49,133 results match your criteria tumor infiltration

Prognostic factors for survival in patients with lung metastases from gynaecological tract cancers.

Interact Cardiovasc Thorac Surg 2021 Aug 3. Epub 2021 Aug 3.

Università Cattolica del Sacro Cuore, Rome, Italy.

Objectives: Lung metastases from gynaecological tract cancers are rare, and prognostic factors are still undefined. The goal of this study was to analyse prognostic factors for survival in this group of patients.

Methods: Data of patients with lung metastases from gynaecological tract cancers who underwent surgical resections from 1 January 2005 to 31 May 2019 were reviewed retrospectively. Read More

View Article and Full-Text PDF

Quantitative whole-body MR imaging for assessment of tumor burden in patients with multiple myeloma: correlation with prognostic biomarkers.

Quant Imaging Med Surg 2021 Aug;11(8):3767-3780

Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: To assess the quantification of tumor burden in multiple myeloma (MM) patients using whole-body magnetic resonance imaging (MRI) and to identify the correlation between MRI parameters and prognostic biomarkers.

Methods: We retrospectively analyzed 95 newly diagnosed MM patients treated at our hospital from June 2018 to March 2020. All patients underwent whole-body MRI examination, including diffusion-weighted whole-body imaging with background body signal suppression (DWIBS), modified Dixon chemical-shift imaging (mDIXON), and short TI inversion recovery (STIR) sequences. Read More

View Article and Full-Text PDF

Unicentric Castleman disease: multidetector computed tomography classification with surgical and pathologic correlation.

Quant Imaging Med Surg 2021 Aug;11(8):3562-3568

Department of Radiology, Beijing Chest Hospital, Capital Medical University, Beijing, China.

Background: This study aimed to correlate multidetector computed tomography (MDCT) classification of unicentric Castleman disease with the surgical and pathologic features.

Methods: The imaging manifestations of 63 cases of unicentric Castleman disease confirmed by pathology were retrospectively analyzed. Every patient underwent an MDCT examination. Read More

View Article and Full-Text PDF

Enhanced antitumor immune response in melanoma tumor model by anti-PD-1 small interference RNA encapsulated in nanoliposomes.

Cancer Gene Ther 2021 Aug 2. Epub 2021 Aug 2.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Programmed cell death protein-1 (PD-1), as an immune checkpoint molecule, attenuates T-cell activity and induces T-cell exhaustion. Although siRNA has a great potential in cancer immunotherapy, its delivery to target cells is the main limitation of using siRNA. This study aimed to prepare a liposomal formulation as a siRNA carrier to silence PD-1 expression in T cells and investigate it's in vivo antitumor efficacy. Read More

View Article and Full-Text PDF

THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.

J Immunother Cancer 2021 Aug;9(8)

Zhongshan-Xuhui Hospital, Shanghai Xuhui Central Hospital, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Fudan University, Shanghai, China

Background: The abnormal upregulation of programmed death-ligand 1 (PD-L1) in cancer cells inhibits T cell-mediated cytotoxicity, but the molecular mechanisms that drive and maintain PD-L1 expression are still incompletely understood.

Methods: Combined analyses of genomes and proteomics were applied to find potential regulators of PD-L1. In vitro experiments were performed to investigate the regulatory mechanism of PD-L1 by thyroid adenoma associated gene (THADA) using human colorectal cancer (CRC) cells. Read More

View Article and Full-Text PDF

Anticoagulation therapy promotes the tumor immune-microenvironment and potentiates the efficacy of immunotherapy by alleviating hypoxia.

J Immunother Cancer 2021 Aug;9(8)

Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Gwanak-gu, South Korea

Purpose: Here, this study verifies that cancer-associated thrombosis (CAT) accelerates hypoxia, which is detrimental to the tumor immune microenvironment by limiting tumor perfusion. Therefore, we designed an oral anticoagulant therapy to improve the immunosuppressive tumor microenvironment and potentiate the efficacy of immunotherapy by alleviating tumor hypoxia.

Experimental Design: A novel oral anticoagulant (STP3725) was developed to consistently prevent CAT formation. Read More

View Article and Full-Text PDF

Sialic acid conjugate-modified liposomes enable tumor homing of epirubicin via neutrophil/monocyte infiltration for tumor therapy.

