98,142 results match your criteria tumor discussed

Bacteria-mediated cancer therapies: opportunities and challenges.

Biomater Sci 2021 Jul 27. Epub 2021 Jul 27.

School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, PR China.

In recent years, cancer therapy strategies utilizing live tumor-targeting bacteria have presented unique advantages. Engineered bacteria have the particular ability to distinguish tumors from normal tissues with less toxicity. Live bacteria are naturally capable of homing to tumors, resulting in high levels of local colonization because of insufficient oxygen and low pH in the tumor microenvironment. Read More

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Osteochondrolipoma of the Hand.

J Hand Surg Am 2021 Jul 23. Epub 2021 Jul 23.

Sanford Orthopedics and Sports Medicine, Sioux Falls, SD; Department of Orthopaedics, University of Kansas Medical Center, Wichita, KS.

Lipoma is the most common type of benign soft tissue tumor and is composed of mature adipose tissue. A neoplasm of adipose tissue with admixed mature bone and cartilage, or osteochondrolipoma, is an extremely rare histologic variant. Most documented osteochondrolipomas have occurred in the soft tissues of the head and neck related to the oral cavity, and the tumor is seen involving the extremities. Read More

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Update of pediatric soft tissue tumors with review of conventional MRI appearance-part 2: vascular lesions, fibrohistiocytic tumors, muscle tumors, peripheral nerve sheath tumors, tumors of uncertain differentiation, and undifferentiated small round cell sarcomas.

Skeletal Radiol 2021 Jul 23. Epub 2021 Jul 23.

Yale Radiology and Biomedical Imaging, 330 Cedar Street, New Haven, CT, 06520, USA.

There are numerous soft tissue tumors and tumor-like conditions in the pediatric population. Magnetic resonance imaging is the most useful modality for imaging these lesions. Although certain soft tissue lesions exhibit magnetic resonance features characteristic of a specific diagnosis, most lesions are indeterminate, and a biopsy is necessary for diagnosis. Read More

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Benign biliary neoplasms and biliary tumor precursors.

Pathologica 2021 Jun;113(3):147-157

Department of Pathology, Azienda ULSS2 Marca Trevigiana, Treviso, Italy.

Benign biliary tumor are common lesions that are often an incidental finding in subjects who undergo medical imaging tests for other conditions. Most are true neoplasms while few result from reactive or malformative proliferation. Benign tumors have no clinical consequences, although the premalignant nature or potential for malignant transformation is of concern in some cases. Read More

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Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and photothermal ablation.

J Nanobiotechnology 2021 Jul 22;19(1):220. Epub 2021 Jul 22.

Department of Breast Surgery, Southwest Hospital, Army Medical University, Chongqing, 400038, China.

Chirality is a fundamental characteristic of natural molecules and a crucial factor in the biochemical reactions of living cells and organisms. Recently, researchers have successfully introduced chiral molecules to the surfaces of nanomaterials, creating chiral nanomaterials that exhibit an upscaling of chiral behavior from the molecular scale to the nanoscale. These chiral nanomaterials can selectively induce autophagy, apoptosis, and photothermal ablation in tumor cells based on their chirality, making them promising for application in anti-tumor therapy. Read More

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Neuroblastoma-associated Renal Cell Carcinoma: A Case Report and Review of the Literature.

J Pediatr Hematol Oncol 2021 Jul 23. Epub 2021 Jul 23.

University College London Medical School University College London Hospitals NHS Foundation Trust, London, UK.

Neuroblastoma-associated renal cell carcinoma (RCC) is a very rare subtype of renal neoplasia and only a handful of cases have been reported. Here we present a 15-year-old boy with metastatic RCC with a previous history of advanced stage neuroblastoma and germline mutation in the TP53 tumor suppressor gene. The probability of the RCC and indeed, the neuroblastoma itself being related to a cancer predisposition syndrome rather than a therapy induced second malignancy, is discussed. Read More

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Prognostic factors and its predictive value in patients with metastatic spinal cancer.

