72,621 results match your criteria tumor extent


Tumors and pseudotumors of foot and ankle: Bone lesions.

Foot (Edinb) 2021 Jun 29;49:101845. Epub 2021 Jun 29.

Radiology & Orthopeadic Surgery, UT Southwestern, 5323 Harry Hines Blvd, Dallas, TX, United States. Electronic address:

Bone tumors and tumor-like lesions (pseudotumors) are not uncommonly encountered as asymptomatic findings on imaging, or as symptomatic lesions clinically. Radiographic imaging is the first diagnostic tool for their management strategy, since the symptoms are commonly non-specific, such as pain, swelling, and redness. Image findings must be analyzed with attention to the specific features such as lesion location, margination, zone of transition, mineralization, size and multifocality, soft tissue component and/or loco-regional extent. Read More

View Article and Full-Text PDF

Prognostic factors for lymph node metastasis from upper gingival carcinomas.

Oral Radiol 2021 Sep 24. Epub 2021 Sep 24.

Department of Oral and Maxillofacial Radiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.

Objectives: This study sought to identify tumor characteristics that associate with regional lymph node metastases in squamous cell carcinomas originating in the upper gingiva.

Materials And Methods: Data from 113 patients from Osaka University Dental Hospital were included. We measured each primary tumor's width, length, depth, and the extent of bone invasion. Read More

View Article and Full-Text PDF
September 2021

Impact of preoperative chemotherapy on pathologic nodal status in muscle-invasive bladder cancer: optimal lymphadenectomy in the preoperative chemotherapy era.

J Cancer Res Clin Oncol 2021 Sep 23. Epub 2021 Sep 23.

Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap2-dong, Songpa-gu, Seoul, 138-736, Korea.

Purpose: To investigate the impact of preoperative chemotherapy (pCTX) on pathologic nodal (pN) status and evaluate the optimal lymphadenectomy method according to clinical nodal (cN) status in patients with muscle-invasive bladder cancer who received pCTX.

Materials And Methods: We retrospectively reviewed 449 patients with muscle-invasive bladder cancer who underwent radical cystectomy. Among them, 139 (31. Read More

View Article and Full-Text PDF
September 2021

Identification and Validation of a Nine-Gene Amino Acid Metabolism-Related Risk Signature in HCC.

Front Cell Dev Biol 2021 7;9:731790. Epub 2021 Sep 7.

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Hepatocellular carcinoma (HCC) is the world's second most deadly cancer, and metabolic reprogramming is its distinguishing feature. Among metabolite profiling, variation in amino acid metabolism supports tumor proliferation and metastasis to the most extent, yet a systematic study on the role of amino acid metabolism-related genes in HCC is still lacking. An effective amino acid metabolism-related prediction signature is urgently needed to assess the prognosis of HCC patients for individualized treatment. Read More

View Article and Full-Text PDF
September 2021

Integrative Analysis of DNA Methylation and microRNA Expression Reveals Mechanisms of Racial Heterogeneity in Hepatocellular Carcinoma.

Front Genet 2021 7;12:708326. Epub 2021 Sep 7.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, United States.

Pathologic alterations in epigenetic regulation have long been considered a hallmark of many cancers, including hepatocellular carcinoma (HCC). In a healthy individual, the relationship between DNA methylation and microRNA (miRNA) expression maintains a fine balance; however, disruptions in this harmony can aid in the genesis of cancer or the propagation of existing cancers. The balance between DNA methylation and microRNA expression and its potential disturbance in HCC can vary by race. Read More

View Article and Full-Text PDF
September 2021

Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: A Tertiary Care Center Experience.

Indian J Radiol Imaging 2021 Apr 4;31(2):270-276. Epub 2021 Aug 4.

Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Portal vein tumor thrombosis (PVTT) is a common complication of hepatocellular carcinoma (HCC) occurring in 30 to 40% of cases. The presence of PVTT in HCC is regarded as an advanced disease that confers poor prognosis and survival. Transarterial chemoembolization (TACE) has traditionally been considered to be contraindicated in cases of PVTT, due to the risk of hepatic infarction, and further deteriorate liver function. Read More

View Article and Full-Text PDF

Prognostic significance of extent of venous tumor thrombus in patients with non-metastatic renal cell carcinoma: Results from a Canadian multi-institutional collaborative.