Acta Biomater 2021 Jul 30. Epub 2021 Jul 30.

College of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China. Electronic address:

Neutrophils and monocytes (N/Ms) are potential candidates for the delivery of therapeutic agents to the tumor microenvironment (TME) because of their tumor-accumulating nature. L-selectin and Siglec-1, receptors for sialic acid (SA), are highly expressed in circulating neutrophils and monocytes, respectively, in tumor-bearing mice, and N/Ms are recruited to tumors in response to inflammatory cytokines secreted by the TME, promoting tumor growth and invasion. Therefore, we constructed a drug delivery nano-platform using N/Ms as vehicles. Read More

View Article and Full-Text PDF

RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer.

Pharmacol Res 2021 Jul 30:105793. Epub 2021 Jul 30.

Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 201203, China; School of Basic Medical Sciences, Fudan Unvieristy, Shanghai 200032, China. Electronic address:

To date, the overall response rate to checkpoint blockade remains unsatisfactory, partially due to the limited understanding of the tumor immune microenvironment. The retinoic acid-related orphan receptor γt (RORγt) is the key transcription factor of T helper cell 17 (Th17) cells and plays an essential role in tumor immunity. In this study, we used JG-1, a potent and selective small-molecule RORγt agonist to evaluate the therapeutic potential and mechanism of action of targeting RORγt in tumor immunity. Read More

View Article and Full-Text PDF

Natural-killer and plasma cell infiltration are associated with a distinct immune subset in non-small cell lung cancer.

J Pathol 2021 Aug 2. Epub 2021 Aug 2.

Dept. of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Immune cells of the tumor microenvironment are central but erratic targets for immunotherapy. This study aimed at characterizing novel patterns of immune cell infiltration in non-small cell lung cancer (NSCLC) in relation to its molecular and clinicopathological characteristics. Lymphocytes (CD3+, CD4+, CD8+, CD20+, FOXP3+, CD45RO+), macrophages (CD163+), plasma cells (CD138+), NK cells (NKp46+), PD1+ and PD-L1+ were annotated on a tissue microarray including 357 NSCLC cases. Read More

View Article and Full-Text PDF

Are cachexia-associated tumors transmitTERS of ER stress?

Biochem Soc Trans 2021 Aug 2. Epub 2021 Aug 2.

Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Cancer cachexia is associated with deficient response to chemotherapy. On the other hand, the tumors of cachectic patients remarkably express more chemokines and have higher immune infiltration. For immunogenicity, a strong induction of the unfolded protein response (UPR) is necessary. Read More

View Article and Full-Text PDF

Prognostic marker identification based on weighted gene co-expression network analysis and associated confirmation in gastric cancer.

Bioengineered 2021 Dec;12(1):4666-4680

Department of Clinical Laboratory, The Affiliated Hospital of Guilin Medical University, Guangxi, Guilin, China.

The aim of this study was to explore the potential molecular mechanisms of Gastric cancer (GC) and identify new prognostic markers for GC. RNA sequencing data were downloaded from the Gene Expression Omnibus database, and 418 differentially expressed genes (DEGs) were screened. Weighted correlation network analysis (WGCNA) was performed to identify six hub modules related to the clinical features of GC. Read More

View Article and Full-Text PDF
December 2021

Sexual Dimorphism in Outcomes of Non-muscle-invasive Bladder Cancer: A Role of CD163+ Macrophages, B cells, and PD-L1 Immune Checkpoint.

Eur Urol Open Sci 2021 Jul 3;29:50-58. Epub 2021 Jun 3.

Queen's Cancer Research Institute, Kingston, ON, Canada.

Background: Non-muscle-invasive bladder cancer (NMIBC) is over three times as common in men as it is in women; however, female patients do not respond as well to immunotherapeutic treatments and experience worse clinical outcomes than their male counterparts. Based on the established sexual dimorphism in mucosal immune responses, we hypothesized that the tumor immune microenvironment of bladder cancer differs between the sexes, and this may contribute to discrepancies in clinical outcomes.

