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Total saponins from Tupistra chinensis Baker inhibits growth of human gastric cancer cells in vitro and in vivo.

J Ethnopharmacol 2021 Jun 8:114323. Epub 2021 Jun 8.

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou 510006, China. Electronic address:

Ethnopharmacological Relevance: Tupistra chinensis Baker (syn. Rohdea chinensis), a antitumor folk herb mainly distributed in China, its rhizome has been historically used to treat gastric cancer. Studies showed that the steroidal saponins were the main bioactive components in the rhizome of T. Read More

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Neurobiol Learn Mem 2021 Jun 8:107478. Epub 2021 Jun 8.

Neuroscience Institute; Department of Psychology, Georgia State University, Atlanta, GA, 30303, USA.

Research involving human participants indicates that memories of recently eaten meals limit how much is eaten during subsequent eating episodes; yet, the brain regions that mediate the inhibitory effects of ingestion-related memory on future intake are largely unknown. We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memories of personal experiences, mediate the inhibitory effects of ingestion-related memory on future intake. Our research program aimed at testing this hypothesis has been influenced in large part by our mentor James McGaugh and his research on posttraining manipulations. Read More

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A pilot study on automatic 3D quantification of Barrett's esophagus for risk stratification and therapy monitoring.

Gastroenterology 2021 Jun 8. Epub 2021 Jun 8.

Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Div., John Radcliffe Hospital, University of Oxford, Oxford, UK;; Oxford NIHR Biomedical Research Centre, Oxford, UK;. Electronic address:

Background Aims: Barrett's epithelium measurement using widely accepted Prague C&M classification is highly operator dependent. We propose a novel methodology for measuring this risk score automatically. The method also enables quantification of the area of Barrett's epithelium (BEA) and islands which was not possible before. Read More

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WFDC2 promotes spasmolytic polypeptide-expressing metaplasia through the upregulation of IL33 in response to injury.

Gastroenterology 2021 Jun 8. Epub 2021 Jun 8.

Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea. Electronic address:

Background & Aims: WAP four-disulfide core domain protein 2 (WFDC2), also known as human epididymis protein 4 (HE4), is a small secretory protein that is highly expressed in fibrosis and human cancers, particularly in the ovaries, lungs, and stomach. However, the role of WFDC2 in carcinogenesis is not fully understood. The present study aimed to investigate the role of WFDC2 in gastric carcinogenesis using preneoplastic metaplasia models. Read More

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High-grade Papillary Early Gastric Carcinoma With High Risk for Lymph Node Metastasis and Poor Prognosis: A Clinicopathologic Study of 96 Cases Among 1136 Consecutive Radical Gastrectomies.

Am J Surg Pathol 2021 Jun 10. Epub 2021 Jun 10.

Departments of Pathology Oncology Gastroenterology of the Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Department of Pathology of the First Affiliated Hospital of Soochow University, Suzhou, China Department of Pathology and Laboratory Medicine of Veterans Affairs Boston Healthcare System, Harvard Medical School and Brigham and Women's Hospital, MA.

Papillary early gastric carcinoma (EGC) is believed to have a low risk of lymph node metastasis (LNM) and thus can be resected endoscopically. We observed anecdotally that some papillary EGC tumors showed conspicuous high-grade dysplastic features, but the significance of these observations is unknown. In this bicenter study we investigated papillary EGCs that were divided into high-grade (n=96) and low-grade (n=118) groups among 1136 consecutive EGC radical resection cases. Read More

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FHOD1 and FMNL1 formin proteins in intestinal gastric cancer: correlation with tumor-infiltrating T lymphocytes and molecular subtypes.

Gastric Cancer 2021 Jun 11. Epub 2021 Jun 11.

Institute of Biomedicine and FICAN West Cancer Centre, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520, Turku, Finland.

Background: Gastric cancer (GC) is the third most common cause of cancer death. Intestinal type GC is a molecularly diverse disease. Formins control cytoskeletal processes and have been implicated in the progression of many cancers. Read More

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Prognostic impact of surgery after chemotherapy for type 4 gastric cancer.

Surg Today 2021 Jun 11. Epub 2021 Jun 11.

Department of Onco-Biological Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.

