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Periocular Presentation of Solitary Plasmacytomas and Multiple Myeloma.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Orbital Service, Moorfields Eye Hospital, London, United Kingdon.

Aims: To describe patients with periocular solitary extramedullary plasmacytoma (SEMP) and multiple myeloma (MM), together with an estimate of the risk of progression from SEMP to MM.

Patients And Methods: A retrospective case-note review for patients seen between 1978 and 2020, examining demographics, presentation, imaging, pathology, management, and outcome.

Results: Twenty patients (10 male; 50%) presented at a mean age of 60. Read More

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Cytological diagnosis of sclerosing adenosis of breast - Diagnostic challenges and literature review.

Cytopathology 2021 Jul 22. Epub 2021 Jul 22.

Department of Pathology & Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhopal, India.

Sclerosing adenosis is a benign proliferative disease of breast involving terminal duct lobular units characterised by proliferation of glandular and stromal elements. It usually manifests as a small lesion and is frequently discovered incidentally. It may uncommonly present as a palpable mass termed as nodular sclerosing adenosis or adenosis tumour. Read More

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A Novel Ferroptosis-Related Biomarker Signature to Predict Overall Survival of Esophageal Squamous Cell Carcinoma.

Front Mol Biosci 2021 5;8:675193. Epub 2021 Jul 5.

Cardiovascular Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Esophageal squamous cell carcinoma (ESCC) accounts for the main esophageal cancer (ESCA) type, which is also associated with the greatest malignant grade and low survival rates worldwide. Ferroptosis is recently discovered as a kind of programmed cell death, which is indicated in various reports to be involved in the regulation of tumor biological behaviors. This work focused on the comprehensive evaluation of the association between ferroptosis-related gene (FRG) expression profiles and prognosis in ESCC patients based on The Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Read More

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Gamma Radiation Induce Inflammasome Signaling and Pyroptosis in Microvascular Endothelial Cells.

J Inflamm Res 2021 15;14:3277-3288. Epub 2021 Jul 15.

Department of Blood Diseases Institute, Xuzhou Medical University, Xuzhou City, 221002, Jiangsu Province, People's Republic of China.

Introduction: The extend to the clinical benefit of radiation therapy is the inability to eliminate only cancer cells and destroy normal cells such as microvascular endothelial in the vascular niche and turn induced-inflammasome signaling and cell death. These unfortunate injuries generated by ionizing radiation alter the therapeutic window and result in the re-occurrence of the malignancy. Therefore, we engaged in vitro studies by demonstrating radiation-induced inflammasome and cell death in endothelial cells. Read More

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Pan-cancer analyses reveal genomics and clinical characteristics of the melatonergic regulators in cancer.

J Pineal Res 2021 Jul 21:e12758. Epub 2021 Jul 21.

Department of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, Guangzhou, 510095, P. R. China.

Melatonin, an endogenous hormone, plays protective roles in cancer. In addition to regulating circadian rhythms, sleep, and neuroendocrine activity, melatonin functions in various survival pathways. However, the mechanisms of melatonin regulation in cancer remain unknown. Read More

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LncRNA PVT1 promotes the progression of ovarian cancer by activating TGF-β pathway via miR-148a-3p/AGO1 axis.

J Cell Mol Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Obstetrics and Gynaecology, Changzheng Hospital, Naval Medical University, Shanghai, China.

Ovarian cancer is a lethal gynaecologic malignancy with poor diagnosis and prognosis. The long non-coding RNA plasmacytoma variant translocation1 (PVT1) and argonaute 1 (AGO1) are associated with carcinogenesis and chemoresistance; however, the relationship between PVT1 and AGO1 and the downstream mechanisms in ovarian cancer remains poorly known. PVT1 and AGO1 expression was assessed through RT-qPCR and Western blotting in both human tissues and cell lines. Read More

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The novel RAF/MEK inhibitor CH5126766/VS-6766 has efficacy in combination with eribulin for the treatment of TNBC.

Cancer Sci 2021 Jul 19. Epub 2021 Jul 19.

