6,221 results match your criteria tumor belongs

Cutaneous metastasis as a first sign of breast carcinoma.

Radiol Case Rep 2021 Jul 26;16(7):1899-1901. Epub 2021 May 26.

Radiology department, Military Hospital Mohammed V, Rabat, Morocco.

Unlike visceral, lymphonodal or bone metastases, skin metastases are rare and their identification portends of a bad prognosis. They may appear as the first sign revealing the primary tumour, synchronous or developing late in the course of neglected primary cancer. We report a case of 86 year-old women witch belongs to this rare group of patients in whom cutaneous metastasis were identified before the primary cancer. Read More

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Anterior Abdominal Wall Synovial Sarcoma: A Rare Presentation.

J Pak Med Assoc 2021 Jun;71(6):1701-1702

Department of Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Abdominal wall sarcoma belongs to a heterogeneous group of uncommon malignant neoplastic conditions with differentiated morphological patterns and originating from mesenchymal tissues. Soft tissue sarcomas predominantly involve the lower and upper limbs and retroperitoneum. We present a case of a 30-year-old patient, complaining of swelling in the left flank whose magnetic resonance imaging (MRI) revealed a solid tumour on the abdominal wall of the flank and biopsy turned out to be synovial sarcoma. Read More

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MicroRNA miR-29a Inhibits Colon Cancer Progression by Downregulating B7-H3 Expression: Potential Molecular Targets for Colon Cancer Therapy.

Mol Biotechnol 2021 Jun 7. Epub 2021 Jun 7.

Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.

MiR-29a belongs to one of the subtypes of miRNAs known as non-coding single-stranded RNAs and is preferentially expressed in normal tissues. B7-H3, a member of the B7/CD28 immunoglobulin superfamily, was shown to be overexpressed in several solid malignant tumors, including colon cancer. In addition, it is associated with tumor progression and poor prognosis. Read More

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The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value.

Front Oncol 2021 19;11:638856. Epub 2021 May 19.

Department of Life Sciences, University of Trieste, Trieste, Italy.

Hephaestin (HEPH) belongs to a group of exocytoplasmic ferroxidases which contribute to cellular iron homeostasis by favouring its export. Down-regulation of HEPH expression, possibly by stimulating cell proliferation due to an increase in iron availability, has shown to correlate with poor survival in breast cancer. The lung is particularly sensitive to iron-induced oxidative stress, given the high oxygen tension present, however, HEPH distribution in lung cancer and its influence on prognosis have not been investigated yet. Read More

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FUT8 and Protein Core Fucosylation in Tumours: From Diagnosis to Treatment.

J Cancer 2021 13;12(13):4109-4120. Epub 2021 May 13.

Special Key Laboratory of Oral Disease Research, Higher Education Institution in Guizhou Province, School of Stomatology, Zunyi Medical University, Zunyi 563006, China.

Glycosylation changes are key molecular events in tumorigenesis, progression and glycosyltransferases play a vital role in the this process. FUT8 belongs to the fucosyltransferase family and is the key enzyme involved in N-glycan core fucosylation. FUT8 and/or core fucosylated proteins are frequently upregulated in liver, lung, colorectal, pancreas, prostate,breast, oral cavity, oesophagus, and thyroid tumours, diffuse large B-cell lymphoma, ependymoma, medulloblastoma and glioblastoma multiforme and downregulated in gastric cancer. Read More

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RON in hepatobiliary and pancreatic cancers: Pathogenesis and potential therapeutic targets.

World J Gastroenterol 2021 May;27(20):2507-2520

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China.

The receptor protein tyrosine kinase RON belongs to the c-MET proto-oncogene family. Research has shown that RON has a role in cancer pathogenesis, which places RON on the frontline of the development of novel cancer therapeutic strategies. Hepatobiliary and pancreatic (HBP) cancers have a poor prognosis, being reported as having higher rates of cancer-related death. Read More

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Development of LC-HRMS methods for evaluation of metabolic conversion of 5-fluorocytosine at GDEPT procedure.

J Pharm Biomed Anal 2021 May 24;203:114168. Epub 2021 May 24.

Comenius University in Bratislava, Faculty of Natural Sciences, Department of Analytical Chemistry, Ilkovičova 6, SK-842 15, Bratislava, Slovak Republic; University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, 389 25, Vodňany, Czech Republic.

Gene-directed enzyme/prodrug therapy represents one of the experimental treatment approaches. The system based on conversion of nontoxic prodrug 5-fluorocytosine to chemotherapeutic 5-fluorouracil by cytosine deaminase or fusion cytosine deaminase::uracil phosphoribosyl transferase belongs to the most frequently used. The detailed analysis of 5-fluorocytosine, 5-fluorouracil and its metabolites enables to understand various responses of tumour cells to treatment as well as mechanisms of resistance. Read More

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Human chorionic gonadotrophin assays to monitor GTD.