World J Clin Cases 2021 Jul;9(20):5470-5478

Department of Gynecology, Shenzhen People's Hospital, 2 Clinical Medical College of Jinan University, Shenzhen 518020, Guangdong Province, China.

Background: The spine is the most common location of metastatic diseases. Treating a metastatic spinal tumor depends on many factors, including patients' overall health and life expectancy. The present study was conducted to investigate prognostic factors and clinical outcomes in patients with vertebral metastases. Read More

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Precision Medicine Gains Momentum: Novel 3D Models and Stem Cell-Based Approaches in Head and Neck Cancer.

Front Cell Dev Biol 2021 8;9:666515. Epub 2021 Jul 8.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Despite the current progress in the development of new concepts of precision medicine for head and neck squamous cell carcinoma (HNSCC), in particular targeted therapies and immune checkpoint inhibition (CPI), overall survival rates have not improved during the last decades. This is, on the one hand, caused by the fact that a significant number of patients presents with late stage disease at the time of diagnosis, on the other hand HNSCC frequently develop therapeutic resistance. Distinct intratumoral and intertumoral heterogeneity is one of the strongest features in HNSCC and has hindered both the identification of specific biomarkers and the establishment of targeted therapies for this disease so far. Read More

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Ultrasound Biomicroscopy Documented Anterior Uveal Melanoma Regression after Ruthenium-106 Plaque Therapy.

Ocul Oncol Pathol 2021 Jun 15;7(3):224-232. Epub 2021 Feb 15.

University Eye Clinic, University Hospital Centre Zagreb, Zagreb, Croatia.

Introduction: Ultrasound biomicroscopy (UBM) is the only widely used method for the evaluation of anterior uveal melanoma (AUM).

Objective: Documentation of regression of AUM treated with ruthenium-106 (Ru-106) plaque types CCB and CCC using UBM.

Methods: This single institution-based retrospective case series involved 10 Caucasian patients with AUM followed after brachytherapy with UBM from January 2014 until February 2019. Read More

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Drug Repurposing of Pantoprazole and Vitamin C Targeting Tumor Microenvironment Conditions Improves Anticancer Effect in Metastatic Castration-Resistant Prostate Cancer.

Front Oncol 2021 7;11:660320. Epub 2021 Jul 7.

Department of Nuclear Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

The effective and economical therapeutic strategy for metastatic castration-resistant prostate cancer (mCRPC) is still requested from patients, who are not available for Lu-177 or Ra-223 treatment. Drug repurposing as a cost-effective and time-saving alternative to traditional drug development has been increasingly discussed. Proton pump inhibitors (PPIs) such as pantroprazole, which are commonly used as antacids, have also been shown to be effective in cancer chemoprevention induction of apoptosis in multiple cancer cell lines. Read More

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Endoscope-Assisted Middle Fossa Approach: Optimizing the Surgical Corridor for the Resection of Multicompartmental Chordomas.

J Neurol Surg B Skull Base 2021 Jul 6;82(Suppl 3):e172-e178. Epub 2020 Mar 6.

São Paulo Skull Base Center, São Paulo, Brazil.

 Skull base chordomas are a major therapeutic challenge. The surgical management involves selecting an approach that will offer the patient the best chance of largest/complete removal while minimizing morbidity and mortality.  Medical records and imaging review of two skull base chordomas involving the middle fossa and posterior fossa that were successfully treated with an endoscope-assisted middle fossa approach. Read More

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Lactic acid in macrophage polarization: The significant role in inflammation and cancer.

Int Rev Immunol 2021 Jul 25:1-15. Epub 2021 Jul 25.

Key Laboratory of Stem Cells and Gene Drugs of Gansu Province, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou, P.R. China.

Metabolite lactic acid has always been regarded as a metabolic by-product rather than a bioactive molecule. Recently, this view has changed since it was discovered that lactic acid can be used as a signal molecule and has novel signal transduction functions both intracellular and extracellular, which can regulate key functions in the immune system. In recent years, more and more evidence has shown that lactic acid is closely related to the metabolism and polarization of macrophages. Read More

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[Experience in the diagnosis and treatment of the postoperative complications of craniopharyngiomas through expanded endoscopic endonasal transsphenoidal approach].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jun;35(6):505-510

Department of Otorhinolaryngology Head and Neck Surgery,Tianjin Huanhu Hospital,Tianjin,300350,China.