Purpose: To assess the clinical indications for, and prognostic impact of surgery after, chemotherapy for type 4 gastric cancer.

Methods: The subjects of this retrospective study were 67 patients who received chemotherapy for type 4 gastric cancer. The patients were grouped into those with progressive disease (PD group) and those without PD (non-PD group), according to the tumor response to chemotherapy. Read More

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Low recurrence rate after endoscopic resection in non-ampullary duodenal lesions: A 16-year single-center retrospective study.

Medicine (Baltimore) 2021 Jun;100(23):e26267

Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.

Abstract: Endoscopic resection (ER) for non-ampullary duodenal lesions (NADLs) is technically more difficult than lesions of the stomach. However, endoscopic treatment of duodenal lesions has been increasingly performed in recent years. This study aimed to evaluate the efficacy and safety of ER for NADLs. Read More

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Effect of the physicochemical properties of zinc oxide sources on their bioavailability in broilers.

Br Poult Sci 2021 Jun 11. Epub 2021 Jun 11.

UMR BOA, INRAE, Université de Tours, F-37380, Nouzilly, France.

The bioavailability of a trace mineral source is related to its intestinal solubility (bioaccessibility), which in turn is determined by its physicochemical properties. It is still not clear which characteristics are more relevant in affecting solubility and bioavailability of mineral sources. Zinc oxide (ZnO) is a common feed additive used to supplement zinc in the diet of monogastric animals. Read More

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β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation.

Drug Deliv 2021 Dec;28(1):1093-1108

Department of Pharmacy, The Women University, Multan, Pakistan.

In this work, series of pH-responsive hydrogels (FMA1-FMA9) were synthesized, characterized, and evaluated as potential carrier for oral delivery of an antiviral drug, acyclovir (ACV). Different proportions of β-cyclodextrin (β-CD), chitosan (CS), methacrylic acid (MAA) and N' N'-methylenebis-acrylamide (MBA) were used to fabricate hydrogels free radical polymerization technique. Fourier transform infrared spectroscopy confirmed fabrication of new polymeric network, with successful incorporation of ACV. Read More

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December 2021

The expression and clinical significance of IQGAP3 in gastric cancer.

Minerva Gastroenterol (Torino) 2021 Jun 11. Epub 2021 Jun 11.

Department of General Surgery, The Third Affiliated Hospital of Soochow, Changzhou, China -

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TMSB10 can serve as a potential prognosis prediction biomarker and promotes the invasion and angiogenesis of gastric cancer.

J Gastroenterol Hepatol 2021 Jun 11. Epub 2021 Jun 11.

Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.

Background: The thymosin beta 10 (TMSB10) was originally identified from the thymus which plays a key role in the development of many cancers. However, the underlying molecular mechanisms of TMSB10 involved in GC have not been understood.

Methods: To determine the expression of TMSB10 in human GC tissues and illustrate whether it is correlated with the clinical pathologic characteristics and prognosis in GC patients. Read More

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Umbrella review of 42 systematic reviews with meta-analyses: the safety of proton pump inhibitors.

Aliment Pharmacol Ther 2021 Jun 11. Epub 2021 Jun 11.

Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.

Background: Proton pump inhibitors (PPIs) are widely used to treat and prevent acid-related disorders. Despite high efficacy, PPI safety has been increasingly scrutinised. However, no comprehensive review summarising investigations of various adverse events is available. Read More

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Comparing immunotherapies to other frequently used treatments of gastric cancer.

Expert Rev Clin Pharmacol 2021 Jun 11. Epub 2021 Jun 11.

Department of Oncology, San Bortolo General Hospital, AULSS8 Berica, Vicenza, Italy.

Introduction: Although standard doublet chemotherapy represents the upfront gold standard to increase survival and improve quality of life of gastric cancer patients, overall improvements in long-term outcomes are modest and novel treatments are urgently needed. Among these, immunotherapy is an increasingly attractive option.

Areas Covered: A number of clinical trials have shown that checkpoint inhibitors may be of value, but many unclear issues remain controversial and should be promptly untangled. Read More

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Mechanism on the Allergenicity Changes of α-Lactalbumin Treated by Sonication-Assisted Glycation during Gastroduodenal Digestion.