Urol Oncol 2021 Sep 20. Epub 2021 Sep 20.

Section of Urology, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Purpose: The prognostic significance of level of venous tumor thrombus (VTT) extension in patients with non-metastatic renal cell carcinoma (RCC) has been controversial. The aim of this study was to examine the prognostic significance of VTT extent in patients who underwent surgery for non-metastatic RCC.

Materials And Methods: The Canadian Kidney Cancer information system database was used to identify patients who underwent surgery for non-metastatic RCC and VTT from January 2011 to December 2019. Read More

View Article and Full-Text PDF
September 2021

Tailored axillary surgery in patients with clinically node-positive breast cancer: Pre-planned feasibility substudy of TAXIS (OPBC-03, SAKK 23/16, IBCSG 57-18, ABCSG-53, GBG 101).

Breast 2021 Sep 8;60:98-110. Epub 2021 Sep 8.

Breast Center Bern, Lindenhof Group, Bern, Switzerland.

Aim: We developed tailored axillary surgery (TAS) to reduce the axillary tumor volume in patients with clinically node-positive breast cancer to the point where radiotherapy can control it. The aim of this study was to quantify the extent of tumor load reduction achieved by TAS.

Methods: International multicenter prospective study embedded in a randomized trial. Read More

View Article and Full-Text PDF
September 2021

Advanced radiotherapy technique in hepatocellular carcinoma with portal vein thrombosis: Feasibility and clinical outcomes.

PLoS One 2021 23;16(9):e0257556. Epub 2021 Sep 23.

Faculty of Medicine, Division of Radiation Oncology, Department of Radiology, Chulalongkorn University, Bangkok, Thailand.

Background: In Thailand, individuals with hepatocellular carcinoma (HCC) who develop portal vein tumor thrombosis (PVTT) have a restricted treatment option because to the extent of the disease, poor underlying liver function, and non-coverage of immuno/targeted therapy. Radiotherapy (RT) plays an increasingly important function in these patients. To investigate the feasibility, efficacy, and adverse event rates, we performed a retrospective analysis of patients with HCC with PVTT who underwent 3-dimensional conformal radiation (3DCRT), intensity-modulated radiation (IMRT), volumetric-modulated radiotherapy (VMAT), and stereotactic body radiotherapy (SBRT) in a single-institution. Read More

View Article and Full-Text PDF
September 2021

Adaptation of laser interstitial thermal therapy for tumor ablation under MRI monitoring in a rat orthotopic model of glioblastoma.

Acta Neurochir (Wien) 2021 Sep 23. Epub 2021 Sep 23.

Department of Neurosurgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI, 48202-2689, USA.

Background: Laser interstitial thermal therapy (LITT) under magnetic resonance imaging (MRI) monitoring is being increasingly used in cytoreductive surgery of recurrent brain tumors and tumors located in eloquent brain areas. The objective of this study was to adapt this technique to an animal glioma model.

Methods: A rat model of U251 glioblastoma (GBM) was employed. Read More

View Article and Full-Text PDF
September 2021

Anatomical phenotyping and staging of brain tumours.

Brain 2021 Sep 23. Epub 2021 Sep 23.

Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich and University of Zurich, 8091 Zurich, Switzerland.

Unlike other tumors, the anatomical extent of brain tumors is not objectified and quantified through staging. Staging systems are based on understanding the anatomical sequence of tumor progression and its relationship to histopathological dedifferentiation and survival. The aim of this study was to describe the spatiotemporal phenotype of the most frequent brain tumor entities, to assess the association of anatomical tumor features with survival probability and to develop a staging system for WHO grade 2 and 3 gliomas and glioblastoma. Read More

View Article and Full-Text PDF
September 2021

Therapeutic Strategy in Low-Risk Papillary Thyroid Carcinoma - Long-Term Results of the First Single-Center Prospective Non-Randomized Trial Between 2011 and 2015.

