Breast Carcinoma Xenografts.

Anal Cell Pathol (Amst) 2021 17;2021:8837950. Epub 2021 Apr 17.

Department of Ultrasound, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

Ultrasound-targeted microbubble destruction (UTMD) has been proven as an effective technique to assist drugs to cross the vascular wall and cell membrane. This study was aimed at evaluating the synergistic antiangiogenic and growth-inhibiting effects of apatinib (APA) and UTMD on the triple negative breast cancer (TNBC). The TNBC xenograft model was established in nude mice ( = 40) which were then randomly divided into the APA plus UTMD (APA-U) group, UTMD group, APA group, and model control (M) group ( = 10 per group). Read More

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Simultaneous Visualization of Tb- and Lu-Labeled Somatostatin Analogues Using Dual-Isotope SPECT Imaging.

Pharmaceutics 2021 Apr 12;13(4). Epub 2021 Apr 12.

Center for Radiopharmaceutical Sciences, Paul Scherrer Institute, 5232 Villigen-PSI, Switzerland.

The decay of terbium-161 results in the emission of β¯-particles as well as conversion and Auger electrons, which makes terbium-161 interesting for therapeutic purposes. The aim of this study was to use dual-isotope SPECT imaging in order to demonstrate visually that terbium-161 and lutetium-177 are interchangeable without compromising the pharmacokinetic profile of the radiopharmaceutical. The Tb- and Lu-labeled somatostatin (SST) analogues DOTATOC (agonist) and DOTA-LM3 (antagonist) were tested in vitro to demonstrate equal properties regarding distribution coefficients and cell uptake into SST receptor-positive AR42J tumor cells. Read More

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Nrf2/HO-1 Axis Regulates the Angiogenesis of Gastric Cancer via Targeting VEGF.

Cancer Manag Res 2021 12;13:3155-3169. Epub 2021 Apr 12.

Department of Pathology, Ningxia Medical University, Yinchuan City, Ningxia Province, 750004, People's Republic of China.

Purpose: Gastric cancer (GC) is one of the most fatal digestive tumors worldwide. Abnormal activation or accumulation of the nuclear factor-erythroid 2-related factor 2/heme oxygenase 1 (Nrf2/HO-1) axis is a malignant event in numerous solid tumors. However, its involvement in angiogenesis of GC remains unknown. Read More

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Inhibits the Development of Cutaneous Squamous Cell Carcinoma By Downregulating in A431 Cells.

Cancer Biother Radiopharm 2021 Apr 20. Epub 2021 Apr 20.

Department of Cardiology, The Second Hospital of Shandong University, Jinan City, China.

Cutaneous squamous cell carcinoma (CSCC) is the most deadly disease among nonmelanoma skin cancers. plays a role in various cancers, but its role in CSCC has not been reported so far. The expression of and in cells was detected by RT-qPCR. Read More

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In vivo Multi-scale Photoacoustic Imaging Guided Photothermal Therapy of Cervical Cancer based on Customized Laser System and Targeted Nanoparticles.

Int J Nanomedicine 2021 15;16:2879-2896. Epub 2021 Apr 15.

The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.

Background: Effective treatment strategy for cervical carcinoma is subject to the limitation of its anatomical location and histological characteristics. Comprehensive imaging before cervical carcinoma treatment is of great significance for the patients. Current imaging methods cannot meet the requirements of high resolution, deep imaging depth and non-invasive imaging at the same time. Read More

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Dynamic Change of Amide Proton Transfer Imaging in Irradiated Nasopharyngeal Carcinoma and Related Histopathological Mechanism.

Mol Imaging Biol 2021 Apr 19. Epub 2021 Apr 19.

Department of Radiation Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.

Objective: To investigate the dynamic change of amide proton transfer (APT) imaging before and after irradiation in nasopharyngeal carcinoma (NPC) and the underlying histopathological mechanism.

Materials And Methods: Tumor-bearing BALB/C nude mouse models were established and randomly divided into three groups: high-dose group (20 Gy/2 fractions), low-dose group (10 Gy/2 fractions), and control group (0 Gy). MRI scanning was performed before irradiation and 3rd, 6th, and 9th day post-irradiation. Read More

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Damage to cardiac vasculature may be associated with breast cancer treatment-induced cardiotoxicity.

Cardiooncology 2021 Apr 19;7(1):15. Epub 2021 Apr 19.

Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Background: Breast cancer is the most common female cancer worldwide. Effective therapies including doxorubicin and trastuzumab have improved survival, but are associated with a substantial risk of cardiovascular disease. Mechanisms underlying cancer treatment-induced cardiotoxicity (CTC) are poorly understood and have largely focused on cardiomyocyte damage, although other cellular populations in the heart such as the cardiac endothelium, may play an important role in cardiac damage. Read More

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Polymeric Lipid Hybrid Nanoparticles as a Delivery System Enhance the Antitumor Effect of Emodin in Vitro and in Vivo.

J Pharm Sci 2021 Apr 15. Epub 2021 Apr 15.