Departments of Drug Discovery Medicine, University of Medicine, Japan.

Various molecular-targeting drugs have markedly improved the treatment of patients with breast cancer. As yet, therapies for triple-negative breast cancer are mainly cytotoxic agents. To investigate the novel therapy for triple-negative breast cancer, we herein examined the effects of a new combination therapy comprising a RAF/MEK inhibitor CH5126766 also known as VS-6766 which we originally discovered, and eribulin. Read More

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Arterial hypertension as an inaugural sign of myomatous uterus.

BMJ Case Rep 2021 Jul 20;14(7). Epub 2021 Jul 20.

Department of Gynecology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Uterine fibroids can be large enough to cause mechanical obstruction of pelvic ureters, which may result in hydroureters and hydronephrosis. Renal impairment frequently results in hypertension due to increased activity of the tubuloglomerular feedback system and renin-angiotensin-aldosterone axis. This process, however, seems reversible because normalisation of blood pressure is possible after the relief of renal obstruction. Read More

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Using esophagus organoid to explore the role of c-Myc in esophageal cancer initiation.

Yi Chuan 2021 Jun;43(6):601-614

School of Life Sciences Fudan University, Shanghai 200433, China.

C-Myc gene is aberrantly highly expressed and participates in cancer initiation and development in various malignant tumors including esophageal cancer, while the underlying mechanism(s) still remains unclear. In order to explore the role of c-Myc in the occurrence of esophageal cancer, we successfully established the esophageal organoids (EOs) as the research model. By constructing a lentivirus overexpressing c-Myc and developing more effective infection method, EOs with stable overexpression of c-Myc were efficiently obtained. Read More

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PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+γδ Tregs polarization.

JCI Insight 2021 Jul 20. Epub 2021 Jul 20.

Department of Colorectal Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

γδ T cell is a promising candidate cell in tumor immunotherapy. However, γδ T cells polarized to CD39+γδ Tregs upon colorectal cancer (CRC) induction and the underlying mechanism remains unclear. Here, we discovered that the frequency of CD39+γδ Tregs, which positively correlated with poor prognosis, was significantly higher in right-sided CRC (RSCRC) than in the left-sided CRC (LSCRC). Read More

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PTEN Loss and ARID1A Mutation in an HPV-positive Metastatic Adenocarcinoma Diagnosed Almost 18 yr After an Intact Cone Excision for Endocervical Adenocarcinoma In Situ.

Int J Gynecol Pathol 2021 Jul 19. Epub 2021 Jul 19.

Departments of Pathology (O.A., S.Y.Z., F.H., A.A.R., O.F.) Obstetrics and Gynecology, University of California, San Diego, San Diego, California (P.B.).

There have been previous reports of neoplasms with the morphology of endocervical adenocarcinoma in situ (AIS) that secondarily involve the ovaries, presumably through transtubal spread, with a smaller subset metastasizing to distant sites. These ovarian metastases have been discovered up to 7 yr postexcision of the endocervical lesion, consistent with the known potential for overtly invasive cervical carcinomas to recur late after primary curative management. Herein, we present a case of a premenopausal woman with a pelvic mass classified as metastatic human papillomavirus (HPV)-associated endocervical adenocarcinoma (p16-block immunoreactive, high-risk HPV positive by in situ hybridization with PTEN loss, ARID1A, and PBRM1 mutations detected by qualitative next-generation sequencing), identified 17. Read More

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Endometrioid Tubal Intraepithelial Neoplasia and Bilateral Ovarian Microcystic Stromal Tumors Harboring APC Mutations: Report of a Case.

Int J Gynecol Pathol 2021 Jul 19. Epub 2021 Jul 19.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Microcystic ovarian tumor of the ovary is a neoplasm of presumed stromal derivation characterized by CTNNB1 or APC alterations leading to nuclear β-catenin expression. This tumor has been described as unilateral and indolent in previously published series. The recently characterized endometrioid tubal intraepithelial neoplasia (eTIN) is an epithelial proliferation of the tube also characterized by nuclear β-catenin staining, and distinct from high-grade serous precursors. Read More

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DFSP of the Breast: Histomorphological, Immunohistochemical, and Molecular Features of a Rare Case in an Unusual Location.