Front Endocrinol (Lausanne) 2021 6;12:718833. Epub 2021 Sep 6.

Department of Nuclear Medicine and Endocrine Oncology, M. Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland.

Optimal therapeutic strategy in low advanced papillary thyroid carcinoma (PTC) is still a matter of debate. The management differs depending on the country. A prospective non-randomized study was performed to evaluate whether less extensive surgery could be a safe, acceptable, and sufficient therapeutic option in PTC cT1N0M0 patients. Read More

View Article and Full-Text PDF
September 2021

MYC levels regulate metastatic heterogeneity in pancreatic adenocarcinoma.

Cancer Discov 2021 Sep 22. Epub 2021 Sep 22.

Ontario Institute for Cancer Research.

The degree of metastatic disease varies widely amongst cancer patients and impacts clinical outcomes. However, the biological and functional differences that drive the extent of metastasis are poorly understood. We analyzed primary tumors and paired metastases using a multi-fluorescent lineage-labeled mouse model of pancreatic ductal adenocarcinoma (PDAC) - a tumor type where most patients present with metastases. Read More

View Article and Full-Text PDF
September 2021

The role of laparoscopic management in perforated gastric cancer.

Ann Surg Treat Res 2021 Sep 31;101(3):151-159. Epub 2021 Aug 31.

Department of Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Perforated gastric cancer is an extremely rare condition and usually presents in advanced stage with poor prognosis. Surgical strategies are still controversial regarding the extent to which complete resection or primary repair is performed and the application of laparoscopic techniques. We aim to determine the role of laparoscopic 2-stage approach in perforated gastric cancer. Read More

View Article and Full-Text PDF
September 2021

Predicting the Effect of Variants of Unknown Significance in Molecular Tumor Boards with the VUS-Predict Pipeline.

Stud Health Technol Inform 2021 Sep;283:209-216

Dept. of Medical Bioinformatics, University Medical Center Göttingen, Germany.

Precision oncology utilizing molecular biomarkers for targeted therapies is one of the hopes to treat cancer. The availability of patient specific molecular profiling through next-generation sequencing, though, increases the amount of available data per patient to an extent that computational support is required to identify potential driver alterations for targeted therapies and rational decision-making in molecular tumor boards (MTBs). For some genetic variants evidence-based drug recommendations are available in public databases, but for the majority, the variants of unknown significance (VUS), this clinical information is missing. Read More

View Article and Full-Text PDF
September 2021

Body fatness and mTOR pathway activation of breast cancer in the Women's Circle of Health Study.

NPJ Breast Cancer 2020 Sep 21;6(1):45. Epub 2020 Sep 21.

Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Energy imbalance has an important role in breast cancer prognosis. Hyperactive mechanistic Target of Rapamycin (mTOR) pathway is associated with breast tumor growth, but the extent to which body fatness is associated with mTOR pathway activities in breast cancer is unclear. We performed immunostaining for mTOR, phosphorylated (p)-mTOR, p-AKT, and p-p70S6K in tumor tissue from 590 women (464 African Americans/Blacks and 126 Whites) with newly diagnosed invasive breast cancer in the Women's Circle of Health Study. Read More

View Article and Full-Text PDF
September 2020

The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape.

PLoS Pathog 2021 Sep 20;17(9):e1009919. Epub 2021 Sep 20.

Laboratory of Viral Interactomes, GIGA Institute, University of Liege, Liege, Belgium.

Viral infections are known to hijack the transcription and translation of the host cell. However, the extent to which viral proteins coordinate these perturbations remains unclear. Here we used a model system, the human T-cell leukemia virus type 1 (HTLV-1), and systematically analyzed the transcriptome and interactome of key effectors oncoviral proteins Tax and HBZ. Read More

View Article and Full-Text PDF
September 2021

Percutaneous ethanol injection enhanced the efficacy of radiofrequency ablation in the treatment of HCC: an insight into the mechanism of ethanol action.