To summarize the clinical characteristics of the postoperative complications of surgical resection of craniopharyngiomas through expanded endoscopic endonasal transsphenoidal approach (EEETA). Strategies for prevention and management were also discussed. The clinical data of the patients who were treated through EEETA were retrospectively reviewed. Read More

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[Perioperative airway management of infantile subglottic hemangioma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jun;35(6):501-504;510

Department of Anesthesiology,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine.

To investigate the relevant influencing factors for perioperative airway events of infantile subglottic hemangioma, and to further discuss the strategies of perioperative airway management. A total of 36 infants with subglottic hemangioma that had no response to the drug therapy and underwent surgical treatment from July 2007 to April 2017 were enrolled. The relevant influencing factors, including gender, age, birth weight, age of onset, degree of tracheal stenosis and histories of underlying diseases(congenital heart disease and respiratory disease), were also recorded simultaneously. Read More

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Zinc finger proteins: insights into the transcriptional and post transcriptional regulation of immune response.

Mol Biol Rep 2021 Jul 24. Epub 2021 Jul 24.

Department of Biochemistry, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India.

Background: Zinc finger proteins encompass one of the unique and large families of proteins with diversified biological functions in the human body. These proteins are primarily considered to be DNA binding transcription factors; however, owing to the diverse array of zinc-finger domains, they are able to interact with molecules other than DNA like RNA, proteins, lipids and PAR (poly-ADP-ribose). Evidences from recent scientific studies have provided an insight into the potential functions of zinc finger proteins in immune system regulation both at the transcriptional and post transcriptional level. Read More

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Regulatory role of Non-canonical DNA polymorphisms in human genome and their relevance in cancer.

Biochim Biophys Acta Rev Cancer 2021 Jul 22:188594. Epub 2021 Jul 22.

Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Simrol, Indore 453552, India. Electronic address:

DNA has the ability to form polymorphic structures like canonical duplex DNA and non-canonical triplex DNA, Cruciform, Z-DNA, G-quadruplex (G4), i-motifs, and hairpin structures. The alteration in the form of DNA polymorphism in the response to environmental changes influences the gene expression. Non-canonical structures are engaged in various biological functions, including chromatin epigenetic regulation, gene expression regulation via transcription and translation, and DNA repair and recombination. Read More

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The Role of Tumor Associated Macrophages (TAMs) in Cancer Progression, Chemoresistance, Angiogenesis and Metastasis - Current Status.

Curr Med Chem 2021 07 20. Epub 2021 Jul 20.

Center of Excellence in Molecular Biology and Regenerative Medicine (CEMR), Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research (JSS AHER), Mysuru 570015, Karnataka, India.

Tumor associated macrophages (TAMs), located in the tumor microenvironment (TME), play a significant role in cancer cell survival and progression. TAMs have been involved in producing immuno-suppressive TME in the tumor by generating inflammatory mediators, growth factors, cytokines, chemokines, etc. TAMs can influence the angiogenesis, metastatic behavior of tumor cells (TCs) and cause multidrug resistance. Read More

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Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming.

Front Med 2021 Jul 24. Epub 2021 Jul 24.

Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing, 100069, China.

Metabolic reprogramming, such as abnormal utilization of glucose, addiction to glutamine, and increased de-novo lipid synthesis, extensively occurs in proliferating cancer cells, but the underneath rationale has remained to be elucidated. Based on the concept of the degree of reduction of a compound, we have recently proposed a calculation termed as potential of electron transfer (PET), which is used to characterize the degree of electron redistribution coupled with metabolic transformations. When this calculation is combined with the assumed model of electron balance in a cellular context, the enforced selective reprogramming could be predicted by examining the net changes of the PET values associated with the biochemical pathways in anaerobic metabolism. Read More

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Delay differential equations based models in NONMEM.