Objective: To determine biological sex-associated differences in the expression of immune regulatory genes and spatial organization of immune cells in tumors from NMIBC patients. Read More

View Article and Full-Text PDF

Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis.

Eur Urol Open Sci 2021 Jul 25;29:19-29. Epub 2021 May 25.

CRUK Beatson Institute, Glasgow, UK.

Background: Pelvic nodal metastasis in prostate cancer impacts patient outcome negatively.

Objective: To explore tumor-infiltrating immune cells as a potential predictive tool for regional lymph node (LN) metastasis.

Design Setting And Participants: We applied multiplex immunofluorescence and targeted transcriptomic analysis on 94 radical prostatectomy specimens in patients with (LN+) or without (LN-) pelvic nodal metastases. Read More

View Article and Full-Text PDF

Infiltration of M2 Macrophages and Regulatory T Cells Plays a Role in Recurrence of Renal Cell Carcinoma.

Eur Urol Open Sci 2020 Jul 20;20:62-71. Epub 2020 Aug 20.

Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Background: It has been hypothesized that M2 macrophages and regulatory T cells (Tregs) may contribute to tumor progression by suppression of antitumor immunity.

Objective: To investigate the association between infiltration of CD163 M2 macrophages and CD4FOXP3 Tregs with clinical outcomes in renal cell carcinoma patients.

Design Setting And Participants: A cohort of 346 patients diagnosed with renal cell carcinoma at Örebro University Hospital between 1986 and 2011 was evaluated for CD163 M2 macrophage and CD4FOXP3 Treg infiltration by immunohistochemistry. Read More

View Article and Full-Text PDF

Crosstalk between Tumor-Infiltrating Immune Cells and Cancer-Associated Fibroblasts in Tumor Growth and Immunosuppression of Breast Cancer.

J Immunol Res 2021 13;2021:8840066. Epub 2021 Jul 13.

Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Signals from the tumor microenvironment (TME) have a profound influence on the maintenance and progression of cancers. Chronic inflammation and the infiltration of immune cells in breast cancer (BC) have been strongly associated with early carcinogenic events and a switch to a more immunosuppressive response. Cancer-associated fibroblasts (CAFs) are the most abundant stromal component and can modulate tumor progression according to their secretomes. Read More

View Article and Full-Text PDF

RUNX3 Expression Level Is Correlated with the Clinical and Pathological Characteristics in Endometrial Cancer: A Systematic Review and Meta-analysis.

Biomed Res Int 2021 14;2021:9995384. Epub 2021 Jul 14.

Geneis (Beijing) Co. Ltd., Beijing 100102, China.

Human Runt-associated transcription factor 3 (RUNX3) plays an important role in the development and progression of endometrial cancer (EC). However, the clinical and pathological significance of RUNX3 in EC needs to be further studied. In order to clarify the clinical and pathological significance of RUNX3, a systematic review and meta-analysis was conducted in EC patients. Read More

View Article and Full-Text PDF

Tumor Immune Microenvironment Characterization of Primary Lung Adenocarcinoma and Lymph Node Metastases.

Biomed Res Int 2021 10;2021:5557649. Epub 2021 Jul 10.

Department of Thoracic Surgery, Xiangya Hospital of Central South University, 410008 Changsha, Hunan, China.

Background: The essential roles of the tumor microenvironment (TME) have been recognized during the initiation and progression of primary lung adenocarcinoma (LUAD). The aim of the present study was to delineate the immune landscape in both primary cancer and matched lymph node metastasis from a cohort of locally advanced stage LUAD patients with distinct outcomes.

Methods: Formalin-fixed, paraffin-embedded samples were collected from 36 locally advanced LUAD patients. Read More

View Article and Full-Text PDF

Cardiac Myosarcoma in a Newborn Infant-A Case Report and Literature Review.

Front Cardiovasc Med 2021 14;8:675202. Epub 2021 Jul 14.

Faculty of Medicine, Medical University of Sofia, Sofia, Bulgaria.