Int J Hyperthermia 2021 ;38(1):1394-1400

Department of Medical Ultrasonics, Division of Interventional Ultrasound, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Purpose: To discuss the possible reasons why percutaneous intratumoral ethanol injection (PEI) combined with radiofrequency ablation (RFA) to treat hepatocellular carcinoma (HCC) reduced the recurrence and metastasis compared with RFA alone.

Materials And Methods: Forty VX2 tumor-bearing rabbits were randomly divided into four groups ( = 10): the PEI, RFA, PEI-RFA, and control groups. Five rabbits from each group were sacrificed on the 3rd and 7th days after ablation. Read More

View Article and Full-Text PDF
January 2021

Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney.

Mod Pathol 2021 Sep 20. Epub 2021 Sep 20.

Kidney Cancer Program at Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Low-grade oncocytic tumor (LOT) of the kidney is a recently described entity with poorly understood pathogenesis. Using next-generation sequencing (NGS) and complementary approaches, we provide insight into its biology. We describe 22 LOT corresponding to 7 patients presenting with a median age of 75 years (range 63-86 years) and male to female ratio 2:5. Read More

View Article and Full-Text PDF
September 2021

Endoscopic approach for giant pituitary adenoma: clinical outcomes of 205 patients and comparison of two proposed classification systems for preoperative prediction of extent of resection.

J Neurosurg 2021 Sep 17:1-15. Epub 2021 Sep 17.

Departments of1Neurosurgery and Pituitary Research Center.

Objective: Giant pituitary adenoma is considered a challenging pathology for surgery owing to its complications and low resection rate. In this study, the authors present their experience of using the endoscopic endonasal approach to treat patients with giant pituitary adenoma, and they aimed to develop a classification system for prediction of extent of resection.

Methods: The institutional medical records of patients diagnosed with giant pituitary adenoma who underwent endoscopic endonasal transsphenoidal surgery between August 1997 and December 2019 were retrospectively reviewed. Read More

View Article and Full-Text PDF
September 2021

Anatomical observation and clinical significance of the left gastric vein in laparoscopic radical gastrectomy.

J Gastrointest Oncol 2021 Aug;12(4):1407-1415

Department of Gastrointestinal Surgery, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.

Background: The left gastric vein (LGV) plays an important role in laparoscopic radical gastrectomy (LRG). However, the anatomy of the LGV is complicated with significant variation, and it is often damaged and bleeding during LRG. The purpose of this study was to observe and analyze the anatomic types of the LGV in patients undergoing LRG and to explore its clinical significance. Read More

View Article and Full-Text PDF

The imaging features of extrapancreatic perineural invasion (EPNI) in pancreatic Cancer:A comparative retrospective study.

Pancreatology 2021 Sep 1. Epub 2021 Sep 1.

Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China. Electronic address:

Background: Extrapancreatic perineural invasion (EPNI) is a risk factor for the prognosis of patients with pancreatic cancer. Few reliable clinical indicators can be used to evaluate EPNI.

Methods: We reviewed clinicopathological information of pancreatic cancer patients received radical surgery in our center from 2014 to 2019. Read More

View Article and Full-Text PDF
September 2021

Recalibrating the decision for MRI-directed breast ultrasound in patients with newly diagnosed breast cancer, factors predicting sonographic success.

Clin Imaging 2021 Sep 7;80:391-399. Epub 2021 Sep 7.

Mayo Clinic Florida, Department of Surgery, 4500 San Pablo Rd, Jacksonville, FL 32224, USA. Electronic address:

Objective: Evaluate utilization of MRI-directed breast ultrasound (US) in patients with newly diagnosed breast cancer and refine practices to increase success of sonographic lesion detection.

Methods: This retrospective single-institution review was restricted to women with breast cancer who underwent MRI from November 2006 to January 2017. Enhancing breast lesions, separate from the index tumor, recommended for MRI-directed US were assessed to see which were detected and which characteristics predicted success in detection. Read More

View Article and Full-Text PDF
September 2021

An experimental study to identify key psychological mechanisms that promote and predict resilience in the aftermath of treatment for breast cancer.