J Pharmacokinet Pharmacodyn 2021 Jul 23. Epub 2021 Jul 23.

Department of Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA.

Delay differential equations (DDEs) are commonly used in pharmacometric models to describe delays present in pharmacokinetic and pharmacodynamic data analysis. Several DDE solvers have been implemented in NONMEM 7.5 for the first time. Read More

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Enhancing the Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Signaling and Arginine Deprivation in Melanoma.

Int J Mol Sci 2021 Jul 16;22(14). Epub 2021 Jul 16.

Department of Veterans Affairs, Miami VA Healthcare System, Research Service, Miami, FL 33125, USA.

Melanoma as a very aggressive type of cancer is still in urgent need of improved treatment. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and arginine deiminase (ADI-PEG20) are two of many suggested drugs for treating melanoma. Both have shown anti-tumor activities without harming normal cells. Read More

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Molecular Determinants of Soft Tissue Sarcoma Immunity: Targets for Immune Intervention.

Int J Mol Sci 2021 Jul 13;22(14). Epub 2021 Jul 13.

Unit of Immunotherapy of Human Tumors, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

Soft tissue sarcomas (STSs) are a family of rare malignant tumors encompassing more than 80 histologies. Current therapies for metastatic STS, a condition that affects roughly half of patients, have limited efficacy, making innovative therapeutic strategies urgently needed. From a molecular point of view, STSs can be classified as translocation-related and those with a heavily rearranged genotype. Read More

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Synoptic Diagnostics of Myeloproliferative Neoplasms: Morphology and Molecular Genetics.

Cancers (Basel) 2021 Jul 14;13(14). Epub 2021 Jul 14.

Institute of Pathology and Neuropathology, University Hospital Tübingen, 72076 Tübingen, Germany.

The diagnosis of a myeloid neoplasm relies on a combination of clinical, morphological, immunophenotypic and genetic features, and an integrated, multimodality approach is needed for precise classification. The basic diagnostics of myeloid neoplasms still rely on cell counts and morphology of peripheral blood and bone marrow aspirate, flow cytometry, cytogenetics and bone marrow trephine biopsy, but particularly in the setting of Ph- myeloproliferative neoplasms (MPN), the trephine biopsy has a crucial role. Nowadays, molecular studies are of great importance in confirming or refining a diagnosis and providing prognostic information. Read More

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Assessment and Prediction of Response to Neoadjuvant Chemotherapy in Breast Cancer: A Comparison of Imaging Modalities and Future Perspectives.

Cancers (Basel) 2021 Jul 14;13(14). Epub 2021 Jul 14.

IRCCS SDN, 80143 Naples, Italy.

Neoadjuvant chemotherapy (NAC) is becoming the standard of care for locally advanced breast cancer, aiming to reduce tumor size before surgery. Unfortunately, less than 30% of patients generally achieve a pathological complete response and approximately 5% of patients show disease progression while receiving NAC. Accurate assessment of the response to NAC is crucial for subsequent surgical planning. Read More

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Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges.

Cancers (Basel) 2021 Jul 8;13(14). Epub 2021 Jul 8.

Department of Radiation Oncology, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment modality for patients with peritoneal metastasis (PM) of various origins which aims for cure in combination with cytoreductive surgery (CRS). Efficacy of CRS-HIPEC depends on patient selection, tumor type, delivery technique, and treatment parameters such as temperature, carrier solution, type of drug, dosage, volume, and treatment duration. Preclinical research offers a powerful tool to investigate the impact of these parameters and to assist in designing potentially more effective treatment protocols and clinical trials. Read More

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A comparison of immune receptor recombination databases sourced from tumour exome or RNAseq files: Verifications of immunological distinctions between primary and metastatic melanoma.