J Agric Food Chem 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330047, People's Republic of China.

Physical-assisted chemical modification is effective to reduce the allergenicity of α-lactalbumin (ALA). However, there are few in-depth studies on the allergenicity changes of physical-assisted chemical-modified ALA during digestion. The effect of gastroduodenal digestion on the allergenicity changes of ALA treated by sonication-assisted glycation was assessed. Read More

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Cutaneous metastases in a patient with adenocarcinoma of the stomach.

Indian J Dermatol Venereol Leprol 2021 May 31:1-3. Epub 2021 May 31.

Department of Medical Oncology, Tata Medical Center, Newtown, Kolkata, India.

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Correlation of gastrointestinal perforation location and amount of free air and ascites on CT imaging.

Abdom Radiol (NY) 2021 Jun 10. Epub 2021 Jun 10.

Department of Diagnostic, Interventional and Pediatric Radiology, INSELGROUP, Radiology Division SLS, University of Bern, Tiefenaustrasse 112, 3004, Bern, Switzerland.

Purpose: To analyze the amount of free abdominal gas and ascites on computed tomography (CT) images relative to the location of a perforation.

Methods: We retrospectively included 172 consecutive patients (93:79 = m:f) with GIT perforation, who underwent abdominal surgery (ground truth for perforation location). The volume of free air and ascites were quantified on CT images by 4 radiologists and a semiautomated software. Read More

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Depletion of Omega-3 Fatty Acids in RBCs and Changes of Inflammation Markers in Patients With Morbid Obesity Undergoing Gastric Bypass.

J Nutr 2021 Jun 10. Epub 2021 Jun 10.

Hackensack University Medical Center, Hackensack, NJ, USA.

Background: Bariatric surgery is considered the most effective treatment for severe obesity. Despite this wide success, bariatric surgery is associated with increased risks of nutritional deficiencies.

Objectives: To examine whether Roux-en-Y-gastric bypass (RYGB) alters essential fatty acid (FA) status and inflammation markers. Read More

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Interactions between and the Gastric Microbiome: Impact on Gastric Homeostasis and Disease.

Curr Opin Physiol 2021 Jun 24;21:57-64. Epub 2021 Apr 24.

Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717.

Like many seemingly inhospitable environments on our planet, the highly acidic human stomach harbors a diverse bacterial microflora. The best-known member of the human gastric flora, , causes a number of gastric diseases, including peptic ulcer disease and gastric adenocarcinoma. In the absence of infection, the gastric microbiota displays some features similar to the oral cavity with Firmicutes the most common phylum, followed by Proteobacteria and Bacteroidetes. Read More

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Constitutive expression of prochymosin B in .

Heliyon 2021 May 28;7(5):e07137. Epub 2021 May 28.

National Center for Biotechnology, 13/5 Kurgalzhynskoye Road, Nur-Sultan, 010000, Kazakhstan.

Camel chymosin can be efficiently employed to produce cheese. Traditionally the rennet enzyme produced by the glands of the fourth stomach of ruminant animals (abomassum) is used in cheese making. Full-length (Bactrian camel) prochymosin gene was synthesized and constitutively expressed in cells under glyceraldehydes-3-phosphate dehydrogenase (GAP) promoter. Read More

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Recent trend in gastric cancer treatment in the USA.

J Cancer Metastasis Treat 2018 Apr 26;4. Epub 2018 Apr 26.

Department of Gastrointestinal Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Gastric adenocarcinoma (GAC) is estimated as the fifteenth most common cancer in the USA. Incidence rate has been gradually decreasing, but prognosis remains dismal. For patients with locally advanced GAC (stage > T1B and < T4B), multimodality therapies, such as surgery, chemotherapy, and radiation therapy, are needed. Read More

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Data on the in-vitro digestibility of acid gels prepared from brewers' spent grain protein isolates.

Data Brief 2021 Aug 21;37:107160. Epub 2021 May 21.

Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST), 5 avenue des Hauts Fourneaux, L-4362, Esch-sur-Alzette, LUXEMBOURG.