Malignant cardiac neoplasms are extremely rare in neonates. Prenatal diagnosis is often not available. Initial symptoms can mimic non-cardiac diseases. Read More

View Article and Full-Text PDF

Bisegmentectomy 7-8 for Small-for-Size Remanant Liver for Cirrhotic Patients Under Right Hemi-hepatectomy With Hepatocellular Carcinoma: A Case-Matched Comparative Study.

Front Surg 2021 15;8:675666. Epub 2021 Jul 15.

Institute of Hepatobiliary Surgery, Southwest Hospital, Army Military Medical University, Chongqing, China.

To compare the short- and long-term treatment outcomes of bisegmentectomy 7-8 vs. right hepatectomy for patients with hepatocellular carcinoma and cirrhosis. Thirty six cirrhotic HCC patients with infiltration of right hepatic vein in segments 7-8 underwent bisegmentectomy 7-8 for small-for-size remanant liver under right hemi-hepatectomy. Read More

View Article and Full-Text PDF

A Novel RNA-Binding Protein Signature to Predict Clinical Outcomes and Guide Clinical Therapy in Gastric Cancer.

Front Med (Lausanne) 2021 15;8:670141. Epub 2021 Jul 15.

Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.

This study aimed to develop an RNA-binding protein (RBP)-based signature for risk stratification and guiding clinical therapy in gastric cancer. Based on survival-related RBPs, an RBP-based signature was established by LASSO regression analysis in TCGA dataset. Kaplan-Meier curves were drawn between high- and low-risk groups. Read More

View Article and Full-Text PDF

High Migration and Invasion Ability of PGCCs and Their Daughter Cells Associated With the Nuclear Localization of S100A10 Modified by SUMOylation.

Front Cell Dev Biol 2021 16;9:696871. Epub 2021 Jul 16.

Department of Pathology, Tianjin Union Medical Center, Nankai University, Tianjin, China.

Our previous studies have confirmed that cobalt chloride (CoCl) or chemoradiotherapy could induce the formation of polyploid tumor giant cells (PGCCs). Polyploid giant cancer cells are a special subpopulation of cancer cells that contribute to solid tumor heterogeneity. The size of PGCC was at least three times larger than regular diploid cancer cells. Read More

View Article and Full-Text PDF

Integrative Analysis of MUC4 to Prognosis and Immune Infiltration in Pan-Cancer: Friend or Foe?

Front Cell Dev Biol 2021 16;9:695544. Epub 2021 Jul 16.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Cancer Bioinformatics, Peking University Cancer Hospital and Institute, Beijing, China.

, a transmembrane mucin, plays important roles in epithelial renewal and differentiation. Recent studies suggest that has been implicated in pancreatic cancer pathogenesis and is expressed in various normal and cancer tissues. The underlying features of across various cancer types may allow us to ensure appropriate treatment and patient monitoring. Read More

View Article and Full-Text PDF

Multi-Omics Data Integration Analysis of an Immune-Related Gene Signature in LGG Patients With Epilepsy.

Front Cell Dev Biol 2021 16;9:686909. Epub 2021 Jul 16.

Department of Neurology, Hunan Aerospace Hospital, Changsha Medical University, Changsha, China.

Background: The tumor immune microenvironment significantly affects tumor occurrence, progression, and prognosis, but its impact on the prognosis of low-grade glioma (LGG) patients with epilepsy has not been reported. Hence, the purpose of this study is to explore its effect on LGG patients with epilepsy.

Methods: The data of LGG patients derived from the TCGA database. Read More

View Article and Full-Text PDF

PSMC5 Promotes Proliferation and Metastasis of Colorectal Cancer by Activating Epithelial-Mesenchymal Transition Signaling and Modulating Immune Infiltrating Cells.

Front Cell Dev Biol 2021 16;9:657917. Epub 2021 Jul 16.

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

We designed the present study to access the roles and mechanisms of PSMC5 in colorectal cancer (CRC). Transcriptomic and clinical data from public datasets and our center were retrospectively analyzed. Functional assays were performed to investigate the effects of PSMC5 on CRC cells. Read More

View Article and Full-Text PDF

LncRNA ELF3-AS1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma.

Can J Gastroenterol Hepatol 2021 9;2021:8323487. Epub 2021 Jul 9.

The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550001, Guizhou, China.