Best Pract Res Clin Obstet Gynaecol 2021 May 12. Epub 2021 May 12.

Hydatidiform Mole Follow-Up Service (HMFUS), Ninewells Hospital and Medical Teaching School, Dundee, Scotland, DD1 9SY, UK.

Hydatidiform mole (HM) occurs in 1:500-1000 pregnancies and are generally characterised as a benign proliferative disorder of chorionic villous trophoblast. HM belongs to the group of disorders, collectively known as gestational trophoblastic disease (GTD), which include invasive mole, choriocarcinoma, placental site trophoblastic tumour and epitheloid trophoblastic tumour. Patients with HM are at increased risk of developing these malignant forms and hence accurate diagnosis is very important for monitoring persistent diseases and informing correct patient management. Read More

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Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients.

Diagnostics (Basel) 2021 May 18;11(5). Epub 2021 May 18.

Department of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", 80131 Naples, Italy.

Alpha B-crystallin (CRYAB, HSPB5) belongs to the small heat shock protein (HSP) family and is highly expressed in various human cancers, suggesting a crucial role in tumor progression. However, few studies have examined CRYAB expression in colorectal cancer (CRC). In the present study, we investigated the relationship between CRYAB expression and the clinicopathological features of CRC samples. Read More

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CD137 Signaling Is Critical in Fungal Clearance during Systemic Infection.

J Fungi (Basel) 2021 May 14;7(5). Epub 2021 May 14.

School of Biological Science, University of Ulsan, Ulsan 44610, Korea.

Invasive fungal infections by frequently cause mortality in immunocompromised patients. Neutrophils are particularly important for fungal clearance during systemic infection, yet little has been known regarding which surface receptor controls neutrophils' antifungal activities. CD137, which is encoded by , belongs to the tumor necrosis receptor superfamily and has been shown to regulate neutrophils in Gram-positive bacterial infection. Read More

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Oncogenic Potential of the Dual-Function Protein MEX3A.

Biology (Basel) 2021 May 7;10(5). Epub 2021 May 7.

Charles Tanford Protein Center, Faculty of Medicine, Institute of Molecular Medicine, Section for Molecular Cell Biology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120 Halle, Germany.

MEX3A belongs to the MEX3 (Muscle EXcess) protein family consisting of four members (MEX3A-D) in humans. Characteristic for MEX3 proteins is their domain structure with 2 HNRNPK homology (KH) domains mediating RNA binding and a C-terminal really interesting new gene (RING) domain that harbors E3 ligase function. In agreement with their domain composition, MEX3 proteins were reported to modulate both RNA fate and protein ubiquitination. Read More

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A novel all-trans retinoic acid derivative regulates cell cycle and differentiation of myelodysplastic syndrome cells by USO1.

Eur J Pharmacol 2021 May 29;906:174199. Epub 2021 May 29.

Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, China. Electronic address:

4-Amino-2-Trifluoromethyl-Phenyl Retinate (ATPR), a novel all-trans retinoic acid (ATRA) derivative, has been demonstrated that it had a variety of anti-tumor effects by exerting regulation on cellular proliferation, apoptosis and differentiation. Here, we found that ATPR is critical for alleviating myelodysplastic syndrome (MDS) and acute myelogenous leukemia. USO1, vesicle transport factor, belongs to tether protein family and involved in endoplasmic reticulum to Golgi trafficking of protein which is important to tumorigenesis. Read More

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Sorafenib is associated with a reduced rate of tumour growth and liver function deterioration in HCV-induced hepatocellular carcinoma.

J Hepatol 2021 May 27. Epub 2021 May 27.

Department of Molecular and Clinical Cancer Medicine, University of Liverpool. Electronic address:

Purpose: Sorafenib has been the standard of care for patients with advanced hepatocellular carcinoma and although immunotherapeutic approaches are now challenging this position, it retains an advantage in HCV seropositive patients. We aimed to quantify the rate of tumour progression in patients receiving sorafenib and relate this figure to survival, both overall, and according to viral status.

Patients And Methods: Using serial data from an international clinical trial we applied a joint model to combine survival and progression over time so as to estimate the rate of tumour growth as assessed by tumour burden and serum AFP, and the impact of treatment on liver function. Read More

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Agrobacterium rhizogenes rolB oncogene: An intriguing player for many roles.

Plant Physiol Biochem 2021 Aug 14;165:10-18. Epub 2021 May 14.