Brewers' Spent Grain (BSG) is the primary waste of the beer brewing process, which comprises a plethora of nutritionally appealing ingredients such as proteins, dietary fibres, essential lipids and micronutrients. In our previous study [1], the acid-induced gelation capacity of BSG protein isolate as influenced by the thermal pre-treatment severity was systematically investigated. In the present work, we aimed at providing a dataset outlining the gastrointestinal fate of the acid gels under simulating pre-absorptive digestion conditions adopting the INFOGEST static in-vitro digestion protocol. Read More

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Human Gastric Cancer Stem Cell (GCSC) Markers Are Prognostic Factors Correlated With Immune Infiltration of Gastric Cancer.

Front Mol Biosci 2021 25;8:626966. Epub 2021 May 25.

Department of Science and Education, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.

The prognosis of patients with gastric cancer (GC) is still unsatisfying. Numerous markers of gastric cancer stem cells (GCSCs) have been identified and were thought to be related to cancer aggressiveness. However, the roles of GCSC markers in GC patients' prognosis and immune infiltration remain unknown. Read More

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Case Report: Complicated Meckel Diverticulum Spectrum in Children.

Front Surg 2021 25;8:674382. Epub 2021 May 25.

Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia.

Meckel diverticulum (MD) is the most common congenital anomaly of the intestines, with an incidence of 2% of the general population. It can present as various clinical features with complications and be life threatening if diagnosis is delayed and treatment late. We report three pediatric cases with complicated MD: one female presented with small-bowel obstruction, one male with peritonitis, and one female with severe iron-deficiency anemia, without gross gastrointestinal bleeding nor any ectopic gastric mucosa. Read More

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The CAGE-MiR-181b-5p-S1PR1 Axis Regulates Anticancer Drug Resistance and Autophagy in Gastric Cancer Cells.

Front Cell Dev Biol 2021 25;9:666387. Epub 2021 May 25.

Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, South Korea.

Cancer-associated gene (CAGE), a cancer/testis antigen, has been known to promote anticancer drug resistance. Since the underlying mechanisms of CAGE-promoted anticancer drug resistance are poorly understood, we established Anticancer drug-resistant gastric cancer cells (AGS ) to better elucidate possible mechanisms. AGS showed an increased expression level of CAGE and autophagic flux compared with anticancer drug-sensitive parental gastric cancer cells (AGS cells). Read More

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Overexpression of GUCY1A2 Correlates With Poor Prognosis in Gastric Cancer Patients.

Front Oncol 2021 25;11:632172. Epub 2021 May 25.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.

Background: Nitric oxide (NO) and cyclic guanosine phosphate (cGMP) play important roles in blood pressure regulation, neurotransmitter delivery, renal function, and tumorigenesis and development. The intermediate link of this signaling pathway, soluble guanylyl cyclase (sGC), is particularly important. However, the role of the GUCY1A2 gene encoding the sGC α2 subunit is unknown. Read More

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Post-transplant relapse of therapy-related MDS as gastric myeloid sarcoma: Case report and review of literature.

Leuk Res Rep 2021 14;15:100244. Epub 2021 May 14.

Department of Hematopathology and Lab Medicine, Moffitt Cancer Center, Tampa, FL, USA.

Introduction: Myelodysplastic syndrome (MDS) are hematologic neoplasms characterized by morphologic dysplasia and ineffective hematopoiesis in the bone marrow. The only potentially curative therapy is stem cell transplant. However, relapse remains a major challenge and is seen in about 25-40% of cases. Read More

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Helicobacter Pylori Eradication Therapy: Still a Challenge.

Cureus 2021 May 6;13(5):e14872. Epub 2021 May 6.

Physiology, Army Medical College, Rawalpindi, PAK.

Introduction Helicobacter pylori (H. pylori) infection is prevalent worldwide. H. Read More

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An Alternative Method for Treating Dumping Syndrome Using Hemoclips.

Cureus 2021 May 6;13(5):e14869. Epub 2021 May 6.

Gastroenterology and Hepatology, Istanbul Medeniyet University Göztepe Research and Training Hospital, Istanbul, TUR.

Surgeries for obesity can lead to complications. Dumping syndrome is one such complication caused by the quick passage of hyperosmolar chyme from the stomach to the duodenum. Mild cases can be cured with dietary modification and medical treatment. Read More

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