Psychooncology 2021 Sep 16. Epub 2021 Sep 16.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Objective: Women living with and beyond breast cancer (BC) frequently encounter cancer-related information in day-to-day life. The extent they are emotionally resilient to this information differs between women. Identifying key modifiable psychological mechanisms predicting resilience in these women could highlight targets for interventions to improve resilience in others. Read More

View Article and Full-Text PDF
September 2021

[Nasal reconstruction with paramedian forehead flaps].

Hautarzt 2021 Oct 16;72(10):913-921. Epub 2021 Sep 16.

Hautklinik, Universitätsklinikum Münster, Von-Esmarch Str. 58, 48149, Münster, Deutschland.

The nose has an important function in the esthetic perception of the face. The esthetic coverage of defects on the nose is therefore of particular importance; however, the position is exposed to sunlight and poses a particular risk for the development of non-melanoma skin cancer (NMSC) and melanomas. After tumor excision, the size of the defect is decisive for defect closure. Read More

View Article and Full-Text PDF
October 2021

Spatiotemporal Patterns of Loco-Regional Recurrence After Breast-Conserving Surgery.

Front Oncol 2021 30;11:690658. Epub 2021 Aug 30.

Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Loco-regional recurrences (LRR) following breast-conserving surgery (BCS) remain a heterogeneous class of disease that has significant variation in its biological behavior and prognosis.

Methods: To delineate the spatiotemporal patterns of LRR after BCS, we analyzed the data of 4325 patients treated with BCS from 2006 to 2016. Clinico-pathological and treatment specific factors were analyzed using the Cox proportional hazards model to identify factors predictive for LRR events. Read More

View Article and Full-Text PDF

Recurrence of Primary Synovial Chondromatosis (Reichel's Syndrome) in the Ankle Joint following Surgical Excision.

Case Rep Orthop 2021 6;2021:9922684. Epub 2021 Sep 6.

Department of Orthopaedics and Trauma, Mater Dei Hospital, Malta.

Primary synovial chondromatosis, or Reichel's syndrome, is a rare benign tumour arising from the synovial lining of a joint. We present the case of a 25-year-old male with Reichel's syndrome of the ankle, with subsequent recurrence following open retrieval of loose bodies. The initial presentation was of lateral malleolus discomfort which limited moderately strenuous exercise. Read More

View Article and Full-Text PDF
September 2021

Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients.

Front Psychiatry 2021 30;12:678594. Epub 2021 Aug 30.

Department of Nursing, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.

Protracted alcohol withdrawal symptoms (PAWS), characterized by the presence of substance-specific signs and symptoms (including anxiety, irritability, mood instability, insomnia, and cravings), make alcohol abstinence difficult and increase the risk of relapse in recovering alcoholics. The goal of this study was to evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) on PAWS and plasma brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and leptin levels in patients with alcohol dependency. A total of 114 patients with alcohol dependence were randomly divided into two groups: the treatment group and the control group. Read More

View Article and Full-Text PDF

Role of miR-182/PDCD4 axis in aggressive behavior of prostate cancer in the African Americans.

BMC Cancer 2021 Sep 15;21(1):1028. Epub 2021 Sep 15.

Department of Urology, Urology Research Center, Veterans Affairs Medical Center and University of California San Francisco School of Medicine (UCSF), 4150 Clement Street, San Francisco, CA, 94121, USA.

Background: Prostate cancer is one of the most commonly diagnosed cancers among men. African Americans (AA) are at an increased risk of developing prostate cancer compared to European Americans (EA). miRNAs play a critical role in these tumors, leading to tumor progression. Read More

View Article and Full-Text PDF
September 2021

Is compartmental surgery always mandatory in retroperitoneal liposarcoma? A case report of multifocal synchronous well-differentiated liposarcoma.

Ann Ital Chir 2021 ;92:419-423

Aim: Sarcomas are rare tumors representing 0.7% of all cancer cases in adults, and approximately 15-20% of those occur in the retroperitoneum. Diagnosis is usually late. Read More

View Article and Full-Text PDF
September 2021