Dipartimento di Biologia, Università degli Studi di Firenze, via Madonna del Piano 6, 50019, Sesto f.no, FI, Italy. Electronic address:

The rolB oncogene is one of the so-called rol genes found in the T-DNA region of the Agrobacterium rhizogenes Ri plasmid and involved in the hairy root syndrome, a tumour characterized by adventitious root overgrowth on plant stem. rolB produces in plants a peculiar phenotype that, together with its root-inducing capacity, has been connected to auxin sensitivity. The gene is able to modify the plant genetic programme to induce meristem cells and direct them to differentiate not only roots, but also other cells, tissues or organs. Read More

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Obscurin: A multitasking giant in the fight against cancer.

Biochim Biophys Acta Rev Cancer 2021 May 18;1876(1):188567. Epub 2021 May 18.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, USA. Electronic address:

Giant obscurins (720-870 kDa), encoded by OBSCN, were originally discovered in striated muscles as cytoskeletal proteins with scaffolding and regulatory roles. Recently though, they have risen to the spotlight as key players in cancer development and progression. Herein, we provide a timely prudent synopsis of the expanse of OBSCN mutations across 16 cancer types. Read More

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Botanical from Fruit Can Help to Combat the Melanoma as Demonstrated by and Studies.

Evid Based Complement Alternat Med 2021 18;2021:8810368. Epub 2021 Jan 18.

Department of Signal Transduction and Biogenic Amines, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700026, India.

belongs to Piperaceae family and has long been used as a traditional medicine to treat various diseases in several parts of Africa. The present study aims to investigate the effect of fruit extract (PCFE) alone and in combination with dacarbazine on metastatic melanoma cell line B16-F10 and in C57BL/6J mice. Cytotoxic effects of PCFE alone and in association with dacarbazine on B16-F10 cells were studied by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and colony formation assay. Read More

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January 2021

: A Review of Ethnomedicinal, Phytochemical, Pharmacological, and Toxicological Findings.

Front Chem 2021 29;9:666280. Epub 2021 Apr 29.

College of Animal Sciences, Jilin University, Changchun, China.

is a dry mature seed of Vaccaria hispanica (Mill.) Rauschert, which belongs to the genus (Neck.) Garcke. Read More

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and Activity-Based Labeling of Fibroblast Activation Protein with UAMC1110-Derived Probes.

Front Chem 2021 14;9:640566. Epub 2021 Apr 14.

Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.

Fibroblast activation protein (FAP) is a proline-selective protease that belongs to the S9 family of serine proteases. It is typically highly expressed in the tumor microenvironment (TME) and especially in cancer-associated fibroblasts, the main cell components of the tumor stroma. The exact role of its enzymatic activity in the TME remains largely unknown. Read More

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Prognosis of duodenal gangliocytic paraganglioma with lymph node metastasis: is follow-up >5 years required?

J Surg Case Rep 2021 May 4;2021(5):rjab159. Epub 2021 May 4.

Department of Anesthesiology, Robert Packer Hospital, Sayre, PA, USA.

Gangliocytic paragangliomas (GP) are rare tumors encountered exclusively in the second portion of the duodenum. Duodenal gangliocytic paraganglioma (DGP) belongs to a subclass of neuroendocrine neoplasms, characterized with unique histologic features of carcinoid tumor, paraganglioma and ganglioneuromas. According to the recent World Health Organization classification of gastrointestinal neuroendocrine tumors (NETs), there is a debate to classify them either as low-grade NETs or as an independent entity. Read More

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Ubiquitin-specific peptidase 53 inhibits the occurrence and development of clear cell renal cell carcinoma through NF-κB pathway inactivation.

Cancer Med 2021 Jun 11;10(11):3674-3688. Epub 2021 May 11.

Department of Urology, Huangshi Central Hospital (Affiliated Hospital of Hubei Polytechnic University), Edong Healthcare Group, Huangshi, P.R. China.

Background: Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent malignant diseases in the urinary system with more than 140,000 related deaths annually. Ubiquitination-deubiquitination homeostasis is an important factor in ccRCC progression; ubiquitin-specific peptidase 53 (USP53) belongs to the family of deubiquitinating enzymes, but its functions are rarely reported.

Methods: Databases obtained from GEO and TCGA were analyzed to reveal the role of USP53 in ccRCC. Read More

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The clinical significance and correlative signaling pathways of paired box gene 9 in development and carcinogenesis.

Biochim Biophys Acta Rev Cancer 2021 May 7;1876(1):188561. Epub 2021 May 7.

Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Rourkela, 769008, Odisha, India. Electronic address:

Paired box 9 (PAX9) gene belongs to the PAX family, which encodes a family of metazoan transcription factors documented by a conserved DNA binding paired domain 128-amino-acids, critically essential for physiology and development. It is primarily expressed in embryonic tissues, such as the pharyngeal pouch endoderm, somites, neural crest-derived mesenchyme, and distal limb buds. PAX9 plays a vital role in craniofacial development by maintaining the odontogenic potential, mutations, and polymorphisms associated with the risk of tooth agenesis, hypodontia, and crown size in dentition. Read More

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Interplay between SOX9 transcription factor and microRNAs in cancer.