Appl Immunohistochem Mol Morphol 2021 Jul 19. Epub 2021 Jul 19.

Department of Pathology, University of Mississippi Medical Center, Jackson, MS.

We present a case of a 21-year-old female with a vague nontender mass in the lower inner quadrant of the left breast discovered incidentally on chest imaging following trauma. A breast ultrasound demonstrated an 8×6×8 mm irregular hyperechoic mass at the 7 o'clock position of the left breast, 9 cm from the nipple. The mass was graded Breast Imaging Reporting and Data System (BI-RADS) category 4 (suspicious finding). Read More

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Expression, methylation and prognostic feature of EMILIN2 in Low-Grade-Glioma.

Brain Res Bull 2021 Jul 16;175:26-36. Epub 2021 Jul 16.

Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, PR China. Electronic address:

Low-grade gliomas (LGGs) are slow-growing brain cancer in central nervous system neoplasms. EMILIN2 is an extracellular matrix (ECM) protein which could influence the progress of some tumour which is unclear in LGG. In our study, the methylation, expression, prognosis and immune value of EMILIN2 in LGG were analysed through bioinformatics analysis. Read More

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The Roles of circMTO1 in Cancer.

Front Cell Dev Biol 2021 30;9:656258. Epub 2021 Jun 30.

Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Circular RNAs (circRNAs) are a recently discovered type of covalently-closed circular non-coding RNAs, mainly formed by non-sequential back-splicing of precursor mRNAs (pre-mRNAs). Recent studies have demonstrated that circRNAs can have either oncogenic or tumor-suppressor roles depending on the cellular context. CircRNA mitochondrial tRNA translation optimization 1 (circMTO1), a recently reported circular RNA originating from exons of MTO1 located on chromosome 6q13, was proved to be abnormally expressed in many malignant tumors, such as hepatocellular carcinoma, gastric carcinoma and colorectal cancer, resulting in tumor initiation and progression. Read More

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Paraneoplastic neurological syndrome: an evolving story.

Neurooncol Pract 2021 Aug 24;8(4):362-374. Epub 2021 Feb 24.

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Paraneoplastic neurological syndrome (PNS) comprises a group of neurological disorders that result from a misguided immune response to the nervous system triggered by a distant tumor. These disorders frequently manifest before the diagnosis of the underlying neoplasm. Since the first reported case in 1888 by Oppenheim, the knowledge in this area has evolved rapidly. Read More

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A Ferroptosis-Related Gene Signature Identified as a Novel Prognostic Biomarker for Colon Cancer.

Front Genet 2021 1;12:692426. Epub 2021 Jul 1.

Institute for Systems Genetics, West China Hospital, Sichuan University, Chengdu, China.

Background: Colon cancer (CC) is a common gastrointestinal malignant tumor with high heterogeneity in clinical behavior and response to treatment, making individualized survival prediction challenging. Ferroptosis is a newly discovered iron-dependent cell death that plays a critical role in cancer biology. Therefore, identifying a prognostic biomarker with ferroptosis-related genes provides a new strategy to guide precise clinical decision-making in CC patients. Read More

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Identifying GNG4 might play an important role in colorectal cancer TMB.

Cancer Biomark 2021 Jul 9. Epub 2021 Jul 9.

Department of Surgery, Forth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, Zhejiang, China.

Background: Colorectal carcinoma (CRC) is one of the most leading cause of cancer death all over the world. The tumor immune microenvironment is illustrated to be necessary for the progress of CRC. And the accumulating evidence indicated that tumor mutation burden (TMB) is effective in differentiating responding population of immune checkpoint inhibitor (ICI) therapies in various cancers. Read More

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Secondary resistance to anti-EGFR therapy by transcriptional reprogramming in patient-derived colorectal cancer models.

Genome Med 2021 Jul 16;13(1):116. Epub 2021 Jul 16.

Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.