Int J Immunogenet 2021 Jul 23. Epub 2021 Jul 23.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

It became apparent several years ago that RNAseq and exome files prepared from tissue could be mined for adaptive immune receptor (IR) recombinations, which has given extra value to datasets originally intended for gene expression or mutation studies. For example, recovery of IR recombination reads from tumour specimen genomics files can correlate with survival rates. In particular, many benchmarking processes have been applied to the two sets of the IR recombination reads obtained from the cancer genome atlas files, but these two sets have never been directly compared. Read More

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Role of macrophages and phagocytes in orchestrating normal and pathologic hematopoietic niches.

Exp Hematol 2021 Jul 21. Epub 2021 Jul 21.

Mater Research Institute, University of Queensland, Woolloongabba, QLD, Australia.

The bone marrow (BM) contains a mosaic of niches specialized in supporting different maturity stages of hematopoietic stem and progenitor cells such as hematopoietic stem cells and myeloid, lymphoid, and erythroid progenitors. Recent advances in BM imaging and conditional gene knockout mice have revealed that niches are a complex network of cells of mesenchymal, endothelial, neuronal, and hematopoietic origins, together with local physicochemical parameters. Within these complex structures, phagocytes, such as neutrophils, macrophages, and dendritic cells, all of which are of hematopoietic origin, have been found to be important in regulating several niches in the BM, including hematopoietic stem cell niches, erythropoietic niches, and niches involved in endosteal bone formation. Read More

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[Study on difference of effect of Huoxue drugs and Yiqi Huoxue drugs on tumor metastasis based on immune remodeling].

Zhongguo Zhong Yao Za Zhi 2021 Jun;46(11):2766-2772

Guang'anmen Hospital,China Academy of Chinese Medical Sciences Beijing 100053,China.

Tumor metastasis is an important cause of tumor treatment failure. Its molecular mechanism is closely related to tumor cells remodeling immune cells and immunosuppressive microenvironment, so as to create a suitable soil for tumor cell invasion and growth. "Huoxue Huayu" is one of the important therapeutic principles in cancer treatment, but the influence of Huoxue drugs on tumor metastasis has been controversial in clinical application. Read More

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CAM-DR: Mechanisms, Roles and Clinical Application in Tumors.

Front Cell Dev Biol 2021 6;9:698047. Epub 2021 Jul 6.

Medical School, Nantong University, Nantong, China.

Despite the continuous improvement of various therapeutic techniques, the overall prognosis of tumors has been significantly improved, but malignant tumors in the middle and advanced stages still cannot be completely cured. It is now evident that cell adhesion-mediated resistance (CAM-DR) limits the success of cancer therapies and is a great obstacle to overcome in the clinic. The interactions between tumor cells and extracellular matrix (ECM) molecules or adjacent cells may play a significant role in initiating the intracellular signaling pathways that are associated with cell proliferation, survival upon binding to their ligands. Read More

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Piwi-Interacting RNAs: A New Class of Regulator in Human Breast Cancer.

Front Oncol 2021 6;11:695077. Epub 2021 Jul 6.

Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

P-element-induced wimpy testis (Piwi)-interacting RNAs (piRNAs) are a class of germline-enriched small non-coding RNA that associate with Piwi family proteins and mostly induce transposon silencing and epigenetic regulation. Emerging evidence indicated the aberrant expression of Piwil proteins and associated piRNAs in multiple types of human cancer including breast cancer. Although the majority of piRNAs in breast cancer remains unclear of the function mainly due to the variety of regulatory mechanisms, the potential of piRNAs serving as biomarkers for cancer diagnosis and prognosis or therapeutic targets for cancer treatment has been demonstrated by and studies. Read More

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Immunotherapy in small cell lung cancer: one step at a time: a narrative review.

Transl Lung Cancer Res 2021 Jun;10(6):2970-2987

Department of Respiratory Medicine, Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology, Maastricht, The Netherlands.

Chemotherapy with or without radiotherapy has been the standard of care for many years for patients with small cell lung cancer (SCLC). Despite exceptionally high responses (up to 80%) with chemotherapy, the majority of patients relapse rapidly within weeks to months after treatment completion. Therefore, new and better treatment options are necessary. Read More

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