Int J Biol Macromol 2021 May 3;183:681-694. Epub 2021 May 3.

Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa. Electronic address:

SOX transcription factors are critical regulators of development, homeostasis and disease progression and their dysregulation is a common finding in various cancers. SOX9 belongs to SOXE family located on chromosome 17. MicroRNAs (miRNAs) possess the capacity of regulating different transcription factors in cancer cells by binding to 3'-UTR. Read More

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The Role of LGR4 (GPR48) in Normal and Cancer Processes.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

Epigenectics Laboratory, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.

Leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) is a receptor that belongs to the superfamily of G protein-coupled receptors that can be activated by R-spondins (RSPOs), Norrin, circLGR4, and the ligand of the receptor activator of nuclear factor kappa-B (RANKL) ligands to regulate signaling pathways in normal and pathological processes. LGR4 is widely expressed in different tissues where it has multiple functions such as tissue development and maintenance. LGR4 mainly acts through the Wnt/β-catenin pathway to regulate proliferation, survival, and differentiation. Read More

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EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis.

Oncogene 2021 May 3;40(20):3610-3623. Epub 2021 May 3.

Department of General Surgery, Xiangya Hospital, Central South University (CSU), Hunan, Changsha, China.

Erythropoietin-producing hepatocellular receptor A2 (EphA2) is a key member of the receptor tyrosine kinase (RTK) family, while YES Proto-Oncogene 1 (YES1) is a non-receptor tyrosine kinase (nRTK) and annexin A2 (ANXA2) belongs to the calcium-dependent phospholipid-binding protein family annexins. Here, we show that EphA2, YES1, and ANXA2 form a signal axis, in which YES1 activated by EphA2 phosphorylates ANXA2 at Tyr24 site, leading to ANXA2 activation and increased ANXA2 nuclear distribution in gastric cancer (GC) cells. Overexpression (OE) of YES1 increases, while knockdown (KD) of YES1 or ANXA2 decreases GC cell invasion and migration in vitro and tumor growth in mouse models. Read More

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Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii.

Nat Commun 2021 05 3;12(1):2491. Epub 2021 May 3.

Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Medical College and School of Basic Medical Sciences, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Mycobacterium kansasii can cause serious pulmonary disease. It belongs to a group of closely-related species of non-tuberculous mycobacteria known as the M. kansasii complex (MKC). Read More

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LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis.

Mol Med 2021 05 1;27(1):44. Epub 2021 May 1.

Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, 410013, Hunan, China.

Background: Leucine rich repeat containing 4 (LRRC4), also known as netrin-G ligand-2 (NGL-2), belongs to the superfamily of LRR proteins and serves as a receptor for netrin-G2. LRRC4 regulates the formation of excitatory synapses and promotes axon differentiation. Mutations in LRRC4 occur in Autism Spectrum Disorder (ASD) and intellectual disability. Read More

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Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin.

Clin Transl Med 2021 Apr;11(4):e390

Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Ferroptosis is essential to regulate tumor growth and serves as a promising therapeutic target to lung cancer. Ubiquitin-specific protease 35 (USP35) belongs to the deubiquitinases family that is associated with cell proliferation and mitosis. In this research, we aim to elucidate the potential role and molecular basis of USP35 in lung cancer. Read More

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Myofibroblastoma of the breast: two case reports and literature review.

J Surg Case Rep 2021 Apr 22;2021(4):rjab133. Epub 2021 Apr 22.

Centro Integrato di Senologia, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Myofibroblastoma (MFB) is a relatively rare tumor of the breast parenchyma, which belongs to the family of the 'benign stromal tumor of the breast'. Two cases of MFB of the breast are described. Radiological imaging is nonspecific in MFB, and pathological examination of needle biopsy or surgically resected specimen is necessary for the diagnosis. Read More

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The Expression of Anti-Müllerian Hormone Type II Receptor (AMHRII) in Non-Gynecological Solid Tumors Offers Potential for Broad Therapeutic Intervention in Cancer.

Biology (Basel) 2021 Apr 7;10(4). Epub 2021 Apr 7.

GamaMabs Pharma, Centre Pierre Potier, F-31100 Toulouse, France.

The anti-Müllerian hormone (AMH) belongs to the TGF-β family and plays a key role during fetal sexual development. Various reports have described the expression of AMH type II receptor (AMHRII) in human gynecological cancers including ovarian tumors. According to qRT-PCR results confirmed by specific In-Situ Hybridization (ISH) experiments, AMHRII mRNA is expressed in an extremely restricted number of normal tissues. Read More

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