Background: The development of secondary resistance (SR) in metastatic colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor (anti-EGFR) antibodies is not fully understood at the molecular level. Here we tested in vivo selection of anti-EGFR SR tumors in CRC patient-derived xenograft (PDX) models as a strategy for a molecular dissection of SR mechanisms.

Methods: We analyzed 21 KRAS, NRAS, BRAF, and PI3K wildtype CRC patient-derived xenograft (PDX) models for their anti-EGFR sensitivity. Read More

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Detection of secondary metastatic breast cancer by measurement of plasma CA 15.3.

ESMO Open 2021 Jul 13;6(4):100203. Epub 2021 Jul 13.

Department of General Medical Oncology and Multidisciplinary Breast Centre, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Background: Most current guidelines do not recommend the serial analysis of tumour marker CA 15.3 in the follow-up of asymptomatic patients treated for early breast cancer (EBC). These guidelines are based on small-scale studies carried out in an era with more limited treatment options than today. Read More

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Temporal responsiveness of adipose-derived stem/stromal cell immune plasticity.

Exp Cell Res 2021 Jul 14;406(1):112738. Epub 2021 Jul 14.

Department of Pathology and Laboratory Medicine, Brown University, United States; Center for Biomedical Engineering, Brown University, United States; School of Engineering, Brown University, United States; Department of Orthopaedics, Brown University, United States. Electronic address:

We determined the role of time in adipose-derived stem/stromal cell (ASC) response to a model inflammatory environment. ASCs and other mesenchymal stem/stromal cells exhibit immune plasticity. We evaluated the persistence of pro- and anti-inflammatory phenotypes for ASCs exposed to a sustained or pulse inflammatory stimulus. Read More

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LINC00205 Promotes Tumor Malignancy of Lung Adenocarcinoma Through Sponging miR-185-5p.

Lab Med 2021 Jul 16. Epub 2021 Jul 16.

Department of Geriatric Respiratory Medicine, PLA General Hospital of Southern Theatre Command, Guangzhou, Guangdong, China.

The emerging role of long noncoding RNAs (lncRNAs) in cancer, especially in lung adenocarcinoma (LUAD), is attracting increasingly more attention as a potential therapeutic target. However, whether lncRNA LINC00205 regulates the malignancy of LUAD has not been characterized. In this study, we discovered that LINC00205 was markedly upregulated in LUAD tissues and cell lines and correlated with poor prognosis of patients with LUAD. Read More

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Modeling genetic epileptic encephalopathies using brain organoids.

EMBO Mol Med 2021 Jul 15:e13610. Epub 2021 Jul 15.

The Concern Foundation Laboratories, Department of Immunology and Cancer Research-IMRIC, The Lautenberg Center for Immunology and Cancer Research, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Developmental and epileptic encephalopathies (DEE) are a group of disorders associated with intractable seizures, brain development, and functional abnormalities, and in some cases, premature death. Pathogenic human germline biallelic mutations in tumor suppressor WW domain-containing oxidoreductase (WWOX) are associated with a relatively mild autosomal recessive spinocerebellar ataxia-12 (SCAR12) and a more severe early infantile WWOX-related epileptic encephalopathy (WOREE). In this study, we generated an in vitro model for DEEs, using the devastating WOREE syndrome as a prototype, by establishing brain organoids from CRISPR-engineered human ES cells and from patient-derived iPSCs. Read More

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ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment.

Blood Cancer Discov 2021 Jul;2(4):338-353

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA.

The bone marrow (BM) microenvironment actively promotes multiple myeloma (MM) pathogenesis and therapies targeting both cancer cells and the niche are highly effective. We were interested in identifying novel signaling pathways supporting MM-BM crosstalk. Mutations in the transmembrane receptor Roundabout 1 (ROBO1) were recently identified in MM patients, however their functional consequences are uncertain. Read More

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Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546.

ACS Med Chem Lett 2021 Jul 14;12(7):1124-1129. Epub 2021 Jun 14.

Medicinal Chemistry, Physical Biochemistry, Drug Metabolism & Pharmacokinetics, Discovery Bioassay, Neurology, Biogen Inc., 225 Binney St, Cambridge, Massachusetts 02142, United States.