Background: Expression of long noncoding RNA (lncRNA) ELF3 antisense RNA 1 (ELF3-AS1) is observed in some cancers, while its role in hepatocellular carcinoma (HCC) is unclear. The study aimed to investigate the relationship between ELF3-AS1 and HCC based on database, bioinformatics, and statistical analysis.

Methods: In this study, Kruskal-Wallis test, Wilcoxon sign-rank test, logistic regression, Kaplan-Meier method, Cox regression analysis, gene set enrichment analysis (GSEA), and immunoinfiltration analysis were used to assess the relationship between ELF3-AS1 expression and clinical characteristics of HCC patients, the relationship between ELF3-AS1 expression and prognosis of HCC patients, and the possible functions of ELF3-AS1 in HCC. Read More

View Article and Full-Text PDF

Identification of the Prognosis Value and Potential Mechanism of Immune Checkpoints in Renal Clear Cell Carcinoma Microenvironment.

Front Oncol 2021 14;11:720125. Epub 2021 Jul 14.

Department of Urology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Kidney Renal Clear Cell Carcinoma (KIRC) is one of the most prevalent types of cancer worldwide. KIRC has a poor prognosis and, to date, immunotherapy based on immune checkpoints is the most promising treatment. However, the role of immune checkpoints in KIRC remains ambiguous. Read More

View Article and Full-Text PDF

Reversing Epigenetic Gene Silencing to Overcome Immune Evasion in CNS Malignancies.

Front Oncol 2021 15;11:719091. Epub 2021 Jul 15.

Neuro-Oncology Branch, National Cancer Institute, Bethesda, MD, United States.

Glioblastoma (GBM) is an aggressive brain malignancy with a dismal prognosis. With emerging evidence to disprove brain-immune privilege, there has been much interest in examining immunotherapy strategies to treat central nervous system (CNS) cancers. Unfortunately, the limited success of clinical studies investigating immunotherapy regimens, has led to questions about the suitability of immunotherapy for these cancers. Read More

View Article and Full-Text PDF

Identification and Validation of a Prognostic Signature for Prostate Cancer Based on Ferroptosis-Related Genes.

Front Oncol 2021 15;11:623313. Epub 2021 Jul 15.

Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, Shanghai, China.

Ferroptosis, an iron-dependent form of selective cell death, is involved in the development of many cancers. However, ferroptosis related genes (FRGs) in prostate cancer (PCa) are not been well studied. In this study, we collected the mRNA expression profiles and clinical information of PCa patients from TCGA and MSKCC databases. Read More

View Article and Full-Text PDF

miR-130-3p Promotes MTX-Induced Immune Killing of Hepatocellular Carcinoma Cells by Targeting EPHB4.

J Healthc Eng 2021 23;2021:4650794. Epub 2021 Jul 23.

The Second Affiliated Hospital of Shandong First Medical University, Tai'an 271000, Shandong, China.

The vast majority of primary hepatocellular cancer is hepatocellular carcinomas (HCCs). Currently, HCC is one of the more common cancers in humans, and it has a high mortality and disability rate. Mitoxantrone (MTX) is an antitumor drug that can block type II topoisomerase. Read More

View Article and Full-Text PDF

Long intergenic non-coding RNA, regulator of reprogramming (LINC-ROR) over-expression predicts poor prognosis in renal cell carcinoma.

Arch Med Sci 2021 17;17(4):1016-1027. Epub 2019 May 17.

Botany Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.

Introduction: Long intergenic non-coding RNA, regulator of reprogramming (LINC-ROR) is a newly identified cytoplasmic long non-coding RNA (lncRNA) implicated in cell longevity and apoptosis. We aimed in the current work for the first time to investigate the association of the expression profiles of LINC-ROR and three stem-related transcriptional factors with clinicopathological data and their impact on renal cell carcinoma (RCC) progression in a sample of RCC patients.

Material And Methods: Expression levels of LINC-ROR and stemness-related factors: SOX2, NANOG, and POU5F1 were detected in 60 formalin-fixed, paraffin-embedded tissues, and their paired adjacent non-cancer tissues ( = 60) by using real-time qRT-PCR analysis. Read More

View Article and Full-Text PDF