College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China; Guangdong Key Lab of Traditional Chinese Medicine Information Technology, College of Pharmacy, Jinan University, Guangzhou 510632, China; Cancer Research Institute of Jinan University, Guangzhou 510632, China. Electronic address:

This study aimed to evaluate the therapeutic efficacy of Emodin-loaded polymer lipid hybrid nanoparticles (E-PLNs) for breast cancer. The size, Zeta potential, surface morphology, encapsulation efficiency, stability, in vitro drug release of E-PLNs prepared by the nanoprecipitation method were characterized. The uptake, in-vitro cytotoxicities and apoptosis of free drug, E-PLNs were investigated against MCF-7 cells. Read More

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GliPR1 knockdown by RNA interference exerts anti-glioma effects in vitro and in vivo.

J Neurooncol 2021 May 15;153(1):23-32. Epub 2021 Apr 15.

Department of Neurosurgery, Section Experimental Neurosurgery/Tumor Immunology, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.

Introduction: In human glioblastomas, glioma pathogenesis-related protein1 (GliPR1) is overexpressed and appears to be an oncoprotein. We investigated whether GliPR1 knockdown in glioma cells by RNA interference exerts anti-glioma effects.

Methods: Experiments used human glioblastoma cell lines transduced with GliPR1 shRNA (sh#301, sh#258). Read More

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An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications.

Proc Natl Acad Sci U S A 2021 Apr;118(16)

Philochem AG, R&D department, CH-8112 Otelfingen, Switzerland;

We describe the development of OncoFAP, an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential. OncoFAP binds to human FAP with affinity in the subnanomolar concentration range and cross-reacts with the murine isoform of the protein. We generated various fluorescent and radiolabeled derivatives of OncoFAP in order to study biodistribution properties and tumor-targeting performance in preclinical models. Read More

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PSMA-D4 Radioligand for Targeted Therapy of Prostate Cancer: Synthesis, Characteristics and Preliminary Assessment of Biological Properties.

Int J Mol Sci 2021 Mar 8;22(5). Epub 2021 Mar 8.

National Centre for Nuclear Research, Radioisotope Centre POLATOM, 05-400 Otwock, Poland.

A new PSMA ligand (PSMA-D4) containing the Glu-CO-Lys pharmacophore connected with a new linker system (L-Trp-4-Amc) and chelator DOTA was developed for radiolabeling with therapeutic radionuclides. Herein we describe the synthesis, radiolabeling, and preliminary biological evaluation of the novel PSMA-D4 ligand. Synthesized PSMA-D4 was characterized using TOF-ESI-MS, NMR, and HPLC methods. Read More

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KMT2D promotes proliferation of gastric cancer cells: evidence from ctDNA sequencing.

J Clin Lab Anal 2021 Apr 1;35(4):e23721. Epub 2021 Apr 1.

Fujian Medical University Union Hospital, Fuzhou, China.

Background: ctDNA sequencing could be used for early cancer screening, prognosis prediction, and medication guidance. However, data of its application in gastric cancer are still lacking. In this study, using ctDNA sequencing, we aimed to screen the mutant genes closely associated with gastric cancer and to explore the impact of these genes on gastric cancer development. Read More

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A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy.

Int J Nanomedicine 2021 23;16:2373-2388. Epub 2021 Mar 23.

School of Pharmacy, Bengbu Medical College, Bengbu, 233030, People's Republic of China.

Aim: The metastasis of breast cancer is an important cause of tumor recurrence. This study highlights that tyrosine kinase inhibitors dasatinib (DAS) and rosiglitazone (ROZ) inhibit tumor growth and reduce the occurrence of tumor cell metastasis. Due to the poor water solubility, short half-time in the body of DAS and ROZ, which increases the difficulty of tumor treatment, as well as the demand for nano-drug delivery systems for organ-specific therapies. Read More

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A Magnetic T7 Peptide&AS1411 Aptamer-Modified Microemulsion for Triple Glioma-Targeted Delivery of Shikonin and Docetaxel.

J Pharm Sci 2021 Mar 27. Epub 2021 Mar 27.

Department of Neurosurgery, School of Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, People's Republic of China; Department of Neurosurgery, Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510315, People's Republic of China. Electronic address:

Glioma-targeted drug delivery is a hugely challenging task because of the multibarrier in the brain. In this study, we report a magnetic T7 peptide&AS1411 aptamer-modified microemulsion for triple glioma-targeted delivery of shikonin and docetaxel ([email protected]/AS1411/DTX&SKN-M). Such a system comprises two tumor-targeted ligands (T7 peptide and AS1411 aptamer), ultra-small superparamagnetic iron oxide nanoparticle (FeO), and shikonin&docetaxel-coloaded microemulsion (SKN&DTX-M). Read More

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A Triptolide Loaded HER2-Targeted Nano-Drug Delivery System Significantly Suppressed the Proliferation of HER2-Positive and BRAF Mutant Colon Cancer.

Int J Nanomedicine 2021 19;16:2323-2335. Epub 2021 Mar 19.

Endoscopy Center, Zhongshan Hospital of Fudan University, Shanghai, 200032, People's Republic of China.

Background: Colon cancer (CRC) was a malignant tumor and there were about 25% of patients with tumor metastasis at diagnosis stage. Chemotherapeutic agents for metastatic CRC patients were with great side effects and the clinical treatment results of advanced CRC were still not satisfactory. Human epidermal growth factor receptor 2 (HER2) is overexpressed in some CRC patients and is an effective target for CRC patient treatment. Read More

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