Autotaxin (ATX) is a lysophospholipase D that is the main enzyme responsible for generating LPA in body fluids. Although ATX was isolated from a conditioned medium of melanoma cells, later it was discovered to play a critical role in vascular and neuronal development. ATX has also been implicated in primary brain tumor, fibrosis, and rheumatoid arthritis, as well as neurological diseases such as multiple sclerosis, Alzheimer's disease, and neuropathic pain. Read More

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Essential Thrombocythemia in Children: A Retrospective Study.

J Hematol 2021 Jun 16;10(3):106-113. Epub 2021 Jun 16.

Department of Pediatric Hematology/Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Background: Essential thrombocythemia (ET) is one of the "classic" Philadelphia chromosome negative (Ph-) myeloproliferative neoplasms characterized by sustained thrombocytosis, increased megakaryopoiesis and high risk of vascular complications. ET is very rare in childhood. The annual incidence is approximately 1 per 10,000,000 in children less than 14 years, and about 60 times lower than adults. Read More

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A Solitary Melanoma Metastasis Confined to the Submandibular Gland.

Case Rep Oncol 2021 May-Aug;14(2):957-962. Epub 2021 Jun 18.

Department of Otorhinolaryngology Head and Neck Surgery, AZ Jan Portaels, Vilvoorde, Belgium.

Malignant melanoma is a type of cancer that most commonly originates from the skin, less frequently from mucosal surfaces, the eye, or meninges [. 2014;9(1):239-71]. In 2019, this type of malignancy was the third most frequent cancer to be diagnosed in males and the fifth most in females according to the American Cancer Society and the National Cancer Institute [. Read More

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Next generation epigenetic modulators to target myeloid neoplasms.

Curr Opin Hematol 2021 Jul 15. Epub 2021 Jul 15.

Department of Hematology, Oncology, and Pulmonary Medicine, University Medical Center, Johannes Gutenberg-University Mainz, Mainz German Cancer Research Center (DKFZ), Heidelberg German Cancer Consortium (DKTK), Mainz, Germany.

Purpose Of Review: Comprehensive sequencing studies aimed at determining the genetic landscape of myeloid neoplasms have identified epigenetic regulators to be among the most commonly mutated genes. Detailed studies have also revealed a number of epigenetic vulnerabilities. The purpose of this review is to outline these vulnerabilities and to discuss the new generation of drugs that exploit them. Read More

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Prokineticin-1 induces normal lymphangiogenic activity and is involved in lymphangiogenesis and lymph node metastasis in colorectal cancer.

Oncotarget 2021 Jul 6;12(14):1388-1397. Epub 2021 Jul 6.

Fukui Health Science University, Fukui 9103113, Japan.

Background: Prokineticin family correlates with important roles in several biological processes, including homeostasis. We discovered novel functions of prokineticin1 (PROK1) in lymphangiogenesis and lymphnode metastasis in colorectal cancer.

Materials And Methods: We examined changes in the number of lymphatic endothelial cells after PROK1 stimulation. Read More

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High-Expression of Cytoplasmic Poly (A) Binding Protein 1 (PABPC1) as a Prognostic Biomarker for Early-Stage Esophageal Squamous Cell Carcinoma.

Cancer Manag Res 2021 5;13:5361-5372. Epub 2021 Jul 5.

Pathology Department of the First Affiliated Hospital, Southwest Medical University, Sichuan, People's Republic of China.

Background And Objective: Poly (A) binding protein cytoplasmic 1 (PABPC1) plays a crucial role in the regulation of RNA polyadenylation, translation initiation, and mRNA stability and may be involved in tumorigenesis. Herein, we set out to identify the prognostic value of PABPC1 expression in esophageal squamous cell carcinoma (ESCC).

Methods: Using quantitative real-time PCR (qRT-PCR) and immunohistochemical analysis, the present study investigated mRNA and protein expressions of PABPC1 in 231 ESCCs and their paired adjacent normal epithelial tissues